• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.198-209
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• 2014

Diabetes Mellitus (DM) is well known for increasing morbidity and mortality, especially related to their complications. The purpose of this study was to investigate the factors affecting the prevalence rate of DM and provide a fundamental material to develop an intervention strategy to reduce the prevalence rate of DM. The study subjects were adults aged over 19 on the basis of the primitive data of "The Fifth Korean National Health and Nutrition Examination Survey, 2012". Therefore, the data of 5995 participants were analyzed. For data process, the complex sample analysis module of SPSS 18.0 program was employed to add weighting before analysis. According to the analysis, the prevalence rate of DM of the study subjects was 10.5%. Regarding the odds ratio of DM prevalence, the subjects who graduated from middle school had the odds ratio 2.51 times higher than those who graduated from college and more; those in subjective bad health condition 4.77 times higher than those in subjective good health condition; those in obesity 1.44 times higher; those with high blood pressure 2.57 times higher; those with hyperlipidemia 2.63 times higher; those who fail to control their weight 1.31 times higher; those going on a diet 2.75 times higher. This study revealed that a level of education, perceived health status, obesity, high blood pressure, hyperlipidemia, weight control, and dietary therapy were the predictable variables of the prevalence rate of DM, and thereby suggested the nursing direction and research direction to reduce the prevalence rate of DM.

• Neonatal Medicine
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• v.18 no.1
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• pp.49-58
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• 2011

Purpose: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM). Methods: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data. Results: Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity. Conclusion: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.

• Journal of radiological science and technology
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• v.40 no.1
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• pp.35-40
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• 2017

The purpose of this study was to investigate the relationship between abdominal subcutaneous fat thickness(ASFT) and maternal gestational diabetes mellitus(GDM) measured by ultrasound at period of pregnancy. We compared maternal age, pre-pregnancy body mass index, and weight gain during pregnancy in 286 pregnant women who were diagnosed with early pregnancy ASFT and high GDM screening test(50 g OGTT) of more than 140 mg/dL. ROC curve analysis was used to determine the cut-off value of ASFT for GDM prediction. Maternal age and weight gain during pregnancy were not related to GDM in the mid-trimester and pre-pregnancy body mass index and earely pregnancy ASFT were significantly different between normal and GDM high risk groups. The cut-off value of ASFT for GDM prediction was 2.23 cm(AUC 0.913. Sensitivity 76.19%, Specificity 93.72%). ASFT measured by ultrasound in early pregnancy was useful as an important index for predicting mid-trimester GDM prediction. Therefore, ASFT can be used as an auxiliary diagnostic index for early recognition of GDM.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.16 no.2
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• pp.144-152
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• 2009

Purpose: The purpose of this study was to predict the risk factors for vascular complications among patients with type 2 diabetes. Method: The data were collected from August to September, 2007 using clinical examination and questionnaires. Patients (N=101) were recruited from the endocrinology department of P University hospital in D city. Descriptive statistics, Pearson correlation coefficients and multiple linear regression were used to analyze the data. Results: The cardiovascular risk of patients with diabetes was significantly related to self care behavior, family history, and smoking status. The risk of peripheral vascular complications was not related to predictors included in the study. With multivariate analyses, significant predictors of cardiovascular risk for these patients were self care behavior, family history, and smoking status ($R^2=.40$, p<.0001). Conclusion: The findings of this study indicate that smoking cessation and improving self-care behavior are essential to reduce the risk of cardiovascular complications among patients with diabetes. To enhance self-care practices for the patients with diabetes, nursing interventions, such as telephone counseling, problem focused nursing counseling, and peer group activities should be considered.

• The Monthly Diabetes
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• s.287
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• pp.52-55
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• 2013

2008년 보건산업진흥원의 "u-Healthcare R&D 기본계획 수립" 연구보고서에서 u-헬스케어 기술개발을 "u-헬스케어 인프라", "u-헬스케어 임상-바이오-생체정보 융합기술", "u-헬스케어 서비스 모델", "자유공모" 등 4개의 사업으로 구성하여 추진할 것을 제안했다. u-헬스케어 인프라는 다양한 형태의 u-헬스케어 기술 및 서비스 지원을 위한 인프라 기술 개발, 전문 인력 양성 및 법 제도 정비 등의 내용을 포함하고, u-헬스케어 임상-바이오-생체정보 융합기술은 임상-바이오-생체정보를 활용하여 u-헬스케어 기반 질병예측 예방, 조기진단, 건강증진 기술개발 등을 포함하며, u-헬스케어 서비스 모델은 국민건강의 안전성과 효율성이 담보되고 산업활성화에 기여할 수 있는 u-헬스케어 서비스 모델 개발 등을 담고 있다. u-헬스케어 자유공모의 내용은 u-헬스케어의 기반이 되는 다양한 인프라, 기술, 서비스를 자유공모 형식으로 발굴함으로써 수용자 중심의 연구개발이 필요함을 제시하였다. u-Health 기술 내용중 세 번째로 u-헬스케어 TRM을 알아본다.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.3
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• pp.155-162
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• 2006

