• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.37 no.9
• /
• pp.807-814
• /
• 2013

A fundamental study on laser-tissue interaction was conducted with the aim of developing a therapeutic medical device that can remove lesions on the intestinal wall by irradiating a high-power 808-nm infrared laser light incorporated in an endoscopic system. The perforation depth was linearly increased in the range of 1~4 mm in proportional to laser output (3~12 W) and irradiation time (5~20 s). We demonstrated that the perforation depth during laser irradiation was varied according to the tissue property of each extracted porcine organ. The measurement of the temperature distribution suggests that the energy is localized in the irradiation spot and transferred to deep tissue, which protects the surrounding tissue from thermal injury. These results can be used to set the driving parameters for a laser incision technique as an alternative to conventional surgical interventions.

• Progress in Medical Physics
• /
• v.6 no.1
• /
• pp.19-37
• /
• 1995

The use of lasers in medicine has opened up entirely new fields of therapy and diagnosis. The process in biotechnical applications of laser is basically different from traditional one in other technical field because of critical account to the human body. This paper surveys the principle of biomedical applications as well as possible future developments in laser medicine. In particular, the following subjects are extensively presented : 1) laser-tissue interaction, 2) therapeutic, and diagnostic technique, 3) laser op tical fiber for medicine, and 4) laser safety.

• Proceedings of the Optical Society of Korea Conference
• /
• 2002.07a
• /
• pp.234-235
• /
• 2002

최근 상호 결합된 chaotic 진동자들 간의 동기화의 문제는 그 시스템이 가지는 여러 가지 응용성 때문에 여러 과학 분야와 기술 분야 예를 들면 동력학, 레이져 동력학, 전자회로, 화학반응, 생물학적인 시스템 등에서 폭넓게 연구되어지고 있다. 더욱이 작은 파라미터의 차이를 제외하고 거의 유사한 chaotic 진동자들간의 상호작용에서 찾아 볼 수 있는 위상 동기화 현상은 뇌세포 조직과 같은 생물학적인 시스템들 사이에 흔히 찾아 볼 수 있는 기본적인 현상이다. (중략)

• Korean Journal of Optics and Photonics
• /
• v.1 no.2
• /
• pp.210-216
• /
• 1990

This study was performed to obtain fundamental data on temperature increases in the dental tissues irradiated by IO.opm laser radiation. For this purpose a experimental facility was established. which was composed of a CO2 laser. a shutter unit and a temperature sensing device. The temperature changes in the pulp chamber of extracted molars. during and after the laser irradiation. were measured as function of laser power. the time of irradration and the thickness of the sample. An empirical formula for the maximum temperature increases, $\DeltaT_m$ was derived from the measured data as follows; $\DeltaT_m=\alphaP\Delta\tauexp(-\betad)$$ where P. $\Delta\tau$ and d are the laser power(W). irradiation time{sec) and the thickness(mm) between pulp chamber and occlusal surface. respectively. Also a theoretical calculation model based on simplified assumptions were established and the results from the calculation were compared with the measured temperature data. A fairly good agreement was obtained.obtained.

• Applied Chemistry for Engineering
• /
• v.32 no.3
• /
• pp.312-319
• /
• 2021

Photothermal therapy is a treatment that necrotizes selectively the abnormal cells, in particular cancer cells, which are more vulnerable to heat than normal cells, using the heat generated when irradiating light. In this study, we synthesized a reduced graphene oxide with carboxyl groups (CRGO)-gold nanorod (AuNR) nanocomposite for photothermal treatment. Graphene oxide (GO) was selectively reduced and exfoliated at high temperature to synthesize CRGO, and the length of AuNR was adjusted according to the amount of AgNO₃, to synthesize AuNR with a strong absorption peak at 880 nm, as an ideal photothermal agent. It was determined through FT-IR, thermogravimetric and fluorescence analyses that more carboxyl groups were conjugated with CRGO over RGO. In addition, CRGO exhibited excellent stability in aqueous solutions compared to RGO due to the presence of carboxylic acid. The CRGO-AuNR nanocomposites fabricated by electrostatic interaction have an average size of ~317 nm with a narrow size distribution. It was confirmed that under radiation with a near-infrared 880 nm laser which has an excellent tissue transmittance, the photothermal effect of CRGO-AuNR nanocomposites was greater than that of AuNR due to the synergistic effect of the two photothermal agents, CRGO and AuNR. Furthermore, the results of cancer cell toxicity by photothermal effect revealed that CRGO-AuNR nanocomposites showed superb cytotoxic properties. Therefore, the CRGO-AuNR nanocomposites are expected to be applied to the field of anticancer photothermal therapy based on their stable dispersibility and improved photothermal effect.