• 대한한방내과학회지
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• 제26권4호
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• pp.785-794
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• 2005

Little is known concerning the pathophysiology and symptomatology of gastric dysmotility of patients who have sought treatment in eastern traditional medicine. The aim of this study was to investigate gastric electrical activity and clinical characteristics between gastroparesis and non-gastroparetic functional dyspepsia(FD) and assess the necessity to distinguish them for eastern traditional medical treatment. 60 patients were surveyed by questionnaire. Gastric electrical activity was recorded and analyzed using electrogas-trography. Patients were divided into gastroparesis and non-gastroparetic FD by 1.0 of power ratio. Healthy persons were used as reference. Postprandial normogastria of gastroparesis decreased and that of non-gastroparetic functional dyspepsia increased compared before and after meals. Suggested causes of onset were the meat diets that most patients were on in the gastroparesis group, and that drugs that patients in the non-gastroparetic FD group were taking. Distribution of main symptom was equally regular in patients with gastroparesis, but patients with non-gastroparetic FD showed mainly upper abdominal pain and fullness. Values for the gastroparesis group were double those for the non-gastroparesis FD group in frequency of upper GI endosopic examination. Results suggest that effective application of eastern traditional medical treatment requires that first a clear distinction be made in state of gastric dysmotility and clinical characteristics of gastroparesis and non-gastroparesis FD when treating dyspepsia.

• 대한한방내과학회지
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• 제42권4호
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• pp.488-509
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• 2021

Purpose: Functional dyspepsia (FD) is a chronic syndrome accompanied by repetitive digestive symptoms that appear in the upper gastrointestinal tract and are not caused by specific diseases. Psychological symptoms like anxiety, depression, insomnia, and somatization are frequently observed in FD. The purpose of this study was to review the effect of herbal medicine on the psychological symptoms that accompany FD. Methods: Database search (PubMed, EMBASE, KISS, Kmbase, KoreanMed, NDSL, OASIS, CNKI) was performed on February 24, 2021; a total of 1825 studies were searched. After the screening, 22 studies were included. Results: The studies were assessed by Cochrane RoB 2 and sorted into a table according to psychological symptoms. Meta-analysis was performed to estimate the effect of herbal medicine. Twenty of the twenty-two studies reported that herbal medicine was significantly more effective than the control group. Only three of the studies did not have a high risk of bias. Conclusion: Herbal medicine was significantly effective with or without Western medicine and had fewer adverse effects. Severe adverse effect was not reported. Psychological symptoms in FD affect onset and duration of FD, and some FD patients want to be treated for their anxiety before other symptoms. Reliable information about treatment for the psychological symptoms of FD is lacking. We reviewed the effect of herbal medicine treatment in this study, the results of which could be selected for primary or secondary treatment for FD.

• 생명과학회지
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• 제29권6호
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• pp.735-739
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• 2019

용담(Gentiana scabra)의 근경 및 뿌리를 말린 한약재는 우리나라, 중국, 일본을 포함하는 동아시아 지역에서 아주 오래 전부터 각종 염증성 피부 질환, 소화불량, 식욕부진, 위염, 당뇨병 등의 치료를 목적으로 한의학에서 널리 처방되어 왔다. 본 연구에서는 용담이 위장관 운동 기능에 미치는 영향을 검정하기 위해 용담의 열수 및 에탄올 추출물을 각각 제조하였으며, 마우스에서 in vivo 위 배출 속도 및 위장관 이송률을 측정하는 실험을 수행하였다. 위 배출 속도는 용담 열수 추출물 1 g/kg 투여 시 유의적으로 증가하였다. 위장관 이송률은 용담 열수 추출물 0.1 및 1 g/kg 투여 시, 그리고 용담 에탄올 추출물 1 g/kg 투여 시 유의적으로 증가하였으며, 두 추출물 모두 용량 의존적 증가 양상을 보였다. 더욱이, 용담 열수 추출물 1 g/kg 투여 시의 위장관 이송률은, 1990년대까지 임상에서 가장 강력한 위장관 운동 촉진제로 쓰였으나 2000년 이후 부작용으로 시장에서 철수된 약물인 cisapride 투여 시보다 그 수치가 높았다. 이러한 결과들은 용담 열수 추출물이 잠재적으로 cisapride를 대체할 수 있는 위장관 운동 촉진제로 개발 가능한 후보 물질임을 시사한다.

