• Pediatric Infection and Vaccine
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• v.18 no.1
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• pp.68-79
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• 2011

Purpose : This post-marketing surveillance study (NCT00750360) assessed the safety and reactogenicity of an inactivated, trivalent split-virion influenza vaccine licensed for use in the Korea since 2002. Methods : Eight hundred and eighty three subjects aged 6 months received a single dose of the ${\geq}$ vaccine; an additional dose was administered to those aged <9 years and unprimed with an influenza vaccine. Four hundred and eleven subjects used diary cards to record safety information; this report presents data from these subjects. Incidence of solicited local, general and unsolicited adverse events (4-days and 21-days post-vaccination follow-up periods, respectively) were recorded. Serious adverse events (SAEs) were recorded throughout the study period. Results : Injection site pain (subjects aged <6 years: 12.6% of subjects, ${\geq}$6 years: 34.7%), fever (<6 years: 1.3%) and myalgia (${\geq}$6 years: 13.9%) were the most frequently recorded solicited local and general adverse events. Grade 3 solicited adverse events were reported by ${\leq}$4.0% subjects. No vaccine-related SAEs were recorded (KFDA criteria). Conclusion : Considering the vaccine's well-established immunogenicity and its favourable safety and reactogenicity profile across all age groups and its high coverage rate in Korea, it may be recommended as a candidate to facilitate annual seasonal influenza vaccination for all ages as part of the Korean National Immunization Program.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.70-70
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• 2003

조류의 배자는 포유류의 배자처럼 모체로부터 영양분을 공급받는 것이 아니라 알속에 저장되어 있는 영양물질로 발육한다. 배자의 발육은 대부분 체외에서 진행된다. 난자는 배란된 후 수정되어 난관팽대부에서 1세포기 수정란이 된다. 그 후 난관협부로 이동하여 최초로 분열이 일어나 배자의 발육이 진행되고, 산란시에는 세포수가 약6만여 개에 달한다. 따라서 수정란에 유전조작기법을 사용하기 위해서는 모체의 난관속에서 일어나는 배발생과 난각속에서 일어나는 개체발생을 위한 체외배양법과 대리난각 배양법이 확립되어 있어야 한다. 그와 같은 기술은 닭 수정란의 배 발생 관찰 및 분석과 유용한 물질을 생산하기 위한 형질전환 가금 연구에 중요한 기술로 사용되고 있다. 따라서 본 연구는 1세포기 닭 수정란의 체외배양과 대리난각 배양에 있어서 수정란의 조건과 대리난각의 조건이 배자의 생존율과 부화율에 미치는 영향을 조사하여 체외배양과 대리난각 배양에 의한 병아리 생산 효율을 제고하기 위한 기초자료를 얻고자 실시하였다. 주요 조사 항목은 수정란의 채란위치, 배자의 발생단계, 수정란의 무게, 대리난각용 계란의 보존 기간, 대리난각의 두께, 대리난각 두께의 감소율, 대리난각의 크기 등을 조사하여 배자의 생존율과 부화율에 미치는 영향에 대하여 조사하였다. 본 실험의 결과는 초기 발생이 빠른 배자가 생존율과 부화율이 높았으며, 본 실험에 사용한 대리난각용 계란의 보관기간이 짧을수록 배자의 생존율과 부화율이 높은 것으로 조사되었다(p<0.05). 그러나 대리난각용 계란의 크기와 대리난각의 두께 차이는 배자의 생존율과 부화율에 큰 영향이 없는 것으로 조사되었다.하였을 때 분할율은 68.0%였으며, 이중 12.0%가 상실배 또는 배반포로 발달하였다. 뿐만 아니라 10% FBS가 첨가된 TCM-199 배양액에 난관상피세포와 공배양을 실시하였을 경우는 72.0%가 분할하였으며, 이중 16.7%가 상실배 또는 배반포로 발달하였다. 이상의 결과로 볼 때 활성화 처리는 ionomycin과 6-DMAP 용액처리가 적합하며, 단위발생란의 체외배양은 보다 적합한 배양조건의 확립이 필요한 것으로 생각된다.icalcium lactate 공동배양은 체외배양에 별다른 영향을 미치지 못하는 것으로 나타났다.생산하는 것을 확인할 수 있었다.4시간에 등급별 회수율이 각각 GI(27.4%), GII(14.7%), GIII(43.2%), GIV(14.7%)로 나타났으며, 46~50시간에는 GI(12.0%), GII(12.0%), GIII(28.0%), GIV(48.0%)로 나타났다. 이상의 결과로 볼 때 미성숙 난자의 회수는 hCG 투여 후 29~34시간이 적합한 것으로 생각된다. 가금의 생산에 있어서 매우 효율적이고 주목할 만한 방법으로 사료된다. 것으로 나타났다.적외선.열풍 복합건조방법이 높게 나타나 이것은 곡물 표면에 원적외선 방사에의한 복사열이 전달되어 열장해를 받았기 때문으로 판단되며, 금후 더 연구하여 적정 열풍온도 및 방사체 크기를 구명해야 할 것이다.으로 보여진다 따라서 옻나무 유래 F는 포유동물의 생식기능에 중요하게 작용하는 것으로 사료된다.된다.정량 분석한 결과이다. 시편의 조성은 33.6 at% U, 66.4 at% O의 결과를 얻었다. 산화물 핵연료의 표면 관찰 및 정량 분석 시험시 시편 표면을 전도

