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Anti-inflammatory Effects, Skin Wound Healing, and Stability of Bluish-purple Color Extracted from Platycodon grandiflorus (Jacq.) A.DC. Flower Extract (도라지꽃 추출물의 항염증, 피부재생 효과 및 색소 안정성 연구)

  • Jin-A Ko;Jiwon Han;Bomi Nam;Beom seok Lee;Jiyoung Hwang
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.4
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    • pp.313-321
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    • 2023
  • Platycodon grandiflorus (P. grandiflorus) flower is a perennial plant belonging to the family Campanulaceae and has many excellent pharmacological effects, so it has been used as a medicinal ingredient since ancient times. In addition, anthocyanin is a purple or blue natural pigment contained in plant flowers and fruits, and is known as a powerful antioxidant. The purpose of this study was to confirm the dermatological functionality of P. grandiflorus flower extract and the value of the bluish anthocyanin contained in flowers as a cosmetic material as a natural pigment. Firstly, 50% ethanol and 80% ethanol were added to the P. grandiflorus flower and extracted under reflux for 4 h at 25, 60, and 80 ℃, and the pH of each treatment group was similar. Based on the anthocyanin content and chromaticity (E*ab), 50% ethanol 60 ℃ extraction conditions showing the color development most similar to the natural color of the P. grandifloras flower were selected, and a sample was prepared by concentrating and lyophilizing. The analysis results showed that the total phenol, total flavonoid, and total anthocyanin contents were in the ranges of 23 ㎍/mL, 16 ㎍/mL, and 0.17 ㎍/mL, respectively. The P. grandiflorus flower extract suppressed the production of nitric oxide (NO) and interleukin-6 (IL-6) in lipopolysaccharide (LPS) induced RAW264.7 cells. Furthermore, the P. grandiflorus flower extract showed wound healing effects through the promotion of skin cell migration in TNF-α stimulated human keratinocytes. The stability of anthocyanin and extract color was studied during a storage period of 50 days at various temperatures (4 ℃, 25 ℃, and 45 ℃). Color values (L, a, and b) of the P. grandiflorus flower extract changed over 50 days, whereas the bluish-purple color of the extract was stabilized using 5% maltodextrin. These results suggest that P. grandiflorus flower extract may be useful as a natural cosmetic pigment.

Adolescent's Risk Behavior and the Quality of Life: the Role of Protective Factors on Risk Behavior (청소년의 위험행동과 삶의 질: 위험행동에 대한 보호요인의 역할)

  • Sang-Chul Han
    • Korean Journal of Culture and Social Issue
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    • v.12 no.5_spc
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    • pp.99-116
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    • 2006
  • This paper discuss adolescent's a quality of life related with risk behavior. The purpose of this study investigate to influence on risk behavior(runaway, smoking, sexual behavior) of the protective factors that moderate adolescent's problem behavior(delinquency). The assumption of this study that the protective factors counterbalance the negative influence of risk factors and finally, diminish a the problem behavior including a delinquent. A total of 1,020 students of a vocational high schook and a 216 adolescents of a special groups(the public institution that consisted with a delinquent young man) completed the questionnaires(risk behavior, 5 protective factors) of compiled by this researcher. The protective factors have selected based on the various prior studies analyzed with adolescent's risk behavior a family functioning, a father(a mother) each and child communication, a self efficacy, and a social support. Statistics appled for the data analysis are Chisqure analysis, two-way ANOVA, and Standard Discrimination analysis. The results of this study are as follows. First, the special group is higher than the general group in the rate of runaway, smoking, and sexual deviant behavior. Second, the protective factors are not action in the special group have experienced delinquency, but are only action in the general group consisted with the students of a vocational high schools. This means that the protective factors discriminating the participation of the risk behaviors, and blocking out the intervention of a problem behavior in the general adolescents. Although each protective factor influence to different according to each risk behavior, a role of a parent-child communication, a family functioning, and self-efficacy high orderly. Finally, discussed based on the previous studies that the protective factors moderate the negative influence of risk factors, offset the connection between a risk behavior and a. problem behavior, and improve and a resilience and the quality of life of the adolescents.

