• Journal of Nutrition and Health
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• v.26 no.1
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• pp.3-12
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• 1993

This study was performed to investigate effects of dietary fat content and degree of saturation on the function of the immune system. Sixty male BALB/c mice average-weighing 17g were divided into three dietary groups: 5% safflower oil group, 20% safflower oil group, 19.3% beef tallow & 0.7% safflower oil group. Food intake and body weight were measured every day. At 4th, 7th, 10th week after dietary treatment, organ weight measurements, delayed-type hypersensitivity test, plaque forming cell test, agglutination test, differential white cell count and histological examination of spleen were performed. Results are follows; 1) Body weight, food intake and calorie intake were not different in the three dietary groups during the experimental period($\alpha$=0.05). 2) Liver weight was significantly higher in 5% safflower oil group($\alpha$=0.05). Spleen index was slightly higher in mice fed 5% safflower oil and 19.3% beef tallow & 0.7% safflower oil. Thymus index in all mice was decreased by aging. 3) Delayed-type hypersensitivity of the mice fed 5% safflower oil and 19.3% beef tallow & 0.7% safflower oil was significantly higher than that of the mice fed 20% safflower oil. 4) The number of plaque forming cell was significantly reduced at 10th week compared to 7th week in all group($\alpha$=0.05). Although there was no difference in plaque forming cell among three groups at 10th week, 5% safflower oil group showed slightly higher plaque forming cell than 20% safflower oil group at 7th week. 5) At 4th week, agglutination test seems to be higher in 5% safflower oil group and 19.3% beef tallow & 0.7% safflower oil group compared to 20% safflower oil group. 6) Percentage of neutrophil and eosinophil was slightly reduced in 20% safflower oil group. 7) Spleen tissue was not affected by and dietary treatments. According to our results, the higher the fat content & unsaturation of the diet the lower the cell-mediated immunity of the mice. Humoral-immunity did not appear to be affected by the dietary manipulation. However humoral-immunity was decreased significantly by aging in all dietary groups.

• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.776-783
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• 2009

This paper is related to a 2D virtual color hairstyler using skinny smudge tool. The smudge tool is the popular graphic tool embedded in Adobe Photoshop. The smudge tool is used to smear paint on your canvas. The effect is much like finger painting. You can use the smudge tool by clicking on the smudge icon and clicking on the canvas and while holding the mouse button down, dragging in the direction you want to smudge. A disadvantage of previous smudge tool is to also smear pixels in the undesired region according to generating the target image as blending all pixels in a diameter of the master. In this paper to reduce the disadvantage, the skinny smudge tool based on the image segmentation for a master shape is proposed. The proposed skinny smudge tool has the advantage of applying the smudge effect to the desired regions regardless of the background as the master shape adhered closely to the contour shape is extracted by color image segmentation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.457-462
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• 2004

Anti-wrinkle effect of N-Acetyl-D-glucosamine (NAG) was evaluated by collagen synthesis and proliferation of normal human fibroblast. NAG was obtained by purifying deacetylated chitin which can be derived from chitin-rich crab shell. We studied in in-vitro cultures of human normal fibroblast, whether synthesis of collagens and fibroblast growth activation in these cells can be enhanced in the presence of NAG. It 야d not show any adverse effects in human shin irritation patch test. In in-vivo mouse test, it showed anti-wrinkle effect in hairless mouse (6W/F). From the HPLC analysis, the stability of NAG in the cosmetics product could be maintained for a long time. These results demonstrated that NAS can be useful anti-wrinkle cosmetic ingredient.

• The Transactions of the Korea Information Processing Society
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• v.3 no.5
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• pp.1082-1092
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• 1996

The design of distrbuted systems is difficult to achieve as the execution patterns of distrbuted systems are typically more complex than those of non- distributed systems. Thus, research toward the development of design methods for distributed systems is quitely needed. As object-oriented systems and distrbuted systems share similar properties, the combination of these two is somehow natural. In this work, a design of distributed systems is introduced. The goal of the method in this paper is to provide assistance to the process of specifying a formal object- oriented specification from graphical representation specification inputs such as data flow diagrams, state transition diagrams and Petri nets. It addresses the extraction of objects, operations and reationshipsfrom the problem domain with emphasis on the specification of the characteristics of distributed systems. This object identification method is supported by a knowledge base that provides for the automated analysis and reasoning about objects and their relationsships. The final object model is represented in a format which provides a formal mechanism for reprsenting the object information.

• Journal of Korean Biological Nursing Science
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• v.2 no.1
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• pp.49-63
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• 2000

