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The Effect of Leukoaraiosis on the Severity and Course of Delirium (백질변성이 섬망의 심각도 및 경과에 미치는 영향)

  • Choi, Won-Jung;Seok, Jeong-Ho;Oh, Seung-Taek;Chung, Tae-Sub;Kim, Jae-Jin
    • Korean Journal of Psychosomatic Medicine
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    • v.26 no.2
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    • pp.194-200
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    • 2018
  • Objectives : The significance of leukoaraiosis on brain magnetic resonance imaging (MRI) is uncertain, but it is often seen with vascular risk factors or in the context of cognitive impairment. We aimed to investigate the effect of leukoaraiosis on the severity and course of delirium. Methods : Periventricular hyperintensity and deep white matter hyperintensity on brain MRI were rated in 42 patients with delirium by semiquantative visual rating scale. Correlations between their grades and the scores of Korean version of Delirium Rating Scale-Revised-98 (K-DRS-R-98) were analyzed, and the interaction effects between the groups according to the levels of leukoaraiosis and two evaluation points were also analyzed. Results : The grade of deep white matter hyperintensity in the occipital lobe was positively correlated with the scores on the total, severity items, cognitive items, and non-cognitive items of K-DRS-R-98. The cognitive items scores of K-DRS-R-98 in the low grade group of periventricular hyperintensity showed significantly steeper decrease than the high grade group. Conclusions : A difference in severity or recovery speed of delirium according to the level of leukoaraiosis may result from disruption in brain functional connectivity. Our results have a clinical implication in that the severity and course of delirium can be possibly predicted using the level of leukoaraiosis.

STAT3 is Activated in a Subset of Benign and Malignant Chondroid Tumors (양성 및 악성 연골 종양에서의 STAT3 활성화)

  • Park, Hye-Rim;Park, Yong-Koo
    • The Journal of the Korean bone and joint tumor society
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    • v.15 no.2
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    • pp.130-137
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    • 2009
  • Purpose: STAT3 is an oncogene that regulates critical cellular processes, and its constitutive activation has been demonstrated to correlate with biological and clinical features in many types of human malignancy. Materials and Methods: In this study, STAT3 activation was assessed in variable benign and malignant chondroid tumors in bone by immunohistochemistry using a monoclonal antibody specific for $tyrosine^{705}$-phosphorylated STAT3 ($pSTAT3^{tyr705}$). Results: Among conventional chondrosarcomas (n=17), three cases(50%) of grade III chondrosarcomas were pSTAT3-positive. All grade I and II chondrosarcomas were pSTAT3-negative. This pSTAT3 positivity according to the histologic grade was statistically significant (p=0.0432). Two cases(50%) of clear cell chondrosarcomas were pSTAT3-positive. Six cases (50%) among 12 benign chondroid tumors(6 enchondromas, 3 chondroblastomas, and 3 chondromyxoid fibromas) were also $pSTAT3^{tyr705}$-positive. Conclusion: In conclusion, STAT3 activation is associated with higher tumor grade in conventional chondrosarcomas. Our results suggest that STAT3 is activated in a subset of benign and malignant chondroid tumors, and may support the extension of the cancer stem cell hypothesis to include tumors of cartilaginous lineage.

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Urinary Tract Infection and Vesicoureteral Reflux in Children (소아에서의 요로감염과 방광요관역류에 관한 고찰)

