• Title/Summary/Keyword: 미만형

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Determination of Practical Dosing of Warfarin in Korean Outpatients with Mechanical Heart Valves (인공심장판막 치환환자의 Warfarin 용량결정)

  • Lee Ju Yeun;Jeong Young Mi;Lee Myung Koo;Kim Ki-bong;Ahn Hyuk;Lee Byung Koo
    • Journal of Chest Surgery
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    • v.38 no.11 s.256
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    • pp.761-772
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    • 2005
  • Background: Following the implantation of heart valve prostheses, it is important to maintain therapeutic INR to reduce the risk of thromboembolism. The objective of this study was to suggest a practical dosing guideline for Korean outpatients with prosthetic heart valves managed by a pharmacist-run anticoagulation service (ACS). Material and Method: A retrospective chart review was completed for all patients enrolled in the ACS at Seoul National University Hospital from March, 1997 to September, 2000. Patients who were at least 6 months post-valve replacement and had nontherapeutic INR value (less than 2.0 or greater than 3.0) were included. The data on 688 patients (1,782 visits) requiring dosing adjustment without any known drug or food interaction with warfarin were analyzed. The amount of adjusted dose and INR changes based on the INR at the time of the event were calculated. Aortic valve replacements (AVR) patients and mitral or double valve replacement (MVR/DVR) patients were evaluated separately. Result: Two methods for the warfarin dosage adjustment were suggested: Guideline I (mg-based total weekly dose (TWD) adjustment), Guideline II (percentage-based TWD adjustment). The effectiveness of Guideline 1 was superior to Guideline II overall in patients with both AVR and MVR/DVR. Conclusion: The guideline suggested in this study could be useful when the dosage adjustment of wafarin is necessary in outpatients with mechanical heart valves.

Incidence of congenital heart disease in the western part of Gyeongnam Province in Korea (서부경남 지역의 선천성 심질환의 발생 빈도)

  • Jang, Sun Hwa;Kim, Jae Hui;Yeom, Jung Sook;Park, Eun Sil;Seo, Ji Hyun;Lim, Jae Young;Park, Chan Hoo;Woo, Hyang Ok;Youn, Hee Shang
    • Clinical and Experimental Pediatrics
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    • v.51 no.8
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    • pp.848-855
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    • 2008
  • Purpose : The objective of this study was to ascertain the incidence of congenital heart disease in the western part of Gyeongnam Province in Korea. Methods : We enrolled 849 children (M:F=390:459) who were diagnosed with congenital heart disease (CHD) and received echocardiography during January 1997 to December 2005 in Gyeongsang National University Hospital. The subjects were limited to patients born from 1997 to 2004. The CHDs were classified into acyanotic types and cyanotic type. Further, acyanotic type CHDs were divided into shunt type and valvular types. Results : Numbers of initially diagnosed patients from 1997 to 2004 were as follows: 113, 128, 116, 104, 129, 97, 84, and 78. The median age of initially diagnosed CHD patients was 1 month in the acyanotic type and 0.5 months in cyanotic type. Also, an annual frequency among CHD types and gender ratio were no significant difference in every year. Incidences of CHD from 2000 to 2004 in the western part of Gyeongnam Province were 8.9, 12.7, 10.9, 10.0, and 9.7 per 1,000 live births, respectively. Conclusion : From 1997 to 2001, 100-130, and from 2002 to 2004, less than 100 patients were diagnosed with CHD. This showed a decrease in the numbers of CHD patients in the last three years. However, the Incidence of CHD was 0.89-1.24% during the last five years. Therefore, the decrease in the annual frequency of CHD was due to the recent decline in birth rate in Korea.

