• Journal of Life Science
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• v.32 no.3
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• pp.189-195
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• 2022

Kinesin-2 comprises two subfamilies of the heterotrimeric or homodimeric motors found in mammalian cells. Heterotrimeric kinesin-2 consists of kinesin superfamily proteins (KIFs) 3A and 3B and kinesin-associated protein 3 (KAP3), which is a molecular motor protein that moves along microtubules. It plays diverse roles in cargo transport, including anterograde trafficking in cilia, and interacts with many different cargoes and proteins, but their binding proteins have not yet been fully identified. In this study, the yeast two-hybrid assay was used to identify the proteins that interact with the cargo-binding domain (CBD) of KIF3A, and an interaction between KIF3A and brain expressed X-linked 2 (Bex2) was found. Bex2 bound to the CBD-containing C-terminal tail region of KIF3A but did not interact with the same region of KIF3B or KIF5A (a motor protein of kinesin-1). KIF3A interacted with another isoform, Bex1, but did not interact with Bex3. In addition, glutathione S-transferase (GST) pull-downs showed that KIF3A specifically interacts with GST-Bex1 and GST-Bex2 but not with GST alone. When co-expressed in HEK-293T cells, Bex2 co-localized with KIF3A and co-immunoprecipitated with KIF3A and KIF3B but not KIF5B. In combination, these results suggest that Bex2 is capable of binding to heterotrimeric kinesin-2 and may serve as an adaptor protein that links heterotrimeric kinesin-2 with cargo.

• Journal of Science Education
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• v.35 no.2
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• pp.159-172
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• 2011

The purpose of this study is to specify the quality of I-R-E pattern and question-answer affiliation between students and teacher, depending on teacher's career. This study analyzes 6 classroom discourse texts of 6th grade science class. The results of this study are as follows. First, in the case of a newly appointed teacher, I-R-E pattern is appeared repeatedly. Second, in the case of experienced teachers, expended I-R-E pattern is appeared compare with a newly appointed teacher. Third, in the case of a newly appointed teacher, independence relational structure is appeared more repeatedly than other structures. But, in the case of experienced teachers, all kinds of question-answer structures - independence, parallel, insertion, and reorganization relational structure - are appeared more evenly.

• Journal of the Korean association of regional geographers
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• v.22 no.1
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• pp.267-285
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• 2016

This study presents a comparative analysis of newly developed curriculum of Travel Geography as the career elective subject in high school for the 2015 revised curriculum in Korea and Tourism Geography in China. Travel Geography Curriculum comprises subject objectives, the contents organization, and achievement standards which reflect the core concept of geography. It utilizes travel as the topic and frame to raise the availability, interest and empathy in the geography classroom. The main research contents are comparative analysis on the similarities and differences of the subject character, goal, content, teaching-learning method and assessment of the national geography curriculum in Korea and China. Practical implications are presented for textbook compilation of the Travel Geography and its Practice classroom teaching-learning.

• Journal of Korean Academy of Dental Administration
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• v.9 no.1
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• pp.1-6
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• 2021

Measuring and quantifying the burden of disease (BoD) is crucial for healthcare policy-related decisions. For this purpose, summary measures of population health (SMPH) have been proposed to overcome the limitations of prevalence, incidence, and mortality. Oral health remains separated from the mainstream healthcare system, and the lack of reliable epidemiological data has been pointed out as the cause. In this study, we aimed to understand the flow of international and domestic BoD research related to oral disorders and the direction in which those studies should advance in the future. It is necessary to continuously revise the previously measured BoD of oral disorders and calculate the BoD by performing subdivisions, starting from the development of lay descriptions. Furthermore, developing elaborate BoD measurement methodologies that reflect the complexity of the oral cavity is essential.

• Annual Conference of KIPS
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• 2022.05a
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• pp.397-400
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• 2022

본 연구에서는 소셜 네트워크 서비스(Social Network Service, SNS) 데이터로부터 약물 부작용 게시글을 추출하기 위한 순환 신경망(Recurrent Neural Network, RNN) 기반 분류 모델을 제안한다. 먼저, 처방 빈도가 높으며 게시글을 많이 확보할 수 있는 케토프로펜 약물에 대하여 국내 최대 소셜 네트워크 플랫폼인 네이버 블로그와 카페의 게시글(2005 년~2020 년)을 확보하고 최종 3,828 건을 분석하였다. 결과적으로 케토프로펜에 대한 3 종(약물, 부작용, 불용어)의 렉시콘을 정의하였으며 이를 기반으로 Bi-LSTM 분류모델 기준 87%의 정확도를 얻었다. 본 연구에서 제안하는 모델은 SNS 데이터가 약물 부작용 정보 획득을 위한 기존 (전자의무기록, 자발적 약물 부작용 보고 시스템 등) 자료원에 대한 보완적 정보원이 되며, 개발된 Bi-LSTM 분류모델을 통해 약물 부작용 게시글 추출의 편리성을 제공할 것으로 기대된다.

