• Electronics and Telecommunications Trends
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• v.32 no.4
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• pp.31-39
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• 2017

뇌에 관한 연구는 상당히 오랫동안 이루어져 왔음에도, 뇌는 여전히 미지의 세계로 남아 있다. 미국에서 2013년 Brain Initiative를 발표한 이후 뇌를 이해하기 위한 연구가 활발히 이루어져 왔다. 최근에는 인간의 생각을 뇌의 활성 패턴 분석을 통해 읽어 내려고 시도하였으며, 심지어는 잠자는 동안 꾸는 꿈을 뇌 활성 패턴 측정을 통해 읽어 내려는 시도도 이루어졌다. 본고에서는 브레인 디코딩을 위해 어떤 기술들이 필요하며, 현재 어떤 연구들이 이루어져 왔는지에 대하여 살펴보고, 향후 브레인 디코딩 기술이 어떻게 발전할 것인지 전망해 본다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.270-270
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• 1994

돼지 뇌조직으로부터 순수 분리 정제된 Glutamate decarboxylase (GAD)는 효소 dimer당 0.8mole 보조 인자인 pyridoxal-5-phosphate(PLP)가 강하게 binding되어 있었다. 이러한 부분적으로 resolved된 효소에 외부로부터 PLP를 넣어주면 효소의 활성도는 최대값으로 증가하였다. 정제된 GAD는 sulfydryl시약에 의한 화학변형에 의하여 효소의 활성도를 상실하였으며 환원제인 dithiothreitol이나 2-mercaptoethanol의 첨가에 의하여 효소의 활성도가 복구되는 것으로 보아 효소의 활성부위의 활성에 직접 관여하는 중요한 cysteinyl잔기가 존재하고 있는 것을 알 수 있다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.01a
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• pp.173-174
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• 2017

본 논문에서는 노화에 의해서 떨어지는 기억력의 저하 뿐 만 아니라 뇌의 비가역적 질환인 치매의 예방을 위하여 기억력 저하에 도움을 줄 수 있는 앱의 개발을 위하여 뇌의 각 영역별 기능이 활성화 될 수 있도록 하는 훈련이 가능할 수 있도록 앱을 설계하고자 한다.

• The Journal of the Korea Contents Association
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• v.17 no.5
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• pp.491-498
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• 2017

This study is to determine the significant effect of white and pink noise on brain. The brain synchronization has been analyzed under the condition of non-noise, white nose and pink noise(male 10, female 10, mean age $23.3{\pm}2.14$). As a result of analysis, pink noise stimulus, alpha, low beta band, and high beta band were significantly decreased than non-noise and white noise. In addition, these brain response pattern significantly increased at frontal lobe and temporal lobe, and dominated on the right hemisphere. This result is considered to be useful of sound design in driving quality of human life on the basis of neuroscience.

• The Korean Journal of Zoology
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• v.38 no.4
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• pp.449-456
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• 1995

Seasonal changes in the activity and charaderistics of brain Na+, K+-ATPase and Mg2+-AWase were investigated in frog (Rana dybowskii) The brain Na+, K+-ATPase adivity during hibernation was similar to that in active period in frogs. The Na+, K+-AWase activity increased in December and March, when the frogs enter into and awake from the hibernation. Over 5-35$^{\circ}C$ temperature range, Na+, K+-ATPase showed non4inear Arrhenius kinetics throughout the year. The brain Mg2+-ATPase activity decreased during hibernation, but markedly increased in March. The Arrhenius plots for Mg2+-AWase activity were linear in frogs both in torpid and active state. The ratio of Na+, K+-AWase activity at 15~C to at 35~C did not change during hibernation. The sensitivity of Na+, K+-AWase to ouabain was also unchanged throughout the year. These results indicate that the activity and charaderistics of brain Na+, K+-AWase remain unchanged during hobernadon in frog.

• Journal of Science Education
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• v.46 no.1
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• pp.30-39
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• 2022

The purpose of this study is to compare and analyze secondary school student's brain activity on assimilation, conflict, and accommodation processes of self-regulation. The self-regulation task was presented a biological phylogenetic task, and the brain activity was measured and analyzed with fNIRS. As a result, a significant activation was found in the left DLPFC, OFC, and FP regions in the conflict process compared to the assimilation process, and a significant activation was found in DLPFC and VLPFC in the accommodation process. As the age increase, the DLPFC also increases in the conflict process and VLPFC increases in the assimilation process. In addition, comparing conflict and accommodation process, the 7th grade students show a significant brain activity in the right VLPFC, the 9th grade students show significant brain activity in the left FP and DLPFC areas in the accommodation process. However, the 11th grade students did not show any significant brain activity at this process. These results presumably show that the neurological research method could be applied to educational research in cognitive activity and classroom instructional situation.

