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Characteristics of Recent Epidemic Strains of Newcastle Disease Virus in Korea (최근 국내에서 유행하는 뉴캣슬병 바이러스의 특성 고찰)

Choi, Kang Seuk
- Korean Journal of Poultry Science
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- v.37 no.1
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- pp.89-99
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- 2010
Newcastle disease (ND), caused by Newcastle disease virus (NDV), has caused periodic epidemics in Korea at an interval of 3 to 5 years until the early 2000s. At least five distinct genotypes of NDV have been responsible for epizootic episodes in Korea; genotype III virus (before the 1970s), genotype V (the mid-1980s), genotype VI (the late 1980s to early 1990s), genotype VIIa (the mid-1990s), and genotype VIId viruses (the late 1990s to present). Recent epidemic strains of NDV (VIId viruses) shared geographical features with neighboring countries such as China and Japan. These VIId viruses as well as genotypes III and V viruses were viscerotropic and highly virulent for chickens. Antigenic variation occurred between VIId field viruses and LaSota vaccine strain, as found in other epidemic strains in past in Korea. Nevertheless the commercial vaccine was considered to effectively protect vaccinated birds from mortality against VIId viruses as well as other viruses belonging to genotypes III and V.
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뉴캣슬병 생독백신 접종효능 및 부작용에 대한 올바른 이해

대한양계협회
- KOREAN POULTRY JOURNAL
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- v.35 no.6 s.404
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- pp.78-82
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- 2003
본고는 질병방역차원에서 지난 4월 30일 전라도 장성을 시작으로 5월 7일까지 전국 3개지역(전남 장성, 경북 대구, 경기 용인)을 대상으로 실시한 `전국 닭질병 방역교육 순회 세미나`에서 `뉴캣슬병 생독백신 접종효능 및 부작용에 대한 올바른 이해`를 주제로 송창선 건국대학교 교수가 발표한 내용을 발췌$\cdot$요약$\cdot$게재한 것이다.
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Molecular epidemiological analysis of viscerotropic velogenic Newcastle disease viruses

Lee, Youn-Jeong
- Proceedings of the Korea Society of Poultry Science Conference
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- 2005.11a
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- pp.44-52
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- 2005
The study, using sequence analysis and phylogenetic relationship of the fusion protein gene, divided the Korean epizootic isolates of Newcastle disease virus (NDV) into several lineages to determine the molecular epidemiology of the virus. A 695 base pair fragment was amplified by polymerase chain reaction between matrix protein gene and fusion protein gene of 30 Korean NDV isolates, which were isolated from field outbreaks of Newcastle disease between 1949 and 2002. All isolates showed the amino acid sequence 112 R-R-Q/R-K-R116 at the C-terminus of the F2 protein and phenylalanine (F) at the N-terminus of the F1 protein, residue 117. These amino acid sequences were identical to a known virulent motif. The region of the F gene between nucleotides 47 and 435 was compared by phylogenetic analysis. Based on nucleotide sequence, the Korean NDV isolates belonged to genotype III, V, VI and VII corresponding to isolates in 1949, 1982 to 1984, 1988 to 1997, and 1995 to 2002, respectively. These data showed that genotypes of five Korean Newcastle disease epizootics had replaced each other serially (III, V, VI and VII) in chronological order. Further, the five Korean Newcastle disease epizootics were closely related with the Necastle disease panzootics or Newcastle disease epizootics in other countries. Present study showed that the Korean genotype V isolated before 1984 was related with European Newcastle disease epizootics in the 1970s, whereas the Korean genotype VI and VII isolated after 1988 were more closely related with Far East Newcastle disease epizootics, especially Newcastle disease3 epizootics in Japan, Taiwan and China. Since 1988, the genotype VI and VII of Far East origin were dominant in South Korea. That might be due to the increased trade of agricultural products including poultry among Far East Asian countries.
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