• 한국과학교육학회지
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• 제35권1호
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• pp.131-142
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• 2015

이 연구의 목적은 실행공동체(Community of Practice)의 관점에서 과학교실문화를 분석하기 위한 조사도구를 개발하고 이를 적용하여 그 활용가능성을 확인하는 데 있다. 문헌연구를 통하여 실행공동체의 구조적 요인을 설정하고 요인에 따른 예비문항을 개발하였다. 초등학교 4학년, 6학년, 중학교 2학년 총 219명의 학생들에게 예비조사를 실시하여 문항 타당도 및 신뢰도를 검증하였다. 탐색적 요인분석을 통하여 수정된 도구는 '학습 책임감'(responsibility for learning), '공동의 관심사'(common interest), '호혜적 인간관계'(mutual relationships), '개방적 참여'(open participation), '실행'(practice)의 총 5개 요인 27개 문항으로 구성되었다. 개발된 조사도구를 사용하여 초등학교 4학년과 6학년 학생 총 706명을 대상으로 본 조사를 실시하고 확인적 요인분석 및 신뢰도 분석을 실시하였다. 이를 통해 조사도구가 타당한 도구임을 확인하였으며, 초등학교 과학교실 공동체의 특성을 구조적 요인별, 학년별, 성별, 교사 특성별로 비교하여 분석하였다. 이 연구를 통하여 개발된 조사 도구는 공동체적 관점에서 과학교실을 분석하는데 활용될 수 있을 뿐만 아니라 바람직한 과학교실의 공동체를 위한 시사점을 제안할 수 있을 것으로 기대된다.

• 대한치과보철학회지
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• 제59권2호
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• pp.238-247
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• 2021

선천성 치아결손은 가장 흔한 치아의 발육장애인데, 이 중 제3대구치를 제외한 6개 이상의 치아가 상실된 경우를 부분무치증(oligodontia)이라 한다. 이러한 치아결손은 부정교합, 치조제 위축, 심미적인 문제 및 사회심리적인 문제 등을 초래한다. 14개의 영구치 결손과 상악궁의 치조제 위축, 하악의 전돌 등이 관찰되는 부분무치증 환자에서 다학제 치료계획을 수립하였다. 만기잔존유치의 발거와 교정치료를 선행하여 보철수복공간을 확보하고 불량한 치축을 개선하였으나, 구치부 절단교합과 상악 치조제의 위축으로 인한 악궁 간 크기 차이가 잔존하였다. 치아결손 부위에 임플란트 식립을 이용한 고정성 보철수복을 계획하여 심미성과 기능성을 회복하고자 하였다. 골이식을 최소화하도록 임플란트의 식립 부위와 개수를 결정하였고, 보철물의 형태를 고려하였으며, 임시수복물에서 심미성과 교합안정성을 평가하였다. 점진적인 임시수복물 조정과정을 통해 적절한 중심교합과 측방운동 시 균형적인 교합을 형성하였으며, 이를 반영한 최종보철물을 제작하여 수복하였다. 현재 안정적으로 기능하고 있으나 전 생애에 걸친 유지관리 치료가 필요하다.

• 대한중풍순환신경학회지
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• 제6권1호
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• pp.25-32
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• 2005

Background and purpose: Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity (PWV) has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. The Framingham risk score was developed using categorized risk factors to predict the 10 year absolute risk of developing coronary heart disease (CHD). This algorithm is established using recommended guidelines for blood pressure, total cholesterol, and high density lipoprotein cholesterol in addition to age, smoking history and history of diabetes. Tongxinluo(TXL) has been shown to have anti hyperlipidemic activity and anti atherogenic effects. To determine its efficacy and safety, we examined whether TXL improves PWV, ABI, Framingham score, blood pressure, and lipid profile in high risk group of cardiovascular diseases. Subjects and methods: 49 subjects with the high risk of cardiovascular diseases were recruited. Subjects were administered TXL with the dose of 1110mg three times a day for 8 weeks. baPWV, ABI, Framingham risk score, Blood pressure and serum lipid profile were assessed at baseline and after 4 and 8weeks. Results: Total cholesterol, LDL cholesterol, triglyceride, total lipid and phospolipid significantly decreased after 4 weeks of medication. Total cholesterol, total lipid and phospolipid significantly decreased after 8 weeks of medication. There were no significant changes in Framingham risk scores, ABI, PWV and blood pressure. On safety assessment, there were no adverse effects, hepatic or renal toxicity. Conclusion: We suggest that TXL is a safe and useful herbal medicine for hyperlipidemia and as for anti-atherognic effects, further research would be necessary.

