• Title/Summary/Keyword: 니티놀

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박막니티놀 생체재료의 혈액적합성 및 소형혈관계 스텐트 연구

  • Cheon, Yeong-Jae
    • Journal of the KSME
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    • v.52 no.12
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    • pp.41-48
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    • 2012
  • 생명을 위협하는 주요한 소형혈관 치료를 위한 의료기기의 생체재료로서 박막니티놀이 최근 소개되었고, 다양한 실험실 실험(in vitro)과 생체실험(in vivo)을 통하여 혈액적합성과 소형혈관치료 디바이스로서의 가능성에 대한 연구가 이루어졌다. 이 글에서는 박막니티놀의 특성, 제조방법 그리고 이 재료를 이용한 디바이스인 뇌동맥류 유량 조절 스텐트(cerebral aneurysm flow-diverting stent)와 말초동맥질환 스텐트 그라프트(peripheral artery disease stent graft)에 대하여 설명을 하였다.

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Grafting and Characterization of Zwitter Ionic Poly(ethylene glycol) on Gold-Coated Nitinol Surface Chemisorbed with L-Cysteine (시스틴으로 화학흡착된 금 코팅 니티놀 표면에 앙쪽성 이온 폴리에틸렌글리콜의 그래프트 및 특성 평가)

  • Shin, Hong-Sub;Park, Kwi-Deok;Kim, Jae-Jin;Kim, Ji-Heung;Han, Dong-Keun
    • Polymer(Korea)
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    • v.33 no.1
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    • pp.84-90
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    • 2009
  • Nitinol alloy (TiNi) has been widely used in vascular stents. To improve the blood compatibility of Nitinol alloy, its surface was chemically modified in this study. Nitinol was first coated with gold, then chemisorbed with L-cysteine (C/N), and followed by grafting of zwitter ionic poly(ethylene glycol) (PEG) (PEG-$N^+-SO_3{^-}$) to produce TiNi-C/N-PEG-N-S. The zwitter ionic PEG grafted on the Nitinol surface was identified by ATR-FTIR, ESCA and SEM. The hydrophilized surface was proven by the decrease of water contact angle. In addition, from the blood compatibility tests such as protein adsorption, platelet adhesion, and blood coagulation time, the surface-modified TiNi alloy exhibited a better blood compatibility as compared to the untreated Nitinol control. These results indicated a feasibility of synergistic effect of hydrophilic PEG and antithrombotic zwitter ion.

Effects of Annealing Heat Treatment Conditions on Phase Transformation of Nitinol Shape Memory Alloy (어닐링 열처리 조건에 따른 NITINOL형상기억합금의 상변환 특성 연구)

  • Yoon Sung Ho;Yeo Dong Jin
    • Composites Research
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    • v.18 no.2
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    • pp.38-45
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    • 2005
  • Phase transformation behaviors and crystal structures of Nitinol shape memory alloy $(54.5Ni-45.5Tiwt\%)$ are investigated by varying annealing heat treatment conditions through DSC (Differential Scanning Calorimetry) and XRD (X-Ray Diffraction). Annealing heat treatment conditions were considered as heat treated times of 5min, 15min. 30m1n, and 45min, as well as heat treated temperatures of $400^{\circ}C,\;500^{\circ}C,\;525^{\circ}C,\;550^{\circ}C,\;575^{\circ}C,\;600^{\circ}C,\;700^{\circ}C,\;800^{\circ}C,\;and\;900^{\circ}C$ According to the results, annealing heat treatment conditions such as heat treated times and heat treated temperatures were found to affect significantly on phase transformation behaviors and crystal structures of Nitinol shape memory alloy.

A Study for Improving Surface Roughness and Micro-deburring Effect of Nitinol Shape Memory Alloy by Electropolishing (니티놀 형상기억합금의 표면 거칠기 향상 및 미세 버 제거를 위한 마이크로 전해연마의 가공특성 분석)

  • Shin, Min-Jung;Baek, Seung-Yub;Lee, Eun-Sang
    • Transactions of the Korean Society of Machine Tool Engineers
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    • v.16 no.6
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    • pp.49-54
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    • 2007
  • Electropolishing, the anodic dissolution process without contact with tools, is a surface treatment method to make a surface planarization using an electrochemical reaction with low current density. Nitinol is a metal alloy composed of Ni and Ti around 50% respectively which has shape memory effect. Nitinol can be put various applications which require purity and high pricision surface of products. The aim of this study is to investigate the characteristic of electropolishing effect for nitinol workpieces. In order to analyze the characteristics of electropolishing effect, surface roughness and micro-burr size were measured in terms of machining conditions such as current density, machining time and electrode gap. The tendencies about improvement of surface roughness and deburring effect by electropolishing for nitinol workpieces were determined.