Proposal for Estimation Method of the Suspended Solid Concentration in EIA (환경영향평가에서 부유사 농도 추정 방법 제안)

  • Choo, Tai Ho;Kim, Young Hwan;Park, Bong Soo;Kwon, Jae Wook;Cho, Hyun Min
    • Journal of Wetlands Research
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    • v.19 no.1
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    • pp.30-36
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    • 2017
  • SS(Suspended Solid) concentration by soil erosion into river at normal and flood season should be measured. However, to present the variation of SS due to various development project such as EIA(Environmental Impact Assessment), River Master Plan, and so on, it is necessary to estimate not measure SS, but there are not exist how to estimate SS. In the present study, therefore, we propose the hydrologic method of estimating SS concentration using the results of particular frequency flood discharge and sediment discharge by RUSLE method. SS consists of silty and clay soil and colloid particle etc. However, in the present study, silty and clay soils of sediment discharge except send set up SS standards. The flow discharge to estimate SS concentration are 1~2 years for normal season, 30~100 years for flood season. Meanwhile, analysis software for probable rainfall uses Fard2006, probable rainfalls under 2-year frequency are estimated using rainfall data and frequency factor of Gumbel distribution. The results of estimating SS concentration using runoff volume by sediment and flow discharges of silty and cray soils as above method show that reliable level of SS concentration is considered in predevelopment of natural condition and under development of barren condition. Especially, SS concentration takes notice that the value of sediment discharge makes a huge difference according to channel slope, it was confirmed that the value obtained by dividing the SS concentration by the channel slope is relatively constant even though the topographical factors are different. Therefore, if the present study will be proceeded for various watersheds, it will be developed as estimation method of SS concentration.

The Radiotherapeutic Significance of Serum NSE Level in Non-Small Cell Lung Cancers(NSCLC) (비 소세포성 폐암의 방사선 치료에서 혈청내 NSE 치의 중요성)

  • Yun Sang Mo;Kim Sang Bo;Park In Kyu;Jung Tae Hoon
    • Radiation Oncology Journal
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    • v.12 no.1
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    • pp.73-80
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    • 1994
  • From December 1989 to February 1993, 108 patients with Non-Small Cell Lung Cancers(NSCLC) were studied retrospectively to evaluate radiotherapeutic significance of serum levels of NSE. We considered elevated serum neuron specific enolase(S-NSE) level as one of the neuroendocrine features in NSCLC. Histopathologic evaluation revealed 86 squamous cell carcinomas, 11 adenocarcinomas.3 large cell carcinomas, 3 mucoepidermoid carcinomas, and 5 unknown pathology. Eight Patients had stage 1,40 stage IlIA, and 60 stage lIIB.S-NSE level greater than 15 ng/ml was considered as elevated, and below this considered as normal. All patients recieved radiotherapy as primary treatment modality. The responders to radiotherapy had significantly higher mean S-NSE level than non-responders (28.5 ng/ml vs 20 ng/ml, p=0.01). Overall 2-year survival rate(YSR) was 23.6$ \% $. According to radiotherapy response, 2 YSR for Patients with CR, PR, and NR were 39.2$ \% $, 28.6$ \% $, and 6.2$ \% $ respectively(p=0.001). 2 YSR for patients with elevated and normal S-NSE were 14.6$ \% $ and 31.7$ \% $(p=0.02). The patients with NR showed no difference in survival according to S-NSE level. When we considered all patients, S-NSE level showed no significant impact on response. But for squamous cell carcinomas alone, patients with elevated S-NSE had more responders(80$ \% $ vs 61$ \% $, p=0.05). There was no correlation between tumor characteristics and S-NSE level. But the patients with elevated S-NSE had more patients with higher nodal stage, Based on our and other datas, NSCLC with neuroendocrine features have different response to treatment and clinical behavior compared to other NSCLC. Thus, this subgroup may need different treatment modality, and S-NSE level may have prognostic significance.

