• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1973-1974
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• 2008

심전도는 심장의 전기적인 활동을 나타내는 지표로, 심장활동 및 자율 신경계를 관찰하기 위해 R 파형의 간격을 측정함으로써 심박변이도를 추출할 수 있다. 심박변이도는 자율신경계의 관찰 이외에도 급성 심근경색의 예후판정이나 심장급사 예견, 당뇨병 관찰, 감성 및 스트레스 평가 등 다양한 분야에서 활용되고 있다. 그러나 심전도의 추출해야하는 과정을 거쳐야 하기 때문에, 임상적인 목적이 아닐시에도 3 전극을 몸에 부착하여 측정하는 것은 심박변이도에 대한 접근성을 떨어뜨리고 있다. 본 연구에서는 심박변이도의 측정을 위하여 수정된 방식의 라플라시안 전극을 설계하고 이를 이용해 심박변이도의 측정 및 분석을 함으로써 접근성 높은 새로운 심박변이도 측정용 전극에 대해 제시하였다.

• Neonatal Medicine
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• v.18 no.1
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• pp.148-152
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• 2011

Necrotizing fasciitis is a rare, but life-threatening infection. Prompt diagnosis and early aggressive intervention is required for survival. However, there has been frequently occurred in delays of diagnosis and treatment due to its non-specific nature. Therefore, a high index of suspicion is needed to ensure timely intervention. We report a case of necrotizing fasciitis in a 7-day-old term healthy neonate.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.7C
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• pp.634-641
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• 2010

End Stage Renal Disease resulting from complications of the 4 top causes of death including diabetes and hyperpiesia becomes one of the major social problems these days in the context that this disease unaffordably increases the medical cost and decreases the quality of life. For a kidney disease, it is hard to diagnose, cure and recover as there are few subjective symptoms. Therefore, the prevention is very important. In this paper, we propose a method, which checks the abnormal state of the kidney, using the patient's face color and gloss which is employed for diagnosis in the oriental medicine. This method composes of two processes. The first is to acquire the patient's face data applying a polarizing filter and the next is to analyse relations between kidney disease and this data.

• Journal of the East Asian Society of Dietary Life
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• v.10 no.1
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• pp.21-36
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• 2000

The purpose of this study was to investigate the effect of knowledge and practice of diet therapy on diabetic control in Insulin-dependent Diabetics. The subjects were 31 patients (male 15, female 16) aged 7 to 16 years old who participated pediatric health camp. The average of diabetic of diabetic duration was4.2 years. 48.4 % of subjects has the motive to diabetics diagnosis because of 3-plentiful symptom in both group. The average of height was 151.5 cm for male and 141.4cm for female, the average weight was 43.1 kg for male and 38.6kg for female. In PIBW, underweight was 53.3 % for male, 37.5% for female, normal weight was 40.0% for male, 56.3% for female. The fasting blood glucose was 173.5mg/dl males, 202.9mg/dl for females, Postprandial blood glucose was 138.8mg/dl for males, 194.3mg/dl for females. Energy intakes were 2,100 -2.600 kcal for males and 1,800-2,600kcal for females. Energy intake of the subjects was higher than that of RDA. Carbohydrate, protein and fat ratio was 58 : 17: 25. The mean score of knowledge before education on diet therapy was 17.07$\pm$2.02 for males, 15.19$\pm$3.58 for females. The mean score of knowledge after education on diet therapy was 17.93$\pm$1.33 for males , 17.31 $\pm$1.49 for females.

• Journal of Pharmaceutical Investigation
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• v.30 no.2
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• pp.107-112
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• 2000

The changes in pharmacokinetic parameters of tolbutamide, such as the area under the plasma concentration-time curve from time zero to time infinity (AUC) and elimination rate constant (Kel) were evaluated after oral administration of the drug to rabbits with acute and chronic alloxan-induced diabetes mellitus (AIDRs). After oral administration, the plasma concentrations of tolbutamide were significantly higher between 9 and 12 hr in chronic AIDRs compared with these in control rabbits. Therefore, the AUC was significantly greater in chronic AIDRs $(3,490{\pm}649\;versus\;5,020{\pm}1,030{\mu}gml{\cdot}hr)$. This could be due to inhibition of tolbutamide metabolism by liver in AIDRs since tolbutamide is essentially completely metabolized in liver. Impaired liver and kidney function in AIDRs were based on blood chemistry and tissue microscopy. The absorption rate constant and Kel were significantly slower in chronic AIDRs compared with those in control rabbits.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.3 no.1
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• pp.4-14
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• 2003

Maple syrup urine disease or branched chain ketoacidurias caused by a deficiency in activity of the branched-chain ${\alpha}$-keto acid dehydrogenase(BCKD) complex. This metabolic block results in the accumulation of the branched-chain amino acids(BCAAs) leucine, isoleucine and valine, and the corresponding branched chain ${\alpha}$-keto acids (BCKAs). Based on the clinical presentation and biochemical responses to thiamine administration, MSUD patients can be divided into five phenotypes : classic, intermediate, intermittent, thiamine responsive and dihydrolipoyl dehydrogenase(E3)-deficient. Classic MSUD has a neonatal onset of encephalopathy, and is the most severe ad most common form. Variant forms of MSUD generally have the initial symptoms by 2 years of age. The majority of untreated classic patients die within the early months of life from recurrent metabolic crisis and neurologic deterioration. Treatment involves both longterm dietary management and aggressive intervention during acute metabolic decompensation. We report here our experience of longterm diet therapy and treatment of acute metabolic decompensation of a case of classic MSUD.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.05a
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• pp.236-237
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• 2018