• 우울조울병
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• 제9권3호
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• pp.189-193
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• 2011

Objectives : Pro-inflammatory cytokines are related to the pathophysiology of both cancer and depression, and their secretion is controlled by the transcriptional activity of particular gene polymorphisms. This study aimed to investigate whether interleukin (IL)-1β -511C/T gene polymorphism is associated with depression following mastectomy for breast cancer. Methods : A total of 309 patients with breast cancer were evaluated one week after mastectomy, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview, and classified into prevalent, persistent, and incident depression. Associations of IL-1β -511C/T polymorphism with the three depressive status were estimated using logistic regression models. Results : At baseline, 74 (24%) patients were classified with prevalent depression ; and at follow up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. The IL-1β -511T/T genotype was independently associated with prevalent and persistent depression, but not with incident depression. Conclusion : IL-1β -511T/T genotype may involve in the etiology of depression occurring in women with breast cancer who receive a mastectomy.

• 과학과기술
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• 제32권3호통권358호
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• pp.22-23
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• 1999

인간의 혈액세포와 관련된 연구를 계속하고 있는 경북대 의대 임상병리학교실 서장수 교수는 최근 혈액종양세포에서의 약제내성기전과 이를 극복하는 방법 그리고 헤라핀이 혈소판감소증 등을 일으키는 부작용을 밝히는 작업을 하고 있다. 서교수는 97년 미국 혈액학 잡지에 '헤파린유도 혈소판감소증 유발항체의 해파린:혈소판 제4인자 복합체 다면인식'등의 논문을 발표해 전 세계 학계의 관심을 모았다.

• 대한두경부종양학회지
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• 제35권1호
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• pp.41-44
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• 2019

Intraductal papilloma is an extremely rare benign tumor especially when it arises from major salivary gland. Recently, we experienced a case of an intraductal papilloma arising from the parotid gland in a 51-year-old woman. The radiologic finding showed lobulated enhancing and cystic solid mass in the left parotid superficial lobe. Superficial parotidectomy was performed. Pathological findings showed papillary proliferations with fibrovascular cores lined with bland cuboidal or columnar epithelial cells, and immunohistochemical stain results were consistent with intraductal papilloma. We report a case of intraductal papilloma in parotid gland with a review of literature.

• 대한두경부종양학회지
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• 제37권2호
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• pp.97-100
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• 2021

Pilomatricoma(or calcifying epithelioma) is a not common benign solitary tumor originated from outer root sheath cell of hair follicle or hair follicle of sebaceous glands. The tumor usually presents as an asymptomatic, hard, superficial located, and skin colored to reddish blue cutaneous mass. Most of the tumors are less than 10mm in diameter and adherent to the skin. Recently, 48-year-old man presented with cheek mass. The tumor was 2.6cm sized and located at the subcutaneous layer of cheek on CT scan. The tumor was clearly removed via transoral approach with buccal incision leaving no wound on face. The mass was confirmed as pilomatricoma on pathologic examination. Herein, we report our experience with literature review.

• 대한신경과학회지
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• 제36권4호
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• pp.345-349
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• 2018

Familial Creutzfeldt-Jakob Disease (fCJD) is characteristic with older age onset, relatively low occurrence rate, slower progression and lower possibility of developing myoclonus, cerebellar, pyramidal signs and visual disturbance compared with classical sporadic CJD. We report a case of 75-year-old male patient presented with sudden onset of right side weakness with Broca's aphasia who has been diagnosed with fCJD with V180I mutation. This case indicates that fCJD with V180I mutation can have stroke-like initial presentation.

• 대한한방부인과학회지
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• 제22권3호
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• pp.257-266
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• 2009

Purpose: The purpose of this study is to report the clinical effectiveness of Traditional Korean therapy on coccygodynia and depression of postpartum. Methods : The patient in this case was 27-year-old female. The chief complains were coccygodynia and depression. She was treated by Traditional Korean medicine, acupuncture and Chuna Manipulation. The progress of symptoms was evaluated by visual analogue scale(VAS) and Oswestry Disability Index(ODI). Results : After those Traditional Korean therapy, most symptoms were improved. Coccygodynia and uncomfortableness in normal life improved, and ODI was decreased from 35 to 17. Conclusion : This case shows that Traditional Korean therapy might be effective in decreasing symptoms on coccygodynia and depression of postpartum.

• 동의신경정신과학회지
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• 제34권4호
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• pp.487-487
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• 2023