• Journal of Life Science
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• v.17 no.5 s.85
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• pp.719-722
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• 2007

IgA nephropathy(IgAN) is considered to be a multifactorial disease with genetic and environmental factors contributing to its pathogenesis. The genes involved in susceptibility and progression of the disease have not yet been clearly elucidated. Megsin is an important candidate gene, predominantly expressed in glomerular mesangium and upregulated in IgAN. To understand biological function of megsin, in this work we have produced transgenic D. melanogaster fly over-expressing human megsin(actin-gal4>UAS-Megsin fly). Introduced human megsin was confirmed by RT-PCR and Western blotting, respectively. Its phenotype is melanin deficiency-abdomen and the megsin gene is stably transferred to the next generations.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.311-316
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• 2017

기후변화는 물 관리 측면에서 많은 변화를 일으키는 것으로 보고되고 있다. 주로 강우의 패턴을 변화시키며, 가용수자원의 지역적 편중을 심화시킨다. 기후변화에 적응하며 안정적이고 균등한 용수확보를 위해서는 홍수와 가뭄을 고려한 연속적인 물 순환 해석기술이 필요하다. 강우유출분석은 강우사상에 대한 수문순환과정을 통해 유출량을 산출하는 것으로, 주로 직접유출과 중간유출이 이에 해당된다. 강우발생 이후 무강우기간에 대해서는 기저시간 이후에 발생되는 유출량의 정량적 산출이 필요하다. 기저유출은 강우 발생 시점에 급격히 발생하기보다는 선행강우에 따른 유역 내 지하수위 분포와 대수층의 특성, 하천수위에 따라 다양한 패턴으로 나타나기 때문에 지하수대의 수리학적 성분들을 반영할 수 있어야 한다. 이를 위해서는 강우유출모의 시 지표유출량 산정과 지하수유동해석을 통한 기저유출량 산정이 동시에 이루어져야 한다. 최근 국내외에서는 다양한 형태의 수문모형과 MODFLOW를 연계한 장기유출분석에 대한 연구가 활발하게 진행되고 있다. 본 연구에서 활용한 K-DRUM(K-water Distribution Runoff Model)은 K-water에서 자체 개발한 물리적 기반의 분포형 강우유출모형으로 강우유출, 유사, 기초수질항목에 대한 3차원 분석이 가능하다. 본 모형의 A층(표층)은 지표유출을 고려한 운동파법이 적용되었고, B층과 C층(중간층), D층(지하수층)은 선형저류법이 적용되었다. MODFLOW(A Modular Three-Dimensional Finite-Difference Ground Water Flow Model)는 1980년대 USGS(United State Geolog ical Survey)에서 개발된 가장 범용적으로 사용되는 지하수유동모형이며, 모듈화 된 구조를 갖고 있어 다양한 패키지 중 필요로 하는 기능을 독립적으로 모의할 수 있는 장점이 있다. 본 연구에서는 향후 기후변화에 따른 강우의 불확실성에 대비한 유역의 장기 물순환 해석을 위해 강우유출모형인 K-DRUM과 지하수유동모형인 MODFLOW를 연계하고자한다. 연계방법은 K-DRUM에서 계산된 D층으로 침루되는 양을 MODFLOW의 함양량으로 적용하고, MODFLOW에서 산출된 기저유량을 K-DRUM의 하천유출에 적용하는 것이다. 본 연구의 성과를 갈수기 유출해석에 적용하면 정확성을 크게 향상시킬 수 있을 것으로 판단된다.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.1
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• pp.225-234
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• 2019

By using the Triboelectric nanogenerators, known as TENG, we can take advantages of high conversion efficiency and continuous power output even with small vibrating energy sources. Nonlinear energy extraction techniques for Triboelectric vibration energy harvesting usually requires synchronized active electronic switches in most electronic interface circuits. This study presents a nonlinear energy harvesting with high energy conversion efficiency to harvest and save energies from human active motions. Moreover, the proposed design can harvest and store energy from sway motions around different directions on a horizontal plane efficiently. Finally, we conducted a comparative analysis of a multi-mode energy storage board developed by a silicon-based piezoelectricity and a transparent TENG cell. As a result, the experiment showed power generation of about 49.2mW/count from theses multi-fully harvesting source with provision of stable energy storages.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.918-925
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• 2021