• Journal of Industrial Convergence
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• v.22 no.1
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• pp.177-183
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• 2024

The study investigates the impact of data quality on the performance of artificial intelligence (AI). To this end, the impact of labeling error levels on the performance of artificial intelligence was compared and analyzed through simulation, taking into account the similarity of data features and the imbalance of class composition. As a result, data with high similarity between characteristic variables were found to be more sensitive to labeling accuracy than data with low similarity between characteristic variables. It was observed that artificial intelligence accuracy tended to decrease rapidly as class imbalance increased. This will serve as the fundamental data for evaluating the quality criteria and conducting related research on artificial intelligence learning data.

• School Mathematics
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• v.16 no.4
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• pp.709-726
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• 2014

The purpose of the study was to pay attention to the studies of P. Cobb which have actively been quoted in the international research of mathematics education for the last three decades and to look at the result and effect of his research. In particular, we in-depth studied theories and the methods of the study which he has tried to reduce the gap in the theory and practice and investigated effects of his research to the Korean societies of mathematics education. Cobb made special effort to integrate radical constructivism and social constructivism and used emergent theory and symbolic interactionism as theoretical background of the study. Also he analyzed the mathematics classroom in individual and social perspectives based on the interpretive frames of social norm, sociomathematical norm and classroom-mathematical practices then dealt with equity and identity of the students. Because Cobb contributed significantly to the development of practical theory using design experiment as the method of studies, we presented the definition, characteristics, principles, processes and practices of the design experiment. We anticipate that his ways of research would be used as means of unifying the theory and the practice in school.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.10a
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• pp.842-843
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• 2013

• Journal of the korean academy of Pediatric Dentistry
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• v.48 no.2
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• pp.198-208
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• 2021

The aim of this study was to evaluate the antibacterial effect on Enterococcus Faecalis and physical properties of chitosan added calcium hydroxide canal filling material. Low, medium, high molecular weights of chitosan powder were mixed with calcium hydroxide canal filling material. Also, for each molecular weight group, 1.0, 2.0, 5.0 wt% of chitosan powder were added. An overnight culture of E. faecalis was adjusted to 1 × 10⁶ CFU/ml. For test of antibacterial effect, three different molecular weights of 2.0 wt% chitosan and three different concentrations of high molecular weight chitosan were mixed with calcium hydroxide canal filling material. The absorbance of plates was analyzed using spectrophotometer at 570 nm with a reference wavelength of 600 nm. Physical properties such as flow, film thickness and radiopacity were examined according to ISO 6876 : 2012. All molecular weight type of chitosan containing material showed inhibitory effect against E. faecalis growth compared to non-chitosan added calcium hydroxide canal filling material group (p < 0.05). High molecular weight chitosan containing material showed the most antibacterial effect. Also, the antibacterial effect decreased as the incorporated amount of chitosan decreased (p < 0.05). Every molecular weight group of material containing chitosan had a tendency for reduced flow and radiopacity, increased film thickness according to amount of chitosan. Low molecular weight of 1.0 wt% chitosan addition did not show any significant difference of physical properties compared to conventional calcium hydroxide canal filling material. In conclusion, for reinforcement of antibacterial effect against E. faecalis and for favorable physical properties, 2.0 wt% of chitosan adding is recommended. Considering its antibacterial effect of chitosan, further studies are required for clinical application of chitosan in endodontics and pediatric dentistry.

• Korean Journal of Psychosomatic Medicine
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• v.26 no.2
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• pp.135-144
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• 2018

Objectives : The purpose of this study was to identify the differences of demographic and clinical characteristics between child-adolescents who received medical inpatient care and non-hospitalized adolescents after suicide attempts. Methods : The study included 35 child-adolescents who were hospitalized (Admission group) and 114 child-adolescents who were not hospitalized (Non-Admission group) as a result of a suicide attempt from 2009 to 2015. We compared sociodemographic, clinical, and suicide attempt-related characteristics through a chi-square test and logistic regression analysis to evaluate the differences between the two groups. Results : Child-adolescents of this study most commonly attempted suicide by poisoning, and for motivation of interpersonal problems. Admission group had significantly fewer attempts through injury by sharp objects (${\chi}^2=4.374$, p=0.037) and attempted suicide with a higher chance of actually dying when compared to Risk-Rescue Rating Scale (t=1.981, p=0.049). In addition, Admission group had relatively common motivation for academic problems (${\chi}^2=12.082$, p=0.001) and less motivation for interpersonal difficulties. (${\chi}^2=9.869$, p=0.002) Psychiatric diagnosis at the time of visiting the emergency department showed higher rates of depression in the admission group than Non-Admission group (${\chi}^2=8.649$, p=0.003). The results of logistic regression showed that depression affects hospitalization (OR=2.783, 95% CI 1.092-7.089, p=0.032). Conclusions : This study is meaningful in that it revealed the social and clinical characteristics of all child-adolescents who were hospitalized at a university hospital after attempting suicide. This study identified differences in motivation, methods, and psychiatric diagnosis of hospitalized adolescents and those who were not. Therefore, the results may help adolescent suicide attempters to get a discriminatory approach based on their admission.