Association between seafood intake and depression in Korean adults: analysis of data from the 2014-2020 Korea National Health and Nutrition Examination Survey (한국 성인의 수산물 섭취와 우울증과의 상관성 연구: 2014-2020년도 국민건강영양조사 자료를 이용하여)

  • Hyemin Shin;Won Jang;Yangha Kim
    • Journal of Nutrition and Health
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    • v.56 no.6
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    • pp.702-713
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    • 2023
  • Purpose: Depression is a prevalent mental health concern globally including South Korea. Given the growing interest in the relationship between diet and mental health, this study aimed to investigate the association between seafood consumption and depression among Korean adults. Methods: A cross-sectional analysis was conducted using data from the Korea National Health and Nutrition Examination Survey (KNHANES, 2014-2020). The study included 18,149 participants (7,541 men and 10,608 women) aged 19 years and older who completed the Patient Health Questionnaire (PHQ-9). Seafood intake levels were assessed using a oneday 24-hour dietary recall, and participants were categorized into three tertiles by gender. Depression status was determined using the PHQ-9 scores and the self-report of the doctor's diagnosis and treatment. Multivariable logistic regression analysis was performed to assess the association between seafood consumption and depression in both genders. Results: Participants with a higher seafood intake had a significantly lower nutritional density of total fat, while the nutritional density of omega-3 polyunsaturated fatty acids was significantly higher. The prevalence of depression was significantly lower in the highest tertile of seafood consumption compared to the lowest tertile in both men (p < 0.001) and women (p < 0.001). After adjusting for confounding factors, the highest tertile of seafood consumption demonstrated a decreased risk of depression compared to the lowest tertile in men (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.51-0.99; p-trend = 0.020) and women (OR, 0.73; 95% CI, 0.59-0.91; p-trend = 0.004). Conclusion: The findings of this study suggest that consuming seafood rich in omega-3 fatty acids may potentially reduce the risk of depression in the adult population.

Mitigation Effect on Airborne Particulate Matter Concentration by Roadside Green Space Type and Impact of Wind Speed (도로변 녹지 유형별 미세먼지 농도 저감 효과와 이에 대한 풍속의 영향 연구)

  • Tae-Young Choi;Da-In Kang;Jaegyu Cha
    • Journal of Environmental Impact Assessment
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    • v.32 no.6
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    • pp.437-449
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    • 2023
  • This study measured PM10 concentrations and wind speeds in buffer green spaces and neighborhood parks located along the road, and compared them with roadside measurementresults to understand the effect of mitigating PM10 concentrations by type of green space and the influence of wind speeds on it. As a result of the analysis, the effect of mitigating PM10 concentration was different depending on the type of roadside green space, and an increase in wind speed had a significant effect on reducing PM10 concentration. In buffer green areas with high planting density, wind speed was low and PM10 stagnated inside, resulting in the highest concentration. On the other hand, green areas in neighborhood parks with relatively low planting density had high wind speeds and the lowest PM10 concentration. The non-green area within the neighborhood park recorded the highest wind speed, which was advantageous for the spread of PM10, but the concentration was higherthan that of the green area. Therefore, in orderto reduce PM10 concentration in roadside green space, it is necessary to create green space with good ventilation, and the combined effect of green space and wind speed seems to be more advantageous in reducing PM10 concentration. Green spaces capture and remove PM inside, contributing to reducing the concentration of PM outside. In order to manage PM in the entire city and on roads, it is necessary to increase planting density and leaf area in roadside green spaces, such as buffer green spaces, so that PM can be removed within the green spaces. However, in green spaces such as neighborhood parks that are actively used by city residents, in orderto minimize damage to users due to PM, it is desirable to create green spaces with a structure that allows PM to spread to the outside rather than stagnate inside.

