• KOGO NEWS
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• v.6 no.2
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• pp.9-19
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• 2006

• KOGO NEWS
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• v.6 no.2
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• pp.6-8
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• 2006

• The KIPS Transactions:PartD
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• v.18D no.2
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• pp.89-100
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• 2011

The CNV (Copy Number Variation) which is one of the genetic structural variations in human genome is closely related with the function of gene. In particular, the genome-wide association studies for genetic diseased persons have been researched. However, there have been few studies which infer the genetic function of CNV with normal human. In this paper, we propose the analysis method to reveal the functional relationship between common CNV and genes without considering their genomic loci. To achieve that, we propose the data integration method for heterogeneity biological data and novel measurement which can calculate the correlation between common CNV and genes. To verify the significance of proposed method, we has experimented several verification tests with GO database. The result showed that the novel measurement had enough significance compared with random test and the proposed method could systematically produce the candidates of genetic function which have strong correlation with common CNV.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.04a
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• pp.255-258
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• 2004

본 연구는 유전자 기능예측에 있어서 유사성 검색과 비교유전체학이 가진 한계를 극복하기 위하여 9종의 Human Herpesvirus를 대상으로 COG와 계통유전학적 방법을 적용하여 향상된 유전자 기능예측을 하고자 하였다. COG의 방법을 이용하여 114 HCOGs (Human Herpesvvirus COGs)를 구축하고, HCOGs를 바탕으로 유전자 컨텐츠트리를 제작하였다. 이 트리를 통하여 각 HCOG는 $\alpha$-특이적 그룹, $\beta$-특이적 그룹, $\alpha$, $\beta$, ${\gamma}$ -특이적 그룹 중 하나에 속함을 보였다. 계통유전체학의 적용을 위하여 u, $\beta$, ${\gamma}$ -특이 그룹에 속하는 ORF중 DNA polymerase를 이용하여 종트리를 제작하였다. SDI (Speciation and Duplication) 알고리즘을 통하여 148개의 당단백질에서 47개의 복제점을 예측하였고, 초기 HCOG의 제작에서 제외되었던 7 ORF는 당단백질과 관련된 5개의 HCOG로 재 정의 하였다. 이 연구를 통하여 COG는 ortholog 그룹을 를러스터링하는데 효과적인 방법이며, 이를 더욱 보완할 수 있는 방법으로 비교유전체학이 사용될 수 있음을 확인하였다. 이는 비교유전체학의 방법과 계통유전체학적 방법을 조화시켜 유전자 기능 예측을 보완할 수 있음을 보여 주었다.

• Journal of the Korean Society of International Agriculture
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• v.23 no.5
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• pp.560-569
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• 2011

In Japan, plant genomics research is mainly leaded by the national research institutes. The various structural studies such as rice genome has allowed researchers to analyze useful traits, and to focus their commercialization. With aims to facilitate structural and functional study in plant genome, NIAS (National Institute of Agrobiological Sciences) constructed Poaceae genome DB and RIKEN (Rikagaku Kenkyusho) built DB for Arabidopsis genome and plant full-length cDNA. NIG (National Institute of Genetics) constructed a national biological resources DB (National Bio Resource Project). This compiling DB provides a variety of genome-related research materials for researchers in the field. Recently, as an effort to resolve global issues of food supply and environmental problems, New Agri-genome Project has been performed aiming to develop an innovative agricultural technologies for the quantity, disease resistance and identifying useful genes related to environmental problems. In addition, in order to improve agricultural productivity in developing countries, JIRCAS assisted technical supports for the plant genome research and developed NERICA rice, which is suitable for African area. Such these approaches are expected to contribute to solving the global issues about food, energy and environment in the world.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.07b
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• pp.635-638
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• 2004

