• Title/Summary/Keyword: 독성지수

Search Result 193, Processing Time 0.026 seconds

Effects of Opuntia ficus-indica on Lipidperoxide and cholesterol level (Opuntia ficus-indica가 과산화지질 및 콜레스테롤에 미치는 영향)

  • 전홍기;정영기;하배진
    • Journal of Life Science
    • /
    • v.13 no.6
    • /
    • pp.865-870
    • /
    • 2003
  • Opuntia ficus-indica is widely used as folk medicine for burned wound, edema and indigestion, etc. After the adaptation of rats for seven days, OF (200mg/kg) was administered into rats intraperitoneally every day for two weeks. On the 14th day, $3.3m\ell$ of $CCl_4$ (50% $CCl_4$ : Olive oil = 1 : 1) was treated to rats and on the 15th day, they were operated. We measured the levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, total lipid and triglyceride (TG) in serum and Malondialdehyde (MDA) in liver tissue. Opuntia ficus-indica and $CCl_4$-treated group (OFC) significantly decreased lipid peroxidation by 32.6% compared to $CCl_4$-treated abnomal group (CTA). Total lipid and TC of OFC administered group were lower than those of CTA group. Cholesterol levels showed significant effect in OFC group. Total cholesterol and LDL-cholesterol in OFC administered group were decreased by 12.7% and 17.4%, respectively, compared to those of CTA group. HDL-cholesterol in OFC administration group was increased by 19.7% compared to CTA group. This finding suggests that lipid peroxidation was inhibited in the significant level when $CCl_4$-induced rats were treated with OF. Based on this analysis, further study to identify the active components in this sample is warranted.

Effects of Turbid Water on Fish Community: Case Studies of the Daegi Stream and the Bong-san Stream (탁수가 어류군집에 미치는 영향: 대기천 및 봉산천의 사례연구)

  • Kim, Jai-Ku;Choi, Jae-Seok;Jang, Young-Su;Lee, Kwang-Yeol;Kim, Bom-Chul
    • Korean Journal of Ecology and Environment
    • /
    • v.40 no.3
    • /
    • pp.459-467
    • /
    • 2007
  • The effects of turbid water on fish community was investigated in a clear reference stream (the Bongsan Steam) and a turbid stream (the Daegi Stream) located in the upstream region of the South Han River, Korea. The stress index (SI) of suspended solids (SS) were calculated during a rain event concentration by the equation SI=LN (SS${\times}$duration). EMC of SS was $1{\sim}13$ mg $L^{-1}$ in the clear stream with a mean SI of 5.2, while SS was $97{\sim}1,150$ mg $L^{-1}$ in the turbid stream with a mean SI of 10.3. Even though the number of species was not much different, the dominant species of the two steams were distinctly different. The reference stream was dominated by upstream species such as Rhynchocypris kumgangensis, Brachymystax lenok tsinlingensis, and Cottus poecilopus which are typical upstream community. Whereas the turbid streams was dominated by Rhynchocypris kumgangensis, Zacco koreanus, and Orthrias nudus which are representatives of middle reache community. Fish density was four times higher in the clear steam than the turbid stream. In the similarity analysis of fish communities the community of the turbid stream showed large dissimilarity with other communities in other streams of similar size. In conclusion, although turbidity might be at the sublethal concentration, fish communities are under stress in some turbid streams of Korea that is strong enough to induce community change. It can be an example of a chronic ecological toxicity of turbidity at the community level.

