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Correlations of Cerebellar Function with Psychotic Symptoms and Cognitive Function in Schizophrenic Patients (남자 정신분열병 환자의 소뇌기능과 정신증상 및 인지기능간의 연관성)

  • Kim, Seo Young;Jun, Yong Ho;Kwon, Young Joon;Jeong, Hee Yeon;Hwang, Bo Young;Shim, Se Hoon
    • Korean Journal of Biological Psychiatry
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    • v.14 no.3
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    • pp.184-193
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    • 2007
  • Objectives:There is increasing evidence that the cerebellum plays an important role in cognition and psychiatric symptoms as well as motor coordination. The concept of cognitive dysmetria has been making cerebellar function in schizophrenia the focus of current studies. In other words, disruption in the corticocerebellum-thalamic -cortical circuit could lead to disordered cognition and clinical symptoms of schizophrenia. The purposes of this study were to determine cerebellar dysfunction in male schizophrenic patients semiquantitatively with ICARS and to investigate the clinical and cognitive correlates of ICARS in patients. Methods:We compared the scores of cerebellar neurologic sign using ICARS in 47 male patients with a DSM-IV-TR diagnosis of schizophrenia with 30 gender and age-matched healthy control subjects. The semiquantitative 100-point ICARS consists of 19 items divided into 4 unequally weighted subscores:posture and gait disturbances, kinetic functions, speech disorders and oculomotor disorders. All subjects were also assessed with cognitive function test. Cognitive functions were evaluated by Korean-Mini Mental Status Examination (K-MMSE), Verbal fluency test, and Clock drawing test. The patients were administered Korea version of Positive and Negative Symptom Scale(K-PANSS) to assess the symptom severity. Results:Schizophrenic patients had significantly higher scores on the ICARS than control subjects with posture and gait disturbances, kinetic functions, and oculomotor disorders. They also showed more significant impairments in cognitive function tests than control subjects. There was a significant correlation between ICARS and negative symptoms of patients. In cognitive function test, Clock drawing test was significantly associated with negative symptoms. In addition, Clock drawing test was negatively correlated with the total score of ICARS. Conclusion:In this study, we confirmed that schizophrenic patients have significant impairments in cognitive and cerebellar function, and that those were related with negative symptoms of schizophrenic patients. These results support a role of the cerebellum in schizophrenia. It is meaningful that we used a structured, and reliable procedure for rating neurological soft signs, ICARS. We hope that future prospective studies using a similar design help that rate of neurological sign should have been visible with the progression of illness.

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A study on the Construction and the Transition of Daebodan in the Late Josun Dynasty (조선후기 창덕궁 대보단의 조성과 변천에 관한 연구)

  • LEE Yeonro
    • Korean Journal of Heritage: History & Science
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    • v.55 no.4
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    • pp.96-116
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    • 2022
  • The Daebodan was an altar, which held a memorial service for emperors of the Ming dynasty. This alter, which was referred to as Hwangdan, was first constructed in 1704. When the Japanese Invasion of Korea commenced in 1592, Shinjong, the emperor of the Ming dynasty, sent reinforcements to Josun to help. This alter was made to repay Shinjong's kindness. Before this, Song-siyeol(宋時烈), Leader of Noron(老論), made a shrine at Hwayangdong to hold memorial services for Shinjong, and after some time, this developed into a national ceremony. Construction of the Daebodan largely changed the backyard of Changdukgung-palace. However considering the construction process, the meaning of the Daebodan was not a big deal. At first, the optimal place for the Daebodan was selected at the site of a inner icehouse. But the inner icehouse could not be transferred to other site due to the circumstances. After all, the Daebodan was constructed at the site of Byeoldaeyeong(別隊營) which was located in the outside of palace. Most of the stones for the new Daebodan were used ones. And the annexe of Byeoldaeyeong was used for Daebodan without any changes being made. The scale of the construction was not particularly grand. After the construction, Sukjong, who made the Daebodan, showed barely any interest in it. But the conception of the Daebodan was back again in the history by Youngjo. He was also not interested in the Daebodan during his early years of ruling time. However, in the 1740's, he started to become interested in the ceremony of Daebodan, and carried out a large-scale reconstruction of the Daebodan. Jegigo(祭器庫) was rebuilt In 1739. And Jaesil(齋室), staying one night before the ceremonial day, was added in 1745. In 1749, the Daebodan was greatly changed by enshrining Uijong and Taejo, emperors of the Ming dynasty. The shape of alter was changed. Moreover this alter was made by newly quarried stones. And several buildings, Junsachung(典祀廳), Jaesaengchung(宰牲廳) and Akgongchung(樂工廳), were added to the site. In 1762, meritorious retainers were enshrined to the Daebodan. After all the Daebodan became an important part of the backyard of Changdukgung-palace. During the reign of Jungjo, the Daebodan also was an important part of backyard of Changdukgung-palace. But significant changes were not made at that time. The only change was the moving of Kyungbonggak(敬奉閣) in 1799. Afterward the Daebodan remained unchanged. The ceremonies at the Daebodan stopped in 1908. And the Daebodan disappeared into the mist of history.

