• Journal of Digital Convergence
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• v.10 no.11
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• pp.535-540
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• 2012

This study is to research the differences of tear film for young people in of a day in a restricted indoor space. The subjects are 58 eyes volunteers for twice preliminary inspection and tear test of a day. 58 healthy individuals with no eye disease, no body disease, orthophoria, corrective visual acuity more than 0.8, binocular spherical equivalence difference over 0.50 diopter, the flattest corneal curvature in horizontal meridian and the steepest corneal curvature in vertical meridian were tested. The uncorrective visual acuity, refractive error, corneal curvature, schirmer test and tear break up test were performed in the morning and afternoon. Schirmer test were $16.0{\pm}7.0mm$ in the morning and $14.1{\pm}7.1mm$ in the afternoon. TBUT were $11.3{\pm}0.6$ sec in the morning and $12.1{\pm}0.9$ sec in the afternoon. They have no significant differences.

• Journal of Convergence Society for SMB
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• v.6 no.4
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• pp.85-91
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• 2016

This study is to research the tear film stability for 48 eyes, agreed the purpose of study, didn't have no contact lens wearing and were tested all two times in a day. Their visual acuity was more than 0.8, corrective visual acuity more than 0.8, the fattest K-reading, apical corneal radius, was in 7.40~8.40mm, corneal astigment was less than 1.00D and orthophoria. The tests, tear scope test, tear film break up time test(TBUT) and schirmer test order, were performed their functions before and after their working at interval of 6 hours over. The tearscope test results was no difference, TBUT was no difference, although 1.2 seconds more in the afternoon, shcirmer test was decreased 2.0mm in the afternoon.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.255-264
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• 2011

Purpose: To study the effect of hyaluronic acid(HA), which was widely used in artificial tears, multi-purpose solution(MPS), cosmetics, and drug acting on the musculo-skeletal system, in wettability and comfort of contact lens, we compared HA including lens(+HA) with HA excluding lens(-HA) by clinical evaluation. Methods: During four weeks, the selected 28 university student volunteers who did not have any eye disease wore +HA contact lens on their right eyes, and -HA contact lens on their left eyes, and then compared right eyes to left eyes as control. After prescribing by spherical equivalent calculation, over-refraction by auto-refractometer, and contact lens wearing for two weeks and four weeks, tear evaluation, the anterior of eyes examination, fitting convenience evaluation, surface wetting test, surveys were checked up. Results: Compared with the control group (-HA contact lens), +HA contact lens provided better wetting properties. The amount of released tear in -HA contact lens group became less in four weeks than before, but that in +HA contact lens group showed no significant difference from the initial one. In terms of the redness in eye, there was no significant difference between +HA and -HA contact lens groups. Fitting of +HA contact lens on eye was much easier than the control, -HA contact lens. From the results of survey, comfort, wettability, ease of cleaning, and dryness of eye in +HA contact lens group were generally better than those of -HA group, but redness and contact lens handling showed little difference. Conclusions: The addition of HA in soft contact lens(+HA) may enhance the wettability of lens during lens wearing, resulted in the better comfortable wearing of lens eventually.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1103-1107
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• 2018

Purpose: To evaluate the clinical effect of intense regulated pulse light (IRPL) and changes in tear film thickness in dry eye patients. Methods: A retrospective study was conducted on 25 patients with Meibomian gland dysfunction who had subjective dry eye discomfort and whose tear film break-up time (TBUT) was < 10 seconds. All patients were treated with IRPL three times on days 1, 15, and 45. TBUT, Schirmer 1 test results, cornea staining score with fluorescein, ocular surface disease index (OSDI), and lipid layer thickness were measured and compared before and after the procedure. Results: TBUT was significantly increased from $3.7{\pm}1.2s$ to $4.4{\pm}2.1s$ after IRPL (p = 0.03). Schirmer 1 test and cornea staining scores changed significantly (p < 0.01 and p = 0.01, respectively). OSDI also showed a statistically significant improvement from $39.5{\pm}17.5points$ to $30.4{\pm}18.7points$ (p = 0.01). However, no significant difference in lipid layer thickness was observed (p = 0.49). Conclusions: IRPL is an effective treatment modality to improve TBUT, Schirmer 1 test scores, cornea staining scores, and subjective dry eye symptoms.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.76-81
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• 2014

