• Childhood Kidney Diseases
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• v.13 no.2
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• pp.170-175
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• 2009

Purpose : FSGS do not respond well to any kind of therapy and gradually progress to end-stage renal disease. This study was conducted to investigate the difference of protein expression between MCNS and FSGS as a preliminary study for understanding the pathophysiology of FSGS. Methods : Renal biopsy samples of MCNS and FSGS were obtained, which was diagnosed by one pathologist. They were solubilized with a conventional extraction buffer for protein extraction. The solution was applied on immobilized linear gradient strip gel (pH 4-7) using IPGphor system. Silver staining was carried out according to standard method. Protein identification was done by searching NCBI database using MASCOT Peptide Mass Fingerprint software. Results : The differences in protein expressions between MCNS and FSGS were shown by increased or decreased protein spots. Most prominently expressed spot among several spots in FSGS was isolated and analyzed, one of which was glutathione S-transferase (GST) P1-1, whereas it was not found in MCNS. So GSTP1-1 was considered as the one of the key biomarkers in pathogenesis of FSGS. Conclusion : This result would be helpful in diagnosing FSGS and researching FSGS. Further studies for glutathione S-transferase P1-1 might be necessary to elucidate the mechanisms regarding FSGS.

• The Journal of the Korean dental association
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• v.27 no.7 s.242
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• pp.609-610
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• 1989

국소적 소인에 의한 구강내 출혈은 구소적 감염이나 원인 혹은 외상등에 의해 야기되는 것으로 혈액응고에 관여하는 여러인자의 양적, 질적 이상으로 유발되는 출혈성 소인에 의한 출혈과는 구별되어 진다. 대부분의 치과의사가 접할 수 있는 가장 흔한 출혈은 국소적 소인에 의한 것이며, 명심해야 될 사항은 이런 국소적 소인에 전신적 출혈성 소인의 한 요소일 수도 있다는 점이다. 이에 치과의사들은 구강내에서 국소적 원인을 쉽게 발견 치료할 수도 있으나, 전신적 출혈성 소인에 대한 연관성 조사를 항시 염두에 두어야 하겠다. 출혈성 소인에 의한 출혈은 특별한 외상 없이도 되부, 점막, 관절등에 자연히 출혈이 일어나며, 가벼운 외상에 의해서도 쉽게 출혈하는 경향이 있는 점이 국소적 소인에 의한 출혈과의 감별사항이다. 가장 관찰하기 쉬운 곳이 피부 및 점막으로 출혈하여 피가 모인 것을 자반(Purpura)이라 하며, 크기 및 정도에 따라 모세혈관에서의 출혈은 점상출혈(Petechia), 세동맥 및 세정맥에서의 출혈은 반상출혈(Ecchymosis), 좀더 심부에서 출혈하여 촉지되는 혈종(Hematoma)으로 나눌 수 있다. 임상적으로 구별되는 이런 양상을 잘 관찰하고 주의해야 하겠다.

• Clinical and Experimental Pediatrics
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• v.46 no.4
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• pp.351-357
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• 2003

Purpose : To raise awareness of the clinical importance of, and the need for proper management of acute focal bacterial nephritis(AFBN), we analyzed 22 AFBN patients and 22 other upper urinary tract infection patients by use of comparative studies. Methods : From January 2000 to May 2002, 22 AFBN patients aged from 1 month to 12 months were selected. As a control group, 22 UTI patients with no radiologic abnormalities were selected and matched by age and sex. Results : The incidence of AFBN was more common in boys than in girls. Since both groups had similar symptoms, it was difficult to diagnose AFBN by clinical presentations alone. ESR and CRP were significantly higher in AFBN patients. The most common causative organism was E. coli in both groups. On the sonographic findings, the most lesions were seen on the upper lobe of the kidney; more frequently, on left kidney. The lesions showed globular or wedge-shaped increased echogenecity. $^{99m}Tc-DMSA$ scan showed the complete coincidence of the location, size and shape in all cases compared to the findings of renal sonography. Conclusion : The roles of renal sonography and DMSA scan were very important, and ultrasonography was an excellent initial tool in diagnosing AFBN. Since the degree of infection in AFBN is more severe than other urinary tract infections and evollution into a renal abscess is possible, early diagnosis and appropriate antibiotics therapy is essential.

• Investigative Magnetic Resonance Imaging
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• v.11 no.1
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• pp.54-57
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• 2007

Localized nodular synovitis of the knee joint is a rare benign tumorous condition, and should be differentially diagnosed with pigmented villonodular synovitis. We report a case of localized nodular synovitis in the knee that was noted to have a pedicle and characteristic findings on MR image.

