• Proceedings of the Korean Society for Cognitive Science Conference
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• 2000.06a
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• pp.405-410
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• 2000

본 연구에서는 기능적 자기공명영상을 이용하여 한글 문장의 의미와 통사 처리에 관한 뇌의 활성화 양상을 비교함으로써 한글문장 이해의 과정에 대한 신경해부학적 증거를 찾고자하였다. 6명의 자원자를 대상으로 문장진위판다과제를 이용하여 활성화를 유도하였다. 1.5T 초전도 자기공명영상 장치에서 EPI로 BOLD 기법을 이용하여 기능적 영상을 얻었으며, 영상 후 처리는 SPM99 분석 프로그램을 이용하였다. 의미관련·통사관련 문장 모두 좌·우 전두회(frontal gyrus) 영역에서 활성화되었다. 의미와 통사처리 영역을 구분하기 위하여 감산법을 적용한 결과, 의미처리는 좌반구의 중측두회(middle temporal gyrus) 영역에서, 통사처리는 우반구의 하전두회(BA44) 부위에서 더 많이 활성화되었다. 의미처리에서 더 우세한 성향을 띠는 부위로 밝혀진 중측두회 영역은 의미처리시에 활성화되는 영역으로 보고하는 기존의 연구와 일치하는 결과이다. 의미와 통사 문장처리시의 뇌 활성화 양상은 뇌의 여러 영역에서 중첩되어 있기는 하지만, 특정영역에서의 차이를 보이고 있으므로, 의미와 통사처리기는 다른 기전(mechanism)에 의해서 일어남을 시사해 준다.

• Proceedings of the KSMRM Conference
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• 1999.11a
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• pp.118-118
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• 1999

• Proceedings of the KSMRM Conference
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• 1996.10a
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• pp.64-64
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• 1996

• Investigative Magnetic Resonance Imaging
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• v.12 no.1
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• pp.33-39
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• 2008

Purpose : There is debate concerning the observation of metabolite changes on MRS at the designated cortex during some tasks. The purpose of this study is to assess the change of the lactate content at the motor cortex during hand-grasping tasks with performing real-time fMRI-guided fMRS. Materials and Methods : Seven healthy volunteers (23-28 years old) underwent realtime fMRI during right hand grasping tasks with using a 1.5 T system. After confirming the activating area, single voxel MRS was preformed at 1) the baseline, 2) during the task and 3) after the task on the activating cortex. The three consecutive spectra were compared for observing the changes of the lactate content by the tasks. The Cho/Cr, NAA/Cr and Lac/Cr ratios were calculated manually from those spectra. Results : MRS during the tasks revealed the lactate peaks at the 1.33 ppm resonance frequency with great conspicuity at the activated area, which was identified on the real-time fMRI. After the task scan, the lactate peaks completely disappeared and the spectra recovered to the values of the baseline scan in all volunteers. At baseline, during the task and after the task, the Cho/Cr ratios were 0.81, 0.76 and 0.77, respectively, and the NAA/Cr ratios were 1.68, 1.65 and 1.72, respectively, and the Lac/Cr ratios were 0.28, 0.41 and 0.30, respectively. During the task, Lac was significantly increased by 46%. Conclusion : We observed prominent lactate peaks on MRS during hand-grasping tasks at the activated area, as was shown on the real-time fMRI. We suggest that fMRS can be used as a sensitive tool for observing the metabolite changes of the functioning brain.

• Investigative Magnetic Resonance Imaging
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• v.1 no.1
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• pp.42-50
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• 1997

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.106-106
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• 2001

목적： 일반인과 외상성 스트레스 장애환자들(PTSD)에서 동일한 공포 자극에 대한 기능적 뇌 자기ㆍ공명영상에서 뇌 활성화 부위의 차이를 알아보고자 하였다. 대상 및 방법： 대조군 (여자9명)과 외상성 스트레스 장애로(PTSD) 진단된 환자군 (여자9명)을 대상으로 하였고 모두 오른손잡이였다. 외상성 스트레스 장애군은 모두 교통사고와 관련되어 있었다. 1.5T MR 기기에서 EPI BOLD 기법을 이용하여 24개의 axial slice를 얻었으며, 시각자극으로 교통사고 현장 사진과 비교군으로 체크 무의 사진을 무작위로 배열하여 각각 1초씩 보여 주었다 (event related design). SOA (Stimulus Onset Asynchrony)는 3.5초로 하였고 전체 영상은 10분 동안 얻었다. 모든 환자에서 기능적 자기공명 영상은 1차례 시행하였다. 영상후 처리는 SPM 분석 프로그램을 사용하였으며 황성화 신호의 유의수준은 p=0.01을 기준으로 활성화 영상을 얻었다. 활성화 신호를 육안으로 비교 분석하였고 해마, 편도핵, 전전두엽의 활성화 정도를 중심으로 평가하였다.