  • Lim Hyun-Suk;Park Chang-Ro;Ko Cheol-Woo;Koo Ja-Hoon
    • Childhood Kidney Diseases
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    • v.1 no.1
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    • pp.46-52
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    • 1997
  • Urinary tract infection (UTI) in children has been known to be a cause of renal damage, leading to scar formation, hypertension and renal failure. And vesico-ureteral reflex (VUR), frequently accompanying UTI in young children, has been incriminated as the main factor causing scar formation. This retrospective study has been undertaken to see the relationship among UTI, VUR and renal scar formation. Study population consisted of 291 children (boy 134, girl 42) with UTI, who have been admitted to the Pediatric Department of Kyungpook University Hospital during 6 1/2 year period from January 1990 to June 1996. VUR was diagnosed by VCUG and renal scar by ultrasonogram, DMSA scan (or DMSA SPECT) and IVP. The following result were obtained. Sexual difference showed male predominance (male to female, 134:42) below 1 year of age, and female predominance (male to female, 11:35) over 5 years of age were rioted. VUR has been found in 64 children (22%) and the degree of reflux, classfied by the method proposed by 'International Reflux Study in Children', were as follows ; Grade I : 4.0%, Grade II : 3.0%, Grade III : 2.7%, Grade IV : 5.8% and Grade V : 6.2%. There was no sexual difference E.coli was the most predominant infecting agent occurring in 167 children (57%), and end-stage renal failure was diagnosed at the time of first admission in 5 children with Grade V VUR. Renal scar has been noted in 49 out of 582 kidneys (8.4%), and the incidence of scar foramation according to the degree of VUR were as follow ; Grade 0 (No reflux) : 1.2%, Grade I : 6.7%, Grade II 27.3%, Grade III 29.4%, Grade IV : 57.1%, and Grade V : 100%. In summary, present study shows that renal scar formation in UTI has close correlation with the severity of VUR occurring more frequently in severe reflux, so that early diagnosis and proper treatment of UTI and VUR is of paramount importance in preventing renal damage in children with UTI.

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Sustainable Water Resources Planning for Rehabilitation of Hydrologic Cycle in the Anyangcheon Watershed: (안양천 유역의 물순환 건전화를 위한 지속가능한 수자원 관리계획)

  • Chung, Eun-Sung;Kong, Ki-Seo;Lee, Kil-Seong;Yoo, Jin-Chae
    • Proceedings of the Korea Water Resources Association Conference
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    • 2007.05a
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    • pp.1640-1644
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    • 2007
  • 본 연구에서는 안양천 유역에 대해 왜곡된 물순환을 건전화시키기 위한 유역통합관리 계획을 수립하였다. 대안의 효과분석은 HSPF 모형을 사용하였으며 평가지수는 건천화 방지와 수질개선 효과 요소로 구성되며 각각은 유역통합관리 6단계 결과를 모두 사용할 수 있도록 복합계획법과 지속가능성 개념(압력-상태-반응)을 활용하여 개발되었다. 특히 수량과 수질에 대한 가중치는 유역주민의 의견을 반영하기 위해 실험선택법으로 정량화하여 유역의 속성별로 달리 적용하였다. 대안은 평가지수에 따라 세 등급(Good, Acceptable, Poor)으로 나누어 제시하였다.

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실내공기질 예측 및 평가방법

  • 송두삼
    • The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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    • v.33 no.6
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    • pp.37-43
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    • 2004
  • 실내공기오염 문제가 미국, 유럽, 일본 등 선진국을 중심으로 고조되면서, 최근 국내에서도 이 문제에 대해 적극적으로 논의되기 시작하였으며, 정부관련기관 및 연구기관을 중심으로 대책마련을 위한 관계법령의 정비 및 연구가 활발히 진행되고 있다. 그 구체적인 법령으로 작년(2003. 5. 29)에 환경부에서 고시한 "지하생활공간공기질관리법개정안(다중이용시설 등의 실내공기질관리법)"을 들 수 있으며, 이 법안에서는 실내공기질 유지기준 및 권고기준, 실내 공기질 공정시험법 등에 대해 공고하고 있다. 또한 건축자재에서 발생하는 오염물질에 관해서도 규정을 하고 있다. 이에 국내에서도 생산된 건축자재에 대해 포름알데히드, TVOC 방출강도를 평가, 등급화 하는 인증제도가 도입되어 있으며, 평가/분석을 실시하는 인증시험기관도 이미 몇 군데 지정되어 있는 상태이다. (중략)상태이다. (중략)

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A Study on Quality Evaluation of ADCP Discharge Measurement for the Moving Boat Method (ADCP 이동보트법 측정유량의 품질평가 방안 연구)