• Journal of Life Science
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• v.7 no.1
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• pp.17-23
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• 1997

This study was designed as a part of efforts to investigate the biochemical pollutant markers for diagnosis of maine pollutions by changes in cholinesterase activity of the flounder (Paralichthys olivaceus)in Yellow Sea of Korea. Acetylcholinesterase (AChE) activities in brain and muscle of cultured flounders in Yellow Sea were remarkably lower (40-50% and 40-55%, respectively)than those of wild flounder in Pohang (control) of East Sea, but AChE activities in brain and muscle of wild flounders in Yellow Sea were significantly lower(15-40% and 25-35%, respectively)than those of wild flounder in Pohang of East Sea. Butyrylcholinesterase(BChE) activities in barin and muscle of cultured flounders in Yellow Sea were remarkably lower(70-75% and 65-75%, respectively) than those of wild flounder in Pohang of East Sea, but BChE activities in barin and muscle of wild flounders in Yellow Sea were significantly lower (15-40%and 25-35%, respectively)than those of wild flounder in Pohang of East Sea. Lactate dehydrogenase (LDH) activities in serum of cultured flounders in Yellow Sea were significantly 10-50% higher than those of wild flounder in Pohang of East Sea, but LDH activities in serum of wild flounders in Yellow Sea were significantly 20-25% higher than those of wild flounder in Pohang of East Sea. It suggests that AChE and BChE activities in brain and muscle of cultured and wild flounders of Yellow Sea may be used as the most effective mean in a biochemical markers for diagnosis of pollutant effects by organophosphorus pesticides.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.32 no.1
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• pp.37-41
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• 1999

This study was designed as a part of efforts to investigate the biochemical pollutant markers for diagnosis of marine pollutions by changes in cholinesterase activity of the flounder (Paralichthys olivaceus) in tie South Sea of Korea. Aceflcholinesterase (AChE) activities in brain and muscle of cultured flounders in the South Sea were significantly lower ($10\~20\%$ and $12\~19\%$, respectively) than those of wild flounder in Pohang of the East Sea as a control. Buthrylcholinesterase (BChE) activites in brain and muscle of cultured flounders in the South Sea were also remarkably lower ($25\~40\%$ and $22\~35\%$, respectively) than those of wild flounder in Pohang. Lactate dehydrogenase (LDH) activites in serum of cultured flounders in South Sea were significantly higher ($10\~55\%$) than those of wild flounder in Pohang. It suggests that AChE, BChE and LDH activities of the flounders clould be used as effective biochemical markers for early warning of environmental damages caused by organophosphorus pesticides.

• Journal of the Korea Computer Graphics Society
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• v.28 no.3
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• pp.101-111
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• 2022

Conditional autonomous vehicles should hand over control to the driver according on driving situations. However, if the driver is immersed in a non-driving task, the driver may not be able to make suitable decisions. Previous studies have confirmed that the cues enhance take-over performance with a directional information on driving. However, studies on the effect of take-over cues on the driver's brain activities are rigorously investigated yet. Therefore, this study we evaluates the driver's brain activity according to the take-over cue. A total of 25 participants evaluated the take-over performance using a driving simulator. Brain activity was evaluated by functional near-infrared spectroscopy, which measures brain activity through changes in oxidized hemoglobin concentration in the blood. It evaluates the activation of the prefrontal cortex (PFC) in the brain region. As a result, it was confirmed that the driver's PFC was activated in the presence of the cue so that the driver could stably control the vehicle. Since this study results confirmed that the effect of the cue on the driver's brain activity, and it is expected to contribute to the study of take-over performance on biomakers in conditional autonomous driving in future.

• The Korean Journal of Nuclear Medicine
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• v.36 no.3
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• pp.166-176
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• 2002

Purpose: The purpose of this study is to investigate the effects of visual activation and quantitative analysis of regional cerebral blood flow. Visual activation was known to increase regional cerebral blood flow in the visual cortex in occipital lobe. We evaluated that change in the distribution of $^{99m}Tc-HMPAO$ (Hexamethyl propylene amine oxime) to reflect in regional cerebral blood flow. Materials and Methods: The six volunteers were injected with 925 MBq (mean ages: 26.75 years, n=6, 3men, 3women) underwent MRI and $^{99m}Tc-HMPAO$ SPECT during a rest state with closed eyes and visual stimulated with 8 Hz LED. We delineate the legion of interest and calculated the mean count per voxel in each of the fifteen slices to quantitative analysis. The ROI to whole brain ratio and regional index was calculated pixel to pixel subtraction visual non-activation image from visual activation image and constructed brain map using a statistical parameter map (SPM99). Results: The mean regional cerebral blood flow was increased due to visual stimulation. The increase rate of the mean regional cerebral blood flow which of the activation region in primary visual cortex of occipital lobe was $32.50{\pm}5.67%$. The significant activation sites using a statistical parameter of brain constructed a rendering image and image fusion with SPECT and MRI. Conclusion: Visual activation was revealed significant increase through quantitative analysis in visual cortex. Activation region was certified in Talairach coordinate and primary visual cortex (Ba17),visual association area (Ba18,19) of Brodmann.