• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.5
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• pp.563-568
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• 1996

This experiment was conducted to obtain basic information of biochemical changes in the process of senescence by measuring the total RNA, protein, protease activity and electrophoretic pattern of protein in tobacco plant. The content of soluble protein increased by 15 days after leaf emergence and its level was not changed from 15 to 35 days after leaf emergence. The content of total RNA showed a maximum value at 15 days after leaf emergence and then decreased rapidly until 30 days after leaf emergence. The activity of protease of neutral fraction was higher than that of acidic fraction and rapidly increased up to the end of senescence after 50 days after leaf emergence. According to the analysis of electrophoresis, polypeptide band of 61kd was developed after 35 days after leaf emergence and increased by the end of senescence.

• Journal of Digital Convergence
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• v.19 no.12
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• pp.513-521
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• 2021

The purpose of this study is to suggest an anti-aging health care plan through a literature analysis of the life activity system of Oriental Medicine. The source of normal maintenace, development, and change of the natural world and the human body's life activity process is the dynamical cooperative equilibrium of the internal Shen-Ji's discipline that creates, grows, changes, makes differences and stores(生长化收藏) and external Qi-Li's process of change from birth to growth, maturity to old age and ending of life(生長壯老已). Therefore, it was analyzed that the natural and human life activity processes are normally maintained, developed, and transformed. As a result, when the natural healing power of Genuine-Qi, the source of the human vitality, rises with the 'breathing massage' that combines a static breathing method which is anti-aging health care method applying the lifting entering movement of Qi and a dynamic abdominal massage, and it harmonizes the Shen-Ji which is the life process system and Qi-Li so that it is believed to be helpful in prolonging a healthy lifespan.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2012.06a
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• pp.371-373
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• 2012

노화-구도 연도교 개설공사 사업에 따라 대상해역을 이용하여 통항하는 선박에 대하여 교량 건설을 고려한 종합적인 해상교통 안전성 향상 방안 제시를 위해 이론적 고찰 및 Full-Mission Shiphandling Simulator를 이용하여 평가하고 근거자료를 작성한 후, 최적의 교량시설을 계획하도록 기초자료를 제공하며, 인허가 과정중 도출된 해상교량안에 대한 해상교통안전진단을 해사안전법 및 동 법 시행규칙에 의거하여 실시하였다.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.13-27
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• 2005

고령화사회(aging society)에 접어 들자 마자, 세계적으로 유례없이 빠른 속도로 고령사회(aged society)에 우리나라가 다가가고 있다. 이러한 과정에서 과거 노인에 대한 개념을 재정비하고 새로운 고령사회에 대비한 장수문화 창출이 시급하다. 노화란 개념에 대해서도 불가피하고 비가역적인 생체의 변화를 거쳐서 죽음에 이르는 도정이라는 피동적이고 자포자기적인 결정론적 시각을 불식하고, 노화가 생명체의 생존을 위한 적응적 반응성 변화이며, 그러한 변화의 요인이 충분히 제어가 가능한 생체의 변화임을 분명하게 인지하여야 할 것이다. 따라서 기능적 장수(Functional Longevity)라는 새로운 개념을 제안하고, 이러한 기능적 장수를 추구함에 있어서 장수문화와 장수과학의 정립이 시급함을 강조하였다.

• Journal of Life Science
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• v.33 no.9
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• pp.736-745
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• 2023

Aging is a complex biological process characterized by a gradual decline in cellular and physiological functions. This natural process is associated with age-related diseases, including Alzheimer's disease, atherosclerosis, and hypogonadism, which are significant health concerns among older individuals and can significantly impact their quality of life. Researchers have found that epigenetic markers play a crucial role in regulating aging and age-related diseases. Epigenetic markers are heritable gene expression alterations that do not change in the DNA sequence. This review focuses on the involvement of various epigenetic marks, such as RNA methylation, DNA methylation, and microRNAs (miRNAs), in regulating gene expression patterns associated with age-related diseases, such as Alzheimer's disease, atherosclerosis, and hypogonadism. These epigenetic alterations can lead to the dysregulation of specific genes and signaling pathways, contributing to the development and progression of Alzheimer's disease, atherosclerosis, and hypogonadism. Understanding the molecular mechanisms behind these epigenetic modifications is essential for both the aging population and individuals seeking ways to promote overall well-being. By gaining deeper insights into how epigenetic marker alteration occurs during aging and age-related diseases, researchers can potentially develop targeted therapeutic strategies to alleviate the impact of these conditions and improve the quality of life for older individuals.

