• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.445-454
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• 2015

Purpose: The present study was aimed to investigate the effect of tear volume on a change of axial rotation according to wearing time of toric soft contact lens and gaze directions. Method: Toric soft contact lenses with double thin zone design applied on 62 eyes. Then, changes in non invasive tear film break-up time and the rotational direction/amount of lens when changing gaze direction were respectively measured after 15 minutes and 6 hours of lens wear. Results: Lens rotation to temporal direction was more found when changing gaze direction after lens wear. However, its rotation was varied according to wearing time and the subjects' tear volume. Furthermore, the frequency of lens rotation to temporal direction was higher in dry eyes compared with normal eyes at nearly all gaze directions after 15 minutes and 6 hour of lens wear. The rotational amount of lens was generally greater in dry eyes after 15 minutes of lens wear. However, its difference between normal eyes and dry eyes was not great after 6 hours of lens wear. Conclusion: The present study revealed that axial rotation of toric soft contact lens was varied according to the wearer's tear volume and lens rotational patterns at the initial, and extending periods of lens wear were different. The change in rotational pattern of toric soft contact lens from these results means the possibility of visual change after extending lens wear, and the identification of its correlation with tear volume suggests the necessity of considering factors for choosing appropriate toric soft contact lens.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.141-150
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• 2015

Purpose: In the present study, a difference in tear volume between the cornea and the rigid gas permeable (RGP) lens relative to corneal shape and corneal astigmatism was investigated by the alignment fitting status of spherical and aspherical RGP lenses. Methods: Spherical and aspherical RGP lenses were fitted with alignment in 77 subjects (135 eyes) who were in their 20~30s. Tear volume stained with fluorescein was qualitatively analyzed by dividing cornea into center, mid-peripheral and peripheral parts. Results: For the spherical RGP lens fitting, tear volume differences were found in each part in all corneal types. For the aspherical RGP lens fitting, tear volume differences were in each corneal part in symmetric bow tie- and asymmetric bow tie-type corneas. However, the tear was equally distributed from the center to the peripheral part in round- and oval-type corneas. In the group with corneal astigmatism lower than 1.25 D, tear volume between center and peripheral parts, and mid-peripheral and peripheral parts, was different when a spherical RGP lens was fitted. However, tear volume in each part was not different in the group with corneal astigmatism over 1.50 D. Moreover, the tear volumes of the central and mid-peripheral parts were proportionally increased with increasing corneal astigmatism in both spherical and aspherical RGP lenses. Furthermore, aspherical RGP lenses showed greater increments than spherical RGP lenses. Conclusions: The results revealed that the difference in tear volume between aspherical RGP lens and cornea was less than spherical RGP lens, and the difference in tear volume varied according to corneal shape and astigmatism. In addition, the method of measuring relative tear volume between RGP lens and cornea that was established in the present study can be used to evaluate tear volume between contact lens and cornea.

• The Journal of the Convergence on Culture Technology
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• v.5 no.4
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• pp.355-359
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• 2019

Schirmer test is one of the most used methods for the diagnosis of dry eye. We attempted to develop a tear level measurement tool to replace unreliable Schirmer test with inaccurate results. Absorbency tests for various absorbents were carried out. As a result, ${\alpha}$ cellulose pulp was selected as the absorbent. Prototypes were produced and evaluated twice. Finally a tear level measurement tool in the form of a strip of ${\alpha}$ cellulose pulp adhered to a polyurethane was prepared. Usability evaluation of prepared tear level measurement tool was performed. As a result, it was confirmed that it has a significant correlation with SM tube developed oversea recently. In addition, it was judged to be useful as an alternative to the Schirmer test in terms of measurement time and accuracy.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.99-108
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• 2016

Purpose: The present study was aimed to compare the tear volume and distribution by corneal eccentricity when fitted with spherical and aspherical RGP lenses. Methods: Spherical and aspherical RGP lenses were fitted in best alignment on a total of 77 subjects (136 eyes) in their twenties and thirties without any ocular disease or ocular surgery experience. The tear volume was analyzed by estimating the concentration of tear stained with fluorescein in the center of RGP lens as well as at the mid-peripheral and peripheral areas, and the difference of tear distributions was analyzed according to corneal eccentricity. Results: Tear distribution from the center to the peripheral area was not significantly different when spherical RGP lenses were fitted on the corneal eccentricities of e < 0.38 and $0.68{\leq}e$, indicating the relatively even tear distribution compared with other corneal eccentricity. In the case of aspherical RGP lenses, the difference of tear distribution between the central and peripheral areas was smaller than spherical RGP lenses. The significant difference of tear distribution according to RGP lens design was observed in the corneal eccentricity of 0.48 < e < 0.68. In other words, more even tear distribution was shown when aspherical RGP lenses were fitted on the cornea with eccentricity of $0.48{\leq}e<0.68$ and spherical RGP lenses were fitted on the cornea with eccentricity $0.68{\leq}e$. Furthermore, tear volume in the mid-peripheral area increased with higher corneal eccentricity. Conclusions: The results suggest that the appropriate selection of RGP lens design according to corneal eccentricity is necessary since tear volume and distribution by the regions of spherical and aspherical lenses are affected by corneal eccentricity.

