• Transactions of Materials Processing
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• v.14 no.6 s.78
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• pp.491-495
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• 2005

Micro injection molding analysis for microneedle fabrication was performed in the present study. The dimensions of width and thickness for in-plane microneedle are $600{\mu}m$, $500{\mu}m$, respectively. A delivery system based on guidelines for traditional injection molding was designed for four-cavities molding system. To investigate the effects of processing conditions in the mirconeedle fabrication, injection molding analysis using commercial code was performed. It was shown that the total injection time has a significant effect on the fabrication of in-plane microneedles.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.55-59
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• 2005

Micro injection molding analysis for microneedle fabrication was performed in the present study. The dimensions of width and thickness for microneedle are 600um, 500um, respectively. A delivery system based on guidelines for traditional injection molding was designed for four-cavities molding system. To investigate the effects of processing conditions in the mirconeedle fabrication, injection molding analysis using commercial code was performed. It was shown that the total injection time has a significant effect on the fabrication of microneedles.

• Journal of the KSME
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• v.35 no.1
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• pp.36-45
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• 1995

주노즐내의 공기제트의 효율을 높이기 위해, 주노즐 제트 속도는 높을수록 높은 마찰력을 초래 하여 위사의 속도를 증가시킨다. 가속관의 길이가 증가하면 노즐출구에서의 공기의 속도와 난 류가 감소하며; 가속관의 직경이 증가할 때에는 공기속도가 감소하며 난류는 증가한다. 탱크압력, 가속관의 길이 등 유동조건에 따라 유동은 니들 끝과 가속관 출구에서 이중 초크(M=1)가 발 생할 수 있다. 에어가이드 직경과 노즐직경의 그 비율이 클수록 제트에 의한 유동의 비말동 반(entrainment)이 크게 된다. 실제 노즐직기내의 유동은 위사를 동반한 유동이므로 위와 같은 정성적인 설명에 위사의 물성치에 따른 고려를 반드시 하여야만 한다. 현장에서의 노즐설계는 노즐형상 자체의 영향은 물론 각종 위사의 물성치에 맞는 압축공기 압력 최적조건이 무엇인가를 찾는 일도 매우 중요하다.

• Journal of Institute of Convergence Technology
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• v.1 no.1
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• pp.48-51
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• 2011

Transdermal drug delivery device is a method of drug delivery through the skin. Skin has a very large area, so it is attractive route to drug delivery. When drug delivery through the skin, microneedle has a advantage that painless, constant drug deliver and penetration efficient; nevertheless the cost is expensive because fabrication process need a particular equipment and not suitable in mass production. This study shows microneedle fabrication process using convergence of general MEMS process and dicing process that can make 3-D sharp microneedle tip and this fabrication process suitable for mass production.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.139-143
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• 2011

금속분말을 청정 에너지원으로 이용하기 위해 금속분말 소형 연소기의 구현이 필요하다. 이를 위한 기초 연구로서 점화성이 뛰어나면서도 경제적인 수십 마이크로 크기의 마그네슘(Mg) 분말을 대상으로 고온 증기(steam)와의 연소 현상 대해 연구하였다. 본 연구에서는 연소실 내 체류시간 및 혼합 효율을 증가시키기 위해 와류 유동을 연소기에 적용하였고 아르곤(Ar) 이송가스를 이용해 마그네슘 분말을 공급하였다. 안정한 화염을 유지시키기 위하여 이송가스의 유량을 변화시켜 공급되는 마그네슘의 양을 조절하였고, 고온 증기의 공급량은 니들 밸브의 개도를 조정하거나 우회시킨 관로로 증기의 일부를 배출함으로써 조절하였다. 고온의 점화원을 사용하여 증기 분위기 내 마그네슘 분말을 점화시켜, 대기압 환경에서 마그네슘/증기/아르곤의 지속적인 화염을 구현하였다.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.249-252
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• 2011

고체로켓추진기관의 추력조절을 위해 핀틀 기술이 사용된다. 아직까지 핀틀 유동에 대해 근본적인 물리적 이해를 돕는 연구가 공개되지 않아, 이 연구에서 다양한 형상의 needle형 핀틀에 따른 유동구조에 대한 수치적 연구를 진행하였다. 2차원 축대칭, 압축성을 고려하여, 상용 열유체 해석 프로그램인 FLUENT 6.2를 사용하여 해석을 수행하였다. 난류 모델을 검증하기 위해 기 수행된 실험 결과와 비교하였다. 핀틀 각도(tip angle)가 작아질수록 노즐에서 유동 박리점이 하류로 이동하며, 핀틀에서 발생하는 끝단 충격파가 약해진다. 핀틀 반경(tip radius)이 작아질수록 핀틀에서 발생하는 끝단 충격파가 하류로 이동하며, 크기는 약해진다. 핀틀 형상(contour)은 유동 박리 지점에 직접적인 영향을 미친다.

