• Childhood Kidney Diseases
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• v.5 no.2
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• pp.117-124
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• 2001

Purpose : Since Mendoza(1990)'s report that long term methylprednisolone pulse therapy by Mendoza protocol (MP therapy) is a good treatment option in focal segmental glomerulosclerosis(FSGS), there have been reports of the effects of this therapy in steroid-resistant nephrotic syndrome. However, no studies have been performed on the effects of MP therapy in steroid- dependent nephrotic syndrome and secondary nephrotic syndrome. In this study, we investigated the effects of long term MP therapy in primary and secondary nephrotic syndrome in which previous treatment options were not effective. Methods : We chose 10 children who were diagnosed with steroid-dependent minimal change nephrotic syndrome(SD-MCNS), who had shown frequent relapse during the immunocompromised or cytotoxic therapy Period, and 6 children with FSGS and 5 children with secondary nephrotic syndrome children, who had shown no response during the previous therapy period. We treated these patients according to Mendoza protocol involving infusions of high doses of methylprednisolone, often in combination with oral cyclophosphamide for 82 weeks. Results : In all the 10 children with SD-MCNS, complete remission was visible on average of $18{\pm}9$ days after MP therapy was started. However, all these children relapsed during or after MP therapy. In these children, the mean relapse rate prior to MP therapy was $2.1{\pm}1.0$ relpases/year, which was reduced to $1.4{\pm}0.9$ relapses/year during MP therapy(P>0.05) and rose to $2.7{\pm}1.0$ relapse/year after MP therapy. Of the 6 children with FSGS, 4 children($67\%$) showed complete remission, of whom 3 children($50\%$) remained in the remission status during the follow up period, $1.2{\pm}0.7$ years, after the end of MP therapy. 2 children($33\%$) showed no response. All of the 5 children with secondary nephrotic syndrome showed remission and remained in the remissiom status during the follow up period, $1.7{\pm}0.6$ years The only side effect of MP therapy was transient hypertension in 10 children of ail subjects during the intravenous infusion of methylprednisolone. Conclusion : We conclude that although long term MP therapy is not effective in the treatment of SD-MCNS, it is an effective therapy against intractable FSGS and secondary nephrotic syndrome. (J Korean Soc Pediatr Nephrol 2001 ; 5 : 117-24)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.3
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• pp.350-354
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• 2008

Mandibular chronic osteomyelitis with diffuse osteosclerosis is recognized as an intractable infectious disease. We emplyed decortication and intraarterial infusion of antibiotics in 6 cases. Decortication on the affected mandible was performed with retrocatherization to the superficial temporal artery of affected side under general anesthesia. Antibiotics, IPM/CS or FOMX was used through the artery for 4-11 days. In addition, we administered FOMX, PIPC intravenously for 8-17 days. CT and MRI were taken postoperatively. The postoperative follow-up period ranged from 1 year and 6 months to 2 years and 5 months. Postoperative MR showed that bone marrow signal was recovered to approximately normal in 4 cases. High signal area of bone marrow and osteosclerosis image remained in 2 cases, but showed improvement. The results were satisfactory without recurrence in all of 6 cases.

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.212-215
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• 2005

Renal artery stenosis is a major cause of renovascular hypertension and the most common cause of treatable secondary hypertension. There are several methods to treat renal artery stenosis, including surgery, percutaneous transluminal renal angioplasty(PTRA), and renal artery stenting(RAS). But, renal artery embolization can be tried in atherosclerotic stenosis, multiple stenosis, microaneurysm, and stenosis difficult to try PTRA or RAS. We report a case of renovascular hypertension in a 14-year-old female who had multiple segmental renal artery stenosis. Hypertension was controlled by renal ablation therapy with renal artery embolization.