• Journal of Digital Convergence
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• v.10 no.11
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• pp.535-540
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• 2012

This study is to research the differences of tear film for young people in of a day in a restricted indoor space. The subjects are 58 eyes volunteers for twice preliminary inspection and tear test of a day. 58 healthy individuals with no eye disease, no body disease, orthophoria, corrective visual acuity more than 0.8, binocular spherical equivalence difference over 0.50 diopter, the flattest corneal curvature in horizontal meridian and the steepest corneal curvature in vertical meridian were tested. The uncorrective visual acuity, refractive error, corneal curvature, schirmer test and tear break up test were performed in the morning and afternoon. Schirmer test were $16.0{\pm}7.0mm$ in the morning and $14.1{\pm}7.1mm$ in the afternoon. TBUT were $11.3{\pm}0.6$ sec in the morning and $12.1{\pm}0.9$ sec in the afternoon. They have no significant differences.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.76-81
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• 2014

Purpose: Diversity and the lachrymal duct deformities and the passage inside the nasal cavity except for anterior image such as epiphora happens during the test were able to express more precisely during the dacryoscintigraphy. Also, we thought about the necessity of a method to classify the passage into the naso-lachrymal duct from epiphora. Therefore, we are to find the validity of the method to obtain both oblique views except for anterior views. Materials and Methods: The targets of this research are 78 patients with epiphora due to the blockage at the lachrymal duct from January 2013 to August 2013. Average age was $56.96{\pm}13.36$. By using a micropipette, we dropped 1-2 drops of $^{99m}TcO4^-$ of 3.7 MBq (0.1 mCi) with $10{\mu}L$ of each drop into the inferior conjunctival fold, then we performed dynamic check for 20 minutes with 20 frames of each minute. In case of we checked the passage from both eyes to nasal cavity immediately after the dynamic check, we obtained oblique view immediately. If we didn't see the passage in either side of the orbit, we obtained oblique views of the orbit after checking the frontal film in 40 minutes. The instrument we used was Pin-hole Collimator with Gamma Camera(Siemens Orbiter, Hoffman Estates, IL, USA). Results: Among the 78 patients with dacryoscintigraphy, 35 patients were confirmed with passage into the nasal cavity from the anterior view. Among those 35 patients, 15 patients were confirmed with passage into the nasal cavity on both eyes, and it was able to observe better passage patterns through oblique view with a result of 8 on both eyes, 2 on left eye, and 1 on right eye. 20 patients had passage in left eye or right eye, among those patients 10 patients showed clear passage compared to the anterior view. 13 patients had possible passage, and 30 patients had no proof of motion of the tracer. To sum up, 21 patients (60%) among 35 patients showed clear pattern of passage with additional oblique views compared to anterior view. People responded obtaining oblique views though 5 points scale about the utility of passage identification helps make diagnoses the passage, passage delayed, and blockage of naso-lachrymal duct by showing the well-seen portions from anterior view. Also, when classifying passage to naso-lachrymal duct and flow to the skin, oblique views has higher chance of classification in case of epiphora (anterior:$4.14{\pm}0.3$, oblique:$4.55{\pm}0.4$). Conclusion: It is considered that if you obtain oblique views of the bilateral orbits in addition to anterior view during the dacryoscintigraphy, the ability of diagnose for reading will become higher because you will be able to see the areas that you could not observe from the anterior view so that you can see if it emitted after the naso-lachrymal duct and the flow of epiphora on the skin.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.3
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• pp.215-225
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• 2016

Purpose: The aim of this study was to figure out how the characteristics of soft contact lens materials and pigmentation affect the adherence of C. albicans on soft contact lenses pre-deposited with tear constituents. Methods: The adherent number of C. albicans on clear soft contact lenses (hereinafter clear lenses) and circle soft contact lenses (hereinafter circle lenses) made of etafilcon A, hilaiflcon B and nelfilcon A, respectively, was measured before and after the deposition of artificial tear. Also, bacteria adherence on lenses were observed by a scanning electron microscope. Results: Adherence of C. albicans was significantly different according to lens materials. The amount of adsorption was not different between clear lenses and circle lenses made of etafilcon A however, the number of bacteria absorption was bigger in hilafilcon B and nelfilcon A lenses. More absorption of C. albicans was found in the non-pigmented central area compared the pigmented area, and non-pigmented peripheral area has more bacterial absorption than non-pigmented central area. The number of C. albicans decreased in the case that tear protein was pre-deposited. The maintenance of antibacterial activity against C. albicans was different according to lens materials thus, etafilcon A has the longest period of its maintenance. Conclusions: It was revealed that the number of C. albicans was different according to the characteristics of lens materials, pigmentation or non-pigmentation, the pigmented area of soft contact lenses. Thus, it is suggested that the management method should be different according to the adsorption characteristics of C. albicans.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.109-117
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• 2016