• 대한한방내과학회지
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• 제26권2호
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• pp.390-397
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• 2005

Background & Object: The aim of this study was to investigate the association of degree of fatigue and gastric motility, measured by EGG, with skin sympathetic tone or cardiovascular reactivity in patients with functional dyspepsia. Methods: Subjects were 56 patients with Functional dyspepsia and eight healthy people. Degree of fatigue was assessed by questionnaires consisting of subjective complaints of fatigue. Skin sympathetic tone was measured by Ryodoraku Score and Cardiovascular Reactivity was checked by Pulse diagnostic apparatus. Gastric motility was estimated by EGG. First, all patients were divided into two groups by Ryodoraku Score $40{\mu}A$(below and above). Second, they were subdivided into two groups by Cardiovascular Reactivity(decreased and increased or not decreased). Estimates were made on the extent differences of degree of fatigue or state of gastric motility in each group. Results: 1. Fatigue scores was significantly higher in females and in the Ryodoraku-Score-below-$40{\mu}A$ group. It was higher in the decreased cardiovascular reactivity group than the increased group, but to no significanct extent. Also, gastric motility was better in the Ryodoraku-Score-above-$40{\mu}A$, group than in the below group. Conclusions: These results suggest that degree of fatigue and gastric motility are associated with skin sympathetic tone, but not associated with cardiovascular reactivity, and that $40{\mu}A$ is a useful cutoff point in Ryodoraku Score for assessing degree of fatigue in functional dyspepsia patients.

• 대한한방내과학회지
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• 제27권2호
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• pp.510-520
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• 2006

Objectives: The aim of this study was to investigate the correlation between fatigue degree and Comprehensive diagnosis of Qui Xui Shui in patients with functional dyspepsia. There again, we investigated an association between scores obtained from Comprehensive diagnosis of Qui Xui Shui and state of skin sympathetic tone or cardiovascular reactivity. Methods: Subjects were 56 patients with Functional dyspepsia and 8 healthy People. Fatigue degree was assessed by questionnaires consisting of subjective complaints of fatigue. Comprehensive diagnoais of Qui Xue Shui was investigated by questionnaire and physical examination, total score and composition score were calculated from the symptom score. Skin sympathetic tone was measured by Ryodoraku Score(RS) and Cardiovascular Reactivity(CV Reactivity) was checked by Pulse diagnostic apparatus. All patients were divided into two groups by RS $40{\mu}A$(below and above) or by CV Reactivity(decreased and increased or not decreased). Results: There was highly significant correlation between Fatigue Degree and total score and each composition score of Comprehensive diagnosis of Qui Xui Shui. And total score of patients was significantly higher than that of health controls : in the patients, females than males. Significance related with the level of RS $40{\mu}Aor$ the state of CV Reactivity were not remarkable in both patients and health control group. Conclusions: Fatigue degree seems to have a special feature reflecting the state of Comprehensive Diagnosis of Qui Xui Shui in patients with functional dyspepsia.

• 대한한방내과학회지
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• 제25권4호
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• pp.346-355
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• 2004

Background & Object : The aim of this study was to investigate the usefulness of electrogastrography on differential diagnosis of deficiency or excess Condition in patients with functional dyspepsia Methods : Selected symptoms for diagnosis of deficiency and excess in functional dyspepsia have been reviewed in some literatures, notably within Oriental medicine, Donguibogam and Gogeumdoseojipseong-uibujeolrok. This is what was investigated in this study. 93 patients (male 32, female 61) were divided into three groups; Non-pain group, Pre-treatment pain group (chief complain was abdominal pain at the first medical examination), and Mid-treatment pain group(they had no pain at the time of first medical examination, but showed abdominal pain within two weeks). 10 healthy people participated as normal controls. Gastric motility were recorded and analyzed using electrogastrography during fasting and postprandial period. In assessment, effectiveness was divided into validity, sensitivity and specificity. Results : Epigastric pain reflected the tendency for excess condition in comprehensive diagnosis, which was linked with postprandial arrhythmia in electrogastrography(p=0.001). Postprandial arrhythmia detected abdominal pain with a validity of 78.6%, a sensitivity of 79.2%, and a specificity of 78%(p<0.001). Conclusions : Results 1Tom Postprandial arrhythmia in electrogastrography support that the index of excess condition in the comprehensive diagnosis of symptoms is useful for patients with functional dyspepsia.