• Journal of Chest Surgery
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• v.30 no.3
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• pp.353-353
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• 1997

Localized fibrous tumor of the pleura is a rare condition. Most follow a benign course and they are round as an incidental finding during routine chest X-ray. A small proportion of these tumors are malignant and have characteristic clinical and histopathological features. In this paper, we report three cases of localized fibrous tumors of the pleura, one malignant associated with asymptomatic hypoglycemia, the others benign. In a malignant case, the tumor was reseated through thoracotomy and the hypoglycemia was relieved immediately. In two benign cases, tumors on small pedicles were resected using video-assisted thoracic surgical technique.

• Journal of Chest Surgery
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• v.30 no.3
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• pp.253.2-356
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• 1997

Localized fibrous tumor of the pleura is a rare condition. Most follow a benign course and they are round as an incidental finding during routine chest X-ray. A small proportion of these tumors are malignant and have characteristic clinical and histopathological features. In this paper, we report three cases of localized fibrous tumors of the pleura, one malignant associated with asymptomatic hypoglycemia, the others benign. In a malignant case, the tumor was reseated through thoracotomy and the hypoglycemia was relieved immediately. In two benign cases, tumors on small pedicles were resected using video-assisted thoracic surgical technique.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.4C
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• pp.374-378
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• 2003

The asymptotic performance of the two-sample locally optimum rank detector for random signals buried in signal-dependent noise and additive noise is consigered in this paper. It is shown that the locally optimum rank detector, a nonparametric detector, has reasonable asymptotic performance for a class of correlated random signals, compared with the locally optimum detector. It is noteworthy that the the two-sample locally optimum rank detector perform almost the same with the one-sample locally optimum rank detector.

• Journal of KIISE:Software and Applications
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• v.27 no.7
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• pp.769-783
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• 2000

In this paper, in order to disambiguate Korean noun word sense, we define a local context and explain how to extract it from a raw corpus. Following the intuition that two different nouns are likely to have similar meanings if they occur in the same local context, we use, as a clue, the word that occurs in the same local context where the target noun occurs. This method increases the usability of extracted knowledge and makes it possible to disambiguate the sense of infrequent words. And we can overcome the data sparseness problem by extending the verbs in a local context. The sense of a target noun is decided by the maximum similarity to the clues learned previously. The similarity between two words is computed by their concept distance in the sense hierarchy borrowed from WordNet. By reducing the multiplicity of clues gradually in the process of computing maximum similarity, we can speed up for next time calculation. When a target noun has more than two local contexts, we assign a weight according to the type of each local context to implement the differences according to the strength of semantic restriction of local contexts. As another knowledge source, we get a co-occurrence information from dictionary definitions and example sentences about the target noun. This is used to support local contexts and helps to select the most appropriate sense of the target noun. Through experiments using the proposed method, we discovered that the applicability of local contexts is very high and the co-occurrence information can supplement the local context for the precision. In spite of the high multiplicity of the target nouns used in our experiments, we can achieve higher performance (89.8%) than the supervised methods which use a sense-tagged corpus.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.2
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• pp.176-181
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• 2019

Traditional removable partial denture is a successful treatment for partial edentulous patients. When the abutment is formed with unilateral minority teeth, satisfaction with the use of removable partial denture may be lowered due to patient's discomfort and damage of the abutment. Recently, it has been reported that the unilateral posterior extension partial denture is used as a bilateral posterior extension partial denture using implant fixed prostheses as abutments. In this case, by using implant surveyed crown prostheses, bilateral posterior extension partial denture is fabricated in site that is predicted to have a poor prognosis. This resulted in improved support, maintenance, and stabilization of the removable partial denture, which were economically beneficial to patient and satisfied with use.

• Journal of the Korean Chemical Society
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• v.64 no.6
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• pp.350-353
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• 2020

The validity of the calculation method based on the local mode in hydrogen-bonded water molecules was investigated by comparing the frequencies of the local and normal modes of OH stretching vibration in water molecules. By calculating a monomer, dimer, and trimer of water molecules using a quantum chemical ab initio theory, we examined how the frequencies of the local and normal modes and the anharmonicity of local modes vary with molecular cluster size. It was shown that, as the number of molecules increases from monomer to trimer, the anharmonicity of OH bonds increases and the difference between local and normal mode frequencies decreases. This confirms that local-mode-based calculations that can easily handle the anharmonicity can be appropriate for the calculation of the OH stretching frequency of water molecules in the condensed phase.