• Industry Promotion Research
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• v.6 no.4
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• pp.47-58
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• 2021

The purpose of this study is to analyze the effect of reminiscence-based collective art therapy on the depression, interpersonal relationships, and the subjective sense of happiness among the elderly with dementia. The study was conducted on 30 volunteers with dementia aged 65 or older attending the S Weekly Care Center located in S-gun as subjects during the period between November 7, 2020 and January 2, 2021 with one session week for a total of 12 sessions. The SPSS 24.0 statistics program has been used for various data analyses, including confidence verification, cross tabulation analysis, independent sample T-test, 3×2 multi-variant analysis. The study findings are as follows. First, the collective art therapy based on reminiscence therapy is effective in reducing the depression among the elderly with dementia. Second, the collective art therapy based on reminiscence therapy is effective in promoting interpersonal relationships among the elderly with dementia. Third, the collective art therapy based on reminiscence therapy is effective in improving the subjective sense of happiness among the elderly with dementia. Therefore, the reminiscence-based collective art therapy is found to serve as an effective means to relieve depression, improve interpersonal relationships and to promote a subjective sense of happiness among elderly people witn dementia.

• Industry Promotion Research
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• v.6 no.4
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• pp.59-68
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• 2021

This study has identified the effect of reminiscence-based collective art therapy on the depression, interpersonal relationships, and the subjective sense of happiness among the elderly with dementia. The study was conducted on 30 volunteers with dementia aged 65 or older attending the S Weekly Care Center located in S-gun as subjects during the period between November 7, 2020 and January 2, 2021 with one session week for a total of 12 sessions. The SPSS 24.0 statistics program has been used for various data analyses, including confidence verification, cross tabulation analysis independent sample T-test, 3×2 multi-variant analysis, and the intergroup independent sample T-test between the groups. The study findings are as follows, First, the collective art therapy based on reminiscence therapy is effective in reducing the depression among the elderly with dementia. Second, the collective art therapy based on reminiscence therapy is effective in promoting interpersonal relationships among the elderly with dementia. Third, the collective art therapy based on reminiscence therapy is effective in improving the subjective sense of happiness among the elderly with dementia. These study findings are meaningful in that they have provided an informative basic data on the reminiscence-based collective art therapy.

• Korean Journal of Head & Neck Oncology
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• v.12 no.1
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• pp.65-68
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• 1996

The incidence of plunging ranula has been reported as about 10% of all ranula cases. Treatment consists of wide surgical excision or marsupialization. However, it seldom provides a satisfactory result and various modalities of treatment have been proposed in addition to surgical extirpation. We reported our experience using intralesional OK-432 sclerotherapy for a case of plunging ranula in 20 year-old male patient. The OK-432 solution was prepared by dissolving 0.1 KE in 2ml of physiologic saline and was instilled in the same amount of the aspirated cystic fluid. Following two instillations, the lesion completely disappeared. The side effects were mild fever for 3 days and a mild local induration for several days. At present, 9 months after instillation, no recurrence was observed. OK-432 sclerotherapy appears to be simple, safe and effective method for the treatment of plunging ranula.

• 건강소식
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• v.32 no.6
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• pp.6-11
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• 2008

매스컴을 통해 유명인사의 갑작스런 죽음에 대한 소식을 접하곤 한다. 그중에는 암이나 교통사고 등이 원인인 경우도 있으나, 최근에는 급성 심장사 또는 급성 심근경색증이 원인인 경우도 많다. 굳이 연예인을 예로 들지 않더라도, 지난 10년 간 심장병 사망률은 약 3배 이상 증가하였다. 이는 대부분 동맥경화성 혈관 변화에 의한 급성 심근경색증이나 급성 심실성 부정맥으로 발생한 급성 심장사가 주 원인이다. 우리나라는 이런 심장병의 발병률 또한 점점 증가하고 있다고 한다. 실제 미국에서는 지난 10년 전과 비교하면 심장병의 발병률은 정체 상태이고, 사망률은 약 30% 정도 감소하였다. 물론 우리나라 국민들도 예방을 위해 식이요법, 운동요법, 금연 등 건강관리에 힘쓰고 있지만, 아직 발병률이나 사망률은 줄이지 못하고 있다. 아마도 사회가 너무 빨리 서구화 되고 인구가 고령화되어, 이러한 변화를 따라가지 못하고 있는 것으로 생각된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.4
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• pp.280-285
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• 2010