형상기억합금의 특성 및 응용

  • Lee, In;Yang, Seung-Man
    • Journal of the KSME
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    • v.44 no.6
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    • pp.34-39
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    • 2004
  • 형상기억합금(SMA : Shape Memory Alloy)은 일반적인 금속이나 합금에서는 찾아볼 수 없는 형상기억효과(shape memory effect)와 초탄성 (superelasticity) 거동을 보이고 있다. 이러한 특성은 1951년에 금-카드뮴(Au-Cd) 합금에서 처음으로 발견되었으며, 1963년에 미국 해군병기연구소(Naval Ordnance Laboratory)에서 니켈-티타늄 (Ni-Ti) 합금에서 형상기억효과를 발견한 후로 널리 상용화되었다. 니티놀(nitinol)이라고 불려지는 니켈-티타늄 계열의 형상기억합금은 단위 부피당 많은 에너지를 낼 수 있고, 내 부식성(corrosion resistance)과 생화학적 적합성(bio-compatibility)이 뛰어나다. 또한 100,000사이클 이상의 긴 사용수명을 갖기 때문에 작동기(actuator)로서 우수한 특징을 갖는다. (중략)

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A Study of Micro Electrolytic-deburring for Nitinol (Nitinol 소재의 미세 전해디버링에 관한 연구)

  • Kim W.M.;Sin M.J.;Lee E.S.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2006.05a
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    • pp.229-230
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    • 2006
  • Shape memory alloy, Nitinol is used for medical stent, artificial human joint, antenna of artificial satellite, fire door, temperature sensor...etc. It is important for some nitinol product high precision and clean surface. In this study, we experiment about deburring of edge and surface of nitinol work piece with micro electrolytic-deburring. We made an observation in case electric currents are $1A{\sim}4A$, above 5A and each machining times.

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Design of flap devices driven by SMA spring actuators (형상기억합금 액추에이터를 이용한 플랩 구동)

  • Shim, Woo-Ram;Park, Eui-Jun;Kim, Ki-Duk;Kim, Yo-Seob;Park, Sun-Hwa;Roh, Jin-Ho
    • Journal of Aerospace System Engineering
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    • v.4 no.4
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    • pp.11-17
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    • 2010
  • In this paper we make an flap actuator by using shape memory effects of SMA spring. We studied that the force and stroke what we need to design and the flap mechanism. The force and stroke was estimated through the analysis program which like a catia, matlab etc. We could design and make flap actuator. So The actuator which used SMA spring can apply to small aircraft.

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Efficacy and Safety of a Newly Developed Self-Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs (새로 개발된 말초동맥용 자가팽창성 개방형 니티놀 스텐트의 유효성 및 안전성 평가: 미니피그 전임상실험)

  • Min Uk Kim;Jae Hwan Lee;Chang Jin Yoon;Won Seok Choi;Saebeom Hur;Jin Wook Chung
    • Journal of the Korean Society of Radiology
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    • v.81 no.4
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    • pp.899-911
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    • 2020
  • Purpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable nitinol stent (NiTi-stent) for peripheral arteries. Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned to the NiTistent group or conventional nitinol stent group. Stents were symmetrically implanted into the iliac arteries of each animal using carotid artery approach and were observed for 1 month (n = 5) and 6 months (n = 9). The angiographic lumen diameter (ALD), late lumen loss, angiographic stenosis, histomorphometric lumen area, neointimal area, and area stenosis were analyzed and compared between the groups. Results Stent migration, stent fracture, or thrombus formation were not observed in either group. At the 1-month follow-up, the neointimal area (p = 0.008) and area stenosis (p = 0.016) were significantly smaller in the NiTi-stent group than in the control group. At the 6-months followup, the NiTi-stent group showed significantly larger ALD (p = 0.014), less late lumen loss (p = 0.019), less angiographic stenosis (p = 0.014), larger lumen area (p = 0.040), and smaller neointimal area and area stenosis (p = 0.004 and p = 0.014, respectively) compared with the control group. Conclusion The NiTi-stent is as safe and effective as the conventional nitinol stent and induces less neointimal hyperplasia in a minipig iliac artery model.