대순진리회의 수도 요체와 심신 수양

  • 양옌
    • Journal of the Daesoon Academy of Sciences
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    • v.21
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    • pp.323-367
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    • 2013
  • 한국의 대순진리회는 증산 성사의 가르침을 숭신하는 종교단체로서, 한국 사회에 상당한 영향력을 가지고 있다. 1969년 창설된 대순진리회는 포덕·교화·수도를 삼대 기본사업으로, '음양합덕·신인조화·해원상생·도통진경'을 종지로, '안심·안신·경천·수도'를 사강령으로, '성·경·신'을 수도의 삼요체로 삼고 있다. 또한 인간개조와 포덕천하·구제창생·보국안민을 통하여 지상천국을 건설하는 것을 목표로 한다. 대순진리회는 사상적 측면에서 무(巫)와 유(儒)·불(佛)·도(道)를 포용하고 있다. 이러한 대순사상을 바탕으로 대순진리회의 도인들은 근엄하고 세밀한 실천수도를 수행하는데, 그 내용을 살펴보면 중국 유·불·도의 양생문화와 많은 공통점이 있는 동시에, 또한 뚜렷한 한국 문화의 특색을 띠는 부분도 있다. 이런 면들은 모두 개인적 수도와 사회적 안정을 실현하는 데 큰 도움이 되고 있다. '안심·안신·경천·수도'의 사강령은 대순진리회의 도인들이 지켜야 할 가장 기본적인 행위규범이다. '성·경·신'의 삼요체는 사강령을 실천하기 위한 내면적 수양으로서 모든 수도활동의 근본이 되는 것이다. 삼요체 중에서 '성'을 가장 근본적인 것으로 생각하는데, 그 이유는 오직 '성'을 갖춘 사람만이 '경'과 '신'을 논할 수 있기 때문이다. 반대로 마음속에 망념이 있거나 경거망동을 하는 사람들은 상제에 대한 '경'과 '신'을 잃게 된다. '성실함'이라는 내면적 도덕 품성은 인간으로 하여금 더욱 정직하고 안정되며 오래 지속되게 한다. 뿐만 아니라 '성'은 수도자들로 하여금 더욱 순수해지고, 어리석음을 버리게 한다. 크나큰 도를 성취하려면 먼저 이렇게 얼핏 보기에는 어리석지만 끈기 있는 마음이 필요하다. '성'하면 기운이 솟구쳐 내면이 더욱 안정되고 번뇌는 사라진다. 성심을 수련하면 마음이 안정되고, 마음이 안정되면 정신이 안정되는데, 정신이 안정되면 걱정이 사라지기에 몸도 건강해진다. 삼요체중 '경'과 '신'에 있는 큰 의미 가운데 하나는 상제님에 대한 경배와 믿음을 끝까지 가지라는 것이다. '해원상생·보은상생'은 대순사상의 가장 중요한 대도(大道) 윤리로서 도인들의 수도를 인도하는 기본적인 법칙이다. 대순진리회에서 말하는 해원은 단지 개인 한 사람의 해원이 아니라 우주의 질서를 바로잡는 해원이라는 점에서 중요하다. 그렇기 때문에 대순진리회 도인들은 개개인으로 시작하여 자신의 원한을 해결할 뿐만 아니라, 땅의 원한, 천민의 원한, 여인의 원한 등 모든 원을 해결해 주고자 한다. 즉 삼계의 모든 불평등을 해소하고 불합리한 부분을 바로잡는 것이다. 해원의 다른 측면은 보은이라 할 수 있다. 해원과 보은은 상보상조의 관계에 있는데, 이는 곧 도인들이 행하는 수도의 양 날개라 생각된다. 해원을 통하여 과거의 장애를 제거하고, 보은을 통하여 현재의 덕을 쌓는 것이다. 보은을 하려면 항상 감사의 마음을 간직해야 한다. 그 의미는 인간관계에 있어서 다른 사람이 베푼 은혜를 항상 고맙게 생각해야 한다는 것이며, 더 나아가 천지가 우리에게 베푼 은혜도 감사하게 생각해야 한다는 것이다. 모든 원한이 풀어지고, 모든 은혜를 다 갚았을 때 삼계가 조화롭고 통하게 될 것이다. 대순진리회에서는 도인들의 실천수도 면에서 두 가지 측면을 강조하는데, 즉 포덕교화와 근언신행이다. 근언신행은 자아발전을 위한 도인들의 내적 수련이며, 포덕교화는 도인들이 외부 세상에 대순사상을 알리고 가르치는 것을 말한다. 양자는 동전의 양면과 같이 떨어질 수 없는 관계에 있다. 다른 사람을 포덕·교화 하려면 도인들 스스로가 먼저 말과 행동에 조심해야 한다. 왜냐하면 말과 행동을 조심하는 것 자체가 곧 포덕교화에서 다른 사람의 모범이 되기 때문이다. 인생을 살면서 추구해야 할 가장 높은 목표는 덕(德)을 세우는 것이고, 그 다음은 공(功)을 세우는 것이며, 그 다음은 언(言)을 세우는 것이다. 덕·공·언은 세월이 지나도 그 가치가 빛을 바래지 않는다. 이 세 가지 중 한 가지를 이룬 사람이면 불후하다고 할 수 있다. 성인들이 성인으로 칭송 받았던 이유는 모두 육체를 초월한 덕·공·언으로 세상을 풍요롭게 했기 때문이다. 그렇기 때문에 비록 그들이 세상을 떠났다 하더라도 마치 살아있는 것처럼 영원히 추앙되니, 이것을 통하여 영생을 얻는 것이다. '영생(永生)' 만큼 높은 경지에 도달하는 '양생'이 또 어디에 있겠는가? 대순진리회 실천수도의 최고목표는 바로 인간 내면의 수양을 최고의 경지로 끌어올리는 것으로서 이는 곧 음양합덕·도통진경이다. 다시 말해서 영원히 불후한 경지에 이르고 만세(萬歲)토록 영생하는 것이며 신(神) 그리고 성인이 되는 것이다.

