• Journal of Korean Society of Transportation
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• v.23 no.8 s.86
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• pp.203-213
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• 2005

Recently, with the increase of the interest to global environmental problems, bicycle has been recognized as the most environmentally friendly transportation mode. To promote cycling, it is necessary to ensure road space that bicycle can keep running safely and smoothly. This paper aims to evaluate the district with rearranged road space and network, given priority to bicycle, comparing the traditional district which are given priority to car from viewpoints of environment, safety and accessibility. As evaluation indicators, the carbon dioxide emission on the environment. the number of collision between car and bicycle on safety and an accumulated frequency measure on accessibility were used. As the result, it was clarified that bicycle road measures to create bicycle road by reallocation of road space and form bicycle exclusive network were effective.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.3
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• pp.255-267
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• 2008

Using the commercial CFD code FLOW-$3D^{(R)}$ which has an implicit General Moving Object (GMO) method, the ship-induced wave has been simulated. In the implicit GMO method of the FLOW-$3D^{(R)}$, a rigid body's motion which is either user-prescribed (prescribed motion) or dynamically coupled to fluid flow (coupled motion) can be computed with six degrees of freedom (DOF). The simulated horizontal wave patterns are agree with the wave patterns represented by depth Froude number. The model has been well-simulated to generate the depth-dependent wave transformation in comparison of uniform depth case to complicated depth case. Additionally, it shows that ship-induced waves have been reasonably generated by two ships passing each other and by a ship moving in a curve. Therefore, it is suggested that the FLOW-$3D^{(R)}$ model calibrated with observed data should provide more accurate prediction for the ship-induced wave in a certain fairway or harbor.

• Investigative Magnetic Resonance Imaging
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• v.15 no.2
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• pp.154-159
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• 2011

Testicular epidermoid cyst is a rare benign tumor, accounting for 1-2% of all testicular tumors. It can be cured by organ preserving surgery, so accurate preoperative diagnosis is very important for preventing unneccessary and extensive orchiectomy. We experienced a case of an 18-year-old man who presented with a painless lump in his right testis. The testicular mass showed an onion ring sign on ultrasonography. Computed tomography images showed the mass as a low attenuating lesion with curvilinear calcification. On Magnetic resonance imaging (MRI), the mass appeared as high signal intensity with internal alternating low signal intensity patterns on T2-weighted images. The mass was displayed as having homogeneous high signal intensity on diffusion magnetic resonance imaging and showed lower apparent diffusion coefficient values than normal testis parenchyma, similar to intracranial epidermoid cysts. Testicular MRI with DWI and ADC map can help to more accurately diagnose testicular epidermoid cyst.

• Korean Journal of Clinical Pharmacy
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• v.16 no.1
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• pp.69-74
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• 2006

날트렉손은 ${\mu}-opioid$ 수용체에 특이적이고 선택적으로 길항작용을 나타내어 마약이나 마약성 진통제의 강한 의존성 치료에 쓰일 뿐만 아니라, 알코올 의존성 치료에도 쓰이는 약물이다. 본 연구는 날트렉손 제제인 레비아 정 (50 mg tablet, 제일약품) 을 대조약으로 하여 시험약인 명인 제약의 트락손 50 mg정의 생물학적 동등성 평가를 하기 위해 22명의 건강한 지원자를 모집하였다. 지원자를 두 군으로 나누어 1정씩 투여하였고 $2{\times}2$ 교차시험을 실시하였다. 날트렉손의 혈장 중의 농도를 정량하기 위하여 발리데이션된 LC/MS/MS를 사용하였다. 채혈 시간은 투약 전 및 투약 후 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 9, 12 시간에 걸쳐 시행하였다. 생물학적 동등성을 판정하기 위한 파라미터로 12시간까지의 혈장 중 농도 곡선 하 면적$(AUC_{12hr})$과 최고 혈중 농도 $(C_{max})$를 사용하였다. $AUC_{12hr}$의 평균은 $43.45ng{\cdot}hr/ml$ (시험약)과 $43.31ng{\cdot}hr/ml$ (대조약) 으로 관찰되었고, $C_{max}$의 경우 각각 12.01 ng/m1 (시험약)과 12.27 ng/ml (대조약)으로 관찰되었다. $AUC_{12hr}$의 경우 로그변환 한 평균치 차의 90%의 신뢰구간이 log0.95-log1.07이었고, $C_{max}$의 경우 log0.87-log1.14로 계산되어 두 항목 모두 log0.8-log1.25이어야 한다는 식품의약품 안전청과 FDA의 기준을 모두 만족시켰다. 이상의 결과를 종합하면 시험약 트락손 정 50mg 은 대조약 레비아 정 50 mg에 대하여 생물학적으로 동등한 것으로 판정되었다.