페로브스카이트 구조를 가지는 $CaZrO_3$ 유전체 세라믹스에 $CaTiO_3$를 부피 비율로 첨가하여 첨가량 변동에 따른 마이크로파 유전 특성을 조사하였다. 또한 저온 동시소성 기능성 LTCC 기판용 유전체 소재로서 활용하기 위하여 저융점의 borosilicate계 유리 프리트를 첨가하여 $CaZrO_3-CaTiO_3$ 복합 유전체 세라믹스의 저온 소결 거동과 마이크로파 유전 특성을 평가하였다. 알칼리가 첨가된 저융점의 borosilicate계 유리 프리트를 $10\sim30$ wt% 범위로 첨가함으로서 $CaZrO_3-CaTiO_3$ 복합 유전체 세라믹스의 소결온도를 $1450^{\circ}C$에서 $900^{\circ}C$이하로 낮출 수 있었으며, 유리 프리트의 첨가량으로 공진 주파수 온도계수 특성을 조절할 수 있었다. 유리 프리트의 첨가량이 15 wt% 첨가시 $875^{\circ}C$에서 충분한 소결이 이루어졌으며, 이 경우 $CaZrO_3-CaTiO_3$ 복합 유전체 세라믹스는 유전율(k) 23, 품질계수(Qxf) 2500, 공진 주파수 온도계수 ($\tau_{cf}$) -3 ppm/$^{\circ}C$의 매우 양호한 마이크로파 유전 특성을 나타내었다. 유리 프리트의 첨가에 의하여 소결 과정에서 주상인 $CaZrO_3$가 $CaZr_4O_9$ 상으로의 변화가 뚜렷이 나타났는데, 이러한 상전이 현상과 함께 미세구조의 변화에 대해서도 고찰하였다.

• Journal of Plant Biotechnology
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• v.37 no.2
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• pp.166-173
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• 2010

The purpose of functional genome research is to identify biological function of useful gene and to give an agricultural value in plant biotechnology. Brassica rapa is an economic crop which recorded 1,000 billion won of domestic market and 100 million dollar of exports and it produces 2.5 million ton in 50,000 ha as a major ingredient of representative Korean food, Kimchi. Furthermore, it is very important crop economically and commercially because Korea is major seed exporter. The fact that Multinational Brassica Genome Project (MBGP) was launched and Arabidopsis thaliana, affiliated to same genus with B. rapa, has been fully sequenced activated functional genome research of B. rapa. Besides new technologies related to gene function analysis keep developing, many results are reporting every year by international research including Korea. This review paper introduces development of Chinese cabbage mutants which is a first step in functional genome research, variant phenotypes of mutants, flanking DNA analysis in B. rapa genome, gene identification, gene analysis using microarray, and representative researches.

• Korean Journal of Breeding Science
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• v.50 no.4
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• pp.364-377
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• 2018

Hexaploid wheat (common wheat/bread wheat) is one of the most important cereal crops in the world and a model for research of an allopolyploid plant with a large, highly repetitive genome. In the heritability of agronomic traits, variation in gene presence/absence plays an important role. However, there have been relatively few studies on the variation in gene presence/absence in crop species, including common wheat. Recently, a reference genome sequence of common wheat has been fully annotated and published. In addition, advanced next-generation sequencing (NGS) technology provides high quality genome sequences with continually decreasing NGS prices, thereby dawning full-scale wheat functional genomic studies in other crops as well as common wheat, in spite of their large and complex genomes. In this review, we provide information about the available tools and methodologies for wheat functional genomics research supported by NGS technology. The use of the NGS and functional genomics technology is expected to be a powerful strategy to select elite lines for a number of germplasms.

• Proceedings of the Korea Information Processing Society Conference
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• 2013.11a
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• pp.1340-1342
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• 2013

최근 대량으로 발생되고 있는 유전체 정보 해석 과정 중의 하나로 유전체 내에서 유전자 기능 분석을 수행하기 위하여 본 논문에서는 C-Hunter 알고리즘을 이용하여 계통 발생 다양성을 대표하는 8종의 생물데이터를 이용하여 유전자 클러스터들을 다양한 OS에서 GUI환경으로 기능 해석을 수행 할 수 있도록 구현하였다. 본 연구를 통하여 NGS 수행 시 대량 생산되는 유전체의 유전자 기능 분석을 보다 빠르고 정확하게 다양한 환경에서 수행할 수 있을 것으로 기대한다.

• The KIPS Transactions:PartD
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• v.13D no.2 s.105
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• pp.207-214
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• 2006

Though the number of completely sequenced genomes quickly grows in recent years, the methods to predict protein functions by homology from the genomes have not been used sufficiently. It has been a successful technique to construct an OPCs(Orthologous Protein Clusters) with the best reciprocal BLAST hits from multiple complete-genomes. But it takes time-consuming-processes to make the OPCs with manual work. We, here, propose an automatic method that clusters OPs(Orthologous Proteins) from multiple complete-genomes, which is, to be extended, based on INPARANOID which is an automatic program to detect OPs between two complete-genomes. We also Prove all possible clustering mathematically.