• The Korean Journal of Applied Statistics
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• v.21 no.1
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• pp.81-94
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• 2008

Family-based tests such as the transmission and disequilibrium tests(TDT) have proved to be powerful tools in the search for disease genes. Unlike case-control studies, the tests are not affected by population admixture, which can lead to spurious association of multiple highly linked makers with disease-susceptible genes. Those tests have largely required knowledge of parental marker genotypes. However, parental data are often not available for late-onset diseases. In this article we propose sib-TDTs that overcome this problem by use of marker data from unaffected sib(s) instead of parents. To do this end, we fist defined a Mantel-Haenszel-type statistic for each haplotype and then proposed two tests based on this statistic. Simulation studies suggest that the proposed tests are robust to population admixture and are monotone increasing as a relative risk increases irrespective of mode of inheritance. We also illustrated the proposed tests with data adopted from Yonsei Cardiovascular Genome Center.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.144-152
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• 2018

Lunar exploration, which was led by the United States and the former Soviet Union, ceased in the 1970s. On the other hand, since massive lunar ice deposits and rare resources were found in 1990s, European Union, China, Japan, and India began to participate in lunar exploration to secure future lunar resource as well as to construct a lunar base. In the near future, it is expected that national space agencies and private industries will participate in the lunar exploration together. Their missions will include the exploration and sample return of lunar resources. Lunar resources have a close relationship with the lunar in-situ resource utilization (ISRU). To construct a lunar base, it is inevitable to bring huge amounts of resources from Earth. Water and oxygen, however, will need to be produced from local lunar resources and lunar terrain feature will need to be used to construct the lunar base. Therefore, in this paper, the global trends on lunar exploration and lunar construction technology are investigated and compared along with the ISRU technology to support human exploration and construct a lunar base on the Moon's surface.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.669-676
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• 2018

As the Moon's scientific, technological, and economic value has increased, major space agencies around the world are leading lunar exploration projects by establishing a road map to develop lunar resources and to construct a lunar base. In addition, as the lunar base construction requires huge amounts of resources from the Earth, lunar in-situ construction technology is being developed to produce construction materials from local lunar resources. On the other hand, the characteristics of lunar topography and resources vary spatially due to the crustal and volcanic activities inside the Moon as well as the solar wind and meteorites from outside the Moon. Therefore, in this paper, the geospatial analysis of lunar resource distribution was conducted to suggest regional consideration factors to apply the lunar in situ construction technologies. In addition, the lunar topographic condition to select construction sites was suggested to ensure the safe landing of a lunar lander and the easy maneuvering of a rover. The lunar topographic and resource information mainly from lunar orbiters were limited to the lunar surface with a low spatial resolution. Rover-based lunar exploration in the near future is expected to provide valuable information to develop lunar in situ construction technology and select candidate sites for lunar base construction.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.11
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• pp.984-997
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• 2015

Chang'e-3 consisting of a lunar lander and exploration rover was launched on December 1, 2013 aboard a Long March 3B rocket flying from Xichang space launch center. Chang'e-3 was inserted into the lunar orbit after about a 5-day transit to the Moon and landed on the targeted landing site after orbiting around the Moon for 8 days. The successful landing of the Chang'e-3 gives a lot of help to analyze the future needs of the subsystem technologies and to figure out the trajectory from launch to lunar landing as well as operation sequences in the development of Korean lunar exploration is scheduled. Therefore, the configuration and analysis of overall mission of Chang'e-3 is performed based on the public information from the press and website. As a result, overall mission trajectory is reconstructed by solving boundary condition and then estimating control variable. Visibility status and eclipse status also analyzes so communication and power charge condition is as good as to operate lunar lander. Mass budget of the lander is derived using ${\Delta}V$ according to specific impulse.

• Journal of Space Technology and Applications
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• v.1 no.1
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• pp.64-75
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• 2021

On the moon as well as the earth, one of the easiest ways to understand geological formation history of any region is to observe the stratigraphy if it is available, the order in which the strata build up. By analyzing stratigraphy, it is possible to infer what geological events have occurred in the past. Mare Nubium also has an unique normal fault called Rupes Recta that shows stratigraphy. However, a rover moving with wheels is incompetent to explore the cliff since the Rupes Recta has an inclination of 10° - 30°. Therefore, a quadruped walking robot must be employed for stable expedition. To exploration a fault with a four-legged walking robot, it is necessary to design an expedition route by taking account of whether the stratigraphy is well displayed, whether the slope of the terrain is moderate, and whether there are obstacles and rough texture in the terrain based on the remote sensing data from the previous lunar missions. For the payloads required for fault surface exploration we propose an optical camera to grasp the actual appearance, a spectrometer to analyze the composition, and a drill to obtain samples that are not exposed outward.

