• Journal of Pharmaceutical Investigation
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• v.34 no.3
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• pp.177-183
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• 2004

Recently, studies on intranasal mucosa delivery of influenza vaccine have been actively developed because of lack of pain and ease of administration. We studied on preparation of nanoparticle delivery system using biodegradable polymer as a poly(DL-lactide-co-glycolide) (PLGA) and their binding characteristics with vaccine. Three kinds of PLGA nanoparticles were prepared by spontaneous emulsification solvent diffusion (SESD) method using sodium dodecyl sulfate and sodium laurate as an anionic surfactant and Lutrol F68 (polyethylene glycol-block-polypropylene glycol copolymer) as a nonionic surfactant. The 5-aminofluorescein labeled vaccine was coated on the surface of nanoparticles by ionic complex. The complexes between vaccine and nanoparticles were confirmed by change of the size. After vaccine coating on the surface of anionic nanoparticles, particle size was increased from 174 to 1,040 nm. However the size of nonionic nanoparticles was not more increased than size of anionic nanoparticles. The amount of coated vaccine on the surface of PLGA nanoparticles was $14.32\;{\mu}g/mg$ with sodium dodecyl sulfate, $12.41\;{\mu}g/mg$ with sodium laurate, and $9.47{\mu}g/mg$ with Lutrol F68, respectively. In conclusion, prepared nanoparticles in this study is possible to use as a virus-like nanoparticles and it could be accept in the field of influenza vaccine delivery system.

• The Korean Journal of Pesticide Science
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• v.8 no.3
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• pp.168-174
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• 2004

In a course of the process for a lead optimization of 2-imino-l,3-thiazolines 1 which show a selective in vivo antifungal activity against rice blast, new compounds 2 in which C-5 was substituted by methyl group of the lead compound were synthesized and tested for the biological activity. Bromination of $\beta$-keto ester 7 followed by the reaction with thiourea and hydrolysis gave 2-imino-5-methyl-l,3-thiazoline carboxylic acid 3. Coupling reactions of 3 with aniline derivatives afforded 17 kinds of the corresponding 2-imino-5-methyl-l,3-thiazoline carboxanilides 2. Their in vivo antifungal activity against rice blast was weaker than that of 1, indicating that the in vivo antifungal activity of 2-imino-l,3-thiazolines was affected by the substituent at C-5. These results would be an important data for the molecular design in the lead optimization process of this series.

• Journal of Digital Convergence
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• v.12 no.5
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• pp.125-130
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• 2014

The competitiveness in today's global market forces many companies to develop families of products to provide enough variety for the marketplace. The challenge when designing a product family is in resolving the tradeoff between product commonality and distinctiveness. Simultaneously it is necessary to consider environmental performance to design a product family as well as to shorten lead-times, improve quality and reduce costs. This paper proposes a metaheuristic algorithm based redesign methodology for green product family considering environmental performance. The proposed method uses a genetic algorithm as metaheuristic algorithm and green product family index (GPFI) to support green product family design. In addition, it provides the redesign methodology such as product family level and component level. A case study used table lamps as an product family's example shows the verification and effectiveness of the proposed method.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.10
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• pp.31-39
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• 2004

This paper illustrates the noise characteristics under chip's core operations according to types of packages and modules for DDR DRAM For analyzing this, the impedance profiles and power noises are analyzed with DRAM chips having commercial TSOP package and commercial FBGA package on TSOP-based DIMM and FBGA-based DIMH In controversy with common concepts, we find that the noise-isolation characteristics of FBGA package are more weak and sensitive on transferred noises than those of the TSOP package. In addition, the simulated results show that the decoupling capacitor locations of modules are more important to control the self and transfer noise characteristics than the lead inductance of the packages. Therefore, satisfying the target spec of the noise suppression and isolation can be achieved through the design of power distribution systems only with considering not only the package types but also the whole module system.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.9
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• pp.1-8
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• 1999

In this paper, we propose and analyze a concatenated coding scheme for DS/CDMA systems in asynchronous channels. In the concatenated coding, bandwidth efficient $2^{2L-2}$-state ${\frac{L}{L+1}}$-rate 2-MTCM with biorthogonal signal constellation is used for the inner code, and $(2^{L-1},\;{\lceil}\frac{2^{L-1}}{L/2}{\rceil})$ RS code is use for the outer code. It is shown that we can get considerable performance gain over the uncoded system without sacrificing the data transmission rate. The proposed system can be used as a coding scheme for reliable and high speed integrated information services of mobile communication systems.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.48 no.6
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• pp.1-5
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• 2011