A study on spatial onset characteristics of flash drought based on GLDAS evaporative stress in the Korean Peninsula (GLDAS 증발 스트레스 기반 한반도 돌발가뭄의 공간적 발생 특성 연구)

  • Kang, Minsun;Jeong, Jaehwan;Lee, Seulchan;Choi, Minha
    • Journal of Korea Water Resources Association
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    • v.56 no.10
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    • pp.631-639
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    • 2023
  • Flash drought (FD), characterized by the rapid onset and intensification, can significantly impact ecosystems and induce immediate water stress. A more comprehensive understanding of the causes and characteristics of FD events is required to enhance drought monitoring. Therefore, we investigated the FD events took place over the Korean peninsula using Global Land Data Assimilation System (GLDAS) data from 2012 to 2022. We first detected FD events using the stress-based method (Standardized Evaporative Stress Ratio, SESR), and analyzed the frequency and duration of FDs. The FD events were classified into three cases based on the variations in Actual Evapotranspiration (AET) and potential Evapotranspiration (PET), and spatially analyzed. Results revealed that there are regional disparities in frequency and duration of FDs, with a mean frequency of 6.4 and duration of 31 days. When classified into Case 1 (normal condition), Case 2 (AET-driven), and Case 3 (PET-driven), we found that Case 2 FDs emerged approximately 1.5 times more frequently than those driven by PET (Case 3) across the Korean peninsula. Case 2 FDs were found to be induced under water-limited conditions, and led both AET and PET to be decreased. Conversely, Case 3 FDs occurred under energy-limited conditions, with increase in both. Case 2 FDs predominantly affected the northwestern and central-southern agricultural regions, while Case 3 occurred in the eastern region, characterized by forested land cover. These findings offers insights into our understanding of FDs over the Korean peninsula, considering climate factors, land cover, and water availability.

Analyze Technologies and Trends in Commercialized Radiology Artificial Intelligence Medical Device (상용화된 영상의학 인공지능 의료기기의 기술 및 동향 분석)

  • Chang-Hwa Han
    • Journal of the Korean Society of Radiology
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    • v.17 no.6
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    • pp.881-887
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    • 2023
  • This study aims to analyze the development and current trends of AI-based medical imaging devices commercialized in South Korea. As of September 30, 2023, there were a total of 186 AI-based medical devices licensed, certified, and reported to the Korean Ministry of Food and Drug Safety, of which 138 were related to imaging. The study comprehensively examined the yearly approval trends, equipment types, application areas, and key functions from 2018 to 2023. The study found that the number of AI medical devices started from four products in 2018 and grew steadily until 2023, with a sharp increase after 2020. This can be attributed to the interaction between the advancement of AI technology and the increasing demand in the medical field. By equipment, AI medical devices were developed in the order of CT, X-ray, and MR, which reflects the characteristics and clinical importance of the images of each equipment. This study found that the development of AI medical devices for specific areas such as the thorax, cranial nerves, and musculoskeletal system is active, and the main functions are medical image analysis, detection and diagnosis assistance, and image transmission. These results suggest that AI's pattern recognition and data analysis capabilities are playing an important role in the medical imaging field. In addition, this study examined the number of Korean products that have received international certifications, particularly the US FDA and European CE. The results show that many products have been certified by both organizations, indicating that Korean AI medical devices are in line with international standards and are competitive in the global market. By analyzing the impact of AI technology on medical imaging and its potential for development, this study provides important implications for future research and development directions. However, challenges such as regulatory aspects, data quality and accessibility, and clinical validity are also pointed out, requiring continued research and improvement on these issues.