• Microbiology and Biotechnology Letters
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• v.34 no.1
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• pp.58-62
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• 2006

Rapid assay of enzyme is a primary requirement for successful application of directed evolution technology. Halo generation on a turbid plate would be a method of choice for high throughput screening of enzymes in this context. Here we report a new approach to prepare turbid plates, by controlling the crystallization of tyrosine to form needle-like particles. In the presence of tyrosine phenol-lyase (TPL), the needle-like tyrosine crystals were converted to soluble phenol rapidly than the usual rectangular tyrosine crystals. When an error-prone PCR library of Citrobacter freundii TPL was spread on the turbid plate, approximately 10% of the colonies displayed recognizable halos after 24 hours of incubation at $37^{\circ}C$. Representative positives from the turbid plates were transferred to LB-medium in 96-wellplates, cultivated overnight, and assayed for the enzyme activity with L-tyrosine as the substrate. The assay results were approximated to be proportional to the halo size on turbid plates, suggesting the screening system is directly applicable to the directed evolution of TPL. Actually, two best mutants on the turbid plates were identified to be $2{\sim}2.5$ and 1.5-fold improved in the activity.

• Applied Chemistry for Engineering
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• v.19 no.4
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• pp.407-412
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• 2008

As an activation procedure, in this study, the oxidation treatment of needle cokes with a dilute nitric acid and sodium chlorate $(NaClO_3)$, combined with heat treatment, was attempted. The structures of acid-treated and pyrolyzed coke were examined with XRD, FESEM, elemental analyzer, BET, and Raman spectroscopy. The behavior of double layer capacitance was investigated with the analysis of charge and discharge. The structure of needle coke treated with acid was revealed to a single phase of (001) diffraction peak after 24 h. On the other hand, thecoke oxidized by heat treatment was reduced to a graphite structure of (002) at $300^{\circ}C$. The distorted graphene layer structure, derived from the process of oxidation and reduction of the inter-layer, makes the pores by the electric field activation at the first charge, and generates the double layer capacitance from the second charge. The cell using pyrolyzed coke with 24 h acid treatment and $300^{\circ}C$ heat treatment exhibited the maximum capacitance per weight and volume of 33 F/g and 30 F/mL at the two-electrode system in the potential range of 0~2.5 V.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.1
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• pp.51-58
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• 2021

In this paper, a multi-scale finite element (FE) modeling methodology for three-dimensional (3D) needle-punched (NP) C/SiC with a complex microstructure is presented. The variations of the material properties induced by the needle-punching process and complex geometrical features could pose challenges when estimating the material behavior. For considering these features of composites, a 3D microscopic FE approach is introduced based on micro-CT technology to produce a 3D high fidelity FE model. The image processing techniques of micro-CT are utilized to generate discrete-gray images and reconstruct the high fidelity model. Furthermore, a subcell modeling technique is developed for the 3D NP C/SiC based on the high fidelity FE model to expand to the macro-scale structural problem. A numerical homogenization approach under periodic boundary conditions (PBCs) is employed to estimate the equivalent behavior of the high fidelity model and effective properties of subcell components, considering geometry continuity effects. For verification, proposed models compare excellently with experimental results for the mechanical behavior of tensile, shear, and bending under static loading conditions.

• Science of Emotion and Sensibility
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• v.25 no.4
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• pp.45-52
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• 2022

Recently, interest in and demand for sensors that recognize physical activity and their products are increasing. In particular, the development of wearable materials that are flexible, stretchable, and able to detect the user's biological signals is drawing attention. In this study, an experiment was conducted to improve the dip-coating efficiency of a single-walled carbon nanotube dispersion solution after fine holes were made in a hydrophobic material with a micro needle. In this study, dip-coating was performed with a material that was not penetrated, and comparative analysis was performed. The electrical conductivity of the sensor was measured when the sensor was stretched using a strain universal testing machine (Dacell Co. Ltd., Seoul, Korea) and a multimeter (Keysight Technologies, Santa Rosa, CA, USA) was used to measure resistance. It was found that the electrical conductivity of a sensor that was subjected to needling was at least 16 times better than that of a sensor that was not. In addition, the gauge factor was excellent, relative to the initial resistance of the sensor, so good performance as a sensor could be confirmed. Here, the dip-coating efficiency of hydrophobic materials, which have superior physical properties to hydrophilic materials but are not suitable due to their high surface tension, can be adopted to more effectively detect body movements and manufacture sensors with excellent durability and usability.