Purpose: Diversity and the lachrymal duct deformities and the passage inside the nasal cavity except for anterior image such as epiphora happens during the test were able to express more precisely during the dacryoscintigraphy. Also, we thought about the necessity of a method to classify the passage into the naso-lachrymal duct from epiphora. Therefore, we are to find the validity of the method to obtain both oblique views except for anterior views. Materials and Methods: The targets of this research are 78 patients with epiphora due to the blockage at the lachrymal duct from January 2013 to August 2013. Average age was $56.96{\pm}13.36$. By using a micropipette, we dropped 1-2 drops of $^{99m}TcO4^-$ of 3.7 MBq (0.1 mCi) with $10{\mu}L$ of each drop into the inferior conjunctival fold, then we performed dynamic check for 20 minutes with 20 frames of each minute. In case of we checked the passage from both eyes to nasal cavity immediately after the dynamic check, we obtained oblique view immediately. If we didn't see the passage in either side of the orbit, we obtained oblique views of the orbit after checking the frontal film in 40 minutes. The instrument we used was Pin-hole Collimator with Gamma Camera(Siemens Orbiter, Hoffman Estates, IL, USA). Results: Among the 78 patients with dacryoscintigraphy, 35 patients were confirmed with passage into the nasal cavity from the anterior view. Among those 35 patients, 15 patients were confirmed with passage into the nasal cavity on both eyes, and it was able to observe better passage patterns through oblique view with a result of 8 on both eyes, 2 on left eye, and 1 on right eye. 20 patients had passage in left eye or right eye, among those patients 10 patients showed clear passage compared to the anterior view. 13 patients had possible passage, and 30 patients had no proof of motion of the tracer. To sum up, 21 patients (60%) among 35 patients showed clear pattern of passage with additional oblique views compared to anterior view. People responded obtaining oblique views though 5 points scale about the utility of passage identification helps make diagnoses the passage, passage delayed, and blockage of naso-lachrymal duct by showing the well-seen portions from anterior view. Also, when classifying passage to naso-lachrymal duct and flow to the skin, oblique views has higher chance of classification in case of epiphora (anterior:$4.14{\pm}0.3$, oblique:$4.55{\pm}0.4$). Conclusion: It is considered that if you obtain oblique views of the bilateral orbits in addition to anterior view during the dacryoscintigraphy, the ability of diagnose for reading will become higher because you will be able to see the areas that you could not observe from the anterior view so that you can see if it emitted after the naso-lachrymal duct and the flow of epiphora on the skin.

• The Journal of the Convergence on Culture Technology
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• v.5 no.4
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• pp.355-359
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• 2019

Schirmer test is one of the most used methods for the diagnosis of dry eye. We attempted to develop a tear level measurement tool to replace unreliable Schirmer test with inaccurate results. Absorbency tests for various absorbents were carried out. As a result, ${\alpha}$ cellulose pulp was selected as the absorbent. Prototypes were produced and evaluated twice. Finally a tear level measurement tool in the form of a strip of ${\alpha}$ cellulose pulp adhered to a polyurethane was prepared. Usability evaluation of prepared tear level measurement tool was performed. As a result, it was confirmed that it has a significant correlation with SM tube developed oversea recently. In addition, it was judged to be useful as an alternative to the Schirmer test in terms of measurement time and accuracy.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.3
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• pp.19-28
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• 2008

Purpose: To understand symptoms and signs in soft contact lens wearers the authors evaluate the attribution of the tear test to the contact lens related symptoms and signs. Methods: Sixty-two healthy soft contact lens wearers (23.95${\pm}$4.38 years old, 18.60${\pm}$16.92 months of prior lens wear) were participated in this study. 3 kinds of tear test and McMonnies' questionnaire test were performed for the soft contact lens wearers and subjective symptoms and objective signs were graded using CCLRU scales during the study period. Results: In this surveys, we found ocular dryness, redness and tiredness are the most common frequent and severe symptoms in soft contact lens wearers. Frequency of the ocular dryness, redness and tiredness are associated with grittiness, burning sensation and foreign body sensation respectively, and severity of the photophobia, foreign body sensation are associated with unstable vision and grittiness and which are associated with score of McMonnies' Questionnaire. Conjunctival redness and limbal redness are major signs but those are not need to be clinical care and rarely occurred corneal and conjunctival staining which are associated with tear break-up-time statistically. Conclusions: Dryness, redness and tiredness are primary common symptoms in Korean soft contact lens wearers. The frequency of those symptoms are increased with the period of soft contact lens wear and those are associated with other symptoms but have no relationship with signs.