Size-dependent Transcriptional Modulation of Genes Involved in Cytochrome P450 Family in the Brackish Water Flea Diaphanosoma celebensis Exposed to Polystyrene Beads (기수산물벼룩 Diaphanosoma celebensis의 미세플라스틱 노출에 따른 크기 의존적 Cytochrome P450 유전자의 발현 양상)

  • Min Jeong Jeon;Je-Won Yoo;Young-Mi Lee
    • Journal of Marine Life Science
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    • v.8 no.2
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    • pp.104-114
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    • 2023
  • As plastic usage increases globally, the amount of plastic waste entering the marine environment is steadily rising. Microplastics, in particular, can be ingested by marine organisms and accumulated in their digestive tracts, causing harmful effects on their growth and reproduction. Cytochrome P450 (CYP) enzymes are known to metabolize various environmental pollutants as detoxification enzymes, but their role in crustaceans is not well understood. In this study, sequences of nine CYP genes (CYP370A4, CYP370C5 from clan 2; CYP350A1, CYP350C5, CYP361A1 from clan 3; CYP4AN-like, CYP4AP2, CYP4AP3, CYP4C33-like1 from clan 4) were analyzed using conserved domains in the brackish water flea Diaphanosoma celebensis. Additionally, after exposure to three different sizes of polystyrene beads (0.05-, 0.5-, 6-㎛ PS beads; 0.1, 1, and 10 mg/L) for 48 hours, the expression of these nine CYP genes were investigated using real-time reverse transcription polymerase chain reaction (RT-PCR). The results showed that all CYP genes possessed conserved motifs, indicating that D. celebensis CYP has evolutionarily conserved functions. Among these CYP genes, the expression of CYP370C5, CYP360A1, and CYP4C122 showed a significant increase after exposure to 0.05-㎛ PS beads, suggesting their involvement in PS metabolism. This research will contribute to understanding the molecular mode of actions of microplastics on marine invertebrates.

A Study on the Bioactivity Exploration of the Collected Marine Microorganisms and Microalgaes in Korea (우리나라에서 확보한 해양미생물과 미세조류에 대한 기초생리활성 연구)

  • Seung Sub Bae;Yong Min Kwon;Dawoon Chung;Woon-Jong Yu;Kichul Cho;Eun-Seo Cho;Yoon-Hee Jung;Yun Gyeong Park;Hyemi Ahn;Dae-Sung Lee;Jin-Soo Park;Jaewook Lee;Dong-Chan Oh;Ki-Bong Oh;EunJi Cho;Sang-Ik Park;You-Jin Jeon;Hyo-Geun Lee;Keun-Yong Kim;Sang-Jip Nam;Hyukjae Choi;Cheol Ho Pan;Grace Choi
    • Journal of Marine Life Science
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    • v.8 no.2
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    • pp.136-149
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    • 2023
  • Basic bioactivities (antioxidant, anti-inflammatory, antibacterial, anticancer, antiviral) were investigated from 370 strains of marine bacteria, fungi, and microalgae obtained from various marine environmental regions in Korea, and the activity results were obtained at the collection site, isolation source, and species level was compared. In the case of marine bacteria, strains belonging to the generally useful genera Streptomyces and Bacillus were observed to have particularly strong efficacy and useful resources were mainly isolated from marine sediments. In the case of marine fungi and microalgae, results showing strong species-specific activity were confirmed, and results showing efficacy-specific activity were also obtained. Based on these results, it is a research result that can facilitate priority access as a strategic material for industrial revitalization and the establishment of a strategy to secure resources based on usefulness when conducting research on chemicals that are selectively effective against specific diseases or when conducting resource-based research. In addition, we believe that by using these results as material for sale through the Marine BioBank (MBB), academia and industry can use them to help accelerate the revitalization of the marine bio industry.