Monitoring and Preventive Preservation of Cultural Heritages to Maintain Original Wooden Architectural Cultural Heritage (목조건축문화재 원형유지를 위한 문화재돌봄 모니터링과 예방보존)

  • CHUN Kyoungmee
    • Korean Journal of Heritage: History & Science
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    • v.56 no.4
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    • pp.192-214
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    • 2023
  • Wooden architectural cultural heritages are one of the visible legacies that show the national's identity. Even when the concept of 'the original' of cultural heritages was not accurately understood, the emphasis of preservation and management of cultural heritages was placed on 'preservation of the original form' or 'maintenance of the original form'. Moreover, these days, following the trend of international preservation principles, cultural heritages are considered important as "values as historical objects." This paper is the result of an attempt to determine the scope and content of what parts should be monitored to maintain the original form of wooden architectural cultural heritage. The first thing to be done in monitoring wooden architectural cultural heritage is to check the condition of the ground and foundation. The second is the column. This is because the instability of the column causes damage to the joint with each member and the fitting part, resulting in physical changes leading to damage to the wall. The third is monitor the roof tiles. If the leak continues into the building due to the separation or damage of the roof, the defect should be partially dismantled and repaired, so it should be monitored to maintain its original shape as much as possible. The monitoring range of the base, column, and roof serves as a reference point for identifying what damage is being done to the relevant cultural heritages. In other words, the data at the time when monitoring began becomes the 'original' for the year. Alternatives based on the analysis of monitoring for the preservation of original cultural heritages should be actively introduced. In addition, by sharing the current state and situation of cultural heritages as a result of monitoring with various related organizations, preventive preservation should be established rather than preservation of cultural heritages by "intervention."

Effects of NG-monomethyl-L-arginine and L-arginine on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion after cerebral hypoxia-ischemia in newborn piglets (급성 저산소성 허혈성 뇌손상이 유발된 신생자돈에서 재산소-재관류기 동안 NG-monomethyl-L-arginine과 L-arginine이 뇌의 혈역학 및 에너지 대사에 미치는 영향)

  • Ko, Sun Young;Kang, Saem;Chang, Yun Sil;Park, Eun Ae;Park, Won Soon
    • Clinical and Experimental Pediatrics
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    • v.49 no.3
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    • pp.317-325
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    • 2006
  • Purpose : This study was carried out to elucidate the effects of nitric oxide synthase(NOS) inhibitor, NG-monomethyl-L-arginine(L-NMMA) and nitric oxide precursor, L-arginine(L-Arg) on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion(RR) after hypoxia-ischemia(HI) in newborn piglets. Methods : Twenty-eight newborn piglets were divided into 4 groups; Sham normal control(NC), experimental control(EC), L-NMMA(HI & RR with L-NMMA), and L-Arg(HI & RR with L-Arg) groups. HI was induced by occlusion of bilateral common carotid arteries and simultaneously breathing with 8 percent oxygen for 30 mins, and followed RR by release of carotid occlusion and normoxic ventilation for one hour. All groups were monitored with cerebral hemodynamics and cytochrome $aa_3$ (Cyt $aa_3$) using near infrared spectroscopy(NIRS). $Na^+$, $K^+$-ATPase activity, lipid peroxidation products, and tissue high energy phosphate levels were determined biochemically in the cerebral cortex. Results : In experimental groups, mean arterial blood pressure, $PaO_2$, and pH decreased, and base excess and blood lactate level increased after HI compared to NC group(P<0.05). These variables subsequently returned to baseline after RR except pH. There were no differences among the experimental groups. In NIRS, oxidized hemoglobin($HbO_2$) decreased and hemoglobin(Hb) increased during HI(P<0.05) but returned to base line immediately after RR; 40 min after RR, the $HbO_2$ had decreased significantly compared to NC group(P<0.05). Changes of Cyt $aa_3$ decreased significantly compared to NC after HI and recovered at the end of the experiment. Significantly reduced cerebral cortical cell membrane $Na^+$, $K^+$-ATPase activity and increased lipid peroxidation products(P<0.05) were not improved with L-NMMA or L-Arg. Conclusion : These findings suggest that NO is not involved in the mechanism of HI and RR brain damage during the early acute phase of RR.