• Journal of Food Hygiene and Safety
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• v.6 no.1
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• pp.27-40
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• 1991

;ABSTRACT-The effects of gastric ulcer induced by restraint and water-immersion stress on gastric carcinogenesis in Wistar male rats treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined. Rats of group 1 were 2iven stress for 8 hours before they were received MNNG (100 mg/l) in drinking water for 20 weeks. Rats of group 2 were received MNNG first for 2 weeks and then were given stress once a week from 3rd to 12th weeks, with simultaneous MNNG adminitration and followed by MNNG only until 20th weeks. Rats of group 3 were received MNNG only as a positive control and rats of group 4 were not treated with carcinogen. All groups were sacrificed in 20 weeks. Sections of the pyloric mucosa were stained by avidin-biotin peroxidase complex (ABC) immuno-histochemical method. PAPG (pepsinogen isozyme 1 altered pyloric gland), body weight change, gross lesions and histopathological changes were examined. The results obtained from these studies were summarized as follows: 1. The mean body weight gains of the rats fed with carcinogens (group 1, 2, 3) were significantly lower than that of group 4 (control group, without carcinogen. p<0.05). However, the differences of the mean body weight of rats treated with carcinogen were not significant. 2. Stress treatment (group 1 and 2) increased the appearance of the numbers of PAPG (Pepsinogen 1 Altered Pyloric Gland) induced by carcinogen significantly compared with that of group 3 (carcinogen only, p<0.01). 3. The incidence rate of mucosal hyperplasia in pylorus was significantly increased in group 2 compared with group 3 (p<0.05).0.05).

• Journal of Chest Surgery
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• v.36 no.5
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• pp.242-254
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• 2003

Background: Most of the studies conducted have investigated the beneficial effects of ischemic preconditioning on normothermic myocardial ischemia. However, the effect of preconditioning could be attenuated through the use of multidose cold cardioplegia as practiced in contemporary clinical heart surgical procedures. The purpose of this study was to investigate whether preconditioning improves postischemic cardiac function in a model of $25^{\circ}C$ moderate hypothermic ischemic heart induced by cold cardioplegia in isolated rat hearts. Material and Method: The isolated Sprague-Dawley rat hearts were randomly assigned to four groups All hearts were perfused at 37$^{\circ}C$ for 20 minutes with Krebs-Henseleit solution before the baseline hemodynamic data were obtained, Group 1 consisted of preconditioned hearts that received 3 minutes of global ischemic preconditioning at 37$^{\circ}C$, followed by 5 minutes of reperfusion before 120 minutes of cardioplegic arrest (n=6). Cold (4$^{\circ}C$) St. Thomas Hospital cardioplegia solution was infused to induce cardioplegic arrest. Maintaining the heart at $25^{\circ}C$, infusion of the cardioplegia solution was repeated every 20 minutes throughout the 120 minutes of ischemic period. Group 2 consisted of control hearts that underwent no manipulations between the periods of equilibrium and 120 minutes of cardioplegic arrest (n=6). After 2 hours of cardioplegic arrest, Krebs solution was infused and hemodynamic data were obtained for 30 minuts (group 1, 2: cold cardioplegia group). Group 3 received two episodes of ischemic preconditioning before 30 min of 37$^{\circ}C$ normothermic ischemia and 30 minutes of reperfusion (n=6) Group 4 soloed as ischemic controls for group 3 (group 3, 4: warm ischemia group). Result: Preconditioning did not influence parameters such as left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), rate-pressure product (RPP) and left ventricular dp/dt (LV dp/dt) in the cold cardioplegia group. (p=NS) However, preconditioning before warm ischemia attenuated the ischemia induced cardiac dysfunction, Improving the LVSP, LVEDP, RPP, and LV dp/dt. Less leakage of CPK and LDH were observed in the ischemic preconditioning group compared to the control group (p<0.05). Conclusion: Ischemic preconditioning improved postischemic cardiac function after warm ischemia, but did not protect cold cardioplegic hearts.

