• Journal of Life Science
• /
• v.32 no.3
• /
• pp.263-269
• /
• 2022

Cancer cachexia-anorexia is a multi-organ metabolic syndrome characterized by anorexia and weight loss. Generally, such symptoms are a serious problem in cancer patients, adversely affecting chemotherapy success and survival rate. Cachexia has been reported to accompany up to 80% of gastrointestinal cancers, such as pancreatic, lung, and colon cancer, though it is relatively rare in lymphoma or breast cancer patients. It is also known that cancer-induced anorexia occurs independently of chemotherapy, although decreased appetite due to chemotherapy is well reported. In terms of pathoflammatory cytokines that are excessively increased by tumor tissues. Since the mechanism of cancer cachexia is not yet fully understood, there are currently no therapeutic agents or diagnostic markers to treat it. A recently published study identified a substance secreted from cancer cells that induces cancer anorexia, and the molecular mechanism causing the eating disorder was discovered. An increase in the expression of this substance has been shown to be statistically correlated with the symptoms of cachexia in cancer patients, and it is therefore expected to be applicable in the diagnosis and development of therapeutic agents for cancer cachexia. This review article aims to provide an overview of the key molecular mechanisms of the anorexia and tissue wasting caused by cancer cachexia.

• Korean Journal of Head & Neck Oncology
• /
• v.31 no.2
• /
• pp.29-35
• /
• 2015

목적 : 국소 재발한 진행된 갑상선 유두암의 치료로 수술 후 외부방사선의 역할을 알아보고자 하였다. 대상 및 방법 : 원자력병원에서 2000년 1월부터 2012년 2월까지 사이버나이프 혹은 외부방사선 치료를 받은 수술과 방사선요오드 치료 후 국소 재발한 진행된 갑상선 유두암 환자 13 명을 대상으로 하였다. 경과관찰 기간 동안 국소 및 부위 재발이 발생환 환자는 6 명이었다. 몇몇의 위험인자를 찾기 위해서 Kaplan-Meier method와 log-rank test를 이용하여 성별, 종양단계, 방사선 치료 전 수술 횟수, 방사선요오드치료 횟수, 수술 후 잔존 암의 여부, 원격전이에 대해 단변량 분석하였다. 결과 : 방사선 치료 후 평균 추적관찰기관은 53.8개월(범위, 36 ~ 108개월)이고 그중 남자는 4 명이었다. 1년, 2년의 무진행 생존률은 각각 76.9와 53.8%였다. 단병량 분석은 성별과 잔존 암여부(p = 0.0475 and p = 0.0475, 각각)에 따라 무진행 생존률이 진행한 그룹과 진행하지 않은 그룹 사이에 유의한 차이가 있다는 것을 보여줬다. 결론 : 외부 방사선 치료 전에 잔존 암이 없었던 환자의 100%에서 국소 및 부위 재발이 일어나지 않았다. 외부방사선 치료는 수술과 방사선요오드 치료에 반응하지 않는 환자 중 수술 후 잔존 암이 없는 경우에 효과적인 치료 방법이 될 수 있다.

• Journal of the Korea Convergence Society
• /
• v.8 no.10
• /
• pp.115-124
• /
• 2017

The purpose of the study was to investigate the convergence factors to posttraumatic growth(PTG) in survivors with female urogenital neoplasm survivors. A self-reported questionnaire was completed by 141 female urogenital neoplasm survivors via e-mail from September to October, 2016. The questionnaire consisted of PTG inventory, illness intrusiveness rating scale, cancer coping, family cohesion evaluation scale, and medical outcomes study social support survey. The data were analyzed by ANOVA, Pearson-correlation coefficient, and multiple regression analysis. Total score of PTG was 84.13points and statistically significant according to age, religion, marital status and positively associated with coping, family cohesion and social support. Results of the regression analysis showed religion(${\beta}=.127$), marital status(${\beta}=.081$), coping(${\beta}=.232$) and family cohesion(${\beta}=.415$), it were explained 44.7%. This study indicates that it is important to understand general characteristics of personal. And a convergent approach is needed to promote PTG by hospital and community.

• The KIPS Transactions:PartB
• /
• v.16B no.2
• /
• pp.165-172
• /
• 2009

According to the American Cancer Society, breast cancer is the second largest cause of cancer deaths and most frequently diagnosed cancer in women. The currently most popular method for early detection of breast cancer is the digital mammography. A mass or calcification lesion has been known as the most important clue for the diagnosis. In this paper, we propose a diagnosis approach based on fuzzy cluster knowledge base. We combine different two sources of feature data in duel OFUN-NET and produce the diagnosis result with possibility degree. We also present the experimental results on the dataset of mass and calcification lesions extracted from the public real world mammogram database DDSM. These results show higher classification accuracy than conventional methods and the feasibility as a decision supporting tool for diagnosis of digital mammogram.

• Korean Journal of Head & Neck Oncology
• /
• v.32 no.1
• /
• pp.21-23
• /
• 2016

The aim of this report was to present a rare case of a tracheotomy site recurrence after operation and post-operative radiotherapy in head and neck squamous cell carcinoma patient. Tracheotomy site recurrence other than subglottic cancer is very rare in head and neck cancer patient. The granulation tissue around tracheotomy was a fertile "soil" for tumor cell implantation. Midline mucosal sparing block which was used to decreased acute toxicity during post-operative radiotherapy could be facilitating the tumor cell implantation. The head and neck surgeon should try every effort to reduce contamination of cancer cells during operation and consider the entire operative field should be included in post-operative radiation portals.

