• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.222-230
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• 2023

Objectives: This study reports the effectiveness of acupuncture and moxibustion for Diabetic Peripheral Neuropathy concurrent with Chemotherapy-Induced Peripheral Neuropathy. Case presentation: A 58-year-old male was admitted for hand numbness and foot pain after his sixth chemotherapy. He was treated with acupuncture and moxibustion for 18 days. Symptoms were evaluated with a numeric rating scale (NRS). After 18 days of treatment, his foot pain improved from NRS 4 to NRS 2. His hand numbness disappeared. Conclusion: This study suggests that acupuncture and moxibustion can be used for managing diabetic peripheral neuropathy concurrent with chemotherapy-induced peripheral neuropathy.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.470-476
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• 2018

Facial motor evoked potential (FMEP) by multi-pulse transcranial electrical stimulation (mpTES) can complement free-running electromyography (EMG) and direct facial nerve stimulation to predict the functional integrity of the facial nerve during cerebello-pontine angle (CPA) tumor surgery. The purpose of this paper is to examine the standardized test methods and the usefulness of FMEP as a predictor of facial nerve function and to minimize the incidence of facial paralysis as an aftereffect of surgery. TES was delivered through electrode Mz (cathode) - M3/M4 (anode), and extracranially direct distal facial muscle excitation was excluded by the absence of single pulse response (SPR) and by longer onset latency (more than 10 ms). FMEP from the orbicularis oris (o.oris) and the mentalis muscle simultaneously can improve the accuracy and success rate compared with FMEP from the o.oris alone. Using the methods described, we can effectively predict facial nerve outcomes immediately after surgery with a reduction of more than 50% of FMEP amplitude as a warning criterion. In conclusion, along with free-running EMG and direct facial nerve stimulation, FMEP is a useful method to reduce the incidence of facial paralysis as a sequela during CPA tumor surgery.

• Journal of Life Science
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• v.27 no.5
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• pp.600-610
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• 2017

It was common that the classification of itching was classified into four categories according to the neurophysiological mechanisms of pruritoceptive itching, neuropathic itching, neurogenic itching and psychogenic itching. Recently it was classified by clinical criteria. The neurotransmission pathway of itch is divided into histamine-dependent pathway and histamine-independent pathway. Different receptors and neuropeptides act on each itch mediator. Itch mediators such as histamine, BAM8-22, and chloroquine are transmitted through the histamine-dependent pathway. Cowhage spicule, protease, and TSLP (Thymic stromal lymphopoietin) have been reported to be related to the histamine-independent pathway. These itch mediators, receptors, and neuropeptides are the targets of treatment for itching. Although itching and pain are typical noxious stimuli, and in the past, it was argued that two senses were transmitted through one noxious stimulus receptor. It has recently been shown that itching and pain have an independent neurotransmitter system and both neuronal systems inhibit each other. In addition, the mutual antagonism between itching and pain is explained by various mechanisms. Recently, many new mediators and receptors are being studied. The studies on histamine 4 receptor (H4 receptor) have been actively conducted. And the H4 receptors are expressed in immune cells such as T cells. The therapeutic agent for blocking the H4 receptor can inhibit the inflammatory reaction itself, which is important for the itching and chronicization. Understanding the underlying mechanisms of itching and studying new itch mediators will lead to the development of effective therapies, and this is what I think the itching study will go on.

• Clinical and Experimental Pediatrics
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• v.46 no.2
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• pp.128-136
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• 2003

Purpose : Hyper IgM syndrome(HIGM) is characterized by severe recurrent bacterial infections with decreased serum levels of IgG, IgA, and IgE but elevated IgM levels. Recently, it has been classified into three groups; HIGM1, HIGM2 and a rare form of HIGM. HIGM1 is a X-linked form of HIGM and has now been identified as a T-cell deficiency in which mutations occur in the gene that encodes the CD40 ligand molecule. HIGM2 is an autosomal recessive form of HIGM. Molecular studies have shown that the mutation of HIGM2 is in the gene that encodes activation-induced cytidine deaminase(AID). Recently, another rare form of X-linked HIGM syndrome associated with hypohydrotic ectodermal dysplasia has been identified. We encountered a patient with a varient form of HIGM2. To clarify the cause of this form of HIGM, we evaluated the peripheral B cells of this patient. Methods : The lymphocytes of the patient were prepared from peripheral blood. B cells were immortalized with the infection of EBV. Cell cycle analysis was done with the immortalized B cells of the patient. Peripheral mononuclear cells were stained with monoclonal anti-CD40L antibody. Total RNA was extracted from the peripheral mononuclear cells. After RT-PCR, direct sequencing for CD40L gene and HuAID gene were done. Immunostainings of a lymph node for CD3, CD23, CD40, Fas-L, bcl-2, BAX were done. Results : The peripheral B cells of this patient showed normal expression of CD40L molecule and normal sequencing of CD40L gene, and also normal sequencing of AID gene. Interestingly, the peripheral B cells of this patient showed a decreased population of G2/mitosis phase in cell cycles which recovered to normal with the stimulation of IL-4. Conclusion : We suspect that the cause of increased serum IgM in this patient may be from a decrease of G2/mitosis phase of the peripheral B cells, which may be from the decreased production or secretion of IL-4. Therefore, this may be a new form of HIGM.

