• Journal of the Korean Society of Food Science and Nutrition
• /
• v.40 no.5
• /
• pp.619-624
• /
• 2011

Tea extract (TE) has been shown to have anti-tumor properties in a wide variety of experimental systems. We evaluated green tea extract (GTE) as a biochemical modulator for the antitumor activity of cisplatin and doxorubicin in the treatment of human lung cancer A549 cells. Cells were grown in RPMI-1640 medium supplemented with 10% (v/v) heat-inactivated fetal bovine serum and two antibiotics (100 units/mL penicillin and $100\;{\mu}g$/mL streptomycin). Two types of TE, epigallocatechin galate (EGCG) and GTE, were used in this experiment. The cells were seeded at $1{\times}10^4$ cells/well in the RPMI-1640 media with or without TE ($100\;{\mu}g$/mL) and then treated with different concentrations of doxorubicin ($0{\sim}14\;{\mu}g$/mL) or cisplatin ($0{\sim}35\;{\mu}g$/mL). After incubation in 5% $CO_2$ at $37^{\circ}C$ for 24 hr, cell viability was determined with a MTT assay. We used a Western blot to detect the influence of EGCG and GTE on the expression of p53 and caspase-3 genes in the A549 cells. A549 cell viability decreased to 15% with a $10\;{\mu}g$/mL concentration of cisplatin, and to 21% with a $8\;{\mu}g$/mL concentration of doxorubicin, as measured with the MTT assay. However, pre-treatment of the cells with EGCG ($100\;{\mu}g$/mL) or GTE ($100\;{\mu}g$/mL) resulted in decreased cell viability with $6\;{\mu}g$/mL of cisplatin and $4\;{\mu}g$/mL of doxorubicin. There was no apparent change in cell viability between EGCG or GTE administration in cisplatin- or doxorubicin-induced cytotoxicity in A549 cells. The levels of p53 and caspase-3 in the A549 cells increased with both EGCG and GTE treatment. We found that GTE could potentially affect cisplatin- or doxorubicin-induced cytotoxicity of A549 cells, which may be useful in the chemotreatment of cancer.

• Korean Journal of Materials Research
• /
• v.15 no.4
• /
• pp.252-256
• /
• 2005

We removed the bluish of the natural ruby successfully by vacuum annealing, and measured the color evolution with annealing time and temperature. We varied the anneal temperature and time $800\~1500^{\circ}C$ and $3\~26$ hrs, respectively. The color evolution of rubies with annealing condition was recorded by a digital camera and a color coordination visible spectrometer. We determined the optimum bluish eliminating annealing condition was $1500^{\circ}C-3hr$, which conserving the natural inclusions. We suggest the bluish shrink with diffusion coefficient of $D=(5\times10^{-3}){\exp}(-200.000/RT)[cm^2/s]$. We propose the color of ruby may be determined as the identical red color if the color difference between two samples are less than 1.0, and the color difference nay be an auxiliary standard to evaluate the color of rubies.

• Proceedings of the IEEK Conference
• /
• 2000.06c
• /
• pp.161-164
• /
• 2000

We propose the genetic algorithm to apply three kinds of FFT data flows to be considered the overhead for the data exchange between processors that have the multi-scheduling problem on parallel computer In the design of genetic algorithm, we propose the chromosome representation which can simply encode and decode a solution without any heuristic information, the evaluation function to be considered an efficiency of processor, and the genetic operator to inherit a superior gene from their parents. And we saw that the simulation result can verify better performance than the existing algorithm(BEA : binary exchange algorithm)in the face of execution time.

• YAKHAK HOEJI
• /
• v.40 no.2
• /
• pp.117-125
• /
• 1996

3'-Deamino-3-hydroxy-4'-fluoro- or 3'-deamino-3'-hydroxy-4'-azido-daunorubicin(6,8) and -doxorubicin(7,9) have been synthesized, respectively. Compounds 7,8 and 9 were mo re cytotoxic than daunorubicin(1) and doxorubicin(2) against L1210 murine leukemic cell in vitro. When administered intraperitoneally for 9 days starting 1 day after tumor inoculation, compounds 7(T/C 605%) and 9(T/C 488%) showed significant antitumor activity for ip-inoculuated L1210 murine leukemia at wide range of doses.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.63 no.7
• /
• pp.924-928
• /
• 2014

LLC resonant converter is used to control laser power density in ruby laser power supply. Zero voltage switching(ZVS) is implemented to minimize the switching loss by the LLC resonant converter. Laser output power is investigated and experimented by changing the output current. That current is controled by the charging voltage of capacitor. From those results, we obtained the maximum laser output of 1.94J at the discharge current of 860A and the pulse repetition rate of 1Hz.