• Journal of Space Technology and Applications
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• v.4 no.2
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• pp.121-136
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• 2024

Korea Pathfinder Lunar Orbiter (KPLO), launched in August 2022, is successfully carrying out its mission. Korea's lunar lander and rover programs are expected to proceed in the future. To successfully carry out the mission after the lunar lander has landed on the surface, the performance of the equipment to be mounted should be checked in a laboratory environment similar to the Moon. Scientists and engineers of several countries, including the United States and China, use lunar soil simulant which is developed to resemble lunar soil for simulating the surface of the lunar landing site. Several lunar probe landing sites are being discussed in Korea, and lunar soil simulants such as Korea Hanyang Lunar Simulant-1 (KOHLS-1), Korea Aerospace University Mechanical Lunar Simulants (KAUMLS), and Korea Lunar Simulant-1 (KLS-1), which are similar to the characteristics of lunar mare soil, have been developed. However, those simulants are not useful if the landing site is chosen as a highland area. In this study, we introduce the process of developing KIGAM-L1, a lunar highland soil simulant similar to the chemical composition of the Apollo 16 lunar soil sample and the particle size distribution of lunar soil sample 60500-1, in case the lunar lander lands at highland area.

• Tunnel and Underground Space
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• v.33 no.4
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• pp.281-298
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• 2023

Continuous research efforts are being devoted to unmanned mobile platforms for lunar exploration. There is an ongoing demand for real-time information processing to accurately determine the positioning and mapping of areas of interest on the lunar surface. To apply deep learning processing and analysis techniques to practical rovers, research on software integration and optimization is imperative. In this study, a foundational investigation has been conducted on real-time analysis of virtual lunar base construction site images, aimed at automatically quantifying spatial information of key objects. This study involved transitioning from an existing region-based object recognition algorithm to a boundary box-based algorithm, thus enhancing object recognition accuracy and inference speed. To facilitate extensive data-based object matching training, the Batch Hard Triplet Mining technique was introduced, and research was conducted to optimize both training and inference processes. Furthermore, an improved software system for object recognition and identical object matching was integrated, accompanied by the development of visualization software for the automatic matching of identical objects within input images. Leveraging satellite simulative captured video data for training objects and moving object-captured video data for inference, training and inference for identical object matching were successfully executed. The outcomes of this research suggest the feasibility of implementing 3D spatial information based on continuous-capture video data of mobile platforms and utilizing it for positioning objects within regions of interest. As a result, these findings are expected to contribute to the integration of an automated on-site system for video-based construction monitoring and control of significant target objects within future lunar base construction sites.

• Progress in Medical Physics
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• v.18 no.2
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• pp.81-86
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• 2007

The cone-beam CT (CBCT) which is acquired using on-board imager (OBI) attached to a linear accelerator is widely used for the image guided radiation therapy. In this study, the effect of respiratory motion on the quality of CBCT image was evaluated. A phantom system was constructed in order to simulate respiratory motion. One part of the system is composed of a moving plate and a motor driving component which can control the motional cycle and motional range. The other part is solid water phantom containing a small cubic phantom ($2{\times}2{\times}2cm^3$) surrounded by air which simulate a small tumor volume in the lung air cavity CBCT images of the phantom were acquired in 20 different cases and compared with the image in the static status. The 20 different cases are constituted with 4 different motional ranges (0.7 cm, 1.6 cm, 2.4 cm, 3.1 cm) and 5 different motional cycles (2, 3, 4, 5, 6 sec). The difference of CT number in the coronal image was evaluated as a deformation degree of image quality. The relative average pixel intensity values as a compared CT number of static CBCT image were 71.07% at 0.7 cm motional range, 48.88% at 1.6 cm motional range, 30.60% at 2.4 cm motional range, 17.38% at 3.1 cm motional range The tumor phantom sizes which were defined as the length with different CT number compared with air were increased as the increase of motional range (2.1 cm: no motion, 2.66 cm: 0.7 cm motion, 3.06 cm: 1.6 cm motion, 3.62 cm: 2.4 cm motion, 4.04 cm: 3.1 cm motion). This study shows that respiratory motion in the region of inhomogeneous structures can degrade the image quality of CBCT and it must be considered in the process of setup error correction using CBCT images.