• Korean Journal of Psychosomatic Medicine
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• v.22 no.1
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• pp.40-45
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• 2014

Objectives : Mild cognitive impairment(MCI) and dementia of Alzheimer's type(AD) are characterized by progressive decline of cognitive abilities and a wide range of neuropsychiatric symptoms like depression. Among various diagnostic tools of AD, many studies showed that elevated levels of serum total homocysteine are associated with increased risk of developing Alzheimer's disease, depression and other neuropsychiatric disorders. We investigated whether elevated homocysteine concentrations are associated with depressive symptoms in MCI and AD. Methods : A total of 86 patients diagnosed with MCI or AD participated. Total serum homocysteine levels in fasting blood samples were measured. We examined cognitive symptoms by MMSE-KC, Global Deterioration Scale(GDS), Clinical dementia rating(CDR) and depressive symptoms by Korean version of Geriatric Depression Scale(K-GDS). Results : The total serum homocysteine levels were significantly higher in MCI with depression than in MCI without depression. There was no significant difference in the mean homocysteine levels between AD patients with depression and AD patients without depression. The total homocysteine levels showed a negative correlation with MMSE-KC and a positive correlation with CDR, GDS. Conclusions : These findings suggest that elevated homocysteine level is a risk factor for the decline of cognitive function and depression. We found a significant relationship between elevated serum homocysteine level and depressive symptoms in MCI. But our study had several limitations, thus more research is needed to confirm this finding.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.178-185
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• 2018

A self-report evaluation is used to prevent driving accidents by elderly drivers. The majority of normal older adults may have mild cognitive impairment with reduced cognitive function. These depressed cognitive functions may be variables that affect the performance of elderly drivers. This study confirmed the cognitive functions that affect the self-reported evaluation for elderly drivers with mild cognitive impairment. Based on the results of the Korean Version of the Montreal Cognitive Assessment, 103 elderly drivers were classified into mild cognitive impairment and normal groups of elderly drivers. The Korean-Drivers 65 plus scores used in the self-reported evaluation of the two groups were compared, and the cognitive functions affecting the evaluation were analyzed. Results found the mild cognitive impairment group showed a significantly lower evaluation performance compared to the normal group, and the self-reported evaluation results of the elderly driver with mild cognitive impairment showed a significant correlation between visuoconstructional skills and delayed recall. As a result of regression analysis, the visuoconstructional skill was identified as the cognitive function with the strongest influence on the self-reported evaluation performance. Delayed recall was also found to have a partial effect but not at the level of altering the self-reported evaluation results of the elderly driver with mild cognitive impairment.

• Journal of Preventive Medicine and Public Health
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• v.30 no.3 s.58
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• pp.630-642
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• 1997

The purpose of this study was to examine the mortality risk associated with cognitive impairment among the rural elderly. The subjective of study was 558 of 'A Study on the Depression and Cognitive Impairment in the Rural Elderly' of Jung Ae Rhee and Hyang Gyun Jung's study(1993). Cognitive impairment and other social and health factors were assessed in 558 elderly rural community residents. For this study, a Korean version of the Mini-Mental State Examination(MMSEK) was used as a global indicator of cognitive functioning. And mortality risk factors for each cognitive impairment subgroup were identified by univariate and multivariate Cox regression analysis. At baseline 22.6% of the sample were mildly impaired and 14.2% were severely impaired. As the age increased, the cognitive function was more impaired. Sexual difference was existed in the cognitive function level. Also the variables such as smoking habits, physical disorders had the significant relationship with cognitive function impairment. Across a 3-year observation period the mortality rate was 8.5% for the cognitively unimpaired, 11.1% for the mildly impaired, and 16.5% for the severly impaired respendents. And the survival probability was .92 for the cognitively unimpaired, .90 for the mildly impaired, and .86 for the severly impaired respondents. Compared to survival curve for the cognitively unimpaired group, each survival curve for the mildly and the severely impaired group was not significantly different. When adjustments models were not made for the effects of other health and social covariates, each hazard ratio of death of mildly and severely impaired persons was not significantly different as compared with the cognitively unimpaired. But, as MMSEK score increased, significantly hazard ratio of death decreased. Employing Cox univariate proportional hazards model, statistically other significant variables were age, monthly income, smoking habits, physical disorders. Also when adjustments were made for the effects of other health and social covariates, there was no difference in hazard ratio of death between those with severe or mild impairment and unimpaired persons. And as MMSEK score increased, significantly hazard ratio of death did not decrease. Employing Cox multivariate proportional hazards model, statistically other significant variables were age, monthly income, physical disorders. Employing Cox multivariate proportional hazards model by sex, at men and women statistically significant variable was only age. For both men and women, also cognitive impairment was not a significant risk factor. Other investigators have found that cognitive impairment is a significant predictor of mortality. But we didn't find that it is a significant predictor of mortality. Even though the conclusions of our study were not related to cognitive impairment and mortality, early detection of impaired cognition and attention to associated health problems could improve the quality of life of these older adults and perhaps extend their survival.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.551-556
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• 2023

