• Clinical Pain
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• v.20 no.2
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• pp.131-134
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• 2021

We report a rare case of anti-viral agent induced hypophosphatemic osteomalacia presented with localized and radicular pain. A 51-year-old man, who had been taking adefovir for chronic hepatitis, had experienced low back pain radiating to his right thigh for 2 years. With impression of lumbar disc herniation, he underwent magnetic resonance imaging and found multi-level disc herniation with facet joint synovial cysts. He received transforaminal epidural steroid injections, however, symptoms did not improve. To find other possible causes, additional tests were performed. Blood tests revealed hypophosphatemia and increased serum alkaline phosphatase, and osteoporosis was noted in dual-energy X-ray absorptiometry with multiple hot uptakes in bone scan. After replacement of adefovir to entecavir and supplement of phosphate and vitamin D, phosphate level and the clinical symptoms were improved. This is the first to report the presentation of osteomalacia due to anti-viral agent as radicular low back pain with facet synovial cysts.

• The Journal of the Society of Stroke on Korean Medicine
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• v.17 no.1
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• pp.23-28
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• 2016

■ Objectives The purpose of this clinical study is to evaluate the effect of Korean Medical Treatment on a 71 years old Korean male with Intractable hiccup for 40 years after gastric perforation operation. ■ Methods He was treated with acupuncture, electroacupuncture, moxibustion and herbal medicine, Jakyakgamcho-tang and Banhasasim-tang. We evaluated the improvement by frequency of hiccup and NRS of hiccup. ■ Results Hiccup disappeared at sixth day of treatment and NRS of hiccup also decreased.. ■ Conclusion Korean medical treatment may be effective in treating intractable hiccup

• Journal of Veterinary Clinics
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• v.32 no.5
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• pp.436-439
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• 2015

Four cases of acute or acute-on-chronic kidney injury were referred for hemodialysis therapy. All cases had a history of uremic syndrome including refractory vomiting, anorexia, diarrhea and depression. They already had been treated with conventional therapies but the intractable clinical signs were remained without response of medications. Intermittent hemodialysis (IHD) sessions were executed in four cases. This study describes the clinical signs and biochemical features of four hemodialysis patients with dialysis adequacy indexed by Kt/V. This report introduced the estimation of hemodialysis adequacy method with clinical cases for establishment of standardization of hemodialysis therapy assess in dogs.

• Clinical and Experimental Pediatrics
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• v.48 no.11
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• pp.1225-1231
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• 2005

Purpose : This study compares the first epileptic seizures between preterm and term-born children with periventricular leukomalacia and epilepsy. Methods : From 108 cases having lesions of high signal intensity around the ventricles in T2 weighted imaging of a brain magnetic resonance study, we selected 37 cases that showed epileptic seizures two times or more and divided them into the group of preterm-born(27 cases) and term-born children(10 cases). A retrospective study was made by comparing the two groups with regard to age, type of the first epileptic seizures, EEG findings and responsiveness to anticonvulsants. Results : The age of the first epileptic seizure was $22.2{\pm}18.3$ months in the preterm-born group and $26.9{\pm}21.1$ months in the term-born group(P=0.505). As for the first epileptic seizure, 11 out of the 27 cases in the preterm-born group had infantile spasms. Out of the 10 cases in the term-born group, 7 had complex partial seizures. In the preterm group, hypsarrhythmias were found in 11 cases, focal epileptiform discharges in 6 cases. In term-born group, focal epileptiform discharges were found in 5 cases but no epileptiform discharge was found in 3 cases. Intractable epilepsies were diagnosed in 6 cases and all of them belonged to the preterm-born group. Conclusion : More severe epilepsies such as infantile spasm and intractable epilepsies seem to be more common in preterm-born epileptic children with PVL as well as more severely abnormal EEG finding compared to term-born epileptic children.

• Journal of Chest Surgery
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• v.30 no.2
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• pp.200-204
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• 1997

This is a report of a successful management of a patient with infective endocarditis involving native aortic valve, mitral valve, tricuspid valve, and Interventric lar septum. A 16 year-old patient who underwent VSD patch closure, and aortic valvuloplasty at the age of 1 1 years showed Intractable congestive heart failure during antibiotics treatment for infective endocarditis. Operative findings revealed that there were large defect along the previous patch, aortic regurgitation with multiple perforations and vegetations, mitral regurgitation with vegetation, aortic paraannular abscess, interventricular myocardial abscess, and tricuspid regurgitation with perforations and vegetations. We reconstructed the interventricular defect with Dacron patch extending to the aortic valve annulus after radical debridement of all infected or devitalized tissues, and could implant aortic valve by anchoring to the reconstructed Dacron patch. Mitral valve was replaced and tricuspid valve was repaired with patient's own pericardium. The patient was discharged after antibiotics treatment for 6 weeks and in good condition without any sequelae for 12 months.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2011.10a
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• pp.5-5
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• 2011

