• Journal of Life Science
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• v.18 no.11
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• pp.1600-1605
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• 2008

This study was performed to verify the gene expression of 3T3-L1 using the siRNA of the aromatase gene, which is the estrogen synthesis enzymes. First of all three pairs of siRNA were designed from the CYP19A1 (aromatase) and analyzed the formation of fat cell mechanism by transferring gene to 3T3-L1 and differentiating it. As a result, the expression of leptin gene, which is the main gene causing the obesity, was controlled and the cause of the obesity is related with the insulin specifically. The overexpression of adiponectin and adipsin was observed. This result showed that the formation of the fat was controlled a little without any side effect by obstructing a specific material out of all the signal systems in the fat formation. This study will be an important clue to make it clear that the lack or overexpression of estrogen might be the cause of fat formation mechanism.

• Journal of The Geomorphological Association of Korea
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• v.19 no.3
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• pp.83-96
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• 2012

The origins of beaches at Byeonsan Peninsular, as a pocket type, are classified to a sand barrier type and wave-cut type. The beaches had developed by the deposition of the silt and clay layers on the 10m height from sea level in the inner bay during climax era of postglacial transgression. At that time, some sands had blown toward the inland hills to form aeolian deposits. After postglacial sea-level stabilization, sometimes, there has been the negative budget of beach materials. Recently, beaches have been transformed by human impact such as construction of Saemangeum sea-wall, especially in the Byeonsan and Gosapo beaches being close to the sea-wall. So the speed of tidal currents become slower and comparatively depositoinal activity stronger. And the level of chemical weathering has been higher. In Byeonsan beach, the ratio of coarse sand decreased with higher ratio of finer materials and by beach erosion dissected runnels developed, running parallel to the coastline. In Gosapo beach, supply of suspended materials are increased through the Garyeok drainage gate, the sands tend to be finer.

• Journal of Life Science
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• v.32 no.9
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• pp.734-741
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• 2022

Currently, around 40 million people worldwide are living with human immunodeficiency virus (HIV) infection making HIV a critical global health risk. Present therapies for HIV infection consist of drug cocktails that target different steps of the HIV life cycle to prevent infection, replication, and release of the virus. Due to its mutating nature, drug resistance coupled with side-effects of long-term drug use, novel strategies, and pharmaceuticals to treat and manage HIV infection are constant needs and continuously being studied. Plants allocate a major repertoire of chemical diversity and are therefore regarded as an important source of new bioactive agents that can be utilized against HIV. Since the early 1990s, upon recommendations of the World Health Organization, numerous studies reported phytochemicals from different structural classes such as flavonoids, coumarins, tannins and terpenes with strong inhibitory effects against HIV infection. The present review gathered and presented recent research (2021-present) on plant extracts and phytochemicals that exhibit anti-HIV properties with the aim of providing insights into future studies where ethnomedical and underutilized plant sources may yield important natural products against HIV. Considering the relation and importance of HIV treatment with current viral infection risks such as SARS-CoV-2, screening plants for anti-HIV agents is an important step towards the discovery of novel antivirals.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.4
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• pp.16-38
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• 2018

Objectives: The objective of this in vivo study is to observe the anti-osteoporotic activities of Gojineumja aqueous extracts (GJEJ) on the ovariectomized (OVX) mice as compared to those of risedronate sodium (RES). Methods: Thirty five days after bilateral OVX, GJEJ was orally administered, for 35 days once a day and then the changes on the body weight and gain during experimental periods, femur weights, bone mineral density (BMD), bone strength (failure load), mineral contents - calcium (Ca) and inorganic phosphorus (IP), histological profiles and histomorphometrical analyses at sacrifice were conducted with serum biochemistry - osteocalcin contents and bone specific alkaline phosphatase (BALP) activities. And the results of GJEJ were compared with RES orally administered OVX mice. Results: As a result of OVX, noticeable increase of body weight and gains and serum osteocalcin levels, decrease of serum BALP activities, femur weights, femur Ca and IP contents, BMD and strength were observed as compared to those of sham control mice, respectively. Also, the decrease of all histomorphometrical indices indicating the bone mass and structure, and the increase of indices about resorption were also detected in the femur of OVX control. However, these estrogen-deficient osteoporotic signs were significantly and dose-dependently inhibited by 35 days of continuous oral treatment of GJEJ, at dose levels of 500, 250 and 125 mg/kg, respectively. Especially, GJEJ 500 mg/kg showed favorable inhibitory activities against estrogen-deficient osteoporosis symptoms induced by OVX as comparable to those of RES 2.5 mg/kg. Conclusions: The results in this study suggest that oral administrations of GJEJ have clear dose-dependent favorable anti-osteoporotic activities in OVX mice.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.431-431
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• 2016

