• 한국콘텐츠학회논문지
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• 제10권10호
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• pp.237-245
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• 2010

신경전도검사는 당뇨병성다발신경병증 및 당뇨병의 불현성 신경병증환자를 진단하기위한 중요한 검사이며 신경의 기능을 정량적으로 측정할 수 있는 검사기법이다. 본 연구에서는 당뇨병성다발신경병증 환자에서 보이는 전기생리학적 특징을 평가하기위하여 당뇨병성다발신경병증으로 진단된 120명과 정상대조군 77명의 운동신경전도검사의 결과를 비교?분석하였다. 상지와 하지의 각 운동신경에서 정상기준치에 대해 비정상 값을 보인 비율의 특징을 신경전도속도, 말단잠복기, 복합근육활동전위의 진폭, No potential의 빈도, 전도차단의 항목으로 나누어 분석하였다. 당뇨병성다발신경병증은 상지에 비해 하지를 더욱 침범하는 전신성 탈수초성 말초다발신경병증의 전기생리학적 특징이 관찰되었고, 특히 비골신경에서 비정상의 정도가 심한 것으로 분석되었다. 하지만 전도차단의 특징은 대조군에 비하여 유의한 차이가 없는 것으로 나타났다. 운동신경전도검사의 결과를 분석하여 당뇨병성다발신경병증의 전기생리학적 특징을 분석한 본 연구의 결과 하지의 비골신경이 중요한 지표가 될 수 있음이 확인되었고, 이는 당뇨병성다발신경병증의 중요한 전기생리학적 소견으로 사료된다.

• 디지털콘텐츠학회 논문지
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• 제19권4호
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• pp.615-620
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• 2018

당뇨병성 다발성 신경병증 환자들을 진단하는 전류지각 역치 시험과 진동 감각 지각 역치의 임상학적 유용성에 대한 평가는 당뇨병성 다발성 신경병증에 대한 진단방법 중의 하나이다. 현재까지 당뇨병성 다발성 신경병증 환자들에 대해 몇 가지 방법들이 사용되어 왔는데, 예를 들면, 하지 신경병증 장애 시험, 신경전도 시험, 냉각감지 역치 시험, 열-고통 역치 시험 등을 들 수 있다. 그러나, 이들 대부분의 시험은 고가이거나 시험하는데 많은 시간을 필요로 한다. 본 논문에서는 진동 감지 능력을 평가하는 새로운 기구가 소개되고, 이를 위해 환자의 말초 신경을 자극하는 보이스 코일 모터(voice coil motor)와 전류 증폭기를 제작하였다. 또한, 당뇨병성 다발성 신경병증 환자들의 정량적 진동 감지 수준을 측정하기 위하여 진동 감지 역치 시험을 센싱하고 구동하는 소프트웨어가 개발되었다.

• 대한영상의학회지
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• 제84권4호
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• pp.964-969
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• 2023

길랑-바레증후군은 면역 매개 탈수초성 다발신경병으로서, 상향 진행성과 좌우 대칭적 마비를 특징으로 하며, 선행 감염이나 예방접종 등에 의해 유발되는 것으로 알려져 있다. 최근 코로나바이러스감염증-19 예방접종 후 길랑-바레증후군 발생이 보고되었다. 길랑-바레증후군에서 보이는 뇌신경병증은 주로 안면신경과 하부뇌신경을 침범한다. 저자들은 코로나바이러스 감염증-19 예방접종 후 발생한 길랑-바레증후군 환자에서 삼차신경, 외전신경, 안면신경을 침범한 다발성 뇌신경병증 사례를 자기공명영상 소견에 기반하여 보고하고자 한다.

• Annals of Clinical Neurophysiology
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• 제6권1호
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• pp.48-51
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• 2004

The occurrence of polyneuropathy in association with monoclonal gammopathy of undetermined significance (MGUS) is quite common. However, reports of MGUS associated cranial neuropathies are rare. A 63 year-old women was presented with diplopia and swallowing difficulty. Neurological examination showed limitation of abduction of right eye, right peripheral facial palsy, decreased hearing and gag reflex, left side deviation of uvula, and decreased DTR. Sensorimotor polyneuropathy were observed with elctrophysiological studies. Protein and immunoelectrophoresis revealed IgG ${\kappa}$monoclonal gammopathy. She was treated with intravenous immunoglobulin and steroid, and her symptoms and signs were improved. This case suggested that she had sensorimotor polyneuropathy and multiple cranial neuropathies associated with IgG ${\kappa}$MGUS.

