• Life and Agrochemicals
• /
• s.276
• /
• pp.35-35
• /
• 2012

• The Korean Journal of Pesticide Science
• /
• v.18 no.4
• /
• pp.342-349
• /
• 2014

Methods of establishment of AOEL (Acceptable Operator Exposure Level), application of oral absorption by country, and calculation of exposure dose for operator risk assessment in USA, EU and Korea were investigated. Oral absorption of 141 active substances for pesticides was also investigated, then operator risk assessment was conducted with AOEL including oral absorption and Korean AOEL. Internal dose converted to external dose with oral or dermal absorption in USA and EU, but external dose to which oral absorption was not applied was used for establishment of AOEL in Korea. Oral absorption of 50 active substances among 141 were below 80%. In case of application of oral absorption as a correction factor in below 80%, AOELs of about 36% active substances were considered to be lower than the current Korean AOELs. Operator risk assessment of 28 active substances among 50 active substances with oral absorption below 80% was conducted with EU AOELs. TER (Toxicity Exposure Ratio) of 12 plant protection products including chlorothalonil WG (Water-dispersible Granule) was less than 1 and the risk was high. Operator risk assessment of 24 active substances among 50 active substances with oral absorption below 80% was conducted with Korean AOELs. TER of 6 plant protection products including chlorothalonil WG were less than 1 and the risk was high. Operator risk assessment of 4 plant protection products not having Korean AOEL was conducted with converted EU AOEL into AOEL not including oral absorption. The results indicated TER of 4 products including daminozide WP (Wettable Powder) was over 1 and risk was low. 22 products except 6 products such as oxadiagyl SC (Suspension Concentration) were shown the same results of risk assessment between EU AOELs and Korean AOELs. As a result, it was considered that AOELs including oral absorption was possible to be used for operator risk assessment. It was considered operator risk assessment with AOEL including oral absorption was more like real assessment method, and improvement of assessment was needed for application to evaluate pesticides in registration.

• The Korean Journal of Pesticide Science
• /
• v.16 no.4
• /
• pp.391-394
• /
• 2012

Exposure and risk assessment during mixing/loading of chlorpyrifos emulsifiable concentrate (EC, 20%) were carried out. Limit of detection and limit of quantitation were 0.02 and 0.1 ng, respectively. Calibration curve linearity and reproducibility were excellent. Recovery of chlorpyrifos from gloves was 72.3-103.4%. During mixing/loading procedure, average hand exposure amount of chlorpyrifos was 3.9 mg which is corresponding to 0.004% of total active ingredient in the prepared spray mixture. In calculation of MOS (Margin of Safety) for risk assessment, male Korean average body weight and AOEL (Acceptable Operator Exposure Level) were used. Nine events of mixing/loading procedure were assumed per day. And 75 percentile of 30 repetition (4.6 mg) was used as for the worst case. MOS was more than 1 for total repetition, indicating mixing/loading work was of least risk. However, MOS of individual repetition was examined, two cases were less than 1 suggesting careful work habit is essential in mixing/loading procedure.