J 호소는 1942년도에 충청남도 아산시 선장면에 설치된 농업용 저수지로서, 현재 COD, TN, TP 모두 등급외의 수질상태를 보이고 있다. J 호소 상류 유역은 축산농가가 다수 위치하고 있으며, 설치된 지 70년이 지난 노후화된 저수지로 고농도의 오염물질 유입뿐만 아니라 호소 바닥의 오염 퇴적물에 의한 내부 부하가 중요한 수질오염원이 되고 있다. 호소의 수질은 현재 COD 10.6~16.5 mg/L, Chl-a $75mg/m^3$ 이상으로 수질오염도가 매우 높으며, 특히 늦봄에서 초가을까지 외기온도 상승 및 저수율 저하와 함께 부영양화 증가, 녹조 대발생 등으로 호 내 물고기 대량 폐사 및 악취발생 등으로 민원이 다수 발생하고 있다. 이러한 현상의 직접적인 원인은 수중의 DO 농도 결핍이며, 따라서 수중의 DO 농도를 일정수준 이상으로 유지시켜 주는 것은 호소 수질관리를 위해 매우 필요하다고 판단된다. 본 연구에서는 공기 중의 산소를 호소 수체에 포기시켜 주는 마이크로버블 발생장치를 J 저수지에 설치하여 수체의 DO 농도 변화 등을 분석하였고, 본 연구결과는 농업용 호소의 수질개선을 위한 기술개발 및 계획수립의 기초자료로 활용하고자 하였다. 마이크로버블 포기장치는 수심이 약 4m 되는 저수지 제방 근처에 100m 간격으로 총 3지점에 설치하였다. 버블 발생기는 기액 2상류 선회형 마이크로 버블 발생장치로 3지점에 각 1set(1set에 3기로 구성)씩 구성하여 저수지 바닥 층에서 상부로 1m 떨어진 지점에 고정식으로 설치하였다. 총 공기흡입량은 380 LPM이며, 사용동력은 12.2kW를 사용하였다. 마이크로 버블 포기장치 설치 후 호 내 DO 농도 변화를 평가하기 위하여 호소 전체에 18개 지점을 선정하여 수심 50cm 간격으로 DO 농도를 측정하였다. 가동 전에는 DO 평균농도가 표층에서는 약 7.7mg/L로 나타났고, 수심에 따라 거의 수직적으로 감소하여 바닥층에서는 약 0.2mg/L로 거의 무산소 상태를 보이고 있었다. 마이크로 버블 가동 2주 후에는 수심 3m까지의 모든 수층에서 DO 농도가 약 6.0mg/L 이상을 보였고, 바닥층에서는 DO 약 3.4mg/의 농도를 나타내었다. 가동 3주 후에도 2주 후와 비슷한 수치를 보이고 있었으나 가동 4주가 지나면서부터는 호소 바닥층(수심 3.5m)에서도 DO 농도가 7.0mg/L 이상의 높은 농도를 유지하는 것으로 조사되었다. 호소 저층에서 호기성 상태의 지속적 유지는 퇴적 오염물질이 수층으로 용출되는 것을 예방할 수 있으므로 마이크로버블을 잘 활용하면 호소의 악취제거 및 수질개선에 많은 도움이 될 것으로 판단된다.

