• Journal of Food Hygiene and Safety
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• v.16 no.2
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• pp.111-116
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• 2001

This study was carried out to evaluate the irritant potential of P-toothpaste in hamster cheek pouch. The test materials were applied once at the beginning of this study into right pouches of hamsters and maintained for 14 days. Animals were administered with P-toothpaste, Bamboo salt toothpaste, D.W. and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, morality, body weights and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between D.W. and P-toothpaste treated group in gross and histopathological findings. Therefore, these results suggest that there was little irritant potential of P-toothpaste in hamster cheek pouch.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.104-116
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• 2003

목적 : 시스테인 단백분해 효소인 cathepsin는 인간과 생쥐의 항원제시세포에서 II형 주적합항원 불변사슬(MHC class II invariant chain)의 분해에 관여한다. 본 연구는 녹용 약침액이 류마티스 관절염 생쥐 모델의 골조직(연골과 활액) 유래 cathepsin 활성에 미치는 영향을 검정하였다. 방법 : 관절염 동물모델은 BALb/c계 생쥐를 생후 3일에 흉선 적출(3d-Tx)을 하여 만들었다. 동물모델의 골조직, 임파절세포, 비장 등을 녹용처치군과 대조군으로 나누어 cathepsin의 활성도 및 자가항원 특이(C-II-specific) T-세포의 활성도를 비교 분석하였다. 결과 : 각 장기에서 cathepsin S의 활성은 녹용약침 처치군에서 농도 의존적으로 유의성 있게 억제되었고, T-세포 특이 자가항원반응은 녹용약침 처치군의 임파절 세포에서 유의성있게 억제되었다. 그리고 T-세포 특이 자가항원 반응의 불활성화에는 녹용 10~20ug/ml의 용량으로 충분하였다. 결론 : 이러한 실험결과는 녹용 약침액이 cathepsin S를 선택적으로 억제시켜 류마티스 관절염과 같은 자가면역 질환에 유효한 치료약물로 사용될 수 있음을 시사한다.

• Journal of Preventive Medicine and Public Health
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• v.36 no.3
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• pp.255-262
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• 2003

Objectives : We carried out tests for neurobehavior by using WHO-NCTB (neurobehavioral core test battery) and Perdue pegboard score test to identify differences between lacunar infarction cases and controls. Methods : Among the subjects who underwent MRI between February 2001 and March 2002 in a university hospital located in Seoul and who were diagnosed only as lacunar infarction without any intracranial disease, 46 patients were selected as cases (male: 21, female: 25). Controls were selected who had no cerebrovascular disease on MRI by matching age (5 years), gender, and education (2 years) in a ratio of 1:1 , Among WHO-NCTB, the following 5 tests and Perdue pegboard score test were used to categorize the study subjects: digit and symbol matching, simple reaction time, Benton visual retention, digit span, and Pursuit aiming test, Results : Among the above 6 tests of neurobehavior, lacunar infarction cases showed lower score than controls except for the simple reaction time test. As the controlling variables of multivariate analysis in the stepwise regression analysis, the followings were selected due to their significant association: age, education, BMI, gender, drinking, exercise, add systolic blood pressure. From multivariate regression analysis, there was significant difference (p<0.05) between lacunar infarction cases and controls in digit and symbol matching, Benton visual retention, digit span, pursuit aiming, and Perdue pegboard score test, but not in the score of simple reaction time test. Conclusions : We suggest that the above 5 tests for neurobehavior, with the exception of the simple reaction time test, might be used as the basis for recommendation of further treatment and other neurological tests by the earlier defection for neurological abnormality in lacunar infarction.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.9
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• pp.347-355
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• 2017