Anti-diabetic effect of mulberry leaf extract fermented with Lactobacillus plantarum (Lactobacillus plantarum으로 발효한 뽕잎 추출물의 항당뇨 효과)

  • Choi, Jisu;Lee, Sulhee;Park, Young-Seo
    • Korean Journal of Food Science and Technology
    • /
    • v.52 no.2
    • /
    • pp.191-199
    • /
    • 2020
  • The purpose of this study was to isolate novel lactic acid bacteria to ferment mulberry leaf extract (MLE) and to investigate its anti-diabetic effect. Lactobacillus plantarum SG-053 isolated from gatkimchi was selected to ferment MLE because it exhibited high α-glucosidase inhibitory activity (96.8%) and enhanced the content of 1-deoxynojirimycin (DNJ), an anti-diabetic substance, in fermented MLE up-to 2.2 times. MLE fermented with L. plantarum SG-053 (FMLE) showed growth promoting activity against L6 myotubes and increased the gene expressions of IRS-1, PI3K p85α, and GLUT-4 up-to 1.4, 2.2, and 1.4 times, respectively, and 2-deoxyglucose uptake up-to 40.7%. In rat skeletal muscle tissue, the expressions of PI3K p85α and GLUT-4 increased by 6.4 and 2.1 times, respectively. These results suggest that L. plantarum SG-053 could enhance the DNJ content of MLE by fermentation and that FMLE is effective in ameliorating insulin resistance via activation of the insulin signaling pathway.

A Health Risk Assessment of Tributyltin Compounds in Fishes and Shellfishes in Korea. (국내 유통중인 어패류 섭취에 따른 유기주석화합물의 인체 위해성 평가)

  • Choi, Shi-Nai;Choi, Hye-Kyung;Song, Hoon;Oh, Chang-Hwan;Park, Jong-Sei
    • Journal of Food Hygiene and Safety
    • /
    • v.17 no.3
    • /
    • pp.137-145
    • /
    • 2002
  • Tributyltin compounds have been increasingly used in the form of plastic stabilizers, catalytic agents, industrial agricultural biocides, antifouling paint, and pesticides. Among these organotin compounds, large amounts of tributyltin(TBT) and triphenyltin(TPT) have been used as antifouling agents because they have a superior ability to prevent marine organism from being encrusted on ship bottoms and in culturing nets. Environmental pollution by these organotin compounds in the aquatic environment were undertaken. The international maritime Organization's established a provisional tolerable daily intake(TDI) of 1.6[micro]g TBTO/kg/ B.W. The Food and Agiculture Organization (of the United Nations)/world Health Organization's (FAO/WHO) proposed a TDI of 0.5ug TPT/kg BW/d. This study is conducted monitoring of TBT on seafoods in Korea and risk assessment for exposure on TBT in seafoods. Total hazard index(using Reference Dose : 0.3 ug TBTO/kg B.W/day) of intake exposure on seafoods is 0.04 as the 50th percentile, 0.08 as the 95th percentile. This value is estimated by Monte-Carlo simulation using Crystal Ball(Decisioneering Co., 2001).

A Study on Anti-oxidant and Anti-wrinkle Effect of Supercritical Fluid Extraction of Black Carrot as a Functional Cosmetic Material (기능성화장품소재로서 자색당근 초임계추출물의 항산화 및 항주름 효능 연구)

  • Kim, Ji-Su;Lee, Ji-An
    • Journal of Convergence for Information Technology
    • /
    • v.11 no.12
    • /
    • pp.236-243
    • /
    • 2021
  • The aim of this study was to evaluate the anti-oxidant and anti-wrinkle effect of the black carrot(BC) extracted by supercritical dioxide(SC-CO2). DPPH/ABTS radical scavenging and total polyphenol contents were measured to investigate the anti-oxidant activity of the BC supercritical extract. Collagen production and MMP-1 expression were assessed in normal human dermal fibroblasts(NHDF) for anti-wrinkle activity, The black carrot extract showed the highest total phenolic content(9.037±1.123 mg GAE/g extract) and the best antioxidant properties as shown by DPPH and ABTS assay. The supercritical fluid extracts of black carrot exhibited low toxicity to NHDF cells. In addition, the supercritical fluid extracts showed MMP-1 inhibition and type I pro-collagen synthesis inducing activities in a dose-dependent manner, respectively. Therefore, these results suggest that the black carrot is a potential source of high anti-oxidative, solvent-free and anti-aging material with promising applications in cosmetic, food, and beauty-food industries.