최근 생활습관정보는 대사증후군을 진단하기 위한 임상적 진단지표로 중요하게 활용되고 있다. 대사증후군은 심혈관 및 간질환 그리고 당뇨와 같은 여러 합병증을 유발할 수 있는 질환으로 질환 정도에 따른 체계적 관리가 필요하다. 그러나 대사증후군 환자의 생활습관을 수집하기 위한 대부분의 시스템은 자가진단 및 예방 중심의 시스템으로 구성되어 있어 정확한 생활습관을 수집하여 생활습관을 관리하기에는 어려움이 있다. 본 논문에서 제안하는 시스템은 임상적 진단지표에 도움이 될 수 있도록 신뢰성 있는 생활습관 정보를 수집하기 위한 방법을 제시하고 수집된 생활습관정보를 모니터링 하여 환자의 생활습관 개선 여부에 따라 지속적인 피드백을 제공하여 체계적으로 생활습관을 관리할 수 있는 시스템을 제안하고자 한다.

• The Korea Journal of Herbology
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• v.24 no.1
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• pp.159-167
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• 2009

Objectives : So-Dang-Hwan (SDH) is used as a traditional treatment of diabetes in oriental clinics in Korea. This study aimed to evaluate antidiabetic effect of SDH in streptozotocin (STZ)-induced diabetic rats. Methods : Diabetes was induced by i.p. injection of STZ (45 mg/kg) to Sprague-Dawley rats. Experimental animals (eight per group), were treated by oral administration of SDH (60 mg/kg body weight) and glibenclimide (1 mg/kg), a known antidiabetic drug for comparison, during 5 weeks. To veridy the effect of SDH, the levels of glucose, triglyceride, insulin, BUN and creatinine were measured in sera from experimental diabetic rats, and an oral glucose tolerance test (OGTT) was also performed. Results : SDH prevented body weight loss in diabetic rats. SDH exhibited at termination, a significant reduction in blood glucose levels in STZ-induced diabetic rats. SDH significantly reduced serum creatinine levels toward the normal levels. The OGTT results showed a significant improvement in glucose tolerance in rats treated with SDH. Conclusions : These data indicate that SDH treatment may improve glocose homeostasis in STZ-induced diabetes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.2
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• pp.923-933
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• 2014

The subject of investigation was 13,828 people who took periodical medical examiner in some health examination centers two times in 2009 and 2011 so as to analyze changes of borderline group, disease group for 4 diseases(hypertension, diabetes, liver disease, hyperlipemia) and health behavior of some medical examiner. For the contents of investigation, drinking and smoking habit was investigated as a general characteristic of subjects. For the items of health examination, there were SBP, DBP, AST, ALT, GGT, Glucose, Total Cholesterol and Triglyceride. The main results are as follows. In comparison with the starting year of research, drinking and smoking rate of the final year was reduced respectively by 1.6% and 1.4%. And, borderline group by examination items, hypertension was reduced by 2.2% from 62.0% to 59.8% in the final year in comparison with the starting year of investigation, And, fasting blood glucose was 17.1%, hyperlipemia was 6.6%, LFT was 2.0% for the reduction. In disease group, hypertension was reduced by 0.6% from 6.7% to 6.1%. And, fast blood glucose was 1.9%, hyperlipemia was 4.2%, LFT was 1.3% for reduction. Borderline group showed more reduction in comparison with disease group in all of items. The above results showed borderline group showed more reduction of manifestation rate than disease group in all of 4 diseases. Therefore, it's expected that disease group will show reduction in the future. But, it's necessary to study on future's changes through the continuous management and tracing observation.

• Clinical and Experimental Pediatrics
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• v.50 no.6
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• pp.565-569
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• 2007

Purpose : With a duration of action of approximately 24 hours and peakless levels, Lantus is a more physiologic basal insulin analogue compared with NPH. The aim of this study was to compare the glycemic control of Lantus plus Humalog with that of premixed insulin in children and adolescents with type 1 diabetes mellitus. Methods : The subjects consisted of 25 patients with type 1 diabetes mellitus, aged 12-19 years, who changed their insulin regimen from premixed insulin to Lantus plus Humalog. Daily insulin doses, frequency of hypoglycemia, fasting blood glucose, C-peptide concentration and HbA1c before and 6 months after Lantus treatment were compared. 24 hour blood glucose of 11 patients among Lantus treatment group (n=25) and premixed insulin treatment group (n=10) were self-monitored and compared. Results : 6 months after Lantus treatment, the episodes of hypoglycemia were reduced by 50%(15.1 vs. 7.6 events/month), especially nocturnal hypoglycemia by 67%(6.7 vs. 2.5 events/month). HbA1c was reduced from 9.3% to 8.7% after Lantus treatment. Self-monitored blood glucose of Lantus treatment group at postbreakfast 30, 60, 90 and 120 minutes were 171.1, 169.5, 171.0 and 154.1 mg/dL respectively and lower than those of premixed insulin treatment group (259.7, 282.7, 280.0 and 250.9 mg/dL respectively). Conclusion : Compared with premixed insulin, Lantus plus Humalog is more effective in glycemic control and reduction in nocturnal hypoglycemia in children and adolescents with type 1 diabetes mellitus.