• Journal of The Korean Ophthalmological Society
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• v.55 no.1
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• pp.1-6
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• 2014

Purpose: To investigate the clinical manifestation of nasolacrimal duct obstruction after radioactive iodine therapy for thyroid cancer. Methods: The authors examined 622 patients who were treated with radioactive iodine therapy after the operation for thyroid cancer from January 2009 to December 2011. Fourteen patients (18 eyes) were diagnosed nasolacrimal duct obstruction based on the lacrimal irrigation test, lacrimal probing test and dacryocystography in our oculoplastic clinic. We analyzed the dose of radioactive iodine therapy, number of treatments, clinical manifestation and treatment type by retrospectively reviewing the patients' medical records. Results: The mean radioactive iodine dose ($215.7{\pm}23.1mCi$, p = 0.01) and the mean number of treatments ($1.36{\pm}0.50$, p < 0.001) were significantly greater in 14 patients who had nasolacrimal duct obstruction than in patients who did not. The average onset of tearing symptoms occurred 10.2 months after radioactive iodine therapy. The mean time between correct diagnosis and therapy was 18.4 months. Three patients (3 eyes) had occlusion at the common cannaliculus and 11 patients (15 eyes) had occlusion at the nasolacrimal duct. Ten patients (13 eyes) underwent endonasal dacryocystorhinostomy for complete obstruction and 4 patients (5 eyes) underwent silicone tube intubation for partial obstruction. Conclusions: Nasolacrimal duct obstruction is a rare complication associated with radioactive iodine therapy for thyroid cancer, thus, clinicians should be aware of this complication and refer patients with symptoms of epiphora to the oculoplastic department for specialized evaluation and treatment.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.519-526
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• 2015

Purpose: To evaluate the changes of OSI value according to tear-film instability measured serially by OQAS(Optical Quality Analysis System, Visiometrics, Spain) every seconds. The presented study analyzed the relationship of the OQAS parameter with the results of the tear-film break-up time, Schirmer test, and the McMonies score. Methods: 147 eyes of 82 subjects were randomly selected from university students (age: $21.51{\pm}3.97$, male 45, female 37). Subjects were measured tear-film break-up time, Schirmer test, McMonies score and once every second for 15 seconds after blinking by continuous measurements from OQAS system. Results: The normal eye groups presented OSI values of $2.13{\pm}1.16$ while the dry eye groups had OSI values of $3.76{\pm}1.42$. Therefore, a significant difference between the normal eye group and dry eye group was discovered (p<0.05). In addition, the OSI value of all subjects increased over time. The OSI value, which was measured every second after blinking occurred, significantly increased between 6 seconds and 7 seconds after the start of the measurement (p<0.05). OSI cut off of 30% (sec.) showed a greater correlation; TBUT (r = 0.855, p = 0.000), McMonies test (r = -0.351, p = 0.003), Schirmer (r = 0.316, p = 0.012). Conclusions: Continuous measurement of OQAS showed a high correlation with the value of the existing dry eye tests. Therefore, Analysis of OSI values by utilization of OQAS could be useful in objectively evaluation of tear film in patients.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.339-346
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• 2010

Purpose: The study was performed to compare the difference of non-invasive tear break-up time (NIBUT) with alignment or steep fitting of soft contact lens in normal and dry eyes. Methods: Total 40 eyes (aged 20~30 years) were classified to the normal (n=20) or dry eye group (n=20) by the diagnosis methods for dry eyes and worn soft contact lens (polymacon material) with alignment or steep fitting. NIBUTs of lens wearers were separately measured at the points of before wearing, immediately after wearing and after stabilization of tear film. Results: With alignment fitting, averaged NIBUT in the dry eye group after stabilization of tear film was not significantly different from that of the normal eye group. However, averaged NIBUTs in the normal and dry eyes had significant difference when measured immediately after lens wearing. However, the number of eyes having NIBUT less than 4.0 second was 30% higher compared to the number of normal eyes with steep fitting when measured immediately after wearing. Some shorten NIBUT in dry eyes with steep fitting was also shown after stabilization of tear film. Conclusions: These results suggest that wearing soft contact lens in dry eyes differently affect tear film compared to normal eyes. Thus, dry eyes need more advertent fitting for contact lens wearing because of unstable tear film.