• Journal of Power System Engineering
• /
• v.10 no.2
• /
• pp.75-82
• /
• 2006

세계적인 환경 보호 정책에 따라 할로겐화탄소 냉매를 대체할 환경 친화적인 초저온 냉매의 개발과 연구가 활발히 진행되고 있다. 일반적으로 캐스캐이드 2원 냉동 시스템에서 아직까지 할로겐화탄소 냉매가 널리 사용되고 있다. 탄화수소 화합물의 한 종류인 에탄은 낮은 지구 온난화 지수와 낮은 오존층 파괴지수를 가진 친 환경적인 자연 냉매이다. 본 연구는 지구 온난화 지수가 높은 R-23 냉매와 비교하여 캐스캐이드 2원 냉동 시스템에서 에탄의 성능 시험을 목적으로 수행 하였다. 1원측에는 R-22를 사용하였으며, 증발 온도에 따른 성능은 R-23 보다 에탄(R-170)이 더 높게 나타났다.

• Korean Journal of Plant Resources
• /
• v.9 no.3
• /
• pp.291-297
• /
• 1996

Many Ascomycetes of higher fungi were collected at Mt.Jiri National Park and Mt.Moak Provincial Park from March 1995 to September 1996. They were identified by the keys of Dennis(1981) and Breitenbach and Kranzlin(1984). Of these, Hypoxylon multiforme, H. rubiginosum, H.udum, H.rutilum, Nectria gallignea, N. coccillea, N. pallidula, and N. fumicola were recorded as new to Korea.

• Proceedings of the Korean Vacuum Society Conference
• /
• 1999.07a
• /
• pp.194-194
• /
• 1999

다이아몬드 박막은 결정립에 의해 심한 표면 거칠기를 나타낸다. 루비를 상대재료로 사용하여 하중 50g, 50rpm의 회전속도로 마모시험을 하였으며 마모 track의 직경은 100mm였다. 마찰계수는 0.5에서 계속 감소하며 0.1이하에서 안정한 상태를 유지하게 된다. 이 다이아몬드 박막위에 저마찰재료로 알려진 PTFE를 타겟으로 RF로 증착한 후 같은 조건으로 마모시험을 행하면 마찰계수가 초기부터 일정하게 유지할 수 있게 된다. 반면에 MoS2박막이 증착된 경우에는 완만한 마찰계수의 감소가 나타난다. 이러한 변화의 원인으로는 DLC 박막에서 보고되고 있는 바와 같이 다이아몬드의 sp3 결합구조가 마모시험중 흑연화하여 sp2 결합구조로 변하기 때문인 것인지 살펴보기 위하여 micro Raman을 통하여 마모 track을 분석하였고 AFM을 통하여 표면거칠기 변화와 표면 스크래치 발생 여부를 살펴보았다.

• Journal of the Korean institute of surface engineering
• /
• v.38 no.2
• /
• pp.83-87
• /
• 2005

We enhanced the color of blue sapphires and rubies successfully by using a oxygen-propane torch flame annealing, which had not been employed so far. We confirmed that about 1 mm-thick de-coloring of the corundum samples were available with 60 minutes flame annealing through eye evaluation, color coordination characterization, and methylene iodide immersion observation. We also suggest that the color centers such as $[Fe_{Al}^{\cdot}]$ may transform into transparent $[Fe_{Al}^{x}],\;[Cr_{A1}^{x}]$ sites with $[V_o^']$ generation at the elevated temperature in oxygen-rich atmosphere by diffusion mechanism. Our results implied that the longer diffusion time and the higher oxygen partial pressure might lead to the better de-coloring enhancement in corundum gem stones.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2017.11a
• /
• pp.975-977
• /
• 2017

본 논문은 링크드 오픈 데이터(Linked Open Data)의 일종인 DBpedia 개체를 위치기반으로 검색하여 지도상에 표시해주고, 표시된 개체중 하나를 선택하게 되면 개체에 관한 RDF 형태의 데이터를 파싱하여 개체에 관한 기본적인 정보와 사진과 외부로의 링크 등을 제공한다. 또한 개체가 가지는 특성을 지정하여 지도에 선택적으로 표시하는 필터링 기능을 제공한다. 이러한 웹 애플리케이션을 개발하기 위해 오픈소스 웹 프레임워크인 루비 온 레일즈(Ruby on Rails)를 사용하였고, HTML5와 Google Map API를 활용한 반응형 웹 애플리케이션으로 구현하였다.