Purpose: Diabetes mellitus (DM) is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is glowing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. Subjects and Methods: 203 diabetic patients (64 male, mean age $64.1{\pm}9.0$ years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was $36{\pm}18$ months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Results: Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the ocurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. Conclusion: Patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.483-492
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• 2021

Agastachis Herba (AH) to treat anorexia and nausea and its antidiabetic efficacy was recently reported. This study examined the antioxidant activities and chemical constituents of AH and predicted the target proteins of each compound using in silico approaches. The results showed that EC50 values of AH methanol extract for DPPH and ABTS radical scavenging were 78.6 ㎍/mL and 31.0 ㎍/mL, respectively. Compared to the EC50 values of ascorbic acid (9.9 ㎍/mL, 5.2 ㎍/mL), the AH methanol extract possessed excellent antioxidant activities. Rosmarinic acid, tilianin, agastachoside, and acetin were confirmed as the major compounds of extracts by qualitative analysis performed with HPLC-PDA-MS/MS. The antidiabetic target proteins of these compounds were predicted by applying a structural similarity and inverse docking methodology using a DIA-DB server. The resulting target proteins were PPAR-γ, DPP IV, glucokinase, α-glucosidase, SGLT2, aldose reductase, and corticosteroid 11-beta-dehydrogenase, some of which have already been proven experimentally as target proteins. Therefore, the in silico methods can be considered valid. Finally, AH were extracted with various solvents to determine the optimal conditions for the extraction of active components. Methanol among organic solvents and 80% ethanol in ethanol-water mixtures were identified as the most effective solvent for the extraction.

• Journal of Industrial Convergence
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• v.21 no.5
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• pp.51-58
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• 2023

The purpose of this study is to analyze suicidal ideation of elderly people with diabetes living alone and to investigate the relationship between suicidal ideation, loneliness, and depression. This study was conducted through secondary data analysis using total survey data for the elderly living alone in O province. The subjects of this study were 466 elderly people who were diagnosed with diabetes among the elderly living alone. The data of this study were analyzed using descriptive statistics, t-test, Pearson's correlation coefficients, multi-linear regression analysis, and the three-step mediating effect verification procedure of Baron & Kenny using the SPSS 26.0 program. The average loneliness score and average depression score of the subjects were 4.52±3.30 and 4.88±4.03, respectively, and 27.3% of the subjects said they had a suicidal ideation. The subject's loneliness (β=.20, p=.005) and depression (β=.30, p<.001) was found to be a significant factor in predicting suicide ideation. In addition, depression was found to be partially mediated in the relationship between loneliness and suicidal ideation. Through the results of this study, loneliness and depression were found to be important factors related to suicidal ideation in the elderly with diabetes living alone. In addition, in order to improve suicidal ideation in the elderly with diabetes living alone, intervention to lower the level of loneliness and depression is necessary.

• Photonics industry news
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• s.36
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• pp.36-41
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• 2006

의료용 광 계측은 의광학의 일부분으로 빛이 생체조직과 일으키는 상호작용을 이용하여 환자의 치료나 진단 또는 의학 기초분야의 발전에 효과적으로 사용하고 있다. 광 계측 및 센서기기를 응용하여 제품화된 의료용품들에는 혈당센서,혈압센서,내시경,검안기,영상진단기 등이 있다. 특히 혈당센서의 경우 급속하게 늘어가고 있는 당뇨병 환자의 수요에 비례한 시장이 현재 세계시장규모인 5조원에서 연간200%씩 증가될 것으로 예측되고 있다. 내시경의 세계시장은 매년 약 5% 내외의 성장을 거듭하고 있으며 검안기는 매년 약 7.2%의 성장률을 기록하고 있다.

• 대한핵의학회:학술대회논문집
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• 2001.11a
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• pp.41.1-41.1
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• 2001