• The Journal of the Petrological Society of Korea
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• v.25 no.3
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• pp.261-281
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• 2016

Our knowledge of the lithosphere beneath the Korean Peninsula has been improved through petrologic and geochemical studies of upper mantle xenoliths hosted by Quaternary intraplate alkali basalts from Jeju Island. The xenoliths are mostly spinel lherzolites, accompanied by subordinate harzburgite and pyroxenites. The mantle xenoliths represent residual mantle material showing textural and geochemical evidence for at least a three-stage evolution, fractional partial melting, recrystallization, and metasomatism. Their composition primarily controlled by early fractional melt extraction and porphyroclastic and mylonitic fabrics formed in a shear-dominated environment, which was subsequently modified by residual slab-derived fluids (or melts). Modal metasomatic products occur as both anhydrous phase(orthopyroxene) and hydrous phase (phlogopite). Late-stage orthopyroxene is more common than phlogopite. However, chemical equilibrium is evident between the primary and secondary orthopyroxene, implying that the duration of post-metasomatic high temperatures enabled complete resetting/reequilibration of the mineral compositions. The metasomatic enrichment pre-dates the host Jeju Quaternary magmatism, and a genetic relationship with the host magmas is considered unlikely. Following enrichment in the peridotite protolith in the mantle wedge, the upper mantle beneath proto-Jeju Island was transformed from a subarc environment to an intraplate environment. The Jeju peridotites, representing old subarc fragments, were subsequently transported to the surface, incorporated into ascending Quaternary intraplate alkali basalt. The result of this study implies that long term material transfer in the transformation of geotectonic setting from a subarc to intraplate may have played a significant role in the evolution of lithospheric mantle, resulting in the enriched mantle domains, such as EM I or EM II in the lithospheric mantle beneath East Asia.

• Journal of Food Hygiene and Safety
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• v.38 no.3
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• pp.79-88
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• 2023

Trifludimoxazin is a triazinone herbicide that inhibits the synthesis of protoporphyrinogen oxidase (PPO). The lack of PPO damages the cell membranes, leading to plant cell death. An official analytical method for the safety management of trifludimoxazin is necessary because it is a newly registered herbicide in Korea. Therefore, this study aimed to develop a residual analysis method to detect trifludimoxazin in five representative agricultural products. The EN method was established as the final extraction method by comparing the recovery test and matrix effect with those of the QuEChERS method. Various sorbent agents were used to establish the clean-up method, and no differences were observed among them. MgSO₄ and PSA were selected as the final clean-up conditions. We used LC-MS/MS considering the selectivity and sensitivity of the target pesticide and analyzed the samples in the MRM mode. The recovery test results using the established analysis method and inter-laboratory validation showed a valid range of 73.5-100.7%, with a relative standard deviation and coefficient of variation less than 12.6% and 14.5%, respectively. Therefore, the presence of trifludimoxazin can be analyzed using a modified QuEChERS method, which is widely available in Korea to ensure the safety of residual insecticides.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.18-44
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• 2017

Purpose: The object of this study was to observe the anti-climacterium activity of Gagamguibiondam-tang (GGOT) on ovariectomized (OVX) rats, a well-documented rodent models resembles with women postmenopausal climacterium symptoms, as including cardiovascular diseases, obesity, hyperlipidemia, osteoporosis, organ steatosis and mental disorders. Methods: In this study, anti-climacteric effects were evaluated separated into three categories; 1) anti-obese, 2) anti-uterine atrophy and 3) anti-osteoporotic effects. Five groups were used (8 rats in each group); sham control, OVX control, GGOT 500, 250 and 125 mg/kg administered groups. Twenty-eight days after bilateral OVX surgery, GGOT were orally administered, once a day for 84 days, and then the changes on the body weight and gain during experimental periods, serum estradiol levels, abdominal fat pad and uterus weights with histopathology of abdominal fat pads (total thickness and mean adipocyte diameters) and uterus (total, epithelial and mucosal thickness, percentages of uterine gland regions) for anti-obese and estrogenic effects. In addition, femur, tibia and fourth or fifth lumbar vertebrae (L4 or L5) wet, dry and ash weights, mineral density (BMD), bone strength (failure load), serum osteocalcin and bone specific alkaline phosphatase (bALP) contents, histological and histomorphometrical analyses - bone mass and structure with bone resorption, were monitored for anti-osteoporosis activity. Results: As a result of OVX, noticeable increases of body weight and gains, food and water consumption, weights of abdominal fat pad deposited in dorsal abdominal cavity, serum osteocalcin levels were demonstrated in this experiment with decrease of uterus, femur, tibia and L5 weights, serum bALP and estradiol levels. In addition, marked hypertrophic changes of adipocytes located in deposited abdominal fat pads, uterine disused atrophic changes, decreases of bone mass and structures of femur, tibia and L4 were also observed in OVX control rats with dramatic increases of bone resorption markers, the Ocn and OS/BS at histopathological and histomorphometrical analysis in this study as compared with sham-operated control rats, suggesting the estrogen-deficient climacterium symptoms - obese and osteoporosis were induced by OVX, respectively. However, these estrogen-deficient climacterium symptoms induced by bilateral OVX in rats were significantly inhibited by 84 days of continuous oral treatment of GGOT 500, 250 and 125 mg/kg, respectively. Especially, GGOT 500, 250 and 125 mg/kg showed clear dose-dependent inhibitory activities on the OVX-induced climacterium signs. Conclusion: The results suggest that oral administration of GGOT 500, 250 and 125 mg/kg has clear dose-dependent favorable anti-climacterium effects - estrogenic, anti-obese and anti-osteoporotic activities in OVX rats in this experiment.