Development of Mineral Admixture for Concrete Using Spent Coffee Grounds (커피찌꺼기를 활용한 콘크리트 혼화재의 개발)

  • Kim, Sung-Bae;Lee, Jae-Won;Choi, Yoon-Suk
    • Journal of the Korean Recycled Construction Resources Institute
    • /
    • v.10 no.3
    • /
    • pp.185-194
    • /
    • 2022
  • Coffee is one of the most consumed beverages in the world and is the second largest traded commodity after petroleum. Due to the great demand of this product, large amounts of waste is generated in the coffee industry, which are toxic and represent serious environmental problems. This study aims to study the possibility of recycling spent coffee grounds (SCG) as a mineral admixture by replacing the cement in the manufacturing of concrete. To recycle the coffee g rounds, the SCG was dried to remove moisture and fired in a kiln at 850 ℃ for 8 hours. Carbonized coffee grounds are produced as coffee grounds ash (CGA) through ball mill grinding. The chemical composition of the prepared coffee grounds ash was investigated using X-ray fluorescence (XFR). According to the chemical composition analysis, the major elements of coffee grounds ash are K2O(51.74 %), CaO(15.92 %), P2O5(14.39 %), MgO(7.74 %) and SO3(6.89 %), with small amounts of F2O3(0.66 %), SiO2(0.59 %) and Al2O3(0.31 %) content. To evaluate quality and mechanical properties, substitutions of 5, 10, and 15 wt.% of coffee grounds ash (CGA) were tested. From the quality test results, the 28-day activity index of CGA5 reached 80 %, and the flow value ratio reached 96 %, which is comparable to the minimum requirement for second-grade FA. From the test results of the mortar, the optimal results have been found in specimens with 5 wt-% coffee grounds ash, showing good mechanical and physical properties.

Combined Effect of Afidopyropen, Chlorfenapyr and Cyantraniliprole to Insecticide-resistant Cotton Aphid, Aphis gossypii (Hemiptera: Aphididae) (살충제 저항성 목화진딧물에 대한 afidopyropen과 chlorfenapyr, cyantraniliprole의 혼합효과 평가)

  • Dong-Hyun Kang;Yuno Lee;Ha Hyeon Moon;Se Eun Kim;Hyun-Na Koo;Hyun Kyung Kim;Gil-Hah Kim
    • Korean journal of applied entomology
    • /
    • v.63 no.1
    • /
    • pp.53-61
    • /
    • 2024
  • The susceptibility of Aphis gossypii populations collected from three fields (WJ, CC, and GS) was evaluated to three insecticides (afidopyropen, chlorfenapyr and cyantraniliprole) and three binary mixtures. Three field populations showed resistance ratios of over 100 to all insecticides. The Combination Index (CI), %M(synergism), Co-Toxicity Coefficient (CTC), Wadley Ratio (WR), Synergism Ratio (SR) and Abbott Ratio (AR) were used to evaluate combined effect of the insecticides. Afidopyropen + chlorfenapyr (CI ≤ 0.16; %M(synergism) ≥ 94; CTC ≥ 764.5; WR ≥ 6.4; SR ≥ 6.9 and AR ≥ 1.1) showed a synergism in all filed populations. WJ and CC populations showed a synergism in all binary mixtures of insecticides, but GS population showed an antagonism for chlorfenapyr + cyantraniliprole (CI, 1.63; %M(synergism), 30; CTC, 64.0; WR, 0.6 and AR, 0.54) and afidopyropen + cyantraniliprole (CI, 6.7; %M(synergism), 1; CTC, 19.8; WR, 0.2 and AR ≤ 0.55). All mixtures (afidopyropen + chlorfenapyr, chlorfenapyr + cyantraniliprole and afidopyropen + cyantraniliprole) showed a control value of over 99% after 21 days of treatment in the field. This study highlights that binary mixtures of three insecticides serve as an effective control strategy for A. gossypii.