• Korean Journal of Clinical Pharmacy
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• v.15 no.2
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• pp.160-164
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• 2005

수마트립탄은 뇌혈관에 분포되어 있는 5-HT1B/1D수용체에 특이적이고 선택적으로 작용하여 뇌혈관 수축 작용을 나타내어 편두통의 치료에 널리 쓰이는 약물이다. 본 연구는 수마트립탄 제제인 이미그란(50 mg tablet, GSK사)을 대조약으로 하여 시험약인 명인 제약의 수마트란 50mg정의 생물학적 동등성 평가를 하기 위해 22명의 건강한 지원자를 모집하였다. 지원자를 두 군으로 나누어 1정씩 투여하였고 $2{\times}2$ 교차시험을 실시하였다. 수마트립탄의 혈장 중의 농도를 정량하기 위하여 발리데이션된 HPLC/FD를 사용하였다. 채혈 시간은 투약 전 및 투약 후 0.5, 1, 1.5, 2, 2.5, 3,4, 5, 7, 9, 12시간에 걸쳐 총 12시점에 걸쳐 시행하였다. 생물학적 동등성을 판정하기 위한 파라미터로 12시간까지의 혈장 중 농도 곡선 하 면적$(AUC_{12hr})$ 최고 혈중 농도$(C_{max})$를 사용하였다. $AUC_{12hr}$의 평균은 $137.87ng{\cdot}ml/hr$(시험약)과 $130.12ng{\cdot}ml/hr$(대조약)으로 나타났다. $C_{max}$의 경우 각 각 29.30 ng/ml(시험약)과 29.25ng/m1(대조약)으로 관찰되었다. $AUC_{12hr}$의 경우 로그변환 한 평균치 차의 90% 신뢰구간이 log0.95-log1.24이었고, $C_{max}$의 경우 log0.90-log1.149로 계산되 어 두 항목 모두 log0.8-log1.25이어야 한다는 식품의 약품 안전청 과 FDA의 기준을 모두 만족시켰다. 이상의 결과를 종합하면 시험약 수마트란 정 50 mg은 대조약 이미그란 정 50 mg에 대하여 생물학적으로 동등한 것으로 판정되었다.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.11
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• pp.966-977
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• 2015

This paper presents a novel modified coaxial cavity resonator and its application to bandpass filters with compact size and improved quality factor(Q-factor). The proposed resonator is made up of ${\Gamma}-shape$ or curved four inner conductive posts within a single cavity, which provides quadruplet to realize bandpass filter. No metallic walls inside the cavity are required, and thus the utilization efficiency of the cavity space is improved. As a result, the unloaded Q can be approximately 15 % higher in comparison to the conventional coaxial resonator, or more than 35 % volume saving can be achieved while maintaining the similar Q-factor value with the conventional designs. In addition, due to the multiple cross-coupling occurring within the cavity, including the source-to-load coupling, four flexible transmission zeros can be created to realize different filtering functions. Simulations as well as experimental results of four- and eight-pole filters are presented to validate this attractive design concept. Good agreement between measured and computed results is obtained.

• Korean Journal of Microbiology
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• v.40 no.3
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• pp.232-236
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• 2004

We investigated hydrogen peroxide resistance of Escherichia coli possessing acetyl xylan esterase(AxeA) of Streptomyces coelicolor A3(2). The induction of AxeA production by isopropyl-$\beta$-thiogalactoside was confirmed by SDS-polyacrylamide gel electrophoresis. The differences in growth between induced and non-induced E. coli were determined by the changes in optical density of cultures after hydrogen peroxide treatment The lethal effect of hydrogen peroxide was observed for non-induced cultures at all concentrations tested in this study (lmM, 2.5mM and 5mM). However, cultures induced for AxeA production resisted the lethal effect, except at 5mM where cells were killed irrespective of the AxeA production. The axeA induction increased survival against 1.5mM hydrogen peroxide from 59% to 74%. In addition, AxeA producing E. coli showed increased survival at $45^{\circ}C$, near maximum growth temperature. Therefore, it was concluded that AxeA conferred a cross-resistance upon the bacterium against both oxidative- and heat stress.

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.456-459
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• 2011

Among the various activated carbons available in the market, an optimum mixing method of two kind activated carbons with different adsorbability was investigated in this study. The representative adsorption behaviors of the activated carbon are the adsorption isotherm plots obtained by the BET-Analysis which suggests also basic information of adsorption filter design. So we have tested three cases with certifications, the one was the extreme case of coal cokes based activated carbon with highest BET-model and coconut-shell based activated carbon with the lowest Langmuir-model, the other middle and cross case were applied this method to two kinds of activated carbons with higher and lower specific surface areas which are not available but supplied as research samples by an authority of an Korean Research Institute.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.3 s.49
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• pp.135-147
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• 2006

The essential information elements for the Earthquake Damage Evaluation System (EDES) of highway bridges are defined in this study, and a database construction method, which fits the circumstances of Korea, is proposed. The information elements for the EDES of highway bridges are categorized in two groups: structure related information, location related information. The structure related information is composed of the fragility curve information which is necessary for earthquake damage evaluation of highway bridges. The data structure of road network, which represents the location related information, is defined in more detail than the existing GIS-based data structure of road network for modeling of junctions. A pilot GIS-based EDES subjected to 110 bridges on expressway in Korea is developed, and it is verified that the proposed database construction method for the EDES can be used to develop a decision making system for quick retrofitting of the seismic damages of highway bridges and road network.

• The Journal of Engineering Geology
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• v.18 no.4
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• pp.439-446
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• 2008

We have developed a method to evaluate pumping rates from a system of pumping-well family. For a given system actual pumping rates depend on pump characteristics and the sum of the static head and the dynamic head. The static head is the elevation difference between the natural groundwater level and the outlet of the pipeline that connects all the wells. Major components of the dynamic head are groundwater drawdown in the well and pipeline head loss. The dynamic head and the pump characteristics depend on the pumping rates. Actual pumping rates are determined at the intersections of the system total-head curves and the pump characteristic curves. The Newton-Raphson's method is used to solve the nonlinear simultaneous equations. The method is applied to a hypothetical well family. Impacts of various design and operational parameters on the pumping rates are analyzed.