• Journal of The Korean Society of Inherited Metabolic disease
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• v.2 no.1
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• pp.1-6
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• 2002

출생 이후 머리둘레가 커지는 1개월 남아에게서 뇌초음파상 지주막하 공간이 확장되어 있고 백질의 음영이 증가되어 있었고 뇌 MRI 소견은 sylvian fissure의 확장과 양측 대뇌, 소뇌 피질과 백질이 T1 강조 영상에서 저신호강도와 T2 강조영상에서 고신호강도를 보였고 검사상 GA1 의심되었고 경피생검으로 얻은 섬유아세포 배양에서 glutaryl CoA dehydrogenase의 활성도가 전혀 없어 GA1을 확진하게 되었다. 이후 특수분유인 Glutatex(Abbott사) 수유와 riboflavin, carnitine 보충요법을 시행하여 대사성 위기나 급성 뇌증 위기는 없었고 양호히 발달하는 것을 경험하였기에 보고하는 바이다.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2011.11a
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• pp.342-343
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• 2011

미디어 디지털컨버전스 환경에서 교육을 수용하는 도구로서 e-Book은 향후 더 많은 확산이 기대되어진다. 본 연구에서는 학습자의 학습도구로서 e-Book과 종이책의 수용 의도를 뇌파를 분석(자기조절지수, 기초율동지수, 주의지수, 활성지수, 정서지수, 항스트레스지수, 좌우뇌균형지수, 브레인지수 분석)하여 실험하였으며, e-Book을 사용후, 성별에 상관없이 내외적 환경 요인으로 인한 육체적, 정신적 피로도에 대한 저항력을 나타내는 항스트레스 지수가 낮아지는 결과를 얻었다. 향후, 본 연구를 기반으로 개선방향을 찾을 필요가 있다.

• The Korean Journal of Physiology
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• v.6 no.1
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• pp.27-31
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• 1972

The activity of Mg and Na-K activated ATPase of homogenate from rat brain cortex was measured in vitro under the variety of conditions. The effects of various hypnotic and tranquilizer such as phenobarbital, amobarbital, diazepam, promazine and chlorpromazine on the activities of both ATPase was investigated and the results was summarized as follows. 1. Na-K ATPase was slightly inhibited by phenobarbital and amobarbital while Mg ATPase was moderately activated by these drugs. 2. Both Mg and Na-K ATPase activities were markedly inhibited by diazepam. 3. Promazine and chlorpromazine markedly inhibited both Mg and Na-K ATPase activities. These findings indicate that remarkable correlation between hypnotic or tranquilizing potency and ATPase inhibition could be observed.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.853-855
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• 2018

현재 맥파(ECG; Electrocardiogram) 및 뇌파(EEG: electroencephalography)의 파형 분석기술은 다양하게 적용되고 있으니 이들을 종합적으로 활용한 개인용 건강서비스 개발은 아직 미비 한 상태이다. 본 논문에서는 측정대상자의 정신적 혹은 육체적 피로도를 나타내는 8가지의 지표로서 집중도, 전두엽 비대칭 정도, 좌우뇌 활성도 대칭 값, 알파파 및 베타파 훈련도 (이상은 뇌파 분석 결과), 스트레스 레벨, 심박 수, 자율신경균형도 (이상은 맥파 분석 결과)]를 개인에게 알려주는 생체정보기반 개인건강 관리 소프트웨어 시스템의 설계 및 개발 결과에 대하여 서술한다.

• The Journal of Korean Society for Neurotherapy
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• v.22 no.3
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• pp.7-10
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• 2018

Purpose The purpose of this study was to investigate the difference of brain activity during action observation training and image training throughout EEG. Methods This study was participated 1 healthy college student without mental illness or cognitive impairment. The subject was randomly selected from university students and was interested in participating in the experiment. The purpose of this study was to investigate the visual and auditory stimuli (action observation) and brain image training. Results The results of our study, EEG value measured o.1 during resting. But brain activity changed to 0.3 during action observation. Finally, it changed to .05 after brain image training. Conclusion EEG measurement results were showed that after watching the Ball squat video, Brain activity increased.