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.6-12
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• 1999

Echo Planar Imaging (EPI) Spiral Scan 영상을 초고속 자기공명영상 기법으로서 전체 k-space의 데이터를 한번 scan에 다 받을 수 있기 때문에 데이터 측정시간을 100ms 이내로 단축시킬 수 있다. 이러한 초고속 영상 기법은 최근 활발히 연구되고 있는 뇌기능 영상과 관련하여 중요도가 더욱 커지고 있다. EPI는 직각좌표계에서 데이터를 받기 때문에 재구성은 비교적 쉬우나 eddy current를 많이 야기시키는 단점을 가지고 있다. 반면에 Spiral Scan 영상은 먼저 데이터를 원 또는 직각좌표계로 interpolation을 한 후 재구성하여야 하는 단점이 있으나, 상대적으로 eddy current가 작고, 방향과 무관하게 균일한 point spread function을 가지며, 혈류와 관련한 위상이 스스로 rephasing 되어 심장 영상 등에 유리한 장점이 있다.

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.53-59
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• 1999

Purpose : To evaluate the usefulness of functional MR imaging (fMRI) for language mapping and determination of language lateralization. Materials and Methods : Functional maps of the language area were obtained during word generation tasks and decision task in ten volunteers (7 right handed, 3 left-handed). MR examinations were performed at 1.5T scanner with EPI BOLD technique. Each task consisted of three resting periods and two activation periods with each period of 30 seconds. Total acquisition time was 162 sec. SPM program was used for the postprocessing of images. Statistical comparisons were performed by using t-statistics on a pixel-by- pixel basis after global normalization by ANCOVA. Activation areas were topographically analyzed (p>0.001) and activated pixels in each hemisphere were compared quantitatively by lateralization index. Results : Significant activation signals were demonstrated in 9 of 10 volunteers. Activation signals were found in the premotor and motor cortices, the inferior frontal, inferior parietal, and mid-temporal lobes during stimulation tasks. In the right handed seven volunteers, activation of language areas was lateralized to the left side. Verb generation task produced stronger activation in the language areas and higher value of lateralization index than noun generation task or decision task. Conclusion : fMRI could be a useful non-invasive method for language mapping and determination of language dominance.

• Journal of the Korean Society of Radiology
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• v.7 no.5
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• pp.305-311
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• 2013

This study involves an experiment using functional magnetic resonance imaging(fMRI) to delineate brain activation for execution functional performance. Participates to this experiment of the normal adult (man 4, woman 6) of 10 people, is not inserts the metal all closed phobia and 24.5 year-old average ages which the operating surgeon experience which are not they were. The subject for a functional MRI experiment word -color test prosecuting attorney subject rightly at magnetic pole presentation time of 30 first editions and after presenting, uses SPM 99 programs and the image realignment, after executing a standardization (nomalization), a difference which the signal burglar considers the timely order as lattice does, pixel each image will count there probably is, in order to examine rest and active crossroad dividing independence sample t-test (p<.05). Overlapped in this standard anatomic image and got a brain activation image from level of significance 95%. With functional MRI resultant execution function inside being relation, the prefrontal lobe, anterior cingulate gyrus, parietal lobe, orbitofrontal gyrus, temporal lobe, parietal lobe was activated. The execution function promotes a recovery major role from occupational therapy, understanding about the damage mechanism is important. When confirms the brain active area which accomplishes an execution function brain plasticity develops the cognitive therapeutic method which is effective increases usefully very, will be used.

• Proceedings of the KSMRM Conference
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• 2004.09a
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• pp.13-13
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• 2004