• Journal of Applied Biological Chemistry
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• 제64권3호
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• pp.245-251
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• 2021

더덕(Codonopsis lanceolata)은 주로 한국, 중국 등 동아시아 지역에 재배되고 있으며, 더덕의 뿌리는 기침, 기관지염, 천식, 결핵, 소화 불량의 증상을 치료하기 위한 기능성 식품 및 전통 의학으로 사용되어져 왔다. 보고된 바에 의하면 phenylpropanoids, polyacetylenes, saponins, flavonoids와 같은 다양한 식물 천연물 성분들이 항비만, 항염, 항암, 항산화, 항미생물 활성과 같은 약리학적 작용에 관여한다고 보고되어 있다. MS기반 대사체학 분석을 이용한 주산지의 마커 성분을 선정하는 것은 다른 지역에서 재배된 약용 식물의 안전성뿐만 아니라 화학적 조성과 생물학적 효능의 변화와도 관련이 있기 때문에 부작용 없이 더덕의 유익한 효과만을 보장하는데 중요하다. 본 연구에서는 국내산 더덕의 주산지 특성을 구별하기 위해 UPLC-QTOF-MS를 기반으로 하는 대사체 프로파일링과 다변량 통계분석 기법인 PCA 분석을 수행하여 판별모델을 확립하였다. 그 결과 인제(강원도), 횡성(강원도), 무주(전라북도)의 3개 그룹이 PCA와 loading plot 분석결과 tangshenoside I, lancemaside A, lancemaside G는 더덕 주산지를 구별하기 위한 잠재적 대사체 마커들로 제안하였다.

• 한국식품위생안전성학회지
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• 제28권4호
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• pp.330-336
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• 2013

현재 대황은 지표성분의 규격이 한국, 일본과 중국이 다르고, 유통시장에서 대황과 종대황이 혼재되어 있으며 다양한 기원식물이 혼재되어 수입되고 있다. 따라서 대황의 효능을 현대 약리학적으로 해석하는 과정을 통해 약재의 표준화, 과학화 및 위염에 대한 지표성분 검색에 기여할 수 있을 것으로 사료되어 Rheum tanguticum(당고특대황)과 그 비교생약으로 Rumex cripus(양제근), Rheum officinale(약용대황), Rheum palmatum(장엽대황) 및 Rheum undulatum(종대황)의 물 및 70% 에탄올 추출물을 비교하였다. 그 결과, 흰 쥐를 이용한 위염 모델에서 양제근 70% 에탄올 추출물(73.2%)와 종대황 물 추출물(71%)이 각각 70% 이상으로 우수한 위손상 억제활성을 보여주었지만, 당고특대황의 70% 에탄올 추출물 투여시 91.8%로 실험군 중 가장 우수한 위염 억제 효과를 확인할 수 있었다. 공격인자로써의 산을 중화시킬 수 있는 능력을 알아보기 위한 제산력 시험법으로는 당고특대황 물 추출물과 70% 에탄올 추출물이 각각 약 14.2%, 약 15.8%로 억제함을 알 수 있었다. 이 결과로 보아 양성대조군으로 사용한 hydrotalcite(49.9%)보다는 제산작용이 약하였지만 과량 혹은 장기간 복용하면 효과가 있을 것으로 생각된다. 소화성궤양, 위암 및 변연부 B세포 림프종 발생에 있어 중요한 원인 인자로 밝혀졌고, 기능성 소화불량증, 위의 과형성 용종, 철결핍성 빈혈 등 기타 질환과의 연관성들이 제시되고 있는 H. pylori에 대한 colonization 억제 활성을 확인한 결과 당고특대황의 70% 에탄올 추출물 $100{\mu}g/mL$에서 H. pylori에 대한 항균작용(+)을 확인할 수 있었다. DPPH 용액을 이용하여 free radical의 소거능을 $IC_{50}$으로 나타낸 결과, 당고특대황은 물 및 70% 에탄올 추출물에서 $IC_{50}$이 $25.9{\mu}g/mL$, $5.8{\mu}g/mL$로 양성대조군으로 사용한 L-ascorbic acid ($IC_{50}=6.5{\mu}g/mL$)와 유사한 free radical 소거능을 나타내었다. 이 결과로 당고특대황의 70% 에탄올 추출물이 휜 쥐 위염모델의 위손상을 가장 우수하게 억제하였으며 항산화 활성 또한 가장 우수한 것으로 확인되었다. 당고특대황의 성분인 chysophanol, chrysophanol-8-O-glc, desoxyrhaponticin desoxyrhapontigenin, emodin, isorhaponticin, 2-methoxy-4-hydroxyanthraquinone-5-O-glc, physcion, piracetannol-3'-O-glc, resveratrol, rhaponticin 및 rhapontigenin을 이용하여 실험한 결과로는 효성분들 중 physcion $100{\mu}M$과 rhaponticin $50{\mu}M$ 및 $100{\mu}M$에서는 실험에 사용한 성분 들 중 비교적 우수한 colonization 억제작용(+)을 나타내었고, DPPH radical 소거 활성은 isorhaponticin, piracetannol-3'-O-glc, resveratrol 및 rhaponticin에서 $IC_{50}$이 각각 $129.5{\mu}M$, $94.1{\mu}M$ $80.1{\mu}M$ 및 $104.6{\mu}M$로 확인되었다. 실험결과를 토대로 항위염 효과가 있는 우수한 약용식물로써 천연물 의약품개발 가능성을 확인하였고 나아가 한약재의 효능을 과학적으로 검증하고 한약재 표준화에 기여할 수 있을 것으로 기대된다.