• Journal of Energy Engineering
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• v.27 no.2
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• pp.14-25
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• 2018

The combined cycle power plant has a cycle of operating the gas turbine with fuel, such as natural gas, and then producing steam using residual heat. The fuel gas is supplied to the gas turbine at a level of 4 to 5 MPa, $200^{\circ}C$ through a compressor and a heat exchanger. In this study, the risk assessment method considering the piping system stress was carried out for safe operation and soundness of the gas fuel supply piping system. The API 580/581 RBI code, which is well known for its risk assessment techniques, is limited to reflect the effect of piping stress on risk. Therefore, the systematic stress of the pipeline is analyzed by using the piping analysis. For the study, the piping system stress analysis was performed using design data of a gas fuel supply piping of a combined cycle power plant. The result of probability of failure evaluated by the API code is compared to the result of stress ratio by piping analysis.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.1
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• pp.211-224
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• 2018

It is important to design tunnel support system considering the various loads acting on the tunnel because they have a direct impact on the stability of tunnels. In Korea, standardized support patterns are defined based on the rock mass classification system depending on the project, and it is stated that it should be modified appropriately considering the behavior of tunnel during construction. In this study, the tunnel support pattern optimization method is suggested based on the convergence-confinement method, earth pressure, axial force of rock bolt, and moment acting on the shotcrete. The length and spacing of the rock bolts and the thickness of the shotcrete were optimized by using the differential evolution algorithm (DEA) and the results were compared to the standard support pattern III for railway tunnel. Rock bolt length can be reduced and the installation interval can be widened for shallow tunnel. As the depth of tunnel increases, the thickness of shotcrete increases linearly. Therefore, the thickness of shotcrete should be thicker than the standard support pattern as the depth of tunnel increases to secure the stability of tunnel.