• Annals of Clinical Neurophysiology
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• 제3권1호
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• pp.40-42
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• 2001

Anorexia nervosa(AN) is a disorder characterized by disturbance of body image, fear of gaining weight, severe weight loss and, in female, amenorrhea. Compared with normal persons, patients with AN have neuropathic symptoms more frequently. But electrophysiologic abnormalities have rarely been reported. We experienced a case with recurrent neuropathic symptoms after severe weight loss. Further evaluation revealed AN. Electrophysiologic study showed sensorimotor polyneuropathy and focal neuropathy with conduction block. As far as we know, this feature of neuropathy in AN has not been described. We describe unusual feature of neuropathy in our patient with literature review.

• Annals of Clinical Neurophysiology
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• 제10권1호
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• pp.33-37
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• 2008

Diabetic polyneuropathy (DPN) is the most common form of diabetic neuropathy, and causes a significant morbidity with an impact on the quality of life in the patients with diabetes. Since DPN frequently induces foot deformity and ulceration, which finally leads to foot amputation, the early detection and treatment is very important for the prevention of a permanent structural change. In the early stage of DPN, the diagnostic methods which can evaluate the function or structure of small nerve fibers should be employed because small nerve fibers are first involved in the course of DPN. However, the nerve conduction study cannot reflect the function of the small nerve fibers, and thus, has a definite limitation in the early diagnosis of DPN. For the early detection of DPN, electrodiagnostic data should be interpreted on a clinical context, along with the careful evaluation of the small nerve fiber functions using the tests such as the analysis of intraepidermal nerve fiber density.

• Annals of Clinical Neurophysiology
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• 제10권1호
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• pp.25-28
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• 2008

Diabetic polyneuropathy (DPN) is the most frequently encountered form of neuropathy in diabetic patients, and it either relentlessly progresses or remains relatively stable for many years, not showing any trend towards improvement. From this point of view, early detection of DPN is very important to prevent the irreversible change of the peripheral nerve from diabetic insults. Although a number of clinical symptoms and/or deficit scales have been developed for clinical or research purposes, nerve conduction study (NCS) has been known one of the most objective and sensitive tools to detect peripheral nerve dysfunctions in diabetic patients. NCS, however, also have several shortcomings. The next two consecutive articles will focus on debates about diagnostic usefulness of NCS and on recent updates of other diagnostic tests including quantitative sensory testings and skin biopsy in the field of diabetic polyneuropathy.

• Annals of Clinical Neurophysiology
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• 제5권1호
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• pp.39-41
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• 2003

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology ogenesis, and most frequently presented with bilateral hilar lymphadenopathy, pulmonary infiltration, skin and eye lesion. However, neurological involvement including peripheral neuropathy is relatively rare. We report a patient who had sensorimotor polyneuropathy without other systemic symptoms or organ involvements frequently reported in sarcoidosis. Laboratory investigation suggestive of sarcoidosis lead to sural nerve biopsy for confirmation, which demonstrated noncaseating granulomatous changes. Sarcoidosis shoud be included in the differential diagnosis in subacute polyneuropathy even if there is no usual symptoms or signs suggestive of the systemic disease.

• Annals of Clinical Neurophysiology
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• 제9권1호
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• pp.19-22
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• 2007

Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) occur commonly in the patients who have been on mechanical ventilation for more than 1 week. Even in some patients diagnosed with CIP, an underlying myopathy may be the primary cause of the muscle weakness. The cormorbid status of CIP and CIM is called as critical illness polyneuropathy and critical illness myopathy (CIPNM). We describe a 56-year-old man with acute quadriparesis and areflexia after systemic inflammatory response syndrome. The diagnosis of CIPNM is important to avoid unnecessary investigations and unreasonably pessimistic prognosis. Electrophysiologic studies are essential for the diagnosis and for planning further clinical management.

• Annals of Clinical Neurophysiology
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• 제3권2호
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• pp.115-121
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• 2001

The occurrence of muscle weakness in patients with sepsis or multiple organ failure managed in the intensive care unit has been recognized with increasing frequency in the last two decades. The difficulty in examining critically ill patients may explain why this complication has been only recently recognized. This weakness is due to an axonal polyneuropathy which is called critical illness polyneuropathy(CIP). It must be differentiated from myopathy or neuromuscular junction disturbance that can also occur in the intensive care setting. Neither the cause nor the exact mechanism of CIP has been elucidated. Electrophysiological studies demonstrated an acute axonal damage of the peripheral nerves. Before the recognition of CIP, these cases were usually misdiagnosed as Guillain-$Barr{\acute{e}}$ syndrome. Clinical recovery from the neuropathy is rapid and nearly complete in those patients who survive. Thus, neuropathy acquired during critical illness, although causing a delayed in weaning from ventilatory support and hospital discharge, does not worsen long-term prognosis.