• Polymer(Korea)
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• v.29 no.3
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• pp.288-293
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• 2005

Osmotic granule system which is one of the drug delivery systems has been developed to improve manufacturing process and other problems of tablet osmotic systems. It consists of water swellable seed layer, nifedipine drug layer, and drug release controlled membrane layer and manufactured by fluidized bed coater. The granule size and mombrane thickness can be controlled by various amounts of seed and coating solution, respectively. It could be observed that the morphology of osmotic granule was different at each coating step as well as type of coating solution. The bigger the size of granule, the slower the release rate was observed due to decreasing the total specific surface wed of granule. Also, it was observed that the increase of membrane thickness was caused to retard the dissolution of nifedipine due to decreasing the water absorption rate. The drug solubility for dissolution media is greatly affected to nifedipine release. From these results, we assured that osmotic granule can be fabricated by fluidized bed coating methods, and the appropriate release profile could be controlled by the controlling of bead size, membrane thickness and dissolution media.

• Polymer(Korea)
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• v.29 no.3
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• pp.260-265
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• 2005

The initial burst of drug release is an important role in the controlled delivery of drug having hish toxicity and narrow therapeutic ranges. Nanosphere composed of monolayer could not achieve precisely controlled drug release because of the initial burst of drug on surface. In this study, double layered nanosphere was prepared for sustained drug delivery without initial burst. Double layered nanosphere composed of dextran and PLGA was fabricated by using conventional W/O/W double emulsion method. To control surface tension on the outer layer of nanospheres, PVA was used as a surfactant. Release behavior of dextran as model drug was observed as the $3{\times}1$mm wafers formed by compression mould in the deionized water for 7 days. Double layered nanosphere has sustained release behavior, in contast to single layered nanospheres. such as mechanical mixture and dextran nanospheres. Especially, nanosphere containing PVA $0.2\%$ has shown nearly the zero-order release profile. As a result of this study, double layered nanospheres has more sustained release profile of drug without the initial burst and the release behavior of dexoan on tile double layered nanospheres was controlled by the contents of PVA as a surfactant.

• Journal of the Korean earth science society
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• v.22 no.5
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• pp.415-422
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• 2001

Studies of atmospheric general circulation in the troposphere and stratosphere are very important to understand the influence of human activities on the global climate and its change. Recently, the existence of an annual cycle in the circulation has been reported by a number of studies. In this study, the residual mean meridional circulation is calculated by the TEM momentum and continuity equations for the period from December 1985 to November 1995 (10 years), and the long-term variations of the circulation and mass fluxes across the 100hPa surface are examined. The multiple regression statistical model is used to obtain quantitatively the long-term variations. This study is focused especially on mean meridional circulation in the troposphere and stratosphere associated with ENSO (El Ni${\tilde{n}}$o-Southern Oscillation) which is known as a cause of the unusual weather, global climate, and its change. The results show that the global scale troposphere-stratosphere mean meridional circulation is intensified during El Ni${\tilde{n}}$o event and QBO (quasi-biennal oscillation) easterly phase and weakened during La Ni${\tilde{n}}$o event and QBO westerly phase. The signal of Mount Pinatubo volcanic eruption in June 1991 is obtained. Due to the volcanic eruption the global scale troposphere-stratosphere mean meridional circulation is abruptly intensified.

• Journal of the Korean earth science society
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• v.28 no.7
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• pp.747-761
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• 2007

This study is to develop teaching aids and materials for geological fieldwork and to maximize their effects in educating high school students in Korea. The site of geological fieldwork, Kyokpo Chaeseokgang area, is located in Byunsan national park in Jeonbuk Province. The sedimentary succession of Chaeseokgang developed in the era of Cretaceous shows large-scale and distinct sedimentary structures on sea cliffs. In this study, teaching aids and materials of earth science for secondary-level students were developed based on the sedimentary structures of Chaeseokgang. A 5-step teaching model of earth science fieldwork was applied to a group of 13 students, who had been involved in clubs related to earth science in a science high school, using teaching aids and materials developed in this study. The teaching aids and fieldwork-related materials were also presented to a group of 37 students, who did not take fieldwork or fieldwork-related classes during the period of the study. The results of this study showed that the use of fieldwork-related aids and materials was effective in helping the students in both groups improve their self-directed teaming and practical understanding of earth science.

• Journal of the Korean earth science society
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• v.38 no.6
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• pp.405-420
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• 2017

We investigated the H I, He II and O III emission lines of the symbiotic star AG Peg, using the spectroscopic data secured at different phases in three periods at the Lick Observatory. We measured FWHM and the intensity of six O III Bowen lines and studied the efficiency of fluorescence mechanism. The mean FWHM of O III normal and Bowen lines observed during three time periods did not make much difference, while Bowen line intensities are about 4.0 times higher than the normal lines. Comparing the predicted and the observed ratios, we found that the observed intensities are higher than predicted intensities, except for O III ${\lambda}$ 3759.87. The O III ${\lambda}$ 3791.26 and 3754.67 intensity ratios observed only in 2001 are in good agreement with the predictions by Saraph and Seaton (1980). We obtained the Bowen efficiency parameter (R)=0.47 for 2002, but we could not find R for the other two periods of time. Because of this, based on the 2002 efficiency result, we calculated the intensity ratio of O III normal and Bowen lines relative to He II ${\lambda}$ 4685.68 and derive the efficiency variation with time period. The result showed that the efficiency is the highest in 1998 and the lowest in 2001. We conclude that the efficiencies with phase are caused by the electron temperature changes in the ionized gas. The efficiencies of AG Peg are likely to increase along with electron temperature. Our analysis results may be useful in understanding the physical conditions of the ionized shell in symbiotic star and the intensity ratio and efficiency variation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.398-411
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• 2020