A Study on Health Impact Assessment and Emissions Reduction System Using AERMOD (AERMOD를 활용한 건강위해성평가 및 배출저감제도에 관한 연구)

  • Seong-Su Park;Duk-Han Kim;Hong-Kwan Kim;Young-Woo Chon
    • Journal of the Society of Disaster Information
    • /
    • v.20 no.1
    • /
    • pp.93-105
    • /
    • 2024
  • Purpose: This study aims to quantitatively determine the impact on nearby risidents by selecting the amount of chemicals emitted from the workplace among the substances subject to the chemical emission plan and predicting the concentration with the atmospheric diffusion program. Method: The selection of research materials considered half-life, toxicity, and the presence or absence of available monitoring station data. The areas discharged from the materials to be studied were selected as the areas to be studied, and four areas with floating populations were selected to evaluate health risks. Result: AERMOD was executed after conducting terrain and meteorological processing to obtain predicted concentrations. The health hazard assessment results indicated that only dichloromethane exceeded the threshold for children, while tetrachloroethylene and chloroform appeared at levels that cannot be ignored for both children and adults. Conclusion: Currently, in the domestic context, health hazard assessments are conducted based on the regulations outlined in the "Environmental Health Act" where if the hazard index exceeds a certain threshold, it is considered to pose a health risk. The anticipated expansion of the list of substances subject to the chemical discharge plan to 415 types by 2030 suggests the need for efficient management within workplaces. In instances where the hazard index surpasses the threshold in health hazard assessments, it is judged that effective chemical management can be achieved by prioritizing based on considerations of background concentration and predicted concentration through atmospheric dispersion modeling.

Dynamic Network Loading Model based on Moving Cell Theory (Moving Cell Theory를 이용한 동적 교통망 부하 모형의 개발)

  • 김현명
    • Journal of Korean Society of Transportation
    • /
    • v.20 no.5
    • /
    • pp.113-130
    • /
    • 2002
  • In this paper, we developed DNL(Dynamic Network Loading) model based on Moving cell theory to analyze the dynamic characteristics of traffic flow in congested network. In this paper vehicles entered into link at same interval would construct one cell, and the cells moved according to Cell following rule. In the past researches relating to DNL model a continuous single link is separated into two sections such as running section and queuing section to describe physical queue so that various dynamic states generated in real link are only simplified by running and queuing state. However, the approach has some difficulties in simulating various dynamic flow characteristics. To overcome these problems, we present Moving cell theory which is developed by combining Car following theory and Lagrangian method mainly using for the analysis of air pollutants dispersion. In Moving cell theory platoons are represented by cells and each cell is processed by Cell following theory. This type of simulation model is firstly presented by Cremer et al(1999). However they did not develop merging and diverging model because their model was applied to basic freeway section. Moreover they set the number of vehicles which can be included in one cell in one interval so this formulation cant apply to signalized intersection in urban network. To solve these difficulties we develop new approach using Moving cell theory and simulate traffic flow dynamics continuously by movement and state transition of the cells. The developed model are played on simple network including merging and diverging section and it shows improved abilities to describe flow dynamics comparing past DNL models.

Analysis of the Effects of Radio Traffic Information on Urban Worker's Travel Choice Behavior (교통방송이 제공하는 교통정보가 직장인의 통행행태에 미치는 영향 분석)

  • 윤대식
    • Journal of Korean Society of Transportation
    • /
    • v.20 no.5
    • /
    • pp.33-43
    • /
    • 2002
  • Travel choice behavior is affected by real-time traffic information. Recently, in urban area, real-time traffic information is provided by several instruments such as transportation broadcasting, internet PC network and variable message sign, etc. Furthermore, it has been increasing for urban travelers to use real-time traffic information provided by several instruments. The purpose of this study is to analyze the effects of advanced traveler information on urban worker's travel choice behavior. Among several Advanced Traveler Information System(ATIS) employed in urban area. This study focuses on examining the effects of transportation broadcasting on urban worker's travel choice behavior. This study attempts to examine traveler's mode change behavior in the pre-trip stage and traveler's route change behavior in the on-route stage. For this study, the survey data collected from Daegu City in 2000 is used. For empirical analysis, several nested logit models are estimated, and among them, the best models are reported in this paper. Furthermore, based on the empirical models estimated for this research, important findings and their policy implications are discussed.