• 대한한방내과학회지
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• 제26권2호
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• pp.360-368
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• 2005

Background & Object: The aim of this study was to investigate the effects of Traditional Korean medical therapy on gastric myoelectrical activity in patients with functional dyspepsia. Methods: 29 patients(male 10, female 19) were divided into two groups; Inpatient group(N=10, male 1, female 9) and outpatient group(N=19, male 9, female 10). 10 healthy people participated in this study as normal controls. Gastric motility was recorded and analyzed by electrogastrography(EGG) during fasting and postprandial periods. Hospital treatment included electroacupuncture on ST36, acupuncture, and herbal medicine. Outpatients were treated with herbal medicine and acupuncture. Inpatients underwent hospital treatment for two weeks, and after discharge they were treated as outpatients for six weeks. In inpatient group, EGG was recorded before and after hospital treatment and it was recorded at six weeks after discharge. In outpatient group, EGG was recorded before starting treatment and it was recorded once a every six weeks for twelve weeks. Results: There was no significant difference in EGG parameters between before and after therapy in outpatient group. In inpatient group, postprandial normal slow wave increased after hospital treatment(from $33.94{\pm}14.13$ to $62.63{\pm}20.18$, p<0.05) and postprandial tachygastria decreased(from $43.53{\pm}13.99$ to $28.30{\pm}16.63$, p<0.05) and arrhythmia decreased(from $20.35{\pm}15.91$ to $5.67{\pm}6.80$, p<0.05). Conclusions: Results suggest that hospital treatment through electroacupuncture on ST36, acupuncture, and herbal medicine is useful to improve gastric myoelectrical activity in Patients with Functional Dyspepsia.

• Journal of Acupuncture Research
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• 제24권1호
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• pp.1-12
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• 2007

Objectives : Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this research is to examine the effect of acupuncture treatment for functional dyspepsia. Methods : In this randomized, single blind, placebo-controlled study, we compared active acupuncture with sham acupuncture for the treatment of functional dyspepsia. Volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index(NDI) and Functional Dyspepsia Quality fo Life(FD-QOL) before and after treatments. Results : 68 subjects finished study. There were not difference between two groups on age, sex, weight, height, severity of dyspepsia, subtype, Byeonjeung, surmise of treatment. After treatment total key symptoms score, improve rate of key symptoms were decreased than before treatment in active acupuncture group, but there were no statistical significance compared with sham acupuncture group. After treatment "pressure in upper abdomen" and " cramps in upper abdomen" were more decreased in active acupuncture group compared with sham acupuncture group(p=0.001, p=0.014). After treatment total symptom score and QOL of NDI were decreased than before treatment in active acupuncture group, but there were no statistical significance compared with sham acupuncture group. After treatment eating status of FD-QOL in active acupuncture group was significantly increased than sham acupuncture group(p=0.008). After treatment liveliness status of FD-QOL and total score of FDQOL in active acupuncture group was increased than sham acupuncture group though statistically insignificant(p=0.095, p=0.077). Conclusion : Acupuncture treatment is effective to improve the symptoms and quality of life in patients with functional dyspepsia.