Purpose: The study was aimed to figure out the effect of materials and pigmentation of soft contact lens on the adherence of Staphylococcus aureus upon soft contact lenses deposited with tear components. Methods: The number of adherent S. aureus on clear and circle soft contact lenses made of etafilcon A, hilafilcon B, nelfilcon A was measured before and after incubation in artificial tear. Furthermore, the denaturalization level of tear protein with time after incubation in artificial tear was estimated by electrophoresis. Results: The adherence of S. aureus was significantly different according to the lens materials. The pattern of bacterial adherence on clear and circle contact lenses was different. That is, the adherent amount of S. aureus was somewhat larger on circle lens made of etafilcon A however, amount on circle lenses made of hilafilcon B and nelfilcon A was 89.3% and 71.3% of the number on clear lenses. When the tear protein was deposited on contact lenses, the number of adherent bacteria decreased and its degree was varied according to the lens material. The degree of decrease was the biggest in clear soft lens made of etafilcon A. Anti-bacterial effect of tear protein decreased with time after deposition of tear protein on soft contact lens and the amount of lysozyme also decreased. The reduction of anti-bacterial effect and quantity of lysozyme was different according to contact lens materials and pigmentation. Conclusions: It was revealed that the adherence of S. aureus depends on contact lens materials and pigmentation, and the specification of lens material affects more on adherence of S.aureus than pigmentation. It was further figured out the denaturalization level of anti-bacterial protein on soft contact lens varies according to lens materials and pigmentation, which produces an effect on the quantity of bacterial adherence.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.1
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• pp.35-42
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• 2015

Purpose: The present study was aimed to compare the difference in adherence level of microorganisms according to contact lens materials and protein deposition and to evaluate disinfection efficacy of multipurpose solution. Methods: The evaluations of micro-organisms' adherence and disinfection efficacy of multi-purpose solution were conducted by employing the Part 2. Regimen Procedure for Disinfecting Regiments in the Disinfection Efficacy Testing under the "FDA Evaluation Criteria & Method". Results: Pseudomonas aeruginosa, Serratia marcescens, Candida albicans except Staphylococcus aureus adhered more on etafilcon A lens and disinfection efficacy of total 4 products investigated was almost perfect except Candida albicans. The 3 micro-organisms except Serratia marcescens adhered more to albumin-predeposited lens. Disinfection efficacy of multi-purpose solution was higher against the micro-organisms adhered to albumin-deposited lens than against the micro-organisms adhered to the lysozyme-deposited lens. Furthermore, disinfection efficacy of multi-purpose solution was different according to types of micro-organisms. Conclusions: It was revealed that the type of micro-organisms, the lens materials and type of absorbed tear protein affected the amount of adhered micro-organisms to contact lens and that adhesion of tear protein could induce the change of disinfection efficacy of multi-purpose solution. It suggest that the hygienic condition of contact lens can vary by these factors influencing on disinfection efficacy and the occurrence of adverse effect can be affected.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.1
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• pp.27-35
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• 2012

Purpose: The present study was conducted to compare any difference caused by pigmentation in the centrations and movement patterns on the cornea between circle and soft contact lens with identical material and parameters during lens wearing. Methods: Soft and circle contact lenses with identical material and parameters were applied to twenty eyes with normal tear volume for 3 hrs a day during a total of 5 days and then their lens centrations, the moving distances and rotations by repeat blinking were compared. Results: The lens centration beyond the fitting criteria was shown in initial wears of both soft contact lens and circle contact lens. However, the centration of soft contact lens was changed to the pupil center for being suitable to the fitting criteria with longer wearing time. On the other hand, the decentration of circle contact lens in the horizontal direction was still presented even with longer wearing time. The moving distances of soft contact lens and circle contact lens decreased with the expand of lens wearing but were not significantly different between total wearing period and daily wearing time. The rotation of circle contact lens by repeat blinking was significantly different from that of soft contact lens even when the wearing period was extended. Conclusions: We revealed that the lens centration and movement of circle contact lens on cornea were different from those of regular soft contact lens resulting in bigger difference with the expand of wearing period in the study.