• Korean Journal of Bronchoesophagology
• /
• v.17 no.1
• /
• pp.14-18
• /
• 2011

The diagnosis and treatment of early gastrointestinal cancers is the gastroenterologists' mission because of national cancer screening program in South Korea. The detection of early cancers is emphasized, because these were previously treated with surgical treatment can be currently cured with endoscopic treatment. Gastroenterologists who achieved at least on some level can make an exact diagnosis regardless of what type of endoscopy, but generally, there are some required conditions for an optimal diagnosis. First, clinically important lesions have to be detected easily. Second, the border and morphology of lesions have to be characterized easily. Third, lesions have to be diagnosed exactly. Precancers and early cancers are often subtle and can pose a challenge to gastroenterologists to visualize using standard white light endoscopy. The use of dye solutions aids the diagnosis of early gastrointestinal cancers, however, it is a quite cumbersome to use dye solutions all the time and the solution often bothers the exact observation by pooling into the depression or ulceration of the lesion. To overcome this weakness, newer endoscopes are now developed so called "image enhanced endoscopy" using optical and/or electronic methods such as narrow band imaging (NBI), autofluorescence imaging (AFI), i-scan, flexible spectral imaging color enhancement (FICE) and confocal endomicroscopy (CLE).

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1991.06a
• /
• pp.16-16
• /
• 1991

렉틴(Lectins)은 세포막의 당단백질의 과당류 말단기에 특이적으로 결합하는 비면역성의 당단백질 혹은 단백질을 말하는데 정상세포와 변형된 세포에서 렉틴반응의 차이가 남으로써 요즘에는 렉틴을 병리학적 진단에 이용 가능하게 되었다. “Loss of contact inhibition”은 세포 악성화의 중요한 특징으로 세포의 악성화는 세포막의 구조의 변화와 관계가 있을 것으로 알려져 왔으며 1989년 후두암에서 PNA의 반응이 양성 반응을 나타낸다고 보고되어 저자들은 7가지의 렉틴을 이용하여 후두암전구증의 하나인 후두각화증에서 이형성(Atypia)의 존재유무에 따른 렉틴 반응의 변화를 알아보고자 본 연구를 시행하여 다음과 같은 결과를 얻었다. 1. 이형성이 없는 단순 후두각화증에서는 Con A와 WGA만이 기저세포에 반응이 있었으며, 후두각화증의 가장 중요한 부위인 극세포층에서는 WGA, RCA-I, PNA, SBA, UEA-I, DBA가 세포질에는 반응이 없이 세포간교에만 염색이 되는것을 관찰할 수 있었고 Con A는 반대로 극세포층의 세포질에 반응을 하였으나 세포간교에는 반응이 없었다. 2. 이형성을 동반한 후두각화증에서, 기저세포에서는 반응의 차이가 없었고 극세포층에서는 UEA-I, RCA-I. WGA, PNA, SBA는 세포간교에서 반응이 나타나지 않았고 세포질에서 양성 반응을 관찰 할 수 있었으며 DBA, Con-A에서는 반응의 차이를 관찰 할 수 없었다. 따라서 후두각화증의 극세포층 세포막에서 UEA-I, RCA-I, WGA, PNA, SBA 반응의 소실은 후두암으로의 진행과 밀접한 관계가 있는 이형성의 존재를 암시한다하겠다.

• Journal of Hospice and Palliative Care
• /
• v.18 no.4
• /
• pp.322-328
• /
• 2015

Purpose: The aging of society has rapidly progressed, especially in Korea. Therefore, the necessity of research on end-of-life (EOL) care in elderly patients has increased. However, there are few studies on EOL care intensity for non-cancer patients. This study was designed to compare the EOL care intensity between cancer and non-cancer patients. Methods: We retrospectively analyzed the EOL care intensity based on medical records of decedents of Kyung Hee University Medical Center, a tertiary referral hospital from December 2014 through March 2015. And we compared EOL care intensity between cancer patients and non-cancer patients using statistical analysis of the frequency of invasive procedures and logistic regression analysis for factors that affect the EOL care intensity. Results: Statistical analysis showed invasive procedures, such as intensive care unit admission, endotracheal intubation followed by mechanical ventilation and emergency dialysis, were performed more frequently in non-cancer patients than cancer patients (29.3% vs. 72.4%, P<0.001). And age (P=0.038) and morbidity of cancer (P<0.001) influenced the invasive procedural decision when analyzed by logistic regression analysis. Conclusion: The EOL care was more intensive in non-cancer patients, and age and morbidity of cancer were major factors for the treatment intensity.

• Korean Journal of Bronchoesophagology
• /
• v.2 no.2
• /
• pp.222-226
• /
• 1996

The increasing incidence of multiple primary carcinomas occuring in the upper aerodigestive tract is well documented, with the accepted incidence being as high as 20-30%. The fiberoptic endoscopy has also enabled visualization of areas previously inaccessible without general anesthesia. A prospective panendoscopic examination of the upper aerodigestive tract was peformed on 104 patients with squamous cell carcinoma of head & neck in our hospital between 1989 and 1994. Five second primary cancers (4.8% ：2 stomach, 2 esophagus, 1 lung cancers) were detected endoscopically. These finding should reinforce the belief that head & neck cancer is a panmucosal disease of the aerodigestive tract that silent second primary cancers are not uncommon. So every effort should be done to detect second primary cancers in head & neck squamous cell carcinomas. Panendoscopy has proved valuable in achieving that.

• Korean Journal of Bronchoesophagology
• /
• v.4 no.2
• /
• pp.225-230
• /
• 1998

Mucoepidermoid carcinoma of the lung is a very rare and potentially malignant tumor that arises from submucosal gland of the trachea and bronchi. We experienced two cases of mucoepidermoid carcinoma which was located in the left main bronchus and right intermediate bronchus. They were treated with left sleeve resection and right bilobectomy. Postoperative course was uneventful, and the followed up for each of them was 3 year and 18 months without any evidence of recurrence.