• The Inventors News
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• no.53
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• pp.1-16
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• 2006

'여성기업지원에 관한 법률' 개정 한 목소리/발행인 칼럼/'제4회 여성발명경진대회' 수준 높아졌다/심사착수 예정시기 직접 통지 서비스 실시/특허청.한국기계연구원, 업무협약체결/낙도어린이들에게 꿈과 희망 심어주는 초청 행사 가져/특허청 팀장 선발 방식 변화 통한 팀제 강화/디자인 권리화 지원사업 실시한다/'DMB 특허품과 지재권전략 세미나'/'2006 독일 국제발명품 전시회' 회원 4명 수상/고성능 하이브리드 보호복, 출원 증가/'이달의 기능 한국인' 박순복 씨 선정/모방상표, 더 이상 등록 받을 수 없다/국내제약업계, 유사브랜드 너무많아/'2006 여성 재활용 발명경진대회' 개최/순수 한방재료로 만든 헤어 클리닉 화제/발명자에게 편리한 특허제도 마련/차로 마시는 '허브 추출물'로 살충제 만들어/종이컵에도 웰빙 바람이 불고 있다/특허공보 통해 '나의 발명' 확인가능/지역특산품도 지리적 표시로 보호 받는다/한미약품,'비만치료제 특허권 분재' 연승/국내특허, 해외에서 신속하게 심사 처리/'스판덱스 특허소송'에서 일본업체 패소/아모레, 다국적 화장품회사 로레알에 승소/제7차 한국.유럽 특허청장 회담 개최/고부가가치 창출하는 단백질 의약품 개발 필요/한방 진료에도 변화의 새바람 분다/에너지 절감'기능성 유리' 출원 급증/역사 속의 발명품/하루 10분 발명교실/특허Q&A/세상을 밝히는 여성들의 발명 아이디어/'특허넷' 정부기관 최초 CMMI 레벨4인증 획득/'해외지재권 보호 가이드북' 제작배포하다/아이디어 착상 및 발명 기법/고정관념을 깨트려 블루오션을 장악하라/에반스의 증기제분기/50년 후엔 동물과도 대화할 수 있다/첩보용 도구 전달 '발명팀' 실제 존재/중소기업 위한'2006 특허유통 페스티벌' 개최/출원료.심사청구료 반환제도 도입, 시행/'지재권 e-러닝 콘텐츠' 전 세계특허청 교육 자료로 활용/대한변리사회, 미 특허법 세미나 개최/한국여성발명협회 회원사 발명품 가이드

• Korean Journal of Food Science and Technology
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• v.36 no.6
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• pp.974-978
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• 2004

Brown-alga-derived natural agent NX42, mainly composed of algal polysaccharides and phlorotannins, showed mild but dose-dependent inhibition of acetylcholinesterase with $IC_{50}=600-700\;{\mu}g/mL$. Phlorotannin-rich fraction of NX42 showed substantial increase of the activity by more than one order of magnitude ($IC_{50}=54\;{\mu}g/mL$) and significant protection of SK-N-SH cells from oxidative stress by $H_2O_2$. Learning trials of mice for 5 consecutive days revealed electric-shock treatment during learning period significantly retarded learning process, whereas NX42-treated mice showed significant resistance against leaning deficiency possibly mainly due to anticholinesterase and neuroprotective activities of phlorotannin.

• Journal of the Korean Geosynthetics Society
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• v.12 no.2
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• pp.43-53
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• 2013

Environmental monitoring analysis were analyzed for the period from 1988 to 2007 near King Sejong Station. Extreme environment structure behaviors(Marine Biology Lab.) were evaluated using monitoring sensors developed commercial sensors. Also when installing the sensors ambient environment of the King Sejong Station, to analyze the measured data and the comparative behavior of the structure were analyzed. As a environmental monitoring analysis result at King Sejong Station temperature, sensors were installed to withstand about $-25.6^{\circ}C$ or less and 49.5m/s. They were needed that the height of 225.0cm or more to be installed during the installation. For several monitoring sensors used in Antarctic, temperature, snow and strong winds were very sensitive to the atmospheric environment. Quite often a camouflage(animals and humans) would make it necessary to provide housing for monitoring sensors. Therefore, protection system developed for these sensors were to protect the sensors and data logger. Protection system the newly developed, is economical, easy to install even in harsh environments. Based on the measurement result of the one year, consider electrode applicability of the protection system, it was confirmed that the behavior of the structure is also predictable.