The purpose of this study was to investigate the effects of pelvic adjustment on low back pain and spino-pelvic parameters in middle-aged women. Thirty-eight middle-aged women with chronic low back pain were randomly assigned to the pelvic adjustment (n = 20) oruntreated control (n = 18) group. Pelvic adjustment interventionswereperformed four times a week for 8 weeksin the former group. At baseline and after 8 weeks, the back pain and back function were evaluated using the visual analogue scale (VAS), Oswestry disability index (ODI), and back flexibility. Additionally, the spino-pelvic radiographic parameters and serum C-reactive protein (CRP) levels were assessed. After 8 weeks, the VAS, ODI, and back flexibility significantly improved in the pelvic adjustment group compared with the control group. It was found that the changes from baseline in the lumbar lordotic angle, sacral slope, pelvic crest unleveling, and femoral head height inequality were significantly greater in the pelvic adjustment group than in the control group. There were no significant changes in the pelvic incidence or serum CRP levels in either group. In conclusion, pelvic adjustment has beneficial effects on chronic low back pain and back function, suggesting that the effects of pelvic adjustment on back pain may at least in part result from changes in the spino-pelvic alignment.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.4
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• pp.439-446
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• 2007

This study was performed to investigate the effect of long-term administration of Saengshik on growth parameters of growing rats. Male Sprague-Dawley rats were fed on AIN-93G basal diets for 12 weeks and assigned to the following groups: rats administrated orally with Saengshik at the dose of 1g/kg/day (1xJS ), 2g/kg/day (2xJS), 4g/kg/day (4xJS) and distilled water (Control). Rats were sacrificed at 4, 8, 12 weeks after oral administration. Bone mineral density (BMD) and bone mineral contents (BMC) were measured by PIXImus densitometry and serum insulin-like growth factor-1 (IGF-1) concentration were determined by using EIA method. Body weight and food intake did not show significant changes within groups for 12 weeks. Physical longitudinal growth indexes, body length and femur length were significantly increased in Saengshik-administered groups at 12 weeks, in which BMD and BMC also significantly increased. Also, in blood IGF-1 level, Saengshik-administered groups were remarkedly higher than control group at 4 week (p<0.001), in which significantly higher at 8 week and 12 week. These results suggest a close relation between administration of Saengshik and increment of longitudingal bone growth. Therefore, as the result of this study, it could be expected that the administration of Saengshik for 12 weeks is helpful to the increase of longitudinal growth and growth factors in rats. Furthermore, we propose that the consumption of Saengshik as dietary supplementation may promote to increase in longitudinal bone growth in growing children.

• Journal of Veterinary Clinics
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• v.25 no.5
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• pp.359-362
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• 2008

This study examined the efficacy of needle-acupuncture (AP) at Nei Guan (PC06) and Xin Shu (BL15) on canine tachycardia. A total of 18 beagle dogs were divided into three groups: a control (6 heads), PC06 (6 heads) and PC06 (6 heads) group. Tachycardia was induced by an intramuscular injection of glycopyrrolate. No treatment was given to the control group. Needle-AP at PC06 and BL15 were applied simultaneously at the same time as the glycopyrrolate injection for 20 minutes in PC06 and BL15 groups, respectively. The changes in R-R intervals and respiration rates were determined. The changes in the R-R intervals in the PC06 and BL15 groups were significantly higher than the control group. The R-R intervals of the BL15 group were significantly higher than in the PC06 group. The changes in the respiration rates in the PC06 group were similar to those of the control group. However, the respiration rates in the BL15 group were significantly lower than the control and PC06 groups. In conclusion, needle-AP at PC06 and BL15 is effective in assisting in the recovery from induced canine tachycardia. However, needle-AP at BL15 is more effective than that at PC06.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.8037-8045
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• 2015

The purpose of this study was to identify the effects of the application of elastic compression stockings and lower extremities exercise on edema and pain of lower extremities in hospital nurses. The participants were 30 hospital nurses working at a general hospital. The participants were categorized into three groups such as, 10 for an experimental group of the application of the elastic compression stocking, 10 for another experimental group of the application of Lower extremities exercise and 10 for a control group. Edema of the lower extremities were measured in terms of the girths of ankles and calves. And pain of the lower extremities were measured in terms of the score by NRS(Numerical Rating Scale). The data were analyzed with Frequency, Percentage, Mean, Standard Deviation, ${\chi}^2$-test and ANOVA to identify the participants' characteristics, SPSS Win 21.0 program was used for analysing. There are significant differences in lower extremity edema among the experimental group of lower extremities exercise, experimental group of elastic compression stocking and control group was supported(Rt Calf F=0.645, p=.000, Lt Calf F=21.941, p=.000). There are significant differences in lower extremity pain the experimental group of lower extremities exercise, experimental group of elastic compression stocking and control group was supported(Rt: F==7.320, p=.000 Lt: F=10.623, p=.000). In conclusion, in has been appeared that the lower extremities exercise and wearing elastic compression stocking have effedted in relieving low extremity edema and pain scale for nurses.