• Journal of Chest Surgery
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• v.36 no.4
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• pp.242-254
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• 2003

Most of the studies conducted have investigated the beneficial effects of ischemic preconditioning on normothermic myocardial ischemia. However, the effect of preconditioning could be attenuated through the use of multidose cold cardioplegia as practiced in contemporary clinical heart surgical procedures. The purpose of this study was to investigate whether preconditioning improves postischemic cardiac function in a model of 25℃ moderate hypothermic ischemic heart induced by cold cardioplegia in isolated rat hearts. Material and Method: The isolated Sprague-Dawley rat hearts were randomly assigned to four groups. All hearts were perfused at 37℃ for 20 minutes with Krebs-Henseleit solution before the baseline hemodynamic data were obtained. Group 1 consisted of preconditioned hearts that received 3 minutes of global ischemic preconditioning at 37℃, followed by 5 minutes of reperfusion before 120 minutes of cardioplegic arrest (n=6). Cold (4℃) St. Thomas Hospital cardioplegia solution was infused to induce cardioplegic arrest. Maintaining the heart at 25℃, infusion of the cardioplegia solution was repeated every 20 minutes throughout the 120 minutes of ischemic period. Group 2 consisted of control hearts that underwent no manipulations between the periods of equilibrium and 120 minutes of cardioplegic arrest (n=6). After 2 hours of cardioplegic arrest, Krebs solution was infused and hemodynamic data were obtained for 30 minutes (group 1, 2: cold cardioplegia group). Group 3 received two episodes of ischemic preconditioning before 30 min of 37℃ normothermic ischemia and 30 minutes of reperfusion (n=6). Group 4 served as ischemic controls for group 3 (group 3, 4: warm ischemia group). Result: Preconditioning did not influence parameters such as left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), rate-pressure product (RPP) and left ventricular dp/dt (LV dp/dt) in the cold cardioplegia group. (p=NS) However, preconditioning before warm ischemia attenuated the ischemia induced cardiac dysfunction, improving the LVSP, LVEDP, RPP, and LVdp/dt. Less leakage of CPK and LDH were observed in the ischemic preconditioning group compared to the control group (p<0.05). Conclusion: Ischemic preconditioning improved postischemic cardiac function after warm ischemia, but did not protect cold cardioplegic hearts.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.12
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• pp.5882-5892
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• 2012

This study was performed to examine the effects of Dan Jeon Breathing on stress, sleep disturbance and self-esteem of hemodialysis patients. This study used the nonequivalent control group pretest-posttest design. Before applying the Dan Jeon Breathing program, the patients were divided into the experimental group and the control group, respectively, and were requested to report their self-ratings to measure their stress, sleep disturbance and self-esteem. The Dan Jeon Breathing program was given to experimental groups for 60 minutes a day and 2 times a week for 12 weeks. The data collected from the program were analyzed by means of ${\chi}^2$ test, Fisher's exact probability test, Shapiro-Wilk and t-test. The analyses revealed that the stress(t=-2.95, p=.006) and sleep disturbance(t=-2.13, p=.041) levels of the experimental group decreased after Dan Jeon Breathing compared to those of the control group. The difference in self-esteem(t=2.44, p=.020) level was statistically significant. From the above results, it was verified that Dan Jeon Breathing could be used as nursing intervention for hemodialysis patients to mitigate their stress, sleep disturbance and to improve their self-esteem.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.412-419
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• 2017

Purpose:This study was conducted to identify the effects of theSemi-Fowler's position on post-operative recovery and pain for patients with laparoscopic abdominal surgery Methods: This study utilized a non-equivalent control group non-synchronized design to validate the effects of theSemi-Fowler's position. After IRB approval, 56 patients took part in this study, 29 in the experimental group and 27 in the control group. Consent was obtained from the participants. The Semi-Folwer's position was applied to experimental group and the supine position was applied to the control group for 24 hours after surgery. All data were reviewed retrospectively from April to June 2016. Collected data, frequency, percentage, average, standard deviation, chi-squared test, independent t-test and repeated measures ANOVA were conducted using SPSS 20.0. Results: There was no significant difference between the experimental and control group with regard to recovery outcomes; however, there was a significance differencebetween groups and among check times with regard to post operational pain. Conclusion:The results of this study provide information that will be usefulto the development of strategies for improving recovery outcomes and pain for laparoscopic operation patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.156-162
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• 2016