• Journal of The Korean Dental Society of Anesthesiology
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• v.7 no.1
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• pp.6-12
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• 2007

배경: 소아 진정 치료 시 서로 다른 용량의 chloral hydrate와 hydroxyzine을 복용 후 midazolam을 구강 점막 하 주사했을 때 행동 반응을 비교하였다. 방법: 총 32회 진정법을 통해 치과치료를 받은 30명의 나이 24-72개월, 체중 20 kg 미만의 미국 마취과학회 신체등급 I의 건강하지만 겁이 많고 협조가 안 되는 소아 환자를 대상으로 2개 치아이상의 보존 치료 및 발치를 필요로 하는 환자를 대상으로 하였다. 호흡기 질환이 있는 아이들은 이 연구에서 제외되었다. 연구 계획은 이대 목동 병원의 임상 실험 심사 위원회에 제출되었다. 1군은 chloral hydrate 50 mg/kg와 hydroxyzine 1 mg/kg 복용 후 점막 하 midazolam 0.2 mg/kg을 추가 투여했고 2군은 chloral hydrate 60 mg/kg와 hydroxyzine 1 mg/kg 복용 후 점막 하 midazolam 0.1 mg/kg을 주사 받았다. 50% nitrous oxide는 치료 중 두 군 모두 유지되었다. 전날 수면 시간과 약물 복용 태도를 기록하였으며 모든 치료 과정은 비디오로 촬영되었다. 맥박 산소 계측기를 이용하여 경피적 산소 포화도와 맥박수를 기록하였고 행동 반응은 Houpt scale을 이용하여 매 2분마다 40분 동안 기록되었다. 전반적인 행동 반응은 Houpt scale를 이용하여 평가되었다. 모든 자료는 SPSS 통계 프로그램을 이용하여 two sample independent t-test를 사용하였다. P 값은 0.05 미만인 경우를 통계학적으로 유의하다고 보았다. 결과: 두 군 간의 경피적 산소 포화도와 맥박수는 모두 정상 범위이며 유의한 차이가 없었다. 행동 반응 비교에서는 치료 처음 10분 동안 2군이 1군에 비해 점수가 높게 나왔으며(P < 0.05), 그 외에는 유의한 차이가 없었다. 전날 총 수면 시간과 약물을 복용하는 태도는 수면 치료 중의 행동 반응에 영향을 주지 않았다. 결론: Chloral hydrate 50 mg/kg 복용과 점막 하 midazolam 0.2 mg/kg은 chloral hydrate 60 mg/kg 복용과 점막 하 midazolam 0.1 mg/kg과 비교할 때 두 약물의 조합은 모두 소아 환자 수면 치료시 안전하고 효과적인 용량이다. Overall behavior와 Q (quiet)의 분포를 비교해 볼 때 두 군 모두 성공적인 진정효과를 기대할 수 있다.

• Fire Science and Engineering
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• v.15 no.1
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• pp.100-107
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• 2001

A Interior material, a main cause of fire-growth and generating toxic gas when it burns, should be dealt with great care in life safety design. Nonetheless, it has been used recklessly with undue attention to its contribution to fire in particular in entertainment occupancy and causes many victims in fire. Therefore, this study attempts to examine the current use of interior material in Korea and find out what to be improved and enhanced in terms of related regulations. Based on the comparison and analysis of the Korea regulation with those of advanced nations, suggestions are made for an effective and efficient improvement and complement to the current system. What can be suggested from this study are as follows. The use of interior material should be controlled under the unified regulation of fire-safety codes. Code should be set up so that the current construction enforcement should be applied in retroactive to those entertainment buildings that obtained a license prior to the implementation of the system certifying that the building is fire-resistant and fire-protective. The legislation should be made to control the fire-protection facilities of small-sized, underground entertainments. It should be obliged to present the blueprint displaying the use of interior material at the time of changing occupancy. Or, it should be compelled to report changes that go way without permit to the administrative office. A compulsory provision should be set up to have a fire-resistant performance to movable furniture. The classification index designating the fire hazard of interior material by flame spread rate and smoke toxicity and its test method should be established.