• The Journal of Dong Guk Oriental Medicine
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• v.8 no.1
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• pp.145-158
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• 1999

Objective : To observe Sagunjatanghapchangchuljiyutang in rectifying the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. Methods : Sagunjatanghapchangchuljiyutang was chosen to treat the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. The model was induced by Rhei Radix and castor oil. The effects on the gastric secretion ability(gastrin, secretin, volume of gastric juice, free acidity, total acidity, pepsin activity) and nutritional condition(protein, albumin, total cholesterol, triglyceride, total lipid, BUN, creatinine, RBC, WBC, hemoglobin, hematocrit) were observed in vivo. Results : The group induced chronic diarrhea by Rhei Radix and castor oil had lower gastric secretion ability and nutritional condition was lower than that of the normal group. The figures for group given Sagunjatanghapchangchuljiyutang showed improvement, especially gastrin, total lipid and hematocrit. Conclusion : Sagunjatanghapchangchuljiyutang have an effect on the digestive dysfunctional spleen deficiency syndrome caused by chronic diarrhea. And experimental study syndrome could be proceed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.421-427
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• 2016

This study was conducted to examine the effects of a gerontological nursing clinical practice course using action learning on undergraduate nursing students. The subjects were 75 undergraduate nursing students from Y University. Data were analyzed using SPSS/Win 21.0. There were significant improvements in problem solving (t=3.58, p<.001) and communication (t=4.15, p<.000) in the experimental group compared to the control group. This study provides evidence that gerontological nursing courses improve undergraduate nursing students' problem solving and communication skills. Accordingly, this course would be a useful teaching and learning method in nursing programs of outcome based curriculum.

• Journal of Embryo Transfer
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• v.13 no.3
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• pp.261-275
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• 1998

본 연구에서는 GnRH가 과배란 처치된 래트의 초기 난포기와 후기 난포기에서 난소기능에 어떠한 영향을 미치는지를 이해하기 위해서, 30IU PMSG와 10IU hCG로 전처치된 미성숙 래트에 있어서 배란반응, 배란 난자의 형태학적 이상 유무 및 핵 성숙도, 난소 중량, 난소의 조직학적인 변화 및 혈중 스테로이드 호르몬 (17$\beta$-estradiol, progesterone 및 testosterone) 농도에 대하여 GnRH agonist의 효과를 검사하였다. GnRH agonist는 PMSG 전처치 후 초기 난포기 (PMSG 투여 후 6시간부터) 또는 후기 난포기(PMSG 투여 후 54시간부터)에 4시간 동안 20분 간격으로 경정맥 카테타를 통해 혈관내로 투여하였다. 각 실험동물은 혈중 스테로이드 호르몬의 변화를 측정하기 위하여 PMSG 투여 후 54시간, 72시간에 혈액을 채취하고 72시간에 희생시켰다. PMSG로 전처치한 미성숙 래트의 초기 난포기에 GnRH agonist의 투여는 GnRH agonist를 투여하지 않은 군(대조군)에 비해 과배란 억제, 형태학적 비정상 배란난자의 증가, 난소 중량의 감소, 난포폐쇄의 증가 및 혈중 스테로이드 호르몬의 농도 감소가 보였다. 한편 후기 난포기에 GnRH agonist의 투여는 대조군에서의 반응과 전반적으로 유사하였다. 이상의 결과, PMSG 및 hCG 처치로 과배란된 래트의 초기 난포기에 GnRH agonist의 투여는 난소기능을 전반적으로 억제하지만, 후기 난포기에 GnRH agonist의 투여는 난소기능에 영향을 미치지 않았다.