  • Song, Jae Hyun;Lee, Geum Young;Lee, Ki Sung;Jang, Bok Jin;Jung, Sung Won
    • Proceedings of the Korea Water Resources Association Conference
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    • 2016.05a
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    • pp.462-462
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    • 2016
  • 하천의 유량은 다양한 방법으로 측정가능한데 그중에 ADCP(Acoustic Doppler Current Profiler)는 1980년대 말 도입된 이래 현재 국내외에서 광범위하게 사용되고 있고, 그 활용성은 점점 더 커지고 있다. 이러한 이유로 최근 미국, 호주, 뉴질랜드 등에서는 ADCP 측정유량에 대한 품질관리와 생산된 자료에 대한 평가를 통해 신뢰성을 확보하기 위한 방안을 마련하고 있다. 본 연구에서는 ADCP 이동보트법 측정유량에 대한 3개국(미국, 호주, 뉴질랜드)의 품질관리 및 신뢰도 확보 방안에 대한 문헌조사를 수행하였고, 각 방안들에 대하여 7개 항목으로 비교 및 분석하였다. 그리고 분석된 내용을 바탕으로 ADCP 이동보트법 측정유량의 품질평가 방안을 제시하고, 유량조사사업단에서 수행한 ADCP 이동보트법 측정유량 자료(2013년~2014년)를 대상으로 측정유량 품질평가 방안을 적용하여 결과를 품질등급으로 제시하였다. 이 지표는 사용자가 ADCP 이동보트법 측정유량의 품질을 확인하고 신뢰할 수 있게 함으로써 향후 활용성을 더욱 향상 시킬 수 있을 것으로 기대된다.

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A Study on the Stability of Using Alkali Solution Desalination on Gilt Plated Silver-Iron Artifacts (알칼리 수용액을 이용한 출토 철지금은장관정의 탈염처리 적용성 평가)

  • Park, Jun Hyeon;Bae, Go Woon;Chung, Kwang Yong
    • Journal of Conservation Science
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    • v.37 no.2
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    • pp.179-189
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    • 2021
  • In this study, the research objects are gilt plated silver-iron nails excavated from the west of the tombs in Neungsan-ri, Buyeo. A gilt plated silver-iron nail was fabricated by combining silver and iron via heating and then gilding amalgam on top of this combination, demonstrating that this ancient artifact that can be replicated using current technology. Since the metal (Au, Ag) surface of these gilt plated artifacts are covered with iron oxide, which slips into the cracks and scratches of the artifacts as well, desalination is essential. Based on the results of the preliminary experiment, the research objects were classified into grades A, B, and C, according to the degree of corrosion and then desalinated using an alkali solution (NaOH, Sodium Sesquicarbonate of 0.1 M) at 60℃. The results demonstrate that the more serious is the degree of corrosion, the more is the amount of Cl- detected. Further, more Cl- was released when NaOH was used than when sodium sesquicarbonate was used, for all grades except Grade A. Furthermore, the more serious is the degree of corrosion, the longer is the desalination period and the reaction with NaOH for all grades except Grade A. A comparison of the Fe composition of the surface before and after desalination shows that Fe composition is the use of NaOH resulted in a smaller increase compared with the use of sodium sesquicarbonate, for all grades except Grade B. However, four of the nails were damaged owing to NaOH (Grade B 3ea, Grade C 1ea) during desalination. Thus, Cl- ions are more stably released when sodium sesquicarbonate is used than when NaOH is used.

The Prediction of Purchase Amount of Customers Using Support Vector Regression with Separated Learning Method (Support Vector Regression에서 분리학습을 이용한 고객의 구매액 예측모형)