• Korean Journal of Plant Resources
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• v.27 no.5
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• pp.534-539
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• 2014

This study was carried out to establish seed propagation method of Hydrangea petiolaris Siebold & Zucc., one of the specific and protected plant species for the floral region. Seed size ranged $1.36{\times}0.84mm$, weight of thousand seeds was $2.3{\pm}0.02mg$. Observation of seed morphology characters showed wrinkled surface and elliptical shape, indicating amber color and fine seeds. Moisture contents of seeds, increased rapidly by water-soaking treatment, recording maximum moisture contents (31.9%) after 48 hours. Percent germination of seeds was higher under the light than dark condition. Seed germination was the best at $25^{\circ}C$ under the light condition (78.0%) among temperature and light conditions treated. Percent germination, germination energy and $T_{50}$ was greatly improved by soaking in $GA_3$ solutions for 48 hours. Especially, $100{\sim}500mg{\cdot}L^{-1}$ $GA_3$ treatment resulted in the highest germination rate as 90.0% and above.

• Journal of the Korean association of regional geographers
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• v.11 no.2
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• pp.278-290
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• 2005

This study deals with the geomorphic, environmental and land use changes by comparative analysis using Landsat TM images of 1988 year and ETM ones of 2002 year, partly together with the new Quick Bird images having 60cm resolution for more detail analysis, focusing on the Oncheon gun(county) in Pyeongnam Province, west coast zone of North Korea. The main analysis methodology is neural network classification, which is more advanced techniques for the classification of land cover and land use, with higher accuracy rate and lower errors. The TM images of 1988 year show, mainly, the on-construction tide embank for the reclamation at Gwangryangman bay and salt farm on the reclaimed tidal flat. But, ETM images of 2002 year present stabilized reclaimed land, salt farm and rice field, recently transformed from salt farm. Especially, new tidal land has been naturally developed on the coastal shallow out of tide embank and salt farm. The results of the study may help to database coastal environmental changes and to support for reasonable and productive land use of North Korea, and to manage and plan unified national land in the near future.

• Clinics in Shoulder and Elbow
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• v.13 no.2
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• pp.223-229
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• 2010

Purpose: The purpose of this study was to determine the correlation between the radiographic and clinical findings of massive rotator cuff tears. Materials and Methods: Forty-five diagnosed cases (35 patients) of massive rotator cuff tears were investigated in this study. Grade of arthritis in the massive rotator cuff tears was classified based on plain radiographs using the method of Hamada et al.. And we clinically evaluated cases using the UCLA scoring system. Results: No statistically significant correlation ($r_s$=0.220, p=0.151) was found between arthritis grades in massive rotator cuff tears and clinical features. Dominant arm involvement appeared to be related to a higher rate of surgical treatment and a lower UCLA score. Conclusion: In massive rotator cuff tear patients, radiographic findings of arthritis may not always correspond to clinical features relevant in daily life. Therefore, we suggest that treatment strategies should be carefully considered when considering treatment modalities.

• Journal of The Korean Society of Grassland and Forage Science
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• v.32 no.2
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• pp.125-130
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• 2012

This study was performed to investigate the nutritive values of white panicled rice (Oryza sativa L., WPR) silage manufactured with WPR grown in reclaimed paddy field of Bigumdo of Korea in 2011. The WPR used in this study were collected in 1,000 ha of reclaimed paddy field of Bigumdo and was harvested at dough stage and ensiled. The yield of whole crop rice (WCR) grown in region received the most severe damage (MSD) was lower as about 800 kg/ha as than that in region of normal growth (NG). The content of crude protein and total digestible nutrient in WCR of MSD slightly increased, as compared to that in WCR of NG, but the contents of acid detergent fiber and neutral detergent fiber significantly decreased (p<0.05). The pH in WCR silage of MSD and NG ranged from 4.5 to 5.0 and pH decreased by the inoculation of lactic bacteria (p<0.05). The content of lactic acid in WCR silage of MSD and NG increased by the inoculation of lactic bacteria (p<0.05), but the content of acetic acid and butyric acid decreased (p<0.05). Flieg's score in WCR silage of MSD and NG inoculated lactic bacteria increased from 2 to 3 grade, as comparing to non-inoculation of lactic bacteria. Therefore, this study suggests that WPR can be utilized as forage.