• 건강소식
• /
• v.30 no.12 s.337
• /
• pp.6-11
• /
• 2006

남성도 갱년기를 겪는다. 중년 여성의 전유물로 여겨졌던 갱년기가 남성에게도 나타나는 것이다. 40세 이후 남성의 신체기능 저하는 최근까지 자연적인 노화현상으로 치부됐다. 그러나 평균수명의 연장과 의학의 발달 등으로 건강한 노년 생활에 대한 욕구가 커지면서 남성의 갱년기 증상이 발견되기 시작했다. 특히 20대에 최고조로 증가하는 남성 호르몬(테스토스테론)이 점차 줄어들다가 40~55세 사이에 급격히 감소하면서 여러 가지 신체적, 정신적, 심리적 변화가 나타난다. 남성호르몬 감소의 첫 번째 징후는 부부관계에 관심이 없어지고, 좀 더 진행되면 만성피로를 느끼고 얼굴이 달아오르거나 식은 땀을 흘리며 손발이 저리기도 하다. 그리고 감정이 잘 조절되지 않아 사소한 일에도 짜증을 내게 되는데, 남성 호르몬 부족 때문에 나타나는 이러한 증상들을‘남성 갱년기’라 한다. 이번 호에서는 서울아산병원 비뇨기과 안태영 교수와 성의학클리닉 연구소 강동우 전문의의 도움으로 남성 갱년기에 관해 자세히 알아본다.

• Korean Journal of Adult Nursing
• /
• v.26 no.2
• /
• pp.159-170
• /
• 2014

Purpose: This research investigated the degree and predictors of hot flashes and hypogonadism symptoms in patients with prostate cancer receiving hormone replacement therapy. Methods: The subjects were 111 patients with prostate cancer receiving hormone replacement therapy in two university hospitals located in D city. The measurement tools included Hot Flash Diary and AMS (Aging Male's Symptoms rating scales). The data were analyzed using t-test, ANOVA, and binary logistic regression analysis. Results: The percentage of patients who experienced hot flashes among the participants was 14.4%. The predictors for hot flashes were eating irregularly, having coffee frequently and the types of hormone. The average score of hypogonadism symptom was 2.16 out of five-point scale and the highest score of hypogonadism symptom was the sexual symptoms (2.77 out of five-point scale). The predictors for hypogonadism symptom were eating habits and years of having the illness. Conclusion: These findings provide the information that irregularly eating habit was an important factor in hot flashes and hypogonadism symptoms of the participants. Therefore the development of a nutritional education encouraging regular meals is necessary for the given population.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2015.07a
• /
• pp.311-312
• /
• 2015

본 논문에서는 노인 대상자들이 신체적, 정신적으로 노령화 되어감에 따라 신체적으로는 내분비계 및 비뇨생식기계통의 기능 저하에 따라 남성 호르몬인 테스토스테론 및 여성 호르몬인 프로게스테론과 에스트로겐의 생산의 차이로 인하여 나타나는 정신적인 우울의 차이점을 알아보고자 141명의 노인을 대상으로 노인우울척도를 실시한 결과 중증도 우울이 여성 노인에게서 남성 노인의 2배 이상 나타나는 것으로 확인 되었다.

• Clinical and Experimental Reproductive Medicine
• /
• v.36 no.3
• /
• pp.219-224
• /
• 2009

Objective: Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility. We investigated the outcome of gonadotropin therapy for restoring fertility and pregnancy outcomes in patients with HH. Methods: Medical charts of 10 infertile male patients with HH treated with gonadotropin were reviewed. Initial testicular volume were estimated. Semen analysis parameters (semen volume, sperm counts, motility), serum leutenizing hormone (LH), follicle stimulating hormone (FSH), total testosterone were determined before and after human chorionic gonadotropin/human menopausal gonadotropin (hCG/hMG) treatment. Differences were analyzed statistically. Results: Of 10 patients, 7 (70%) succeed at pregnancy (nature pregnancy in 4). Semen analysis parameters, serum FSH, and testosterone were increased significantly after treatment. The population was stratified according to initial testicular volume into a small testis subset (testicular volume less than 10 cc in 4) and a large testis subset (testicular volume 10 cc or greater in 6). Semen analysis parameters and serum testosterone were increased significantly after treatment in large testis subset. Conclusion: Infertile men with HH initiate and maintain spermatogenesis with gonadotropin (hCG/hMG alone or combined) therapy, thus gonadotropin therapy is good choice in infertile men with HH.

• Journal of Life Science
• /
• v.29 no.10
• /
• pp.1159-1163
• /
• 2019

Although there is a growing interest in male menopause, a phenomenon associated with male hormone depletion, current kits using antibodies to quantify male hormones are expensive. In this study, we constructed an in vitro system for verifying the activity or concentration of male steroid hormones using a transcriptional activity test. A reporter plasmid, pGL2-Neo-ARE-AdE1BTATA, which reacts to testosterone, was constructed. In this plasmid, the ARE-AdE1bTATA sequences can be bounded by the testosterone - androgen receptor complex to express luciferase as a reporter. Then, a stable transfection was performed on the human prostate cancer cell line, LNcap-LN3. The constructed LNcap-LN3/pGL2-Neo-ARE-AdE1BTATA testosterone compound detection (TCD) system showed quantitatively proportional luciferase activities to concentrations of $10^{-13}$ to $10^{-8}M$ of standard testosterone. The established in vitro TCD system will contribute to the development of materials for health/functional foods and drugs as it will be possible to search en masse for testosterone-like or testosterone-inhibiting substances derived from natural materials.

