• Title/Summary/Keyword: 노출 허용시간

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Residue level and pharmacokinetics of trichlorfon in the Japanese eel (Anguilla japonica) after bath treatment (Trichlorfon (TCF)의 약욕 투여에 따른 뱀장어 체내 약물 잔류량 및 약물동태학 연구)

  • Jo, Hyun Ho;Chung, Joon Ki
    • Journal of fish pathology
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    • v.35 no.1
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    • pp.93-102
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    • 2022
  • This study performed a trichlorfon (TCF) residue and pharmacokinetic analysis with Japanese eels, Anguilla japonica, to obtain baseline data to establish the maximum residue level (MRL) of TCF in A. japonica. After dipping A. japonica in 30 ppm and 150 ppm of TCF at 28℃ and 18℃, drug residue in the body was analyzed with LC-MS/MS, and these results were further analyzed with the PK solver program to obtain the pharmacokinetic parameters of TCF in the serum, muscles, and liver. The maximum concentrations (Cmax) in the serum, muscles, and liver were 25.87-357.42, 129.91-1043.73, and 40.47-375.20, respectively, and the time to maximum concentration (Tmax) was 0.13-1.32h, 1.17-3.34h, and 0.14-5.40h, respectively. The terminal elimination half-life (T1/2) was 2.13-3.92h, 5.30-10.35h, and 0.65-13.81h, respectively. In the 30 mg/L concentration group, TCF was not detected in the serum of eels 96 hours after bathing, and was below the detection limit after 336 hours in muscle and liver. On the other hand, in the 150 mg/L concentration group, TCF was not detected in the serum of eels 336 hours after bathing, but was detected in muscle and liver at 336 hours. In conclusion, the results of this study would be useful in establishing the MRL of TCF in farmed A. japonica.

A Study of Dermal and Ocular Exposure to Isocyanate-Based Paints in Crash Repair Workshops (차량수리업에서 사용하는 이소시안계 페인트에 의한 피부와 눈의 노출에 관한 연구)

  • Lee, Su-Gil;Pisaniello, Dino;Lee, Nae-Woo;Tkaczuk, Michael
    • Journal of the Korean Society of Safety
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    • v.24 no.6
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    • pp.72-78
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    • 2009
  • Exposure to HDI(hexamethylene di-isocyanate) commonly used in vehicle crash repair workshops remains a leading cause of occupational asthma. Although skin and eye contamination are considered as absorption routes, there are no occupational exposure standards for skin and ocular exposure. This is the reason why there are more empirical data should be provided. Therefore this study was to determine contamination levels of HDI on the skin, eyes, work surfaces, respirators and eye protectors. There was evidence of contamination on a variety of work surfaces, for example, door handles, bench top and spray gun, etc. A high proportion(47~80%) of skin wipe samples from neck, forehead, back hand, palm and wrist was positive for HDI contamination, even though spray time was relatively brief. The contamination levels from spraying inside spray booth were generally higher than outside booth due to poor work practices and inappropriate personal protective use like safety gloves. Apprentices had higher exposure levels than the qualified painters, likely due to lack of the recognition of safety and hygiene. The extent of contamination inside the PPE might provide an indication of the potential for respiratory & skin exposure and ocular exposure. Eye fluid samples from 4 out of 14 workers had the positive detection of HDI contamination, due to poor work practices like no or inappropriate eye protection. Considering the potential for dermal & ocular exposure to contribute to possible health symptoms including respiratory sensitization, the empirical data point to a need for improving work practices and appropriate PPE selection, use and maintenance.

Tidal Flat Simulation Characteristics of the Hydrodynamic Models (해수유동모형의 조간대 모의 특성)

  • Kang, Ju-Whan;Park, Seon-Jung;Kim, Yang-Seon;So, Jae-Kwi
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.21 no.5
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    • pp.357-370
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    • 2009
  • EFDC, ESCORT and MIKE21 models are applied at the Gomso Bay to investigate each models' facilities of tidal flat simulation. Comparisons with observation data show that all models simulate hydrodynamic phenomena and tidal flat well. CPU time and WCM are examined to evaluate the efficiency of the models, and the effects of flooding/drying depth and bottom friction are examined to analyze models' facilities of simulating tidal flat. The EFDC model is considered to be fairly good in accuracy, stability and applicability, it is, however, poor in efficiency and its complexity. While the ESCORT model is superior to the EFDC in simulation of tidal flat, it is inferior to the EFDC in CPU time and simulation of bottom friction. The MIKE21 model is excellent in efficiency, but some numerical noise would be detected at low water, not permitting correction of the model.