• Journal of Chest Surgery
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• v.41 no.4
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• pp.405-416
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• 2008

Background: Spinal cord ischemic injury during thoracic and thoracoabdominal aortic surgeries remains a potentially devastating outcome despite using various methods of protection. Neuronal voltage-dependent sodium channel antagonists are known to provide neuroprotection in cerebral ischemic models. This study was designed to compare the neuroprotective effects of phenytoin with those of hypothermia in a rabbit model of spinal cord ischemia. Material and Method: Spinal cord ischemia was induced in New Zealand white rabbits by means of infrarenal aortic cross clamping for 25 minutes. Four groups of 8 animals each were studied. The control group and the hypothermia group received retrograde infusion of saline only ($22^{\circ}C$, 2 mL/min); the normothermic phenytoin group and the hypothermicphenytoin group received retrograde infusion of 100 mg of phenytoin at different rectal temperatures ($39^{\circ}C$ and $37^{\circ}C$, respectively) during the ischemic period. The neurologic function was assessed at 24 and 72 hours after the operation with using the modified Tarlov criteria. The spinal cords were harvested after the final neurologic examination for histopathological examination to objectively quantify the amount of neuronal damage. Result: No major adverse effects were observed with the retrograde phenytoin infusion during the aortic ischemic period. All the control rabbits became severely paraplegic, Both the phenytoin group and the hypothermia group had a better neurological status than did the control group (p < 0.05). The typical morphological changes that are characteristic of neuronal necrosis in the gray matter of the control animals were demonstrated by means of the histopathological examination, whereas phenytoin or hypothermia prevented or attenuated these necrotic phenomena (p < 0.05). The number of motor neuron cells positive for TUNEL staining was significantly reduced, to a similar extent, in the rabbits treated with phenytoin or hypothermia. Phenytoin and hypothermia had some additive neuroprotective effect, but there was no statistical significance between the two on the neurological and histopathological analysis. Conclusion: The neurological and histopathological analysis consistently demonstrated that both phenytoin and hypothermia may afford significant spinal cord protection to a similar extent during spinal cord ischemia in rabbits, although no significant additive effects were noticed.

• The Korean Journal of Pesticide Science
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• v.16 no.3
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• pp.261-266
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• 2012

It is common to use many experiment animals to evaluate the toxicity of chemicals including pesticides. For protecting animal, the concepts of 3R (Reduction, Replacement, Refinement) were introduced and in vitro alternatives methods actively have been developed all over the world. Many experimental animals for toxicological tests have been used, so that it is important to establish the alternative methods. In this study, the alternative method using reconstituted human skin model (Keraskin$^{TM}$) was conducted for classification of skin irritation on pesticides. Sixteen formulations selected on the basis of the degree of irritation were treated by Keraskin$^{TM}$ test. The percent of cell viability was measured into the culture medium collected after treatment of the pesticides for 24-72 hrs. The skin irritations of formulations were evaluated by the cell viability. In this study, The 4 formulations with mild irritation in rabbits were evaluated as nonirritant, the 6 formulations with moderate and severe irritation were evaluated as irritant in human skin model test. We suggest that the alternative test using Keraskin$^{TM}$ model could be used as toxicity evaluation for primary irritation index (P.I.I.) score of greater than or equal to 2.1 of pesticides. The further studies should be required to apply for hazardous assessment of pesticides on alternative skin irritation methods because of the interindividual variability of the sensitivity of skin irritation on pesticides.

• Journal of Applied Biological Chemistry
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• v.59 no.3
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• pp.265-271
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• 2016

Recently, liver damage contributes to big percentage of the morbidity and mortality rates worldwide. Excessive intake of alcohol is one of the major causes of liver injury. When liver injury is repeated and becomes chronic, it leads to development of fibrosis and cirrhosis. In the liver, TGF-${\beta}$ is a profibrogenic cytokine, which participates in various critical events cause liver fibrosis. Seahorse (Hippocampus abdominalis) is a common traditional Chinese medicine and has been widely used for centuries. Seahorse has been known to have a variety of bioactivities, such as anti-oxidant, anti-fatigue, and anti-tumor. Peptide is one of the main compounds of seahorse. In this study, we isolated enzymatic hydrolysate from seahorse H. abdominalis by alcalase hydrolysis and investigated the effect of the hydrolysate on liver injury. In the present in vitro studies, the hydrolysate increases cell viability of Chang cells and protects Huh7 cells from ethanol toxicity. In addition, the hydrolysate inhibits TGF-${\beta}$-induced responses. In vivo studies show that the pretreatment of hydrolysate reduces alcohol-induced increases of serum Glutamic oxaloacetic acid transaminase and Glutamic pyruvate transaminase activities and increases liver weight and body weight. These results suggest that seahorse may have a hepatoprotective effect.

