• Korean Journal of Psychosomatic Medicine
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• v.26 no.1
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• pp.26-34
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• 2018

Objectives : This study tried to explore the prevalence of chronic physical diseases in patients with schizophrenia and its effects on total medical costs. Methods : The Health Insurance Review and Assessment Service data in 2014-2015 was employed. Only the injuries and diseases, identically diagnosed 3 times or more as a major or minor injury and disease, were classified into chronic physical diseases to improve data accuracy. Total medical costs included out-of-pocket and insurer's costs from health care system perspective. Results : It was shown that 24.5%, 17.3% and 23.4% of schizophrenia patients had one, two and three or more chronic physical diseases, respectively. There was a high prevalence of not only metabolic, but also musculoskeletal, diseases in those patients. The amount of 2015 total medical costs of patients with schizophrenia in 2014 was about 1.08 trillion won. The factors affecting the costs included sex, age, number of chronic physical diseases, and health insurance status. Conclusions : It is considered that clinical practice guidelines based on personal diseases may not sufficiently solve the problems for comorbidities in schizophrenia patients. Accordingly, it should be required to develop models for new types of medical systems capable of treating and caring varied illnesses at the same time.

• Journal of Veterinary Clinics
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• v.26 no.2
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• pp.170-175
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• 2009

A 7-year-old, intact male Pomeranian(weighing 2.2 kg), was presented with clinical signs of prolonged anorexia, polydypsia/polyuria, severe azotemia, proteinuria and heart murmur. Diagnostic studies found chronic kidney disease, severe hypertension and hypertrophic cardiomyopathy. The dog was treated with 2-day peritoneal dialysis, blood transfusion, anti-hypertensive therapy with amlodipine and conservative therapies direct to chronic renal failure. This is a rare case of hypertensive cardiomyopathy complicated with chronic kidney disease in dogs.

• Journal of the Korea Convergence Society
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• v.12 no.6
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• pp.49-56
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• 2021

This study aimed to identify the factors affecting the health-related quality of life in terms of periodontal disease by using the data from 8,035 respondents aged ≥40 years, excepting those with cancers having an serious impact on the quality of life, in the seventh Korea National Health and Nutrition Examination Survey (KNHANES) (2016-2018). The risk of quality of life deterioration was 1.32 times higher in the periodontal disease group than in the healthy periodontal group, those who were ≥50 years of age and had ≥2 comorbidities showed lower quality of life in the periodontal disease group. These results have confirmed that adults with periodontal disease get aware of the adverse quality of life though they have only a few chronic conditions and are expected to be useful as basic data necessary to develop health promotion programs that can help prevent periodontal disease and improve the health-related quality of life for adults.

• Childhood Kidney Diseases
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• v.7 no.2
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• pp.217-222
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• 2003

Chronic granulomatous disease(CGD) is a rare inherited disorder of phagocytic cells which results in a susceptibility to infections by catalase-positive bacteria and fungi, as well as granuloma formation. And acute poststreptococcal glomerulonephritis(APSGN) is one of the most common glomerular lesions of gross hematuria in children. We experienced a case of APSGN accompanied with CGD presenting with a liver granuloma.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.649-659
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• 2005

The purpose of this study was to quantify and compare the level of MMP-1 in the healthy or inflamed gingival tissue of patients with or without type 2 diabetic mellitus. We investigated whether mean amount of MMP-1 was changed by chronic periodontitis and type 2 DM. Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was divided into the three group. Group 1(n=8) was clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2(n=8) was inflamed gingiva from patients with chronic periodontitis. Group 3(n=8) was inflamed gingiva from patients with chronic periodontitis and type 2 diabetes. Tissue samples were prepared and analyzed by Western blotting. The quantitative analysis of MMP-1 was performed using a densitometer and statistically analyzed by ANOVA. MMP-1 was expressed in all samples and an increased MMP-1 level was observed in group 2 compared to group 1 and decreased MMP-1 level was found group 3 compared to group 2, but the differences among 3 groups were not statistically significant. In conclusion, this study demonstrated that MMP-1 levels of inflamed gingiva of systemically healthy patient(group 2) were higher than normal gingiva of systemically health patients and although the severity of gingival inflammation in group 2 and 3 were similar, MMP-1 expression was decreased in diabetic patients than systemically healthy periodontal patients.

• The Monthly Diabetes
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• s.200
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• pp.22-25
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• 2006

만성 간질환자는 간과 근육의 에너지 저장소로서의 역할이 장애를 받고, 에너지 대사상 지방조직의 활용도가 높아지는 변화와 함께 질환 자체의 합병증으로 인한 식사섭취 감소로 영양 불량이 흔히 동반되므로 영양공급이 매우 중요하다.

