• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.1
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• pp.1-8
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• 2023

This study focused on the development of a vegetable recombinated oil to mimic the animal-derived mink oil. Various vegetable oils and fatty acid substrates were mixed and an immobilized enzyme was utilized in the reaction to synthesize a plant-derived mink oil through deacidification and purification processes. The chemical composition and thermal properties of the recombined oil were confirmed using gas chromatography and differential scanning calorimetry. Our results show a high similarity between mink oil and our synthesized plant-derived mink oil, revealing the potential of utilizing vegetable alternatives for the substitution of animal raw materials, which have been gradually discontinued as cosmetic ingredients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.137-147
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• 2018

This study is a descriptive evaluation of the differences in biomedical ethics consciousness, related knowledge, awareness, and attitude of nursing college students according to the completion of biomedical ethics education. The data were collected from 112 nursing students using self-report questionnaires and analyzed by t-test, Chi-Square test, Fisher's exact probability test and Pearson's correlation coefficient using SPSS 21.0. There were significant differences between the two groups in the sub-domains of biomedical ethics consciousness, artificial insemination, euthanasia and organ transplantation. The biomedical ethics consciousness was positively correlated with attitudes toward human tissue donation and transplantation, awareness of death, and awareness of hospice palliative care. The results of this study showed that after participating in the biomedical ethics education, nursing college students had statistically significant differences in the consciousness of artificial insemination, euthanasia, and organ transplantation. Moreover, the consciousness of biomedical ethics was related to attitude toward human tissue donation and transplantation and awareness of hospice palliative care. Based on the results of this study, we would like to suggest the need for development of various curricula related to death, hospice palliative care, human tissue donation and transplantation in the biomedical ethics curriculum. In addition, as the study was conducted in a single college, it is difficult to generalize the results; therefore, additional studies at different facilities are recommended.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.1
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• pp.19-27
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• 2024

This study is to propose Lagerstroemia indica flower as an anti-acne cosmetic material, and confirmed the sebum control, anti-inflammatory, and antioxidant effects using Lagerstroemia indica flower extract (LIFE) . As a result of evaluating the sebum control effectiveness, it was confirmed that LIFE inhibited the production of sebum excessively induced with palmitic acid up to 65%. Subsequently, it was confirmed that LIFE has an antibacterial effect and the ability to inhibit lipase activity against Cutibacterium acnes (C. acnes), which mainly appears in acne lesions, and can also reduce the inflammatory response caused by virulence factors secreted by C. acnes. It was also confirmed that LIFE inhibited the secretion of nitrogen monoxide (NO) and prostaglandin E2 (PGE2), which are inflammatory mediators induced by LPS in macrophages, by 75% and 54%, respectively, and that it also had a high DPPH radical scavenging ability similar to that of ascorbic acid. These results suggest that LIFE, a natural extract, can be used as an anti-acne material to relieve and treat acne, a complex disease, by controlling sebum production and having antibacterial and lipase activity inhibiting against C. acnes, and anti-inflammatory, antioxidant properties.

• Food Science and Preservation
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• v.30 no.3
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• pp.526-537
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• 2023

This study aimed to evaluate the antioxidant and hepatoprotective effects of aqueous and 60% ethanol extracts of Allium ochotense Prokh. against alcohol-induced cytotoxicity as well as on the activities of alcohol-metabolic enzymes. Antioxidant effects of the extracts were analyzed using 3-ethylbenzothiazoline-6-sulfonic acid, 1,1-diphenyl-2-picrylhydrazl, ferric reducing antioxidant power, and malondialdehyde assays, and found that both extracts exhibited considerable antioxidant activities. Additionally, both extracts showed synergistic effects on the activities of alcohol-metabolic enzymes, such as alcohol dehydrogenase, but not on the activity of aldehyde dehydrogenase. In addition, 2'-7'-dichlorodihydrofluorescein diacetate (DCF-DA) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays revealed that aqueous and 60% ethanol extracts reduced oxidative stress and increased cell viability. Moreover, both extracts regulated the expression of apoptosis-related proteins, namely B-cell lymphoma (BCl-2), BCl-2 associated X (BAX), and pro-caspase-3, in HepG2 cells. In conclusion, aqueous and 60% ethanol extracts of A. ochotense Prokh. might be valuable functional materials derived from natural resources for the prevention of ethanol-induced cytotoxicity.

• Proceedings of the Korea Contents Association Conference
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• 2013.05a
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• pp.275-276
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• 2013

생명현상은 다양한 단백질들 간의 상호작용으로 외부의 환경에 대처하고 생명유지를 위한 다양한 생화학반응을 수행한다. 이러한 복잡한 생명현상의 과정을 이해하기 위해서 생명과학자들은 유전자 조절네트워크, 신호전달네트워크, 대사네트워크 등 다양한 종류의 네트워크를 모델링하고 있다. 하지만 각각의 모델링방법은 각 분야별로 다양하게 존재하고 있는 실정이다. 본 연구에서는 이러한 다양한 종류의 생물학적 네트워크를 통합적으로 모델링할 수 있는 통합적 모델링 시스템을 설계하고 구현하였다. 특히 신호전달 과정에 대한 블리온 모델링기법, 유전자 발현조절 및 대사과정에 대한 ODE(Ordinary Differential Equation)모델링 그리고 유전적 표현형을 분석할 수 있는 Flux 모델링을 하나의 모델링 시스템에서 설계 하였다. 또한 이 같은 다양한 종류의 모델링을 지원하기 위해서 SBML포멧을 기준으로 가시적인 모델링 시스템을 구현하였다. 특히 연구자가 모델링한 생물학적 모델이 다른 형태의 모델링기법에도 적용될 수 있도록 전환할 수 있도록 하였다. 이러한 통합적인 모델링 시스템은 향후 복잡해지는 생물학적 네트워크를 손쉽게 모델링 할 수 있는 시스템으로 활용될 것이다.