• Journal of Life Science
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• v.23 no.8
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• pp.1019-1024
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• 2013

The aims of this study were to determine antioxidation effect and neuroblastoma cell protection effect of donkey's bone and skin extracts (DBSE). DBSE was extracted by a pressure-cooker for 48 h and lyophilized. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was significantly increased with increased doses of DBSE and 40 mg/ml of DBSE showed 95.43% of the DPPH scavenging effect, which was equivalent to 1 mg/ml of vitamin C. The 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulphonic acid) (ABTS) radical scavenging activity was also increased in a dose-dependent manner, and 20 mg/ml of DBSE showed 88.73% of the ABTS scavenging effect. The oxygen radical absorbance capacity (${\mu}M$ Trolox equivalent) of DBSE was significantly increased at a concentration of 10 mg/ml, which showed $132.53{\mu}M$ TE. The viability of oxidatively stressed brain cells induced by $500{\mu}M\;H_2O_2$ was protected by DBSE at concentrations greater than $50{\mu}M$. Cell viability after DBSE treatment at 50 and $100{\mu}g/ml$ was 53.78 and $54.34{\mu}M$ TE, respectively. There was no significant difference between both doses; however, 200 and $500{\mu}g/ml$ of DBSE showed 59.74 and 66.08% of cell viability, respectively indicating that DBSE protected SK-N-SH from oxidation stress. These results suggest that DBSE may have potential to be used as natural antioxidants in food industry, while in vivo evidence is necessary to support DBSE's in vitro-based antioxidative efficiency.

• Journal of Forest and Environmental Science
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• v.29 no.1
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• pp.90-98
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• 2013

The purpose of this study was to understand the geographical and environmental distribution of wild animals in Baekdudaegan region using field survey and GIS data. Crucial factors were selected and analyzed to understand the distributional characteristics of wild animals (7 species in 6 families) and rare endemic plants (14 species in 11 families). These crucial factors include stand factors (forest type, DBH class, and crown density), soil factors (bed rock, soil texture, and organic matter), geographical factors (elevation, slope, aspect) and climatic factors (temperature, rain fall, humidity). Finally, 10 factors were selected by statistical analysis and categorized for analyzing geographical and environmental features. Four families such as Muridae, Sciuridae, Suidae and Talpidea in wild animal showed the similar habitat characteristics with the 10 factors.

• Tribology and Lubricants
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• v.11 no.3
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• pp.1-10
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• 1995

전세계적으로 환경보호의 중요성에 대한 인식이 높아짐에 따라 "환경수용성(Environmentally Acceptable) 윤활기유에"에 대한 관심도 늘어나고 있으며, 선진국에서는 이미 이에 관한 연구가 국가적인 차원에서 진행되고 있다. 환경수용성 윤활기유는 크게 식물성 오일, 동물성 오일 및 합성 윤활기유로 분류된다. 환경수용성 윤활기유의 중요한 물성으로는 기유의 화학적 조성, 물리적 및 화학적 성질에 따른 생분해성 및 산화 안정성 등을 들 수 있다. 대표적인 환경수용성 윤활기유는 정제된 유채오일과 선택적으로 합성된 에스테르오일이 점차 주목을 받고 있으며 특히 이들의 생분해성이 우수하므로 그 중요성이 증가되고 있다. 유채오일과 에스테르오일을 비교해 보면 유채오일은 공급이 충분하고 비교적 값이 싼 반면에 에스테르오일은 식물성 오일보다 윤활 안정성은 우수하나 가격이 비싼 단점 때문에 광범위하게 사용되는데 다소 문제가 되고 있다. 이러한 문제에도 불구하고 생분해성이 우수한 에스테르오일이 오늘날 환경에 해로운 영향을 미치는 광유계 윤활기유를 대체할 수 있을 것으로 추정된다. 본고에서는 환경수용서 윤활기유의 중요성과 그 종류 및 개발동향에 관하여 고찰하고자 한다. 고찰하고자 한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.11a
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• pp.1007-1010
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• 2005

RFID(Radio Frequency IDentification)란 일정(무선) 주파수 대역을 이용한 자동인식기술로 원거리에서도 대상물을 분석하여 개체의 정보를 읽거나 기록할 수 있는 시스템이다. 현재 RFID기술은 바탕으로 한 유비쿼터스(Ubiquitous)환경 및 물류시스템, 바코드 시스템을 사용하기 힘든 동물 태깅이나 고속도로 요금부과, 도난 방지, 치매환자의 보호관리 등에 사용할 수 있다는 점으로 사회 전반에 걸쳐 그 사용 폭을 넓혀 가고 있다. 그러나 RFID의 낮은 연산능력과 기억능력의 특징상 정보 보안이나 개인의 프라이버시측면에서 여러 문제들을 발생시킨다. 본 논문에서는 기존의 RFID 인증 프로토콜들을 비교 분석하고, 태그와 리더기 사이의 정보 전송 중 공격자에 의한 정보의 변형을 방지하는 RFID 인증 프로토콜을 제안한다.