• Title/Summary/Keyword: 만성 손상

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특집 : 미세혈관 합병증 - 당뇨병은 혈관병 - 당뇨병은 혈관에 어떤 영향을 미칠까?

  • 사단법인 한국당뇨협회
    • The Monthly Diabetes
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    • s.259
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    • pp.14-16
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    • 2011
  • 당뇨병을 장기간 앓게 되면 혈관이 분포한 모드 조직 또는 기관을 침범하는 임상 증후군이 발생하는데 이를 당뇨병의 만성 합병증이라고 부른다. 당뇨병 만성 합병증의 기본적인 병리생리는 혈관 질환이며 침범하는 장기와 혈관의 크기에 따라 다음과 같이 분류된다. 눈에 생기는 망막증, 신장에 생기는 신장병증, 신경 특히 말초신경에 발생하는 신경병증들은 미세혈관의 손상에 따라 발생하므로 미세혈관 합병증이라고 부르며 심장에 생기는 협심증, 뇌혈관 경색으로 대표되는 뇌졸중, 하지 동맥폐색증은 대혈관 합병증이라고 부른다.

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Effect of Celecoxib on Lung Injury Improvement by Controlling Epithelial-Mesenchymal Transition(EMT) in Chronic Obstructive Pulmonary Disease(COPD) (만성폐쇄성폐질환에서 상피중간엽이행 조절을 통한 Celecoxib의 폐 손상 개선효과)

  • Lee, Sun-Kyung
    • Journal of Convergence for Information Technology
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    • v.11 no.11
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    • pp.248-255
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    • 2021
  • This study confirmed the effects of improving lung damage of celecoxib using an animal model of chronic obstructive pulmonary disease(COPD). It was induced in models LPS + CSE and performed in vitro and in vivo. MTT assay and real-time PCR were performed in MRC5 cells as in vitro, and mRNA expression, BALF, collagen content, and protein expression were confirmed as in vivo. Celecoxib reduced the number of inflammatory cells, cytokine and soluble protein accumulation in BALF, decreased body weight and lung weight in animal models, and improved lung collagen deposition. In addition, the reduction of EMT markers was confirmed through Western blotting and real-time PCR. Consequently, celecoxib is thought to improve lung damage of COPD induced to LPS+CSE by regulating EMT.

Throwing injury of elbow

  • 최창혁
    • 대한정형외과스포츠의학회:학술대회논문집
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    • 2003.11a
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    • pp.158-166
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    • 2003
  • 반복적인 투구동작은 성장기의 주관절에 손상을 주기 쉬우며 투구 시 통증을 유발할 경우, 투구를 중지하고 관절의 능동적 휴식을 통해 유연성을 회복하고 점차 근력강화운동을 시행해야 한다. 유소년기 Little league elbow의 주된 병변인 상완골 내상과 골단염을 포함한 대부분의 손상은 보존적 요법으로 치료가 가능하며, 굴곡구축 등의 운동제한을 동반한 통증이나 관절 내 유리골편 등의 감입으로 인한 증상이 있을 경우 수술적 치료를 요하며, 성인의 경우 내측 측부인대의 만성 불안정성 둥에 대해서 인대 재건술 등의 수술적 치료가 고려된다. 투구 시 주관절의 손상은 대부분의 경우 과 사용으로 인한 것이며, 특히 성장기에 손상의 예방이 무엇보다 중요하다. 따라서 부모와 코치 그리고 경기 관계자 둥이 성장기 소년의 근력과 관절의 상태가 성인과 다름을 이해하고, 운동의 강도와 횟수를 적절히 조절하며 손상시 조기치료를 받을 수 있는 환경을 조성하는 것이 필요하다.

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Risk Factors for Renal Function Impairment Following Radiofrequency Ablation of Renal Tumors (신장 종양 고주파 절제술 이후 신장 기능 저하의 위험요소)

  • Il Cheol Park;Seong Kuk Yoon;Dong Won Kim
    • Journal of the Korean Society of Radiology
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    • v.83 no.2
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    • pp.317-330
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    • 2022
  • Purpose To evaluate the various factors that affect renal function following percutaneous radiofrequency ablation (RFA) therapy in patients with renal tumors. Materials and Methods Between 2010 and 2018, 91 patients diagnosed with renal tumors using ultrasonography and CT-guided RFA were enrolled. We retrospectively investigated the serum creatinine (SCr) level and estimated glomerular filtration rates immediately prior to RFA and during post-treatment follow-up. The patients were divided into two groups based on the degree of change in SCr level (0.3 mg/dL). Group comparisons were performed using univariable and multivariable logistic regression analyses to determine the factors impacting renal function. Results Impaired renal function was associated with solitary kidney, chronic kidney disease (CKD) over stage 3, and pyeloureteral injury. Sex, age, other cancers, tumor size, location, growth pattern, and proximity to the collecting system were not significantly associated with impaired renal function. There was a difference in the overall change over time between the association with and without solitary kidney, CKD stage 3, and pyeloureteral injury. Conclusion Among the medical conditions present prior to RFA, solitary kidney and CKD over stage 3 could be considered as risk factors for impaired renal function. Post-procedural pyeloureteral injury can also be considered a risk factor.