• Journal of Life Science
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• v.29 no.8
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• pp.888-894
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• 2019

Cartilage diseases, such as rheumatoid arthritis (RA) and osteoarthritis (OA), are associated with the loss of chondrocytes and degradation of articular cartilage. Recent studies revealed that inflammatory reactive oxygen species (ROS) and age-related oxidative stress can affect chondrocyte activity and cartilage homeostasis. We investigated changes in the levels of intracellular antioxidants during cellular senescence of primary chondrocytes from rat articular cartilages. Cellular senescence was induced by serial subculture (passages 0, 2, 4, and 8) of chondrocytes and measured using specific senescence-associated ${\beta}$-galactosidase ($SA-{\beta}-gal$) staining. ROS production increased significantly in the senescent chondrocytes. In addition, total glutathione (GSSG/GSH) and superoxide dismutase (SOD) levels and heme oxygenase-1 (HO-1) expression increased in senescent chondrocytes induced by serial subculture. Analysis of changes in intracellular antioxidant levels in articular cartilage from rats of different ages (5, 25, 40, and 72 wk) revealed that total glutathione levels were highest after 40 wk and slightly decreased after 72 wk as compared with those after 25 wk. SOD and HO-1 expression levels increased in accordance with age. Based on these results, we conclude that intracellular antioxidants may be associated with cartilage protection against excessive oxidative stress in the process of chondrocyte senescence and age-related cartilage degeneration in an animal model.

• Development and Reproduction
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• v.11 no.1
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• pp.13-20
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• 2007

In all female mammals, reproductive system is one of the first biological systems to show age-related decline. Female mammals in reproductive aging, though the phenomena is somewhat species-specific, start to show declining fertility and changes of numerous physiological functions. This review will present a current information on the aging of the female reproductive hormonal axis and introduce three useful rodent models for studying this field. Middle age($8{\sim}12$ months old) in female rats and mice is comparable to the stage prior to the entry of menopause in human. In this period pulsatile and surge GnRH secretion from hypothalamus gradually attenuated, then reduced pulsatile and surge LH secretion is followed consequently. This age-related defects in GnRH-LH neuroendocrine axis seem to be highly correlated with the defects in brain signals which modulate the activities of GnRH neuron. Many researchers support the idea which the age-related hypothalamic defects are the main cause of reproductive aging, but some ovarian factors such as inhibin response also could contribute to the induction of reproductive senescence. Some rodent models are quite valuable in studying the reproductive aging. The follitropin receptor knockout(FORKO) mice, both of null and haploinsufficient state, could produce depletion of oocyte/follicle with age. Dioxin/aryl hydrocarbon receptor(AhR) knockout mice also show severe ovarian defects and poor reproductive success early in their life compared to the age-matched normal mice. Further studies on the reproductive aging will be a great help to evaluate the benefits and risks of hormone replacement therapy(HRT) and to improve the safety of HRT.

• Journal of Digital Convergence
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• v.12 no.9
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• pp.417-422
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• 2014

This paper was to explore the effect of aging anxiety of the middle-aged on depression in aging society. This survey was conducted from September, 2013 to December, 2013 and 302responses from the survey were used for the analysis. The data was analyzed by descriptive statistics, t-test, ANOVA, pearson correlation and Multiple Regression. The research findings could be summarized as the followings. First, the mean scores of aging anxiety and depression were lower than average. Second, aging anxiety was the significant predictor to explain depression. Third, income also was the significant predictors which have the effectiveness to the depression.

• Journal of Life Science
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• v.30 no.9
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• pp.819-825
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• 2020

All living organisms exhibit the characteristics of aging, such as skin wrinkle formation, muscle degeneration, cataracts, and hair graying as the number of aged cells increases over time. Senescence, which is known as a key cause of aging, is directly related to the aging of living organisms because cells are aged by external and internal factors and eventually cell proliferation is stopped. Senescence is caused by the gradual shortening of the telomere with cell division, and lifespan is determined by the length of the telomere. Recently, it has been found that the histone deacetylase, which can influence gene expression, is not only involved in yeast but also deeply involved in anti-aging mechanisms in both C. elegans and humans. It was also discovered that old cells play a decisive role in the aging phenomenon, and it has been reported that it is possible to promote the proliferation of young cells and delay aging by removing these senescent cells from the inside. Therefore, in order to develop potential anti-aging agents in the future, research should begin with an in-depth study of telomerase activators, sirtuin activators, and senolytics.

• Journal of the Korea Convergence Society
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• v.8 no.10
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• pp.351-358
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• 2017

This study analyzed the process of mourning for aging in the film 'Miss Granny' in a convergent method. In exploring the contents of the movie repeatedly and interpreting the feeling of loss of old age in aging process as mourning process, I explored them in a psychoanalytic way. In other words, in a psychoanalytic method, I analyzed the aging process as a process of reinterpreting life and the change in developmental attitude toward the future life as a psychological world of mourning. The results of the study show that the process of mourning follows 'loss and deficiency', 'escape and regression', 'disidentification and decentralization', and 'adaptation to the new reality'. Based on these results, this research suggests that the counselor should not only focus on creating a psychological mood environment so that the client's mourning work will be smooth, but also should be able to use a complex counseling technique to improve the mental ability of the client.