The perovskite solar cell is a next-generation solar cell that replaces the existing silicon solar cell. It is a solar cell device using an organic-inorganic hybrid material having a perovskite structure as a photoactive layer. It has advantages for the process and has shown rapid efficiency improvement over the past decade. In the process of commercialization of such perovskite solar cells, research and development for a large-area coating method should be carried out. As one of the large-area perovskite solar cell large-area coating methods, the slot-die coating method was studied. By using a meniscus to pass over the substrate and coating the solution, the 3D printer was equipped with a meniscus so that it could be coated. Variables that act during coating include bed temperature, coating speed, N₂ blowing interval, N₂ blowing height, N₂ blowing intensity, etc. By controlling these, the perovskite absorption layer was manufactured and the coating conditions for manufacturing large-area devices were optimized.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.195-195
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• 2021

최근 기후변화, 과도한 지하수 이용 등으로 유역 환경이 변화하고 있으며, 이에 따른 부작용으로 하천의 건천화, 지표유출량 증가, 증발산량 감소 등 물순환 구조가 왜곡되고 있다. 물순환 과정은 지역적 조건에 따라 다르게 나타나며, 모의 요소와 해석 기법도 다르다. 따라서 지속가능하고 건전화된 물순환을 위해 해당 유역의 물순환계를 정확히 파악하고 고려하여 객관적으로 정량화할 수 있어야 한다. 현재 우리나라 농업유역은 논, 용·배수로, 농업용 저수지가 존재하며, 종합적인 농촌용수 물순환 해석을 위해 농촌용수 요소별 해석 기술 및 모듈 개발, 모델링 기법 등을 이용하여 농촌수자원의 체계적·과학적 해석 및 관리 시스템 개발이 이루어져야 한다. 본 연구에서는 강원도 원주시에 위치한 흥업저수지를 대상으로 농촌용수의 물순환 과정을 정립하였으며, 저수지 시점부·말단부, 농업용 저수지, 저수지 유역으로 구분하여 물순환 분석을 수행하였다. 물순환 모의 요소로 저수지 수위, 유역 유출량, 수로부 공급량 및 배수량, 회귀수량 등으로 선정하였으며, 수로 네트워크 기반의 SWMM (Storm Water Management Model) 모형을 이용하여 종합적인 농촌용수 물순환 해석을 수행하였다. 또한, 물순환 해석 기법의 적용성 검증을 위해 모의 요소별 모니터링을 수행하였으며, SWMM 모형과 모니터링을 비교하여 적용성을 평가하였다. 본 연구 결과를 통해 농촌지역 특성 및 기후변화를 고려한 농촌수자원의 안정적인 공급과 국가 청정 수자원 확보를 위한 통합 물관리 정책을 실현하는데 기초 자료로써 활용 가능할 것이라 사료된다.

• Korean Chemical Engineering Research
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• v.61 no.4
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• pp.598-603
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• 2023

Electrochemical ammonia production using catalysts offers a promising alternative to the conventional Haber-Bosch process, allowing for ambient temperature and pressure conditions, environmentally friendly operations, and high-purity ammonia production. In this study, we focus on the nitrogen reduction reactions occurring on the surfaces of ruthenium catalysts, employing first-principles calculations. By modeling reaction pathways for nitrogen reduction on the (0001) and (1000) surfaces of ruthenium, we optimized the reaction structures and predicted favorable pathways for each step. We found that the adsorption configuration of N₂ on each surface significantly influenced subsequent reaction activities. On the (0001) surface of ruthenium, the end-on configuration, where nitrogen molecules adsorb perpendicularly to the surface, exhibited the most favorable N₂ adsorption energy. Similarly, on the (1000) surface, the end-on configuration showed the most stable adsorption energy values. Subsequently, through optimized hydrogen adsorption in both distal and alternating configurations, we theoretically elucidated the complete reaction pathways required for the final desorption of NH₃.

• The Korean Journal of Applied Statistics
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• v.37 no.1
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• pp.61-72
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• 2024

The purpose of this study is to investigate retest reliabilities in longitudinal study, the same test is administered repeatedly over time. Linear mixed models were used to establish various situations of tests occurred in longitudinal study. Combination of two types of true value and three types of systematic error was considered. In order to apply the models to real longitudinal data, height data from the Berkeley growth study and vocabulary score data from the University of Chicago experimental school were used. Using the mixed model, there is an advantage that the reliability can be determined by selecting the covariance structure of the true value and the error separately. However, in order to properly analyze the reliability, researchers need to consider variations that can occur in measurement, such as characteristics of subject, the test, and the the treatment applied in the study. And the proper model should be selected and the quality of the measurement should be evaluated for each trial.