• Journal of the Korean Chemical Society
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• v.47 no.5
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• pp.466-471
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• 2003

The effect of polyamines on the cabbage phospholipase D(PLD) activity was investigated. The PLD activity was determined by pH-stat titration of phosphatidic acid, one of the enzymatic reaction product, using phosphatidyl choline small unilamellar vesicles as a substrate. The cabbage PLD was activated approximately 4 fold by spermine at 1 mM concentration. This spermine effect appears to be similar to the previous report on the PLD activation of rat brain mitochondrial fraction. It was also found that cationic polypetides such as polylysine and polyhistidine exerted a marked enhancement effect on the cabbage PLD. Particularly polyhistidine exerted approximately 5.5 fold enhancement effect at 0.062 mM concentration. The polyamine effect on the cabbage PLD was reexamined in the phosphatidylcholine/sodium dodecyl sulfate mixed micellar system. The relevance of polyamine effect on PLD activity is discussed in relation to the active site of PLD.

• Journal of the Korean Chemical Society
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• v.53 no.1
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• pp.34-41
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• 2009

A new series of hydrazone derivatives were synthesized from 4-(2-chloroethyl)semicarbazide and their antiproliferative activity against human brain (U251) and liver (Hepg2) carcinoma cell lines were evaluated. The hydrazone compounds are benzaldehyde (2a-2g), acetophenone (3a-3f), and 3-formylindole derivatives (4a-4d). Among the acetophenone derivatives, 3e (p-methoxy substituted) and 3f (p-nitro substituted) showed the highest cytotoxic activity against Hepg2 cell line (I$C_{50}$ = 6 and 8 $\mu$g/ml, respectively). Among the 3-formylindole derivatives, 4a (hydrazone of 3-formylindole itself) showed a pronounced cytotoxic activity against both U251 (I$C_{50}$ = 21 $\mu$g/ml) and Hepg2 (I$C_{50}$ = 7 $\mu$g/ml).

• Journal of Life Science
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• v.19 no.6
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• pp.836-838
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• 2009

Tissue plasminogen activator (tPA) is very useful for dissolving the clots of blood, however, the use of tPA is limited to only 3-5% of ischemic stroke patients because of the narrow therapeutic time windows and negative side effects. Previous evidences suggest that limitation of tPA in thrombolytic therapy may be related to the upregulation of MMPs. However, little is known about the regulatory mechanism. In this study, we examined the role of tPA on MMP upregulation in rat neuronal cells. tPA (5 ${\mu}g$/ml) increased MMP-9 levels of neuronal cells in a time dependent manner. Hypoxia/reoxygenation amplified tPA-induced MMP-9 levels significantly. Pretreatment with JNK inhibitor SP600125 reduced the MMP-9 response. These results suggest that tPA can upregulate MMPs in neuronal cells and that JNK kinase may be involved.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.5
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• pp.791-796
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• 2004

This study was peformed to screen the biological activities of Pleurotus ferulea (K5 and K8 strains). The cap of K5 strain is well developed than stalk, and vice versa in K8. The ethanol extract of Pleurotus ferulea exhibited significant free radical scavenging activity (35∼36%), suggesting possible effect on many degenerative diseases originated from the reaction of oxygen species. Acetylcholinesterase inhibitor is proven to be the most effective factor for Alzheimer disease induction, and ethanol extract of Pleurotus ferulea significantly inhibited acetylcholinesterase activity (25∼35%) in uitro. Moreover, ethanol extract of Pleurotus ferulea suppressed liver fibrosis by 3∼12% in uitro. However, Pleurotus ferulea feruled to inhibit glucose uptake in human intestinal cell line. Viability of gastric and colon cancer cells was also not affected by Pleurotus ferulea extract. In conclusion Pleurotus ferulea exhibited significant effect on free radical scavenging, acetylcholinesterase inhibiton and brain cell protection. However, Pleurotus ferulea failed to affect glucose uptake, and cytotoxicity of gastric and cancer cells. In general, K8 revealed more significant effects than K5.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.6
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• pp.2561-2566
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• 2011

The purpose of this study was to verify the effect of Neurofeedback training on adolescence groups that are different in Age. The experiment was carried out with 90 students who living in Kyonggi-do. From Nov. 2009 to Mar. 2010, each were under training about 20-25 times, 2-3 times a week, during 20 to 50 minutes, was conducted by limiting training. Statistical data collected were processed with the SPSS 12.0. For the purposes of t-test showed that differences in the effects of age. The result, the effects of Neurofeedback training on age difference groups were reflected characteristics of brain's development in adolescence. The most effective showed in middle school students. Also, Significant effects of Neuofeedback training that were confirmed in attention quotient, Activation quotient, Stress resistence quotient.