• Title/Summary/Keyword: 레이저 유도 후전달

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Hydrophobic Surface Treatment with Anisotropic Characteristics Using Laser Selective Deposition (레이저 선택적 증착을 통한 이방특성의 소수성 표면처리)

  • Kim, Ji-Hun;Kwon, Ye-Ji;Yang, Hoon-Seok;Kim, Joohan
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.19 no.11
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    • pp.109-115
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    • 2020
  • Surfaces with various roughnesses were produced through laser processing, and the anisotropy and hydrophobicity of the surfaces were examined in the context of the microstructures. The fine particles transferred to the glass surface exhibited different sizes, and the roughness increased. Due to the change in the roughness, the liquid could not penetrate the space between the fine particles, and it was thus exposed to the air. We analyzed this phenomenon using the combined Wenzel and Cassie-Baxter models. Excessive fine particle formation on the substrate tended to increase the roughness and surface energy. The silver-glass-air contact analysis could clarify the mechanism of the reduction of the contact angle and differences in the metastable and stable states when the particles did not completely cover the glass substrate. The formation of microstructures with fine particles through the laser selective deposition led to the generation of an anisotropic surface as the water droplets diffused toward the glass substrate with a relatively high surface energy level.

Development and application of non-invasive drug delivery systems utilizing pulse power, and its application to mouse models (펄스파워를 적용한 비침습 약물 전달기 개발 및 마우스 모델로의 적용)

  • Hwi-Chan Ham;Kyu-Sik Kim;Ji-Hwan Lee;Hyung-Jin Choi;Do-Nyun Kim;Jai-Ick Yoh
    • Journal of IKEEE
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    • v.28 no.1
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    • pp.97-103
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    • 2024
  • Some drugs can offer far better medical effectiveness as it is injected through the intradermal layer of the skin, known as a needle-free injection. However, conventional needle-free devices might deliver a relatively large amount of drug in a just single spot of skin, splitting open the tissue layer structure, which might cause bruising and bleeding. By injecting the small volume with a fast repetition rate in a large surface area of skin, the patient may get much fewer injuries and pain. To achieve that specification, the driving force must be instantaneous and short-pulsed. Such a form of an injection device has been developed but the efficacy of those devices has been rarely examined. Therefore, this study developed the laser-induced microjet device that ejects microjet whose speed is ~310 m/s, during the 400~800 ㎲ of pulse time. The device can eject ~1 µL of the drug at the rate at which each shot repeated 10 shots per second. Using this specification, we evaluated the efficacy of drug injection onto mouse models. After injecting the insulin solution into the mouse model, the blood insulin level is detected, resulting in 20 % of blood insulin level with the ordinary needle syringe injection method.