최근에 고령화 사회에 접어들면서 건강하게 활동하며 수명을 다하는 것이 중요한 연구과제가 되고 있다. 이 때문에 영양, 운동, 스트레스, 환경 등과 관련하여 암, 당뇨병, 고혈압, 비만, 동맥경화 등 생활습관병의 극복이 사회문제가 되고 있는 실정이다. 지금까지 고려인삼의 대표적인 동물실험 및 임상학적 연구결과를 종합하여 보면 성인의 난치성 만성질환에 대해서 치료제보다는 질병을 예방하고 회복촉진에 보다 큰 효과 있음을 확인할 수 있다. 이는 인삼이 식품과 의약품의 중간에 위치한 식품의약품(Nutraceutical)의 용도로 활용할 수 있음을 시사한다. 현재까지 인삼제품에 표시되는 기능성의 내용은 약 3,000여편 이상의 약리효능에 관련된 논문이 발표되었다 하더라도 "피로회복, 면역력 증진, 혈소판 응집 억제를 통한 혈액흐름에 도움이 됩니다"이며 이외의 기능성 표시는 현재로서 원칙적으로 불가한 것으로 되어 있다. 그러나 시험물질의 규격화 및 임상시험의 검토기준을 만족시키는 과학적 자료제출에 의한 개별 평가 후 표시내용의 확대가 가능하다. 고려인삼의 다양한 성분 중 ginsenoside는 주요 약효성분으로 인정을 받고 있으며 현재 품질관리의 지표성분으로 활용되고 있다. 이러한 개별 ginsenoside의 약리작용을 보면 서로 유사 또는 상반된 효과를 보여주는 성분들이 공존하고 있어 인삼의 다양한 약리효과와 일맥상통하는 것으로 보고되고 있다. 아울러, ginsenoside는 인삼의 부위 별로 현격한 차이를 보여주기 때문에 소재의 규격화는 매우 중요하다고 판단된다. 따라서, 인삼제품 개발의 가장 중요한 조건은 의약품에 가까운 기능성식품으로 세계적인 제품을 만들기 위해서는 표준화가 선행되어야 한다. 이와 같은 조건을 잘 충족시키는 제품이 스위스 "파마톤의 진사나(백삼추출물, G115)" 제품으로 생각할 수 있다. 따라서, 고려인삼의 수출시장 확대 및 세계적인 제품을 위해서는 진사나에 필적할 수 있는 새로운 홍삼의 표준화된 추출물을 도출하는 것이 무엇보다 급선무라 생각한다. 아울러 고려인삼의 특장점 발굴을 위한 표준화 된 추출분획물, 활성성분 및 효능과 연계한 새로운 고부가가치 창출제품(식품/의약품)개발에 주력해야 할 것이다.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.31 no.1
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• pp.35-38
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• 2020

Spasmodic dysphonia is a disease presumed to be a form of focal laryngeal dystonia. The widely used first-line treatment is botulinum toxin injection to the thyroarytenoid muscles. In spite of the effectiveness and safety of this method, it has a temporary effect that lasts only several months, resulting the patients' symptom fluctuating, called 'Botox rollercoaster.' Some surgical techniques had tried, but they had shown several limitations including high rate of recurrence. We tried thyroarytenoid myectomy with selective recurrent laryngeal nerve section in a patient with intractable spasmodic dysphonia. This procedure is an alternative treatment of spasmodic dysphonia to prevent recurrence and improve symptoms. During five years of follow-up, she has shown steady quality voice without any complication. To the best of our knowledgement, this is the longest follow-up case of this operation in South Korea.

• The Journal of Internal Korean Medicine
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• v.45 no.1
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• pp.111-118
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• 2024

This case report highlights the efficacy of traditional Korean medicine in treating chronic levator ani syndrome. A 47-year-old male suffered from chronic anorectal pain for 14 years. Over the last 5 months, the severity and frequency of the pain increased, and he was unresponsive to Western medicine and acupuncture outside Korea. The patient reported moderate anorectal pain from early morning until midday, affecting daily efficiency and concentration. The pain was triggered by defecation and alleviated by lying down. He was diagnosed with levator ani syndrome related to "cold symptoms of the liver and kidney - Yin", for which modified Nangan-jeon was prescribed. Indirect moxibustion (CV4, Ki1), Aconitum ciliare Decaisne pharmacopuncture (GV1, BL33), and acupuncture (HT7, ST36, SP6, LR3, LI4) were also administered weekly. After 8 weeks, the anorectal pain decreased by 2 points on a numeric rating scale, leading to patient satisfaction and return to his home country.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.316-317
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• 2000

양식 넙치의 스쿠티카충은 겨울에서 다음해 봄까지 육상넙치 양식장에서 발생하여 체표, 지느러미, 주둥이에 부종성 궤양을 형성하고 심한 경우에는 뇌에 침입하여 많은 폐사와 손실을 가져오는 난치성질병으로 알려지고 있다. 스쿠티카충에 관해서는 배양 및 분열(이 등, 1997), 분류·동정, 배양특성, 실험적 감염 및 발병에 미치는 물리·화학적 요인(지 등, 1999발표)에 대한 연구가 진행되고 있으며 일부에서는 실험적인 스쿠티카충 구제방법에 대한 연구(최 등,1997)가 있으나 양식현장에서의 치료률은 극히 낮은 실정이다. (중략)

• 건강소식
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• v.34 no.1
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• pp.38-39
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• 2010

담배를 끊는 사람들의 마음은 애절하다. 물론 애절함이 더 욱 크기에 완전한 '금연'에 도달하는 사람 또한 드물다. 매년 연말이 되면, 새해 꼭 지켜야 할 자신과의 약속 몇 가지를 품게 된다. 아마 흡연자들의 가장 큰 목표가 금연일 것이다. 하지만 지키기 가장 어려운 것 또한 금연이다. 매해 연초, 담배 판매량이 줄었다가도 이내 제자리로 돌아오는 것은 그만큼 금연이 힘들다는 방증이다. TV 뉴스에서는 흡연의 폐해를 수시로 보도하고, 대표적인 난치병인 각종 암을 소개할 때도 '흡연자가 비흡연자보다 발생률이 몇 배 더 높다'라는 멘트를 귀에 딱지 앉을 만큼 자주 듣게 된다. 이처럼 담배, 즉 흡연의 위험성을 알면서도 사람들은 왜 죽음(?)을 각오하면서 담배를 피우는 걸까?