Scar Formation of the Chronic ACL Rupture (만성 전방 십자 인대 파열의 반흔 형성)

  • Choi Eui-Seong;Won Choong-Hee;Kim Yong-Min;Seo Joong-Bae;Lee Ho-Seung;Lee Sin-Ro
    • Journal of the Korean Arthroscopy Society
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    • v.5 no.1
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    • pp.17-21
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    • 2001
  • Purpose : To analyze changes of the anterior translation, MRI findings and associated injuries at scarring of the torn ACL in the chronic ACL rupture. Materials & Method : From Dec. 1996 to May 2000, 19 patients who were diagnosed as the chronic ACL rupture were studied. We analyzed KT-2000 side to side difference of maximal manual anterior displacement(MMAD), MRI findings and associated injuries. Results : There was statistically significant difference in the average MMAD between the 7 cases$(37\%)$ with scar formation$(2.78{\pm}2.41mm)$ and the 12 cases without scarring$(5.75{\pm}2.52mm)$. The chronic ACL rupture without scarring had more meniscal injuries$(67\%)$ than with scarring$(28\%)$. MRI showed that relatively straight bands toward expected insertion site with single large fragment(5 cases) and continuous band with focal angulation(2 cases). Conclusion : If relatively straight bands toward expected insertion site with single large fragment or continuous band with focal angulation on MR imaging is showed in the patient without significant anterior translation at arthrometer, the possibility of the scar formation of the torn ACL should be considered. We think that the chronic ACL rupture with scarring had less meniscal injuries than without scarring will give additional information on the natural history of ACL injuries.

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The Determinants of Community Service Utilization Among Family Caregivers of the Impaired Older Persons (만성질환 및 기능손상노인 가족수발자의 재가복지서비스 이용 결정요인에 관한 연구)

  • Lee, In-Jeong
    • Korean Journal of Social Welfare
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    • v.56 no.3
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    • pp.183-205
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    • 2004
  • This Study explored three issues in regard to the determinants of community service utilization among family caregivers of the dependent older persons. First, the differences between users and nonusers of community services were compared regarding to predisposing, enabling, need characteristics of the primary caregiver as well as the elder care recipient. Second, the variables which determined the contact of community services were examined. Third, the influence of the variables on duration of the community services among users was also examined. The data collected from 164 family caregivers were used for analyses. Findings suggest that community service users had higher education and higher emotional support, lower family income than nonusers. The level of cognitive impairment of the elder was also higher for users than nonusers. The entry into community services is more likely for elders cared for by caregivers who have higher educational attainment, lower family income and lower level of instrumental support. Once interaction terms for relationship between need factors and social support are entered, caregivers with poorer level of his/her perceived physical health and lower level of instrumental support are more likely to report use of community services. Among those reporting contact with services, more extensive use occurs for caregivers with lower emotional support and lower depression. The entry of interaction terms for relationship between need and support reveals that the combination of lower support(instrumental and emotional) and elder's greater physical impairment are associated with longer period of community service use. However, the effect of caregivers' depression followed the different pattern. For caregivers with greater depression, more supports are related with more service utilization. According to the results, implications for research and practice are discussed.

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Effects of the Inspiratory Muscle Strengthening Training on the Respiratory Functions and the Quality of Life in Patients with Cervical Spinal Cord Injury Patients (들숨근 훈련이 경수손상환자의 호흡기능 및 삶의 질에 미치는 영향)