  • Hong, Tae-Ho;Kim, Eun-Mi
    • Journal of Intelligence and Information Systems
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    • v.16 no.4
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    • pp.213-225
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    • 2010
  • Data mining has empowered the managers who are charge of the tasks in their company to present personalized and differentiated marketing programs to their customers with the rapid growth of information technology. Most studies on customer' response have focused on predicting whether they would respond or not for their marketing promotion as marketing managers have been eager to identify who would respond to their marketing promotion. So many studies utilizing data mining have tried to resolve the binary decision problems such as bankruptcy prediction, network intrusion detection, and fraud detection in credit card usages. The prediction of customer's response has been studied with similar methods mentioned above because the prediction of customer's response is a kind of dichotomous decision problem. In addition, a number of competitive data mining techniques such as neural networks, SVM(support vector machine), decision trees, logit, and genetic algorithms have been applied to the prediction of customer's response for marketing promotion. The marketing managers also have tried to classify their customers with quantitative measures such as recency, frequency, and monetary acquired from their transaction database. The measures mean that their customers came to purchase in recent or old days, how frequent in a period, and how much they spent once. Using segmented customers we proposed an approach that could enable to differentiate customers in the same rating among the segmented customers. Our approach employed support vector regression to forecast the purchase amount of customers for each customer rating. Our study used the sample that included 41,924 customers extracted from DMEF04 Data Set, who purchased at least once in the last two years. We classified customers from first rating to fifth rating based on the purchase amount after giving a marketing promotion. Here, we divided customers into first rating who has a large amount of purchase and fifth rating who are non-respondents for the promotion. Our proposed model forecasted the purchase amount of the customers in the same rating and the marketing managers could make a differentiated and personalized marketing program for each customer even though they were belong to the same rating. In addition, we proposed more efficient learning method by separating the learning samples. We employed two learning methods to compare the performance of proposed learning method with general learning method for SVRs. LMW (Learning Method using Whole data for purchasing customers) is a general learning method for forecasting the purchase amount of customers. And we proposed a method, LMS (Learning Method using Separated data for classification purchasing customers), that makes four different SVR models for each class of customers. To evaluate the performance of models, we calculated MAE (Mean Absolute Error) and MAPE (Mean Absolute Percent Error) for each model to predict the purchase amount of customers. In LMW, the overall performance was 0.670 MAPE and the best performance showed 0.327 MAPE. Generally, the performances of the proposed LMS model were analyzed as more superior compared to the performance of the LMW model. In LMS, we found that the best performance was 0.275 MAPE. The performance of LMS was higher than LMW in each class of customers. After comparing the performance of our proposed method LMS to LMW, our proposed model had more significant performance for forecasting the purchase amount of customers in each class. In addition, our approach will be useful for marketing managers when they need to customers for their promotion. Even if customers were belonging to same class, marketing managers could offer customers a differentiated and personalized marketing promotion.

Distribution of Vascular Plants at the Ecological Landscape Conservation Area Heoninlleung in Seoul (서울시 생태.경관보전지역 헌인릉의 관속식물 분포)

  • Kim, Kun-Ok;Hong, Sun-Hee;Lee, Yong-Ho;Na, Chae-Sun;Kang, Byeung-Hoa;Son, Yo-Whan
    • Korean Journal of Plant Resources
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    • v.23 no.1
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    • pp.60-78
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    • 2010
  • To clarify the distribution of vascular plants and their usefulness in Heoninlleung, Ecological Landscape Conservation Areas of Seoul, we investigated it from April, 2006 to June, 2009. Total 313 taxa; 68 families, 191 genera, 264 species, 41 varieties and 8 forma were distributed in Heoninlleung. Among them, 37 taxa were highly abundant everywhere (3A), 16 taxa were highly abundant locally (3B), 70 taxa were moderately abundant everywhere (2A), 96 taxa were common in certain regions locally (2B), 9 taxa were rare but observed everywhere with low frequency (2A) and 85 taxa were rare and observed locally (1B). The economic plants were 293 taxa. There were 156 taxa of edible source, 223 taxa of medicinal source, 141 taxa of ornamental source, 69 taxa of pastoral source, 12 taxa of industrial, and 8 taxa of timber source. Twelve Korean endemic plants were collected. Based on the list of rare plants by the Korea National Arboretum and Ministry of Environment, 2 rare species were found. The specific species of I~V grades by phytogeography were 19 taxa. And twentyfour taxa of naturalized plant species were distributed. Naturalization Index was 7.7% and Urbanization Index was 8.4% in the investigated area.

기술가치평가 체제와 발전방향

  • 김흥수
    • Journal of Technology Innovation
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    • v.11 no.1
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    • pp.1-27
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    • 2003
  • In the knowledge-based economy, technology valuation of patents, brand name, know-how is presented for as key subject of intangible assets management science. This paper reviews the methods of technology valuation that have been developed by valuation specialists. Also, is talking about the practical application by income approach (DCF) method. The function and role of technology valuation analysts such as the related organizations and the reference of foreign organization is appeared through the examples.

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