• Proceedings of the Korea Information Processing Society Conference
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• 2003.05c
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• pp.1717-1720
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• 2003

소프트웨어 개발 응용 패러다임이 분산 환경 기반을 두면서 보안 문제가 매우 중요시되고 있다. 정보통신 제품이나 시스템을 개발할 경우 보안에 대한 평가를 위해서 표준화된 요구사항들의 목록으로 공통평가기준이 정의되어 있다. 공통기준에서 고려되어야할 결함 교정에서 구체적인 절차와 결함 항목의 식별, 속성, 행위 정의가 필요하다. 본 논문에서는 소프트웨어공학 프로세스에서 보안측면을 고려하여, 생명주기의 자원과 프로세스에서 결함 추적 및 교정을 위한 기능적, 비기능적인 엔티티와 이를 기반으로 한 프로세스를 제안한다. 즉, 생명주기를 통한 개발과 평가를 지원하고, 개발자와 평가자에게 고려해야할 기준 이외에 생명주기 상에서의 자원 처리의 유무나 중요도 제공이 가능하다. 결함 추적과 교정을 위한 엔티티 적용에 대한 부가적인 비용과 노력을 감소시키고 정보보호 제품 개발과 밀접하게 연관된 결함을 검증하고 교정함으로써 제품의 개발과정의 신뢰성을 제공하고 생명주기 관리의 효율성을 증가시키고자 한다.

• Journal of Information Management
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• v.40 no.1
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• pp.157-181
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• 2009

As the information technology is evolved and the human genome project is finalized over the world, the Bioinformatics - the integration of abundant Biological science and information technology - has shown up and is continuously being advanced. Together with the evolution of Bioinformatics, the websites dealing with Bioinformation have been set up to provide relevant information to the Bioscientists. Among the numerous global websites, the preferred websites by the majority of domestic Bioscientists are BRIC (Biological Research Information Center) of POSTECH(Pohang University of Science and Technology) in Korea, CCBB(Center for Computational Biology and Bioinformatics) of KISTI(Korea Institute of Science and Technology Information), KOBIC(Korean Bioinformation Center) of KRIBB(Korea Research Institute of Bioscience and Biotechnology), NCBI(National Center for Biotechnology Information) in USA, EBI(European Bioinformatics Institute) in Europe and DDBJ(DNA Data Bank of Japan) in Japan. In this paper, the comparative analysis was executed by investigating contents status and functions of the above-mentioned 6 websites. In addition, questionnaire survey of Bioscience Researchers' utilization status and their needs to those 6 websites was conducted.

• Korean Journal of Microbiology
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• v.55 no.2
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• pp.164-166
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• 2019

The complete genomic information of Microbacterium aurum KACC $15219^T$ (= IFO $15204^T$ = DSM $8600^T$) is described. The genome of M. aurum KACC $15219^T$ contains 3,096 protein coding genes and an average G+C content of 69.9% in its chromosome (3.42 Mbp). This strain can use various carbon sources for growth, including quinic acid. Quinic acid is used as a substrate for the synthesis of aromatic amino acids via the shikimate pathway which are useful in the industry. M. aurum KACC $15219^T$ will provide basis to improve our understanding of this organism and allow more efficient application of the strain to industry.

• Journal of Hospice and Palliative Care
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• v.16 no.1
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• pp.1-9
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• 2013

Purpose: The aim of this study was to investigate nursing students' awareness of biomedical ethics and attitudes toward death of terminal patients. Methods: A structured questionnaire was developed to examine nursing students' biomedical ethics. Their attitudes toward terminal patients' death were measured by using the Collett-Lester Fear of Death Scale. Surveys were conducted with 660 nursing students enrolled at a three-year college located in Daejeon, Korea. Data were analyzed using descriptive statistics, Wilcoxon rank sum test and Kruskall Waills test. Results: Students who have experienced biomedical ethics conflicts, agreed to prohibition of cardiopulmonary resuscitation (CPR) and have no religion exhibited more negative attitudes toward death compared to students without the above characteristics. Of the participants, 81.2% answered that life sustaining treatment for terminal patients should be discontinued and 76.4% replied that CPR on terminal patients should be prohibited. The majority of the correspondents stated that the two measures above are necessary "for patients' peaceful and dignified death". Conclusion: Study results indicate the need to establish a firm biomedical ethics value to help nursing students form a positive attitude toward death. It also seems necessary to offer students related training before going into clinical practice, if possible. The training program should be developed by considering students' religion, school year, experience with biomedical ethics conflicts and opinion about CPR on terminal patients. The program should also include an opportunity for students to experience terminal patient care in advance via simulation practice on standardized patients.

• The Korea Journal of Herbology
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• v.34 no.1
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• pp.125-131
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• 2019