Community Structure of Natural Monument Forest (Forest of Japanese Torreyas in Pyeongdae-ri, Jeju and Subtropical Forest of Nabeup-ri, Jeju) in Jeju-do (제주도 천연기념물 수림지(제주 평대리 비자나무 숲과 제주 납읍리 난대림)의 군집구조)

  • Jeong Eun Lee;Yo Seob Hwang;Ho Jin Kim;Ju Heung Lee;Chung Weon Yun
    • Journal of Korean Society of Forest Science
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    • v.112 no.4
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    • pp.393-404
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    • 2023
  • The Natural Monument Forest (NMF) is a form of natural and cultural heritage that has symbolized the harmony between nature and culture in Korea for a long time. Recently, the NMF has deteriorated due to industrialization and reckless city expansion. Given this situation, it is necessary to preserve and manage the ecosystem of the NMF through preferential research regarding the forest community structure. Accordingly, this study sought to identify the community structure by analyzing the vegetation classification, stratum structure,and species diversity using vegetation data collected from the Forest of Japanese Torreyas in Pyeongdae-ri, Jeju and the Subtropical Forest of Nabeup-ri, Jeju. The results classified the forest vegetation as a Litsea japonica community group divided into two communities: a Torreya nuciferacommunity and a Quercus glauca community. The T. nuciferacommunity was subdivided into the Idesia polycarpa group and Dryopteris erythrosora group, while the Q. glauca community was subdivided into the Mercurialis leiocarpa group and Arachniodes aristata group. The T. nucifera species showed the highest level of importance in vegetation units 1 (Litsea japonicacommunity group-Torreya nucifera community-Idesia polycarpa group) and 2 (Litsea japonica community group-Torreya nucifera community-Dryopteris erythrosora group), whereas Q. glauca showed the highest level of importance in vegetation units 3 (Litsea japonica community group-Quercus glauca community-Mercurialis leiocarpa group) and 4 (Litsea japonica community group-Quercus glauca community-Arachniodes aristata group). In terms of the species diversity, vegetation units 1, 2, 3, and 4 had 2.866, 2.716, 2.222, and 2.326 species, respectively. These findings suggest that it is necessary to prepare a differentiated management plan for each vegetation unit.

Evaluation of Applicability of Sea Ice Monitoring Using Random Forest Model Based on GOCI-II Images: A Study of Liaodong Bay 2021-2022 (GOCI-II 영상 기반 Random Forest 모델을 이용한 해빙 모니터링 적용 가능성 평가: 2021-2022년 랴오둥만을 대상으로)

  • Jinyeong Kim;Soyeong Jang;Jaeyeop Kwon;Tae-Ho Kim
    • Korean Journal of Remote Sensing
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    • v.39 no.6_2
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    • pp.1651-1669
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    • 2023
  • Sea ice currently covers approximately 7% of the world's ocean area, primarily concentrated in polar and high-altitude regions, subject to seasonal and annual variations. It is very important to analyze the area and type classification of sea ice through time series monitoring because sea ice is formed in various types on a large spatial scale, and oil and gas exploration and other marine activities are rapidly increasing. Currently, research on the type and area of sea ice is being conducted based on high-resolution satellite images and field measurement data, but there is a limit to sea ice monitoring by acquiring field measurement data. High-resolution optical satellite images can visually detect and identify types of sea ice in a wide range and can compensate for gaps in sea ice monitoring using Geostationary Ocean Color Imager-II (GOCI-II), an ocean satellite with short time resolution. This study tried to find out the possibility of utilizing sea ice monitoring by training a rule-based machine learning model based on learning data produced using high-resolution optical satellite images and performing detection on GOCI-II images. Learning materials were extracted from Liaodong Bay in the Bohai Sea from 2021 to 2022, and a Random Forest (RF) model using GOCI-II was constructed to compare qualitative and quantitative with sea ice areas obtained from existing normalized difference snow index (NDSI) based and high-resolution satellite images. Unlike NDSI index-based results, which underestimated the sea ice area, this study detected relatively detailed sea ice areas and confirmed that sea ice can be classified by type, enabling sea ice monitoring. If the accuracy of the detection model is improved through the construction of continuous learning materials and influencing factors on sea ice formation in the future, it is expected that it can be used in the field of sea ice monitoring in high-altitude ocean areas.