  • Shim, Yu-Jin;Moon, Ok-Kon;Choi, Wan-Suk;Kim, Bo-Kyung
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.11
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    • pp.1785-1792
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    • 2013
  • For patients suffering from spinal cord injuries, both of the possibility of having complications with the respiratory system and the related fatal rate are still high, while pneumonia is the most important cause of these fatalities. This research was carried out to find out what effects does a breathing exercise have on the respiratory functions and the improvement in the quality of life. The study was carried out for male patients suffering cervical spinal cord injuries for the purpose of inspiratory muscle strengthening. The objects of the study were 17 non-smoking-at-present male patients with C4 to C6 cervical spinal cord injuries. They had practiced inspiratory muscle strengthening training for three times a week for six weeks. The quality of life and the dyspnea (breathing difficulty) were self-measured before and after the training. As a result, the change in respiratory function was only significantly reduced (p<0.01) within the chronic group. In terms of the changes in the quality of life, the sub-acute group has only seen a significant improvement (p<0.05) for the VT(vitality), while the chronic group has seen significant improvements(p<0.05, p<0.01) in: GH(general health); BP(back pain); and VT(vitality). In this research, the inspiratory muscle strengthening has reduced the dyspnea (breathing difficulties) and improved the quality of life.

Perforation of IVC by Chest Draings Tube -Report A Case (흉강삽관술시 하대정맥 천공 치험 1례)

  • Jeong, Won-Seok;Mun, Dong-Seok
    • Journal of Chest Surgery
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    • v.30 no.11
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    • pp.1128-1131
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    • 1997
  • Injuries to versa cave continue to be associated with a high mortality. Essentials to successful treatment are immediate recognition of the injury and prompt control of the hemorrhage. We have experienced one case of inferior versa java perforation by a chest rainage tube in the patient with post-operative chronic empyema thoracic. The patient was 38-year old male who was taken RLL lobectomy after 6 cycle of chemotherapy due to small cell carcinoma in the RLL & suffered from post-operative chronic empyema thoracis at D hospital. He moved to our hospital for further evaluation with accidental removal of chest drainge tube. We inserted closed drainage tube and dark blood gushed out abruptly just after insertion of the drainage tube. CTscan, MRI, and angiogram were performed and showed the perforation of IVC just below RA. The IVC was repaired using simple interrupted 4-0 Prolene suture through right posterolateral thoracotomy. The patient recovered without event and doing well until now.

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Spur-like Lesion on the Lateral Tibial Condyle - A Sign of Chronic ACL tear - (경골 외과의 골극 유사 병변 - 만성 전방 십자 인대 파열의 징후 -)

  • Cho Sung-Do;Ko Sang-Hun;Hwang Su-Yeon;Yang Jung-Hun
    • Journal of the Korean Arthroscopy Society
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    • v.7 no.2
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    • pp.201-205
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    • 2003
  • Purpose : Authors experienced cases of chronic ACL tear with spur-like lesion on the tibial condyle which is different from the lateral capsular sign and degenerative change and evaluated the significance of 'spur-like lesion' in relations with chronic ACL injury. Material and Method : We have 5 patients with spur-like lesion on the lateral tibial condyle in simple radiogram. The location, shape and size of the lesion were studied using radiogram and MRI. Cause of injury, associated injury and chronicity of the ACL tear were analyzed. All 5 patients were male, and mean age was 33.8 $(17\~46)$ years. Result : The spur-like lesion was located from 3.8 mm(avg.) below the articular surface of the lateral tibial condyle to the apex of the fibular head and protruded laterally or inferolaterally from just posterior to the Gerdy's tubercle with a round or sharp-end triangular shape. Average length was 6 mm and average width ortho base was 9.2 mm. The cause of injury were sports jnjury 4 cases and traffic accident in one. The chronicity of the ACL tear was average 10.7(8 months$\~$23 years) years and medial meniscus tear was shown in all cases and lateral meniscus tear in three. Conclusion : We suggest that a patient who has a history of trauma with spur-like lesion on the lateral tibial condyle of the knee is expected to have chronic ACL tear.

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Analysis of sports injuries among Korean national players during official training (국가대표 선수들의 훈련 기간 동안 발생한 스포츠 손상 분석)

  • Kim, Eun Kuk;Kim, Tae Gyu
    • Journal of the Korean Data and Information Science Society
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    • v.25 no.3
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    • pp.555-565
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    • 2014
  • The purpose of this study was to analyze sports injuries which occurred in Korea National Team during official training period. All sports injuries are recorded on injury report form by physicians, medical staffs and athletic trainer, and only acute and recurred injuries were analyzed. Total 3,421 injuries were reported, and 1,560 injuries were newly incurred and 1,861 injuries were recurrent with previous history. The frequency of new injuries in male and female athletes was highest in boxing (n=130, 14.5%) and hockey (n=75, 11.3%) respectively. The frequency of recurred injuries in male and female athletes was highest in wrestling (n=147, 14.8%) and fencing (n=103, 11.9%) respectively. Our data provides incidence rates, characteristics of acute and recurrent sports injuries during official training period and thus these results could provide relevant information for the sports injury prevention at Korea National Team player.