The strategic behaviors of incumbent pharmacy groups in the retail market of pharmaceuticals in response to the entry trials by the online platform firms delivering medicines - A perspective of market entry deference model in game theory (온라인 의약품배송플랫폼기업의 시장 진입 시도에 대한 기존 의약품 공급자의 전략적 행동 - 게임이론의 시장진입 저지 모형 관점)

  • Lee, Jaehee
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.4
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    • pp.303-311
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    • 2022
  • Recently the telemedicine platform firms which have been temporarily permitted since COVID-19 outbreak have increasingly provided online prescription drugs delivery, causing concerns among incumbent providers of medicine, some of whom began to take aggressive actions again them. In this study, using game theoretic market entry - deterrence model, we show that although the incumbent medicine provider can effectively deter entry by the telemedicine platform firms by its preemptive action, accommodation could be a optimal action when telemedicine platform firms already have penetrated the market with their being permitted to do business due to the COVID-19. However, for the incumbent to cooperate for the successful change in the retail market for medicines, policies like placing a ceiling on the maximum number of taking prescriptions by the pharmacists a day in the telemedince platform network, providing favorable exposure of community pharmacists on the telemedicine platform user interface, and allowing community pharmacies to participate as shareholders of the telemedicine platform firms in its initial public opening of capital, are suggested.

RESEARCH ON SPACE ENVIRONMENTAL EFFECT OF ORGANIC COMPOSITE MATERIALS FOR THERMAL MANAGEMENT OF SATELLITES USING MC-50 CYCLOTRON (MC-50 싸이클로트론을 이용한 위성용 열조절 유기복합재료의 우주환경 영향 연구)

  • Kim, Dae-Weon;Kim, Dong-Iel;Huh, Yong-Hak;Yang, Tae-Keun;Lee, Ho-Young;Kim, Yong-Hyup
    • Journal of Astronomy and Space Sciences
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    • v.22 no.4
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    • pp.441-450
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    • 2005
  • The organic material is one of the most popular material for the satellites and the spacecrafts in order to perform the thermal management, and to protect direct exposure from the space environment. The present paper observes material property changes of organic material under the space environment by using ground facilities. One of the representative organic thermal management material of satellites, 2 mil ITO(Indium Tin Oxide) coated aluminized KAPTON was selected for experiments. In order to investigate the single parametric effect of protons in space environment, MC-50 cyclotron system in KIRAMS(Korea Institute of Radiological and Medical Science) was utilized for the ion beam irradiation of protons and ion beam dose was set to the Very Large August 1972 EVENT model, the highest protons occurrence near the earth orbit in history. The energy of ion beam is fixed to 30MeV(mesa electron volt), observed average energy, and the equivalent irradiance time conditions were set to 1-year, 3-year, 5-year and 10-year exposure in space. The procedure of analyses includes the measurement of the ultimate tensile strength for the assessment of quantitative degradation in material properties, and the imaging analyses of crystalline transformation and damages on the exposed surface by FE-SEM(Field Emission Scanning Electron Spectroscopy) etc.

Study on Dynamic Trust-based Access Control in Online Social Network Environment (소셜 네트워크 환경에서 동적 신뢰 중심의 접근 제어 모델에 관한 연구)

  • Baek, Seungsoo;Kim, Seungjoo
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.23 no.6
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    • pp.1025-1035
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    • 2013
  • There has been an explosive increase in the population of OSN(online social network) for 10 years. OSN provides users with many opportunities to have communication among friends, families and goes so far as to make relationships among unknown people having similar belief or interest. However, OSN also produced adverse effects such as privacy breaches, leaking uncontrolled information or disseminating false information. Access control models such as MAC, DAC, RBAC are applied to the OSN to control those problems but those models in OSN are not fit in dynamic OSN environment because user's acts in OSN are unpredictable and static access control imposes burden on users to change access control rules one by one. This paper proposes the dynamic trust-based access control to solve the problems of traditional static access control in OSN.