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The Prevalence of Obesity and Metabolic Abnormalities in Korean Pediatric Population (한국 소아 청소년에서 비만 및 대사 이상의 유병률)

  • Nho, Han-Nae;Kim, Cu-Rie;Uhm, Ji-Hyun;Kim, Jeong-Tae;Jin, Sun-Mi;Seo, Ji-Young;Hahn, Hye-Won;Park, Hwa-Young;Yoon, Hye-Sun;Ahn, Young-Min;Shon, Keun-Chan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.12 no.2
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    • pp.207-214
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    • 2009
  • Purpose: Childhood obesity can be complicated by hypertension, hyperlipidemia, non-alcoholic fatty liver disease, and diabetes mellitus. The aim of this study was to evaluate the prevalence of obesity and metabolic complications of children and adolescents based on the degree of obesity. Methods: We analyzed the records of 8,880 students who received student health examinations between May 2006 and October 2008 at the Eulji General Hospital. The prevalence of obesity was evaluated by the body mass index and obesity index. A total of 1,076 obese students had blood tests. We analyzed aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting glucose, total cholesterol, and blood pressure according to the degree of obesity. Results: According to the body mass index, the overall prevalence of obesity was 7.2% (7.8% of male and 6.5% of female students). Based on the obesity index, 12.3% of students (mild: 6.3%, moderate: 5.0%, and severe: 1.0%) were obese. The prevalence of hypercholesterolemia, ALT elevation, and hypertension were increased as a function of the degree of obesity (p<0.05), but hyperglycemia showed no significant differences (p=0.298). The overall prevalence of ALT elevation was 17.7% (mild obese group, 10.4%; moderate obese group, 20.5%; and severe obese group, 46.8%). The prevalence of hypercholesterolemia, hypertension, and hyperglycemia were significantly higher in the elevated ALT group (24.7%, 42.6%, and 5.2%, respectively) compared to the normal ALT group (11.1%, 29.8%, and 2.0%, respectively; p<0.05). Conclusion: Hypercholesterolemia, liver function test abnormalities, and hypertension were associated with the degree of obesity. We should focus our attention on managing obese children and adolescents to prevent metabolic complications.

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Safety Assessment of Oriental Medicines and Their Preparations (한약 및 한약제제의 안전성 평가)

  • Jeong, Il-Hyung;Kim, Jong-Hwa;Jeon, Jong-Sup;Cho, Sang-Hun;Park, Shin-Hee;Jo, Hyun-Ye;Kim, Young-Sug
    • Journal of Food Hygiene and Safety
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    • v.25 no.3
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    • pp.232-237
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    • 2010
  • This study was carried out to evaluate the safety of circulated oriental medicines and their related preparations in Gyeonggi-do. Total 366 samples (165 species) were analyzed about heavy metals, residual contents of sulfur dioxide ($SO_2$), and 68 samples were analyzed about preservatives. 17 samples (13 species, 4.6%) were exceeded the legal limit of heavy metal. The concentrations over the legal limit for Pb, Cd, As and Hg were 6.1~19.2 mg/kg, 0.4~0.7 mg/kg, 6.9 mg/kg and 0.7 mg/kg, respectively. In particular, the exceeding ratio (5.9%) of the legal limit of heavy metals in foreign products was 3.3 times more than domestic products (1.8%). 13 samples (10 species, 3.6%) exceeded the limit of residual sulfur dioxide and the concentration ranges were 105 to 428 mg/kg in domestic products, on the other hand foreign products were from 114 to 2,468 mg/kg. The mean concentration over the limit of residual sulfur dioxide of foreign products (804 mg/kg) was 2.4 times more than domestic products (338 mg/kg). In studying of the preservatives in oriental preparation, the contents of dehydroacetic acid (48.9~64.1%) in 3 samples of labeled solutions were under the labeled preservative contents and the contents of benzoic acid (139.9%) in 1 sample of labeled pill product was exceeded the labeled preservative contents. The numbers of the detected preservatives in unlabeled solutions, pills and granules were 4, 11 and 7, respectively.

