In this study, which is based on the findings of the preceding studies, the researchers determined social support and Career Decision Self-efficacy as the key influencing variables for the successful Career Preparation Activities, to analyze the relationship between Career Preparation Activities and these variables, while identifying the mediating effect of Career Decision Self-efficacy in the relationship between social support and Career Preparation Activities. In addition, there is an objective to provide effective career counseling materials. For this study, a total of 174 North Korean adolescent defectors, who were in their middle and high schools, were interviewed and the resultant data were analyzed the data based on the questionnaire data of 204 copies from March 12 to 19, 2019. For the analysis of the data, SPSS and AMOS statistical suites were used to verify the hypothesis. The result of the analysis showed that, first, in the relationship between the social support, Career Decision Self-efficacy, and Career Preparation Activities of the North Korean adolescent defectors social support, Career Decision Self-efficacy, and Career Preparation Activities were all positively related. Especially, Career Decision Self-efficacy has been identified as the variable that is highly related to Career Preparation Activities. Second, rather than social support(${\beta}=.107$), Career Decision Self-efficacy(${\beta}=.388$) turned out to have more profound direct influence on Career Preparation Activities. Third, social support did not influence Career Preparation Activities directly(${\beta}=.107$, p>.05) but completely intermediated Career Decision Self-efficacy to influence Career Preparation Activities(Indirect effect=.307, p<.05, Z-value=2.924, p<.01). The findings of this study show that, in order to enhance the Career Preparation Activities of the North Korean adolescent defectors, it is necessary to examine how they perceive the emotional, informational, material, and evaluative supports from the surrounding environment are perceived and identify the abilities, values, and career desires of themselves through a behavioral planning that can establish a professional and value system in accordance with them.