Hemangioma and vascular malformation is a common vascular benign lesion in the head and neck region. The lesion is a congenital malformation observed in neonates. The treatment this lesion includes surgical excision, cryotherapy, selective embolization and treatment with sclerotic agents. We present three cases of benign oral vascular lesions treated with an intralesional injection of sodium tetradecyl sulfate. The lesions virtually disappeared after three sessions of sclerotherapy, leaving an inconspicuous scar. No side effects were observed. Sclerotherapy with sodium tetradecyl sulfate is effective in treating benign oral vascular lesions, and the use of the sodium tetradecyl sulfate provides alternative or support for surgical methods.

• The Monthly Diabetes
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• s.285
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• pp.35-40
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• 2013

최근 몸짱에 대한 열풍은 연예인들이 몇 달간 식이요법과 유산소 운동 그리고 웨이트 트레이닝을 통한 자기관리로 멋진 근육을 드러내 보이면서 많은 이들에게 호감을 갖게 한다. 운동의 효과는 전세계적으로 하루에도 수십편의 연구논문들이 쏟아져 나오고 있다. 현재까지 죽상동맥경화로 인한 심혈관 질환과 뇌혈관질환의 예방과 치료에 있어 운동은 절대적인 역할을 하고 있다. 뇌심혈관질환의 위험요인 중 흡연이나, 음주, 비만, 당뇨, 고혈압 외에 증상이 거의 없어 고혈압과 더불어 "침묵의 살인자"라고 불리우는 고지혈증은 건강검진을 받아보다가 우연하게 발견되기도 한다. 일반인들도 뇌심혈관질환에 위험요인이 위 항목들인 것을 대부분 알고 있지만 운동을 하지 않는 좌업식 생활을 하는 비활동인이 뇌심혈관 질환의 위험요인으로 포함된 것은 오래된 일이 아니다. 이번을 기회로 운동의 중요성을 언급하면서 고지혈증과 운동을 중심으로 기술하고자 한다.

• Tuberculosis and Respiratory Diseases
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• v.54 no.4
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• pp.415-428
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• 2003

Background : This study assessed the efficacy and toxicity of etoposide and carboplatin(EC) combination regimen as a first line therapy for small cell lung cancer(SCLC), and determined the efficacy and toxicity of topotecan for relapsed SCLC. Methods : One hundred and ten patients with previously untreated SCLC received etoposide($100mg/m^2$ i.v., day 1 to 3) and carboplatin($300mg/m^2$ i.v., day 1) combination chemotherapy every 3 weeks. For patients with relapsed SCLC after EC therapy, topotecan($1.5mg/m^2$) was administered for 5 consecutive days every 3 weeks. Response rate, survival and toxicity profiles were assessed. Response was recorded as CR(complete remission), PR(partial remission), SD(stable disease) and PD(progressive disease). Results : One hundred and one patients were assessed for response to EC. Overall response rate to EC was 57.4%(CR 15.8%, PR 41.6%) with a time to progression of 10.3 months(median). The toxicity was tolerable and there was no treatment-related death. Twenty one relapsed SCLC patients were treated with topotecan. Of those who relapsed within 3 months of EC(refractory relapse, RR), 15.4%(2/13) showed PR, while of those who relapsed after 3 months(sensitive relapse, SR), 25%(2/8) exhibited PR. Grade 4 neutropenia was noted in 9.5% and 14.3% showed thrombocytopenia(G4). Conclusion : The EC regimen showed a moderate response rate for SCLC with minimal toxicity. The use of topotecan for relapsed SCLC warrants further investigation.