Early Pulmonary Irradiation in Paraquat ($Gramoxone^{(R)}$) Poisoning (Paraquat 중독 환자에서 전폐 방사선치료의 효과)

  • Lee, Chang-Geol;Kim, Gwi-Eon;Suh, Chang-Ok
    • Radiation Oncology Journal
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    • v.13 no.4
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    • pp.321-330
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    • 1995
  • Purpose : To evaluate whether the early pulmonary irradiation can prevent or decrease the pulmonary damage and contribute to improve ultimate survival in paraquat lung. Materials and Methods : From Jun. 1987 to Aug. 1993, thirty patients with paraquat poisoning were evaluated. Fourteen of these patients were received pulmonary irradiation(RT). All of the patients were managed with aggressive supportive treatment such as gastric lavage, forced diuresis, antioxidant agents and antifibrosis agents. Ingested amounts of paraquat were estimated into three groups(A : minimal 50cc). Pulmonary irradiation was started within 24 hours after admission(from day 1 to day 11 after ingestion of paraquat). Both whole lungs were irradiated with AP/PA parallel opposing fields using Co-60 teletherapy machine. A total of 10Gy(2Gy/fr. x 5days) was delivered without correction of lung density. Results : In group A, all patients were alive regardless of pulmonary irradiation and in group C, all of the patients were died due to multi-organ failure, especially pulmonary fibrosis regardless of pulmonary irradiation. However, in group B, six of 7 patients($86{\%}$) with no RT were died due to respiratory failure, but 4 of 8 patients with RT were alive and 4 of 5 patients who were received pulmonary irradiation within 4 days after ingestion of paraquat were all alive though radiological pulmonary change. One patient who refused RT after 2Gy died due to pulmonary fibrosis. All 3 patients who were received pulmonary irradiation after 4 days after ingestion were died due to pulmonary fibrosis in spite of recovery from renal and hepatic toxicity Conclusion : It is difficult to find out the effect of pulmonary irradiation on the course of the paraquat lung because the precise plasma and urine paraquat concentration were not available between control and irradiation groups. But early pulmonary irradiation within 4 days after paraquat poisoning with aggresive supportive treatment appears to decrease Pulmonary toxicity and contribute survival in patients with mouthful ingestion of paraquat who are destined to have reversible renal and hepatic damage but irreversible pulmonary toxicity.

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Studies on Hilly Pasture Landscape Expectancy, Satisfaction of Tourist on Grassland Facility: A case Study of Yangtae Farm Visitor (산지목장 방문자의 목장 경관 기대와 목초지 및 초지시설 만족도에 관한 연구 : 양떼목장 방문객의 경우)

  • Kang, Dae-Koo;Lee, Hyo-Jin;Lee, Hyowon
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.37 no.1
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    • pp.68-79
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    • 2017
  • The objective of study was to find the relationship in hilly pasture landscape expectancy and tourist's satisfaction on grassland facility. It was followed by literature reviews and visitors' survey in Daegwallyeong Yangtte Farm on 31, July, 2014. 367 respondents were analyzed by F-test, t-test, Chi-square and Fisher's Exact Test at 0.05 level after data screening process. Computing factors were sex, marital status, age, academic career and occupation. The results was as followed; First, major respondents group of survey were in oder of woman, forty years old group, married office worker, and university graduate. Second, the expectancy for grassland was significant difference in age, but pasture color expectancy was not significant difference in gender, age, educational background, marital status, and there was significant difference in favorite grassland type with age, marital status. Third, favorite fence type was not significant difference along with all group of participants. However, color and material of fence was significant difference in marital status. Fourth, preferred ranch road was significant difference with occupation and marital status. There was significant difference in favorite grassland type near ranch road along with age and occupation type. Fifth, the mean satisfaction was 3.6 point in 5.0. Therefore, all respondents were generally satisfaction in visited. Tourists were more interested in ranch landscape than experience or contacts to animal.