• Journal of Acupuncture Research
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• v.25 no.3
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• pp.87-94
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• 2008

Objectives : This study was to compare the effect of moxibustion therapy on peripheral facial para- lysis according to location of acupoint. Methods : We investigated 41 cases of inpatients with Peripheral Facial Paralysis, and divided them into two groups, One group was treated by moxibustion on local point(ML), and the other was treated by moxibustion on distant point(MD). We evaluated the effect of moxibustion in each group by using Gross Grading System of House-Brackmann(HB score) and Yanagihara's Unweighed Grading System(Y score). Results : 1. In ML and MD, compared with baseline, at final, HB score was significantly decreased and Y score was significantly increased. 2. At final, ML showed significant decrease on HB score and significant increase on Y score compared with MD. Conclusions : These results suggested that ML should be more useful for improving symptoms related with peripheral facial paralysis than MD.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.41-49
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• 2009

Objectives : This study was designed to evaluate the effect of Soyeom Pharmacopuncture on postauricular pain accompanied acute peripheral facial paralysis. Methods : We observed thirty peripheral facial palsy inpatients with postauricular pain at Cheonan oriental hospital of Daejeon university from Jan. 1st, 2009 to July 31th, 2009. These inpatients were divided into two groups; Group A was treated using general treatment and Group B was treated using general treatment and Soyeom Pharmacopuncture on the posterior ear area. Results : 1. Postauricular pain was significantly decreased in Group B. 2. Duration of postauricular pain was significantly reduced in Group B. 3. Improvement of facial paralysis was not significantly different between Group A and Group B. Conclusions : Soyeom Pharmacopuncture has significant effects on a postauricular pain accompanied with peripheral facial paralysis.

• Journal of Acupuncture Research
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• v.24 no.3
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• pp.1-8
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• 2007

Objectives : This study was to evaluate the influence of dysgeusia on prognosis of peripheral facial paralysis. Methods: We investigated 40 cases of patients with Peripheral Facial Paralysis, and classified them as existence of dysgeusia. we evaluated the treatment effect of each group by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System before treatment and after final treatment. Results: 1. Postauricular pain showed the highest frequency in symptoms at onset. 2. As a result of evaluation by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System, treatment score after final treatment was marked higher than that before treatment within each group. 3. After final treatment, non-dysgeusia group showed signficant difference on Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System compared with dysgeusia group. Conclusions: These results suggested that non-dysgeusia group should be get better than dysgeusia group in the patient with peripheral facial paralysis.

• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.648-655
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• 2009

Peripheral neuropathy is a disease of multiple Peripheral nerves. Tingling, pins-and needles, numbness, burning and raw sensation are symptoms of peripheral neuropathy. These symptoms are frequently complained by patients who suffered from obstructive syndrome of Ki and blood (痺證). This case was reported to evaluate the effects of oriental medicine therapy on a patient with obstructive syndrome of Ki and blood (痺證). The subject was a female patient who had obstructive syndrome of Ki and blood (痺證). She complained of calf pain, cold sense, walking discomfort, insomnia, dyspepsia, anorexia etc. We administered the medicine with dispeling the cold pathogenic factor (寒邪), adjusting the constructive and defensive energy (調營衛), tonifying the Ki and blood (補氣血) by stage. After the treatment, the symptoms improved. This case suggests that oriental medicine therapy can be applicable to improve in symptoms with Peripheral neuropathy.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.119-125
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• 2011

Objectives : This study was to investigate the effectiveness of cupping therapy on peripheral facial paralysis. Methods : We investigated 39 cases of patients with peripheral facial paralysis, and devided patients into two groups : We treated one group by complex oriental medical treatment with cupping therapy, and did the other group by complex oriental medical treatment without cupping therapy. To evaluate the effectiveness of treatment applied for two groups, we used gross grading system of House-Brackmann(HB score), Yanagihara's unweighed grading system(Y score) at baseline and final. Results : 1. In cupping group and non-cupping group, compared with baseline, at final, HB score was significantly decreased and Y score was significantly increased. 2. At final, cupping group showed significant decrease on HB score and significant increase on Y score compared with non-cupping group. Conclusions : Cupping therapy can be available for relieving symptoms related with peripheral facial paralysis.

• The Journal of Korean Medicine
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• v.31 no.4
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• pp.164-170
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• 2010

Objective: This study aimed to produce an overview of RCT for treatments of diabetic peripheral neuropathy. Method: All RCT studies for treatments of diabetic peripheral neuropathy were selected via PubMed. The general trend of RCT number, subject and result, including Oriental medicine, were analyzed. Result: A total 147 RCT studies were found. The number of RCT has rapidly increased since 2003. 114 RCTs were conducted with western drugs, while RCTs with electrical stimulation and Oriental medicine were eight and ten respectively. All RCTs with acupuncture, moxibustion and herbal drugs showed positive results. Conclusion: Oriental medicine-derived RCTs for diabetic peripheral neuropathy are very rare, even their potential was sufficient. This study may provide valuable information for development of Oriental medicine against diabetic peripheral neuropathy in the future.