We present the Multi-band orthogonal frequency division multiplexing ultra-wideband (MB-OFDM UWB) technology for increasing the transmission reach of wireless speaker systems. The proposed scheme adopts the Reed-Solomon coding for preventing the random error perfectly and shows the SNR gain in low bit error rate (BER) especially. So, we can increase the maximum reach of MB-OFDM UWB technology since the receiver sensitivity is improved. The simulation environment includes most effects of realistic channel environments such as Additive White Gaussian Noise (AWGN), CM1 channel model, Sampling frequency offset (SFO), Carrier frequency offset (CFO) to improve the simulation accuracy. The simulation results show that the proposed scheme can give a maximum 2 dB SNR gain and increase the transmission reach up to 12.6m.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.6
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• pp.1-8
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• 2012

This paper presents a fully-integrated buck converter equipped with packaging inductors. These inductors include parasitic inductances of the bonding wires and lead frames in the package. They have significantly better Q factors than the best on-chip inductors implemented on silicon. This paper also proposes a low-swing gate driver for efficient regulation of high-frequency switching converters. The low-swing driver uses the voltage drop of a diode-connect transistor. The proposed converter is designed and fabricated using a $0.13-{\mu}m$ CMOS process. The fully-integrated buck converter achieves 68.7% and 86.6% efficiency for 3.3 V/2.0 V and 2.8 V/2.3 V conversions, respectively.

• Korean Journal of Clinical Pharmacy
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• v.10 no.1
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• pp.25-29
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• 2000

Bioequivalence of cisapride-containing $Cisaplus^{(R)}$ tablets (Daewoong Co.) to reference $Prepulsid^{(R)}$ tablets (Janssen Co.) was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered orally at a cisapride dose of 10 mg in a $2\times2$ crossover design. There was a 1-week washout period between the treatments. Blood samples were taken at predetermined time intervals for 48 hr and the plasma cisapride concentrations were determined by an HPLC with UV detector. The area under the plasma drug concentration-time curve (AUC) was caltulated from time zero to the last sampling time by a linear trapezoidal method. The maximum observed plasma drug concentration ($C_{max}$) and the time to $C_{max}\;(T_{max})$ were estimated directly from the drug concentration-time data. Analysis of variance (ANOVA) showed that the apparent differences for AUC, $C_{max}\;and\;T_{max}$ were $-7.52\%,\;-8.91\%\;and\;-15.55\%$, respectively. The minimum detectable differences for AUC, $C_{max}\;and\;T_{max}$ between formulations were $14.52\%,\;11.57\%\;and\;28.00\%$ respectively, at $\alpha=0.05\;and\;1-\beta=0.8\;levels.\;The\;90\%$ confidence intervals for AUC, $C_{max}\;and\;T_{max}\;were\;-16.00\sim0.97\%,\;-15.67\sim-2.15\%\;and\;-31.88\%\sim0.84\%$, respectively. These results satisfy the bioequivalence criteria of KFDA guidelines, indicating that the two formulations of cisapride are bioequivalent.

• Journal of the Korea Concrete Institute
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• v.23 no.3
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• pp.289-294
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• 2011

The installation of joint is to prevent random cracking due to drying shrinkage stress of concrete slab. However contraction joint spacing is empirically implemented into slab constructions without detail calculation based on quantitative criteria. In this study, shrinkage strain of concrete due to concrete shrinkage stress was measured to suggest joint spacing based on the study results. The test environmental conditions were applied temperature of $15^{\circ}C$ and relative humidity of 60%. The design compressive strength used was 30 MPa and 40 MPa, which are currently used in concrete slab designs. The drying shrinkage test result was applied to drying shrinkage models (ACI 209R, CEB MC 90, B3, GL 2000 and Sakata). The results showed that the most appropriate model was ACI 209R model. Based on the research findings, quantitative contraction joint spacing locations were calculated.

• Journal of the Korea Convergence Society
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• v.8 no.7
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• pp.191-198
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• 2017

This study offers the possibility of a new integrated product of video technology and public culture content. The Development of 'the Urinal of Emotional Type with Screen' will introduce a new sanitary pottery product and it will be a new attempt to combine hygiene pottery product with high-tech electronic product. It is a product development idea that presents the new marketability of the sanitary pottery product with the improvement of awareness of the restroom and the idea of wit through public information notification and advertisement effect. For the commercialization of the product, the prototype will be made through a separate production process with the design of this project, through 3D rendering, 3D mockup and so on. Various product expansions can be consulted with manufacturers after that. It is a new approach of image making with high quality and differentiated pricing strategy, that targeting small-scale business, such as franchise coffee shops and liquor stores with high quality and differentiated pricing strategy, and it will lead the market trend with various marketing availability through differentiated video contents.