Changes of Chemical Components in Persimmon Leaves during Growth for Processing Persimmon Leaves Tea (감잎차 제조를 위한 감잎의 성장시기별 함유 성분의 변화)

  • Chung, Sun-Hwa;Moon, Kwang-Deok;Kim, Jong-Kuk;Seong, Jong-Hwan;Sohn, Tae-Hwa
    • Korean Journal of Food Science and Technology
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    • v.26 no.2
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    • pp.141-146
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    • 1994
  • As a foundational study for processing persimmon leaves tea, the physico-chemical characters were investigated in persimmon leaves from Chungdo Bansi, Sagoksi, Kyungsan Bansi and Hiratanenasi during growth. Flesh weights increased rapidly until the middle of May and then decreased slightly. Moisture contents decreased continuously from $79{\sim}81%$ at the beginning of May during growth. Water soluble tannin contents reached $1.55{\sim}2.25%$, maximum values at the middle of May and at the beginning of June, and increased again at the middle of July and then decreased. Contents of catechins, precursor of condensed tannin, indicated $12{\sim}27\;mg%$ at the middle of May and reached $17{\sim}34\;mg%$, maximum values at the middle of June. Contents of catechin were low in order of (+)-catechin, (-)-epicatechin, (-)-epicallocatechingallate, (-)-epigallocatechin and (-)-epicatechingallate. Sugars present in persimmon leaves were composed of sucrose, glucose, fructose, raffinose and mannitol. Sucrose increased continuously, glucose and fructose decreased during growth. Raffinose content was less than 0.1%. Glucose and fructose took more than 90% until the beginning of May, and then sucrose took up $60{\sim}80%$ of total sugar contents. Total vitamin C contents indicated maximum values at the middle of May and at the beginning of June in Chungdo Bansi, Sagoksi and Kyungsan Bansi, maximum vaule at the middle of July in Hiratanenasi. From the basis of these data It was suggested that proper period for picking persimmon leaves prior to processing persimmon leaves tea was from the middle of May to the beginning of June. Since maximum values for most of chemical components occurred at the middle of May and at the beginning of June and persimmon leaves thicken after the middle of June.

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Study on the Stability Evaluation of Concrete Erosion Control Dam by using Non-destructive Test for Compressive Strength (콘크리트 비파괴시험법을 이용한 사방댐 안정도 평가에 관한 연구)

  • Park, Ki-Hyung;Kim, Min-Sik;Joh, Sung-Ho;Lee, Chang-Woo;Youn, Ho-Joong;Kim, Kyong-Ha
    • Journal of Korean Society of Forest Science
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    • v.102 no.1
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    • pp.90-96
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    • 2013
  • This study was conducted to investigate a stability trend within 6 above average and 4 blow average erosion control dams, which were selected by The Korean Association of Soil and Water Conservation and were built in 1990s in Gyeonggi and Gangwon Province. The study was aimed to measure rebound hardness of upstream face, flood way and downstream face from those dams selected by using 'Concrete Test Hammer'. The main purposes of the study are selection of compression strength prediction equation and scope of wavelength, which successfully demonstrate non-destructive test results for erosion control dams. There is an opportunity to increase disaster prevention ability when stability vulnerability of concrete erosion control dam is detected in a timely manner. Results of the compression strength investigation express that there is a consistency with visual inspection of stability that has been processed by The Korean Association of Soil and Water Conservation. We concluded that a prediction equation, which was developed by Architectural Institute of Japan (AIJ), shows highest suitability in Korean erosion control dams when stability investigation is performed. The detailed criteria for the test result are 'stable', 'detail inspection required' and 'poor' for over 300 $kgf/cm^2$, 250~300 $kgf/cm^2$ and below 250 $kgf/cm^2$ respectively. Standards for stability of Korean erosion control dam and a compression strength prediction equation (that corresponds to the standards of the stability) should be established on the basis of chronological data of erosion control dam compression strength. Systematical approach for stability inspection that carries out remodeling or repair when problem on erosion control structures are detected through visual inspection and simple stability test, is necessary for the future disaster prevention.