This study explored the case of non-face-to-face classes at colleges initiated in the Corona 19 environment. The scope of this study was to analyze the learning development process of the non-face-to-face class case facing the Corona 19 environment in university classrooms in terms of class and learning content, interaction, assignment activity, and teaching-learning activities. It was conducted for first-year students at H University's Early Childhood Education Department of Startup Basic Course. Study results found that, first, interest in entrepreneurship increased as learning content. Second, as a result of exploring the teaching and learning process, there is no significant difference in understanding the content or achieving learning goals. Third, the most regrettable thing about non-face-to-face teaching-learning is the lack of interaction activities. Fourth, the students finished by adapting to the new non-face-to-face teaching-learning environment. In the future, a non-face-to-face environment platform should be established, and studies that can deal with new perspectives and approaches, such as an educational interaction system including online and offline, should be continued.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2007.12a
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• pp.141-142
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• 2007

In recent years, the rate of mean sea level rise is increasing rapidly from the phenomena of global warming, together with the increasing trend of the storm scale. The issue of sea level rise is multifaceted and produces a range of environmental problems. Especially, high tides and the tidal currents become higher, and wave base increases, so the energy received at the coastal boundary may increase. This brings that many coastal environments go into disequilibrium, such as damages to the structures, erosion, and deposition Similarly it was known that the problems of nearshore processes and damage of berth and counter facilities during storm period had appeared at the small fishery port. Here we try to analyze the impact of the rearrangement of counter facilities and berth layout adopted for tranquility of its'inner harbor. Because this harbor is being connected to channel and open sea, the rearrangement of the structures might affect to the current speed and direction and wave height, so do to the sea bottom undulation. Therefore, we made model test for the several layouts of the berth and breakwater in this area.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.2
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• pp.242-251
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• 2010

In comparison with other terrestrial ecosystems, rice paddies are unique because they provide the primary food source for over 50% of the world's population, and act as major sources of global methane. The present paper summerizes a long-term field study that combine carbon isotopes, and canopy-scale flux measurements in an irrigated rice paddy, in conjugation with continuous monitoring of environmental, and vegetational factors. Both $CO_2$, and methane fluxes were largely influenced by soil temperature, and moisture conditions, especially across drainage events. Soil-entrapped $CO_2$, and methane showed a gradually increasing trend throughout growing season, but rapidly decreased upon flood water drainage. These variations in flux were well correlated with changes in concentration, and isotope ratio of soil $CO_2$, and methane, and of atmospheric $CO_2$, and methane within, and above the canopy. The isotopic signature of the gas exchange process varied markedly in response to change in contribution of soil respiration, belowground storage, fraction of $CO_2$ recycled, magnitude, and direction of $CO_2$ exchange, transport mechanism, and fraction of methane oxidized. Our results clearly demonstrate that stable isotope analysis can be a useful tool to study underlying mechanisms of gas exchange processes under natural conditions.

• Journal of Christian Education in Korea
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• v.63
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• pp.407-433
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• 2020

South Korea is currently facing multiculturalism, appropriately demanding broadened view and access to the study of Unification, especially in terms of who should be the subject. In congruence, recent Unification Education studies are proposing values stressed in Multiculturalism to function as the core ground, upon which other traits and contents are to follow. Similarly, Christian Education field is also reflecting the recent trend, welcoming 'everyone' to participate in preparing reunification of Korean Peninsula. However, most studies consist of suggesting and introducing directions for new approaches, not so much of dealing with systems or guidelines for practical practices. Information provided in fragments can rather cause confusion in understanding the concept, and lack of specific guidelines can soon lead to poor performances. In this study, Universal Design for Learning (UDL) is introduced as a methodology to be examined, whether it could effectively embody and systemize the newly emerged Multicultural Christian Unification Education. Therefore, the purpose of this study is 1) to generalize the concept of Christian unification education introduced in the multicultural era and 2) examine whether UDL is suitable for uniformizing and spreading the Multicultural approach of Christian Unification Education. Specifically, this study highly focused on examining whether UDL is a suitable methodology to achieve the goal of Multicultural Christian unification education, while uniformizing the diversities within multicultural Christian Unification Education. Through a thorough research, it was proved that the purpose and characteristics of multicultural Christian unification education are similar to those of UDL in that both focus on accepting heterogeneity as something "different" rather than something "wrong." Also, it was found that the application of the theory and guidelines of UDL can effectively unify while respecting the diverse methodologies used in Multicultural Christian Education.

• Development and Reproduction
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• v.13 no.2
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• pp.79-87
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• 2009

Due to its well-known function in parturition and milk ejection, oxytocin (OT) has been considered as a 'female neurohypophyseal hormone'. Recent studies, however, clearly indicate that OT has some local roles in male reproduction via both central and peripheral routes. In experimental rodents, OT is released within distinct brain regions in response to social stimuli, and the brain OT receptor (OTR) mediated actions were strongly involved in the regulation of a variety of male behaviors such as mating-associated behaviors. In particular, OT and/or OTR knockout mice provide important clues about the molecular regulatory mechanism of the socio-sexual behaviors. Several lines of evidence also show that OT is synthesized within rodents testis, epididymis and prostate, and the presence of OTRs in these organs. In rodent testes, OT might have a role in the modulation of steroidogenesis via stimulation of the conversion of testosterone (T) to dihydrotestosterone (DHT) by 5alpha-reductase. Similar effects of OT on this androgen conversion were observed in epididymis and prostate suggesting the OT's modulatory role, such as contractility induction, in these androgen-dependent organs. In this context, further investigations on the OT's role in male CNS and reproductive organs are likely to provide better understanding on the complex socio-sexual behaviors and a platform for development of therapeutics to treat some psychological and/or andrological problems.