• Korean Journal of Environmental Biology
• /
• v.35 no.1
• /
• pp.21-36
• /
• 2017

Phthalates, known as typical endocrine disruptors, are plasticizers used to soften plastics such as polyvinyl chloride (PVC). Because of their material properties, phthalates are used extensively in the production of toys, flooring, wood processing, detergents, and even cosmetics as lubricants and perfume solvents. Due to their endocrine disrupting effect and other adverse health effects published, recently, phthalates have been regulated in many countries. Besides, in an effort to replace phthalates, several chemical plasticizers such as trioctyltrimellitate (TOTM) and dioctylterephthalate (DIOP) have been used instead of the existing harmful phthalates, and novel alternatives are continuously being developed. Nonetheless, phthalates are still being detected in several plastic products, and the safety of alternatives that are considered safe is being questioned. In this review, we describe the adverse health effects of phthalates, their regulation and the current status of their alternatives.

• Korean Journal of Food Science and Technology
• /
• v.47 no.4
• /
• pp.492-498
• /
• 2015

Testosterone deficiency syndrome (TDS) is normally observed in elderly men and is a clinical and biochemical syndrome, characterized by a decline in plasmic testosterone levels resulting in a significant decrease in quality of life. The aim of this study was to evaluate the effect of a mixed extract of fenugreek seeds and Lespedeza cuneata (YHM) on TDS. Rats were divided into three groups: the negative control, YHM-40 (40 mg/kg), and YHM-80 (80 mg/kg) groups. After 4 weeks of YMH administration, an increase was observed in the plasmic testosterone levels, vastus lateralis muscular strength, forced swimming time, total sperm counts, and motile sperm counts in YHM-40 and YHM-80 groups compared to the negative control group. Moreover, sex hormone binding globulin, the epididymal fat pad, total plasmic cholesterol, and triglyceride levels were significantly decreased in the YHM-fed groups. However, prostate specific antigen, aspartate aminotransferase, and alanine aminotransferase levels did not differ among the groups. These results suggest that YHM may enhance testosterone levels in elderly men and alleviate TDS without common side effects.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.45 no.11
• /
• pp.1571-1579
• /
• 2016

We investigated the effect of peanut sprout extract (PSE) on andropause symptoms. PSE was evaluated for impotency and benign prostatic hyperplasia via phosphodiesterase (PDE) or 5-alpha reductase II inhibition assay. Inhibition of PDE and 5-alpha reductase II activities in PSE was significantly higher than that of the non-treated control. To investigate the effects of testosterone levels by PSE, we performed cell media test using TM3 cells. Production of testosterone in TM3 cells was elevated by PSE. These results indicate that PSE was able to alleviate andropause symptoms.

• Journal of Life Science
• /
• v.26 no.9
• /
• pp.1063-1073
• /
• 2016

Male climacteric syndrome, andropause, or testosterone deficiency syndrome (TDS) is one of the new health issues in elderly men. It is a natural phenomenon that happens with age in men, which is clinically characterized by a decline in levels of serum testosterone resulting in a significantly decreasing of physical and mental activities. The aim of this study was to investigate the putative alleviative effects of dandelion extract on the symptoms of TDS by increasing serum testosterone levels and compare the efficacy between dandelion extract (DE) and fermented dandelion extract (FDE). After daily intake of DE and FDE for 4 weeks, serum testosterone levels, muscles of vastus lateralis, forced swimming time, total sperm counts, and motile sperm counts were significantly increased in older rats (22 weeks). Additionally, SHBG, epididymal fat pad, total serum cholesterol and triglyceride were significantly decreased in DE and FDE fed groups. However, PSA levels were not different among all groups. Furthermore, DE and FDE enhanced the expression of genes related to testosterone biosynthesis in TM3 Leydig cells. Overall, these positive effects on andropause were greater in FDE compared to DE. These results suggest the potential of FDE as a safe and efficacious natural material for recovering testosterone levels and reducing andropause symptoms.

• Journal of Nutrition and Health
• /
• v.25 no.6
• /
• pp.485-491
• /
• 1992

The effects of varying doses(1, 4 and 10mg/kg body weight/day) of testosterone propionate (TP) on body weight gain and composition and energy and muscle protein metabolism were investigated in female rats. TP had no effect on food intake at any dose but injection of 1mg/kg resulted in an in crease in body weight gain which was associated with increases in body protein and fat. At higher doses(4 and 10mg/kg) body protein content was still increased but body fat was not affected. Increases in energy gain and gross energetic efficiency were observed at a dose of 1mg/kg but neither parameter was affected at other doses. The mass protein and RNA content of gastrocnemius muscle were incerased by TPbut the ratio of RNA to protein and the rate of muscle protein synthesis measured in vivo were not affected at any dose of TP The results indicate that the effect of testosterne on body composition are highly dose-dependent and the anabolic action of testosterone is not through stimulation of protein synthesis.