• Tuberculosis and Respiratory Diseases
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• v.41 no.3
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• pp.205-214
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• 1994

만성 폐쇄성 폐질환(COPD)은 하부 기도 즉 말초기도의 지속적인 미만성 폐쇄로 인하여 불가역성 기류폐쇄를 나타내는 질환을 말하며, 임상적으로 만성 기관지염과 폐기종으로 분류할 수 있으나, 이들은 기능적으로나 병리적으로 서로 중첩되어 임상적으로 명확하게 구별할 수 없기 때문에 만성적, 비특이적으로 진행하는 기류폐쇄의 포괄적인 용어로 COPD를 사용한다. COPD의 특징적인 병리변화는 소기도 즉 막성 세기관지염과 호흡세기관지염이며, 호흡세기관지염을 동반하는 폐기종의 중증도가 기류폐쇄의 정도를 결정하는 중요한 인자로 작용한다.

• Sleep Medicine and Psychophysiology
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• v.2 no.1
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• pp.55-64
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• 1995

During sleep, relatively major respiratory physiological changes occur in healthy subjects. The contributions and interactions of voluntary and metabolic breathing control systems during waking and sleep are quite different Alterations of ventilatory control occur in chemosensitivity, response to mechanical loads, and stability of ventilation. The activities of intercostal muscles and muscles involved in regulating upper airway size are decreased during sleep. These respiratory physiological changes during sleep compromise the nocturnal ventilatory function, and sleep is an important physiological cause of the nocturnal alveolar hypoventilation. There are several causes of chronic alveolar hypoventilation including cardiopulmonary, neuromuscular diseases. Obstructive sleep apnea syndrome (OSAS) is an important cause of nocturnal hypoventilation and hypoxia. Coexistent cardiopulmonary or neuromuscular disease in patients with OSAS contributes to the development of diurnal alveolar hypoventilation, diurnal hypoxia and hypercapnia. The existing data indicates that nocturnal recurrent hypoxia and fragmentation of sleep in patients with OSAS contributes to the development of systemic hypertension and cardiac bradytachyarrhythmia, and diurnal pulmonary hypertension and cor pulmonale in patients with OSAS is usually present in patients with coexisting cardiac or pulmonary disease. Recent studies reported that untreated patients with OSAS had high long-term mortality rates, cardiovascular complications of OSAS had a major effect on mortality, and effective management of OSAS significantly decreased mortality.

• Proceedings of the KSLP Conference
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• 1998.11a
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• pp.187-187
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• 1998

위식도 역류 질환의 전형적인 증상에 반하여 인후두에서 나타나는 애성, 만성 기침, 헛기침, 인후두 이물감등의 비전형적인 증상에 대해 최근 관심이 높아지고 있다. 특히 애성이 주된 증상으로 나타나는 경우 일부에서 후두 후방에 점막의 비후 소견이나 육아종을 보이기도 하지만 많은 경우 후두내 기질적 병변을 찾기 어려울 때가 많으므로 의식도 역류 질환과 연관된 애성으로 진단하기 위해서는 자세한 병력 파악 및 이학적 검진, 그리고 위식도 역류 진단을 위한 검사 둥이 요구된다. 저자들은 인후두 이물감을 주소로 내원하여 위식도 역류 검사상 위식도 역류 질환으로 판명되었던 환자 중 애성이 동반된 환자 20례에 대하여 치료전 음성 검사를 시행하였으며 일반적인 치료 후 8주째 추적 검사를 시행하여 그 결과를 문헌 고찰과 함께 보고하고자 한다. (중략)

• The Monthly Diabetes
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• s.288
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• pp.21-26
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• 2013

1990년대 이후 국내 노령인구 비율이 급격히 증가하고 있다. 2018년에는 전 인구의 14%, 2026년에는 전 인구의 20% 정도를 차지할 것으로 예상되고 있다. 노령 인구는 만성질환의 유병율이 높으며 이와 함께 노령 인구의 특성상 인지기능저하가 동반되는 경우가 많아 환자 관리에 있어서 어려움이 많다. 당뇨병은 인지기능장애의 주요 위험 인자를 차지하고 있다. 그러나, 일반적으로 당뇨병 치료에 있어 혈당관리, 미세혈관 및 대혈관 합병증에 대한 관심 및 관리는 잘 이루어지고 있지만, 이에 반해 인지기능장애 부분에 있어서는 다소 간과하고 있는 부분이 많다. 당뇨병이 있는 환자에서 치매 발생 위험율이 2배 이상을 높은 점을 감안할 때, 고령 환자에서는 인지기능장애에 대한 세심한 관심이 필요하다.