• Journal of Korean Philosophical Society
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• no.123
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• pp.137-185
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• 2018

This article aims to deconstruct the mechanism of male domination that constantly reproduces the hegemonic class of men. In order to overcome misogyny, we should no longer deny the ontological dimension of the reality of women's oppressions and the pre-eminence of the material condition of women's existence. In addition, the possibility of the category of women as a modality of resistance should be taken into consideration. First, I will highlight the correlation between penis and phallus according to which the phallus refers to the penis which is malleable and fragile and which disappears without being castrated by the external factor. From here we could deduce the fragility and imperfection, the non-absoluteness of the phallic order. Secondly, I will analyze the mechanism of penis-narcissism, which is the modality of the constitution of the individual identity of man. The penis is not only a physiological organ, but a site of self-estimation and the validity of the succession of power and authority of the father's law. With this penis-narcissism, man is constituted as a hegemonic body that can let itself go without worrying about the reactions of others. Thirdly, I will focus on the mechanism of the penis-cartel which is the modality of the formation of the collective identity. The penis-cartel is reinforced by the mutual affirmation of the superiority of men among themselves, but also by the permission and the tacit agreement of their absurdity and lack of rationality and corruption. Because the privilege of men is not monopolized by a small part of the elite, but is consciously and unconsciously shared by all men who are part of the hegemonic and collective category. In order to deconstruct the penis-narcissism and the penis-cartel, it is necessary to demonstrate that the penis is not a self-sufficient body, nor a closed and impermeable body, but that it is a porous body where the organ serves both ejaculation and urinary ejection. The penis is a porous body that is at once the site of sublimity and degradation, purity and impurity. In addition, the penis is no longer an all-powerful and aggressive organ, but it is a malleable and fluid flesh that constantly changes its shape. Linked to a phallus-organ that is the notion of Jacques-Alain Miller, it is a site of deficiency and vulnerability that is not the axis of the penis-cartel. It is through the notion of the double porosity of the penis and the phenomenology of the flesh of the penis, I try to provide the modality of undoing the reproductive mechanism of predatory masculinity. Because this would be an effective strategy to overcome misogyny.

• Journal of the Mineralogical Society of Korea
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• v.18 no.3 s.45
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• pp.165-181
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• 2005

The granitic rocks distributed in the southern part of the Yangsan Fault are classified into five distinct rock facies based on the field relation, petrography and geochemical characteristics. These five different rock facies can be grouped into two considering their origins. Group I, which reveals various evidences of magma mixing, includes three rock facies of granodiorite, enclave-rich porphyritic granite, and enclave-poor porphyritic granite. Group H intruding Croup I includes equigranular granite and micrographic granite with no evidence of magma mixing. It is suggested that the distinctively different trace element and isotopic chemistries between group I and II, support evolution from the different parental magma. It is suggested that the three rock facies in group I were generated by different degrees of magma mixing in addition to fractionation of plagioclase. MMEs experienced fractionation of biotite. The two facies in group H seem to have been generated from different parent magma from group I and evolved by fractionation of K-feldspar. The Rb-Sr whole-rock ages of the group I rocks yield $59.2\~58.9Ma$, and those of the group II rocks give 53. $3\~51.7Ma$, regardless of their distribution whether they occur in the eastern or western parts of the Yangsan Fault. Based on Sm-Nd isotope compositions, depleted mantle model ages $(T_2DM)$ of the group I range $0.8\~0.9Ga$, while those of the group II$0.6\~0.7Ga$.