Aflatoxin $B_1(AFB_1)$ is a potent hepatotoxic and hepatocarcinogenic mycotoxin in human beings. It is accumulated in animal tissues and injured cell through variable metabolic pathway. This study was conducted to determine the effect of antioxidant vitamins on liver function enzymes and hepatic damage of $AFB_1$ treated mice. The 6 weeks old male ICR mice were randomly separated 6 groups, vehicle solvent or vitamin C(10 mg/kg/day) and vitamin E(63.8 mg/kg/day) were administered by intraperitoneal(i.p.) injection and 1 hr later, vehicle solution(DMSO) or $AFB_1$(0.4 mg/kg) were injected. The results obtained as follow ; The levels of liver function enzymes such as GOT, GPT, LDH, and alkaline phosphatase, in sera of mice were remarkably elevated by treatment with $AFB_1$ only. However, those enzymes were significantly alleviated by co-treatment with antioxidant vitamins(p<0.01). Especially the levels of LDH and ALK phosphatase were similar to those of control groups(p<0.01). The transmission electron microscopy(TEM) image of intracellular microrganelles on the liver cell of mice was also degenerated extremely by treatment with $AFB_1$, but vitamin C and vitamin E gave good effects on cellular deformation. The intracellular microrganelles such as mitochondria, endoplasmic reticulum, nucleus and nucleic membrane were nearly disappeared the cellular deformation by antioxidant vitamins co-administration. With above results, we could estimated that antioxidant vitamins blocked AFB1 induced hepatic cell damage.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.123-128
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• 2004

Numerous novel ingredients have been introduced for the higher functionality of whitening cosmetics. Through the preliminary research, we have found Trichosanthes kirilowii root, Prunella vulgaris leaf and Clematis chinensis root have high whitening efficacy. But they are insoluble. Moreover the discoloration of and decrease in content take place when they are exposed to light, heat or oxygen. From Trichosanthes kirilowii root, Prunella vulgaris leaf and Clematis chinensis root, efficacious ingredients were ethanol-extracted by heating to 75∼85$^{\circ}C$ for 6∼8 h. These extracts have the inhibitory activity of tyrosinase and B16 melanin formation, thus enhancing whitening effect. We made liposomes using propylene glycol (PG)/hydrogenated lecithin/middle chain triglycerides (MCT)/glycerin/water and microfuidizer to stabilize extracts. The stability against heat and light was enhanced by 3∼5 times compared with untreated extracts. Particle size analyzer, freeze fracture transmission electron microscopy (FF-TEM), chromameter and HPLC are used for the analysis.

• Korean Journal of Veterinary Research
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• v.55 no.2
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• pp.111-116
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• 2015

In the present study, the effects of different photoperiods on stress, immunity, and hematological parameters in ICR mice were evaluated. Fifty male ICR mice 7 weeks old (body weight, $27.3{\pm}2.5g$) were divided into five groups: DP-0 (0/24-h light/dark cycle), DP-6 (6/18-h light/dark cycle), DP-12 (12/12-h light/dark cycle), DP-18 (18/6-h light/dark cycle), and DP-24 (24/0-h light/dark cycle). During the experimental period, no significant differences in body weight or feed intake were observed between the groups. Hematological analysis revealed that white blood cell, red blood cell, and hemoglobin values for the DP-0 group were significantly different compared to those of the other groups. After 28 days, no significant difference in serum cortisol concentration was observed among the groups, but serum cortisol levels increased in a light exposure-dependent manner. Total serum immunoglobulin G (IgG) concentrations of the DP-0 and PD-6 groups were significantly increased compared to those of the other groups (p < 0.05), and serum total IgG levels decreased in a light exposure-dependent manner. Results of the present study indicated that various photoperiods affect hematological parameters and total serum IgG levels in ICR mice while having no significant effects on body weight, feed intake, or cortisol levels.

• The Journal of the Korea Contents Association
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• v.10 no.3
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• pp.132-140
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• 2010

RFID-based games, which use a RFID reader and RFID chips, will expand existing computer games, which use a computer screen, a keyboard or a mouse. This paper presents 4 RFID digital board game contents which are conducted by initial developers; the three of them use the screen and control the games with RFID chips and, one is a different attempted game which can exclude the screen and be immersed to the board. While initial developers use object recognition of RFID, we need to develop game contents and game interface which can recognize positions of the objects. According to the initial developer"s developing process, the cooperative system between the game technical developers and the contents developers should be necessary. Also, the interface should be developed for young children to participate and operate.

• Journal of The Korean Association of Information Education
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• v.8 no.1
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• pp.113-125
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• 2004

A new on-line essay test system that write the articles to manuscript paper which has two hundred squares for characters, look over and correct the manuscript paper in environment of on-line network like the real essay test is designed and implemented in this thesis. Using this system, a participant can write the articles to manuscript paper, a scorer look over and can correct the articles on manuscript paper directly. When looking over and correcting manuscript paper in this system, scorer can use a pen-mouse and a tablet. To reduce the network traffic, bitmap format of the manuscript paper is compressed to JPEG format before it is transmitted to server. The system is cost-effective and has lots of advantages in efficiency and usability. Furthermore, it is expected that the developed system can be used to improve the field of on-line subjective examinations as a counterproposal.

• Journal of The Korean Association of Information Education
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• v.8 no.1
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• pp.1-13
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• 2004

A new on-line essay test system that write the articles to manuscript paper which has two hundred squares for characters, look over and correct the manuscript paper in environment of on-line network like the real essay test is designed and implemented in this thesis. Using this system, a participant can write the articles to manuscript paper, a scorer look over and can correct the articles on manuscript paper directly. When looking over and correcting manuscript paper in this system, scorer can use a pen-mouse and a tablet. To reduce the network traffic, bitmap format of the manuscript paper is compressed to JPEG format before it is transmitted to server. The system is cost-effective and has lots of advantages in efficiency and usability. Furthermore, it is expected that the developed system can be used to improve the field of on-line subjective examinations as a counterproposal.