This study was conducted to investigate the effects of a death education program on self-esteem, spiritual well-being, and pain in adults. This investigations employed a nonequivalent control group non-synchronized design, and was performed in C hospital located in Chungju, Chungcheongbukdo province, Korea from January 4-13, 2016. The study included 48 participants who agreed to enrolled. Participants were randomly divided into an experimental and a control group of 22 and 26 applicants each. Participants (n=22) in the experimental group participated in the death education program for 2 hours, three times a week for 2 weeks. The effects of treatment were measured using a structured questionnaire to evaluate self-esteem, spiritual well-being, and pain before and after 2 weeks of intervention. Data were analyzed using a t-test, chi-squared test, Fisher's Exact-test and a paired t-test. The experimental group showed significantly increased self-esteem (P<0.002) and spiritual well-being (P<0.015), and significantly reduced pain (P<0.014) compared to the control group after 2 weeks of intervention. Overall, the death education program was shown to be an effective nursing intervention for adults; therefore, of its use in various fields should be considered.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.487-495
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• 2020

This study examined the effects of auricular acupressure on female college students with functional constipation to propose auricular acupressure as an effective and evidence-based nursing intervention. This is an experimental study designed with randomization and single-blind in a Sham-control approach. The subjects included 44 female college students with functional constipation whose symptoms met the Rome IV criteria. In this study, five different acupressure sites were applied to each group; the experimental group (n=23) received auricular acupressure on rectum, large intestine, lung, san jiao, and shenmen, whereas the Sham control group (n=21) received acupressure on ankle, helix, tooth, jaw, and external ear. The intervention was implemented once a week for a total of six weeks. After six weeks, the severity of constipation, stool form, and quality of life regarding constipation in the experimental group significantly improved compared to that of the Sham control group (p<.001). Consequently, the study showed that auricular acupressure can be used as an effective nursing intervention to alleviate constipation in female college students.

• Biomedical Science Letters
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• v.5 no.1
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• pp.51-58
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• 1999

To evaluate an effect of liver damage on the dermal oxygen free radical metabolizing enzyme activities, the $CCl_4$ (0.1 ml/ 100 g body wt., 50% $CCl_4$ in olive oil) was intraperitoneally given to the rats every other day for 2 weeks. Based on the histopathological findings, liver weight (%), serum alanine aminotransferase, xanthine oxidase activities and hepatic lipid peroxide contents, the animals were induced severe liver damage. In the present liver damaged animal, all the activities of dermal scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase were significantly decreased compared with central. And under the cytochemical electron microscopy the more coarse granules of cerrous perhydroxide were found compared with the control. In conclusion, the $CCl_4$-induced liver damage may influence upon the activities of some dermal oxygen free radical scavenging enzymes.

• Biomedical Science Letters
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• v.6 no.4
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• pp.245-251
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• 2000

In order to search the target organ of cylclohexane toxicity, the rats were intraperitoneally treated with cyclohexane (1.56 g/kg of body wt.) four times every other day. In the increasing rate of organ weight per body weight (%) in cyclohexane-treated animals, the lung was highest among the liver, spleen, small intestine, stomach, heart and kidney. And in the decreasing rate of glucose-6-phosphatase (G-6-Pase) activity in each organ, that of lung was also highest among all organs. Lung MDA content was significantly increased (p<0.05) by the cyclohexane treatment. On the other hand, microsomal aniline hydroxylase activity in lung tissue both of control and cyclohexane-treated rats was greatly low as could be scarcely measured, but that in liver possessing high activity was significantly increased (p<0.05) in cyclohexane-treated rats compared with control. Alcohol dehydrogenase activity in lung was markedly higher than that of liver and the latter was significantly (p<0.05) increased by the cyclohexane treatment. In conclusion, cyclohexane treatment to the rats showed mainly lung toxicity and it may be responsible for cyclohexanon, cyclohexane metabolite, distributed from liver.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.4
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• pp.1810-1819
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• 2013

This study is a nonequivalent-comparison-group-quasiexperimental-study which tries to establish the effect of a laughter therapy program on the blood pressure, depression, and the life quality of elderly women in rural area. The subjects are 49 females aged 65 living in S-myeon, 24 and the other 25 of whom are put into an experimental group and a comparison group, respectively. The laughter therapy was performed to the experimental group for 60 minutes a time, twice a week for 13 weeks, from January 5 to April 5 in 2011. To find out the intervention effect, the program was analyzed by a t-test. The result showed that the therapy lowers the systolic blood pressure, relieves depression, and enhances the life quality of them. Therefore, it is expected that the therapy, a useful program contributing to the health improvement of elderly women, can be made use of nursing intervention in clinical trials or communities.