Calculation of Induced Current in the Human Body around 765 kV Transmission Lines (765 kV 초고압 송전선 주변의 인체 유도전류 계산)

  • 명성호;이재복;허창수
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.9 no.6
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    • pp.802-812
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    • 1998
  • Safety related to electric field exposure for the personnel of high voltage power plant and substation is of importance. To analyze the induced current influencing on human body in this paper, we calculate directly capacitance in three dimension which is complex and time consuming, as not to separate the voltage source and the induced object using a effective modeling technique. The proposed algorithm in this paper has been applied to 765 kV high voltage transmission line to evaluate human hazard for the induced current through the case study. As the results, the short circuit current of human body has been identified in the range of 0.3 mA to 6.8 mA. Closing to transmission line, this range of short current can exceed 5 mA that ANSI recommended let-go current. Therefore, it is necessary to countermeasure such as putting on conductive clothing in live-line maintenance of transmission line.

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Success Run Test for Reliability Demonstration of 1100℃ Gas Turbine Blades (1100℃급 가스터빈 동익의 무고장시험을 통한 HCF 신뢰성 평가)

  • Lee, Dooyoung;Goo, Jaeryang;Kim, Doosoo;Kim, Donghwan
    • KEPCO Journal on Electric Power and Energy
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    • v.3 no.2
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    • pp.107-111
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    • 2017
  • The reliability on high cycle fatigue damage mechanism for new blades manufactured by reverse-engineering is demonstrated by success-run test. Turbine blades always experience various dynamic loads in turbine operation, as well as being in resonance condition and forced by fluid-induced vibrations mostly during run-up/down, which may accumulate high cycle damage to the blades. The accidents caused by blade failure especially incur not only a lot of troubles to the machinery but also huge financial losses. Therefore it is necessary to verify the reliability of blades in advance for the safe use. The success run test for the reliability demonstration is designed and performed for the new blades using the technique known as resonant high cycle fatigue testing.

Formation of Luteoskyrin by Penicillium islandicum (Penicillium islandicum에 의한 황변미독(黃變米毒) Luteoskyrin의 생성(生成))

  • Kim, Yong-Hwa;Lee, Su-Rae
    • Korean Journal of Food Science and Technology
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    • v.10 no.1
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    • pp.46-51
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    • 1978
  • One of yellowed rice toxins, luteoskyrin, was investigated with respect to its identification, quantitation and producibility by Penicillium islandicum isolated from deteriorated rice. 1) Luteoskyrin was best resolved by thin-layer chromatography with silica gel G plate impregnated with 0. 5 N oxalic acid and acetone : n-hexane : water (6 : 3 : 1.5, upper layer) solvent system. The isolated yellow spot showed maximum absorption bands at 426 and 448 nm and changed to purple color upon exposure to sunlight for $2{\sim}3$ hours. 2) Detection limit for luteoskyrin was 4 ppm in elution-colorimetry and 0.1 ppm in densitometry after TLC. Assuming that the tolerance for luteoskyrin in rice is set below 3.68 ppm, densitometry is usable for its screening in grain samples 3) Producibility of luteoskyrin by Pen. islandicum was shown to be 11 mg/g mycelial mat in liquid culture and 40 mg/g autoclaved rice.

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Real-time Remote Monitoring System of Chemical Accident Response based on Multi-hop Communication (멀티 홉 통신을 기반한 화학 사고 대응 실시간 원격 모니터링 시스템)

  • Lee, Seung-Chul;Kim, Nam-Ho
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.26 no.11
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    • pp.1706-1712
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    • 2022
  • Recently, the safety of chemical substances has gained attention due to incidents occurring in petrochemical industrial complexes, such as gas leaks and fires. In particular, industrial complexes in Ulsan and Yeosu (South Korea) are valuable as they significantly contribute to the petrochemical industry, but accidents may occur due to chemical leakage. Therefore, in this study, sensor nodes are configured at an interval of 20 [m] based on outdoor facilities standards to respond to chemical accidents, and exposure consideration of 8 h (TWA) and 15 min (STEL) are proposed in TLVs. The proposed system pre-processes data collected in multi-hop communication at a cycle of 0.6-0.75 [s] using Python and stores it in the MySQL database through SQL and a real-time remote monitoring system that updates the stored data once every 5 s is implemented by linking MySQL and Grafana.