• Journal of the Korea Society of Computer and Information
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• v.29 no.10
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• pp.157-164
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• 2024

In this paper, we propose a technique that utilizes the physical properties of foam particles to synthesize foam sounds and efficiently control their size. A typical way to represent sound in physics-based simulation environments is to generate and synthesize virtual sounds. In particular, foam particles have a large number of particles, so synthesizing sounds using only particles is computationally expensive, and a way to reduce the amount of computation is to use spatial information, lattices. In this paper, we present a method for reliably mapping and clustering foam particles into a lattice space. Furthermore, we utilize this structure to control the loudness of the sound according to the location of the sound source and the audience. As a result, the method proposed in this paper proposes an efficient way to synthesize the sound of bubble particles, which utilizes the velocity and position of the bubble particles projected in the lattice space, and synthesizes the sound of bubble particles based on the position relationship of the audience and the directionality of the sound.

• Journal of School Social Work
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• v.43
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• pp.49-79
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• 2018

The purpose of this study was to understand the experiences on the school life and career choice of youths who aged out from institutional care. For the purpose, we conducted two sessions of in-depth interviews for each of eight youths We analyzed youth descriptions by utilizing Giorgi's phenomenological approach for qualitative research. For this, firstly, we separated meaning units from the youths' descriptions and drew three categories and eight sub-categories from the meaning units. The three categories were 'What I learned at school is shame', 'I learned how to live in school', and 'The graduation of high school as a good student is a condition for safe escape from the institution. The study participants became aware of the negative social perceptions toward institution children in their school lifes. The participants have commonly shared their experiences of being hurt by the perceptions. However, they have learned how to protect themselves and adapted to school life. Additionally, they took advantage of the public benefits and cares in career choice by adapting to the controls of institutions for successful aging out. Based on the findings, we suggest practice and policy implications for youths in institutional care.

• Journal of Life Science
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• v.18 no.2
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• pp.264-272
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• 2008

The lactate dehydrogenase (EC 1.1.1.27, LDH) isozymes in tissues from Acanthogobius hasta were characterized by biochemical, immunochemical and kinetic methods. The activities of LDH in skeletal muscle and eye tissues were 65.30 and 53.25 units, but LDH activities in heart and liver tissues were very low. LDH/CS (EC 4.1.3.7, citrate synthase) in skeletal muscle was the highest as 22.29. Specific activities of LDH in brain, eye and skeletal muscle were 56.45, 38.04 and 11.0 units/mg, respectively. The LDH isozymes in tissues were separated by polyacrylamide gel electrophoresis after immunoprecipitation with antiserum against $A_4,\;B_4$ eye-specific $C_4$ and liver-specific $C_4$. LDH $AC_4$ isozymes were detected predominantly in skeletal muscle, brain and eye tissues, and $B_4$ isozyme was detected in heart. Anodal eye-specific $C_4$ and cathodal liver-specific $C_4$ were coexpressed in A. hasta. The eye-specific $C_4$ isozyme showed higher activity in eye tissue, but liver-specific $C_4$ isozyme showed lower activity in liver. As a result, one part of molecular structures in $A_4\;and\;C_4,\;A_4\;and\;B_4$, and eye-specific $C_4$ and liver-specific $C_4$ were similar, but in $B_4\;and\;C_4$ were different with each other. Therefore the subunit A may be conservative in evolution, and the evolution of subunit B seems to be faster than that of subunit A. The LDH $A_4$ isozyme of skeletal muscle was purified in the fraction from elution with NAD+ containing buffer of affinity chromatography and eye-specific $C_4$ isozyme was eluted right after $A_4$, so the structure of eye-specific $C_4$ isozyme is similar to $A_4$. And LDH activity remained 35.22-43.47% as a result of the inhibition by pyruvate, the Michaelis-Menten constant values for pyruvate was 0.080-0.098 mM, and Vmax were 153.85 units, 35.09 units in skeletal muscle and eye, respectively. Also the $B_4$ isozyme was the thermo-stablest and $C_4$ was stabler than $A_4$ isozyme. The optimum pH of LDH was 6.5. The results mentioned above indicate that isozymes in tissues showed the properties between LDH $A_4\;and\;B_4$ isozyme as A. hasta was adapted to hypoxic conditions. Also LDH seems to function more effectively under anaerobic condition because LDH in skeletal muscle and eye tissues have high affinity for pyruvate.