• The Korean Journal of Oral and Maxillofacial Pathology
• /
• v.41 no.4
• /
• pp.155-162
• /
• 2017

Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.

• The Korean Journal of Oral and Maxillofacial Pathology
• /
• v.42 no.6
• /
• pp.167-174
• /
• 2018

Natural products are vastly utilized as a source of chemotherapeutic agents for human cancers. Kochia scopraia is traditionally used for the cure of urological and dermatological diseases. Recently, methanol extract of Kochia scoparia (MEKS) has been shown to have anti-cancer activity to various human cancers. However, there is no report demonstrating the anti-cancer activity of MEKS in human mucoepidermoid carcinoma (MEC) cells. In this study, the authors studied the effects of MEKS on the cell proliferation and underlying mechanism in YD15 human MEC cells. MEKS decreased YD15 cell proliferation proven by trypan blue exclusion assay and induced apoptosis, evidenced by cell cycle analysis and western blotting. Autophagy induction by MEKS was verified by western blotting. In addition, MEKS regulated the expression of phosphorylated Akt, phosphorylated p38 and Nrf2 protein. This results can imply that MEKS might be a potential candidate for the treatment of human MEC cells.

• The Journal of the Korean dental association
• /
• v.22 no.5 s.180
• /
• pp.387-392
• /
• 1984

외상의 처치는 일반적으로 응급처치기(emergency 혹은 initial phase), 중간처치기 (intermidiate 혹은 planning phase) 그리고 항구치료기 (definitive phase)로 구분되며 응급처치의 범주내에서는 우선 환자의 생명유지를 고려하고 다음엔 창의 생활력(vitality)을 유지하여 장차의 조직결손과 기능적 결합을 예방하는 데 목적이 있다. 그러므로 구강 및 악안면의 광범한 외상은 기도확보, 대량실혈의 방지, shock의 예방 (수액보충 등) 및 감염대책 등의 순으로 응급대처하게 된다. 그러나 일반 개원임상의들이 자주 접하는 비교적 작은 외상에서는 위의 대원칙에 더하여 창상의 효과적인 1차적 처치에 더욱 관심을 갖어 조직의 괴사나 결손 및 변형으로 인한 기능적 심미적 장애를 최솔 하는 것이 중요하다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.19 no.4
• /
• pp.435-446
• /
• 1997

Overall study was carried out for the patients visiting Department of Oral & Maxillofacial Surgery through Emergency Room in Chonnam University Hospital, from Jan. 1, 1992 to Dec. 31, 1996. Result obtained were as follows ; Male predilection was shown, the male to female ratio being 2.5 to 1. The frequently developing age group were the first 3rd and 4th decade and under the age of 9 was followed. The number of patients for emergency was peak in September and October to 11%. About the causes for emergency, traffic accident was the most, and fall down injury and assault were followed. About the injury lists, facial laceration was preceded and the next facial bone fracture and the tooth injury followed. In the facial bone fracture, fracture in the mandible only was the most, and zygomaticomaxillary complex fracture, and mandible-maxilla complex fracture were followed. when the case of the mandible fracture, symphysis, condyle, angle were marked in succession. 57% was predomunatly ranged in the timea of 18 : 00 to 03 : 00 for the emergency. From injury onset to visiting emergency room, the range of 8 hours to 12 hours was predominant. Above results suggest that urgent patients of oral and maxillofacial area were relatively so high that division of oral and maxillofacial surgery should be established immediately.

• The Journal of the Korean dental association
• /
• v.27 no.4 s.239
• /
• pp.363-365
• /
• 1989

• The Journal of the Korean dental association
• /
• v.43 no.10 s.437
• /
• pp.654-661
• /
• 2005

• The Journal of the Korean dental association
• /
• v.46 no.12
• /
• pp.716-726
• /
• 2008

• Journal of The Korean Dental Society of Anesthesiology
• /
• v.11 no.1
• /
• pp.1-8
• /
• 2011

• Journal of The Korean Radiological Technologist Association
• /
• v.29 no.1
• /
• pp.257-257
• /
• 2003

• The Journal of the Korean dental association
• /
• v.20 no.9 s.160
• /
• pp.749-752
• /
• 1982

언청이 환자에 있어 문제가 되는 것은 Speech, mastication, Deglutition, Occlusion, Cosmetics 등이며 소아과, 성형외과, Speech therapist, 구강외과, 교정과, 악안면 보철과 등이 Team member로 구성되고 개개인의 환자는 각자의 상태에 따라서 기능적으로나 심미적으로 최선의 치료를 받게된다.