• The Journal of the Korean bone and joint tumor society
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• v.12 no.1
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• pp.47-51
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• 2006

Osteofibrous dysplasia is a rare bone tumor arising in patient younger than 10 years. Because of the frequent local recurrences after intralesional curettage and even after wide extraperiosteal resection, it is difficult to treat. Recurred lesions often showed increased disease activities. We experienced a case of osteofibrous dysplasia arisen in tibia. We treated the recurrent lesion occurred after two times of curettages and bone grafts with wide extraperiosteal segmental resection and reconstruction with free vascularized fibular graft. Here we report the case with review of the related literatures.

• The Journal of the Korean bone and joint tumor society
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• v.5 no.4
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• pp.216-220
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• 1999

The purpose of this study was to evaluate the role of c-fos oncogenes in the development of fibrous dysplasia and osteofibrous dysplasia. The immunohistochemical expression of c-fos protein was evaluated in 15 cases of fibrous dysplasia and 8 cases of osteofibrous dysplasia. Ten cases of fibrous dysplasia were weakly positive with c-fos. Six cases of osteofibrous dysplasia were weakly positive and the remaining two cases were strongly positive. The overall expression of c-fos protein is weaker than high-grade osteosarcoma, thus the implication of c-fos protein is little in the development of these tumors. Fibrous dysplasia and osteofibrous dysplasia share some features of characteristic histology and c-fos expression.