This study was attempted to confirm whether the color therapy intervention study on the elderly with mild cognitive impairment was effective in cognitive function and depression as a method of meta-analysis. In this study, the size of the effect of cognitive function and depression on the final eight studies of the experimental study was calculated through a domestic database from 2000 to October 2022. As a result, the statistically significant average effect size of the entire study was confirmed. In the test of the difference in effect size between groups, both cognitive function and depression were found to have significant effect sizes. Through this study, it was confirmed that calerotherapy is an effective intervention that can improve cognitive function and alleviate depression in the elderly with mild cognitive impairment. Based on the results of this study, it is necessary to develop an intervention program for the elderly with mild cognitive impairment using calerotherapy.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.295-303
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• 2020

The purpose of this study was to find out whether the cognitive function, depression, and health promotion lifestyle changes are maintained or improved through the dementia prevention program when applying the dementia prevention program along with the daily life management program to the elderly with mild cognitive impairment. The study was conducted from April 1 to August 9, 2019, and 30 elderly people with mild cognitive impairment who participated in the dementia prevention program at the Dementia Safty Center in Seoul were studied. The study found that cognitive function (MMSE-DS) and health promotion lifestyle (HPLP-II) were maintained and improved compared to control groups in the experimental group that voluntarily implemented daily life management programs along with dementia prevention programs, and that depression (SF-GDS) decreased. Therefore, based on the results of this study, in future studies, we hope to develop a variety of voluntary daily life management programs to maintain and improve the effectiveness of the dementia prevention program for a long period of time. I hope that the prospective study will be done.

• Journal of the Korean Society of Radiology
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• v.8 no.4
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• pp.163-170
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• 2014

This study is to investigate neuro-anatomical correlation between neuropsychological results and cerebral cortex thickness of cognitive ability in the brain MRI targeting the patients with mild cognitive impairment. It was that 78 people who were diagnosed as first Parkinson's disease followed by neuropsychological screening battery(Parkinson's disease with mild cognitive impairment: 39 people; Parkinson's disease with normal cognition: 39 people) and 32 people of normal group were selected. Correlation between mild cognitive impairment and normal cognitive impairment and correlation between neuropsychological screening battery and cerebral cortex thickness in the brain MRI were performed by independent sample t-test or Pearson correlation coefficient and then level of significance of collected data was verified in p<0.05. As a result, cerebral cortex thickness of the Parkinson's disease with mild cognitive impairment in both side precuneas and right inferiortemporal lobe had statistically significant decrease. In addition, function of visuospatial ability, verbal and visual memory was reduced in neuropsychological screening battery for cognitive assessment. Especially, there was correlation between neuropsychological screening battery of verbal and visual memory anatomical left precuneus.

• 한국노년학
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• v.38 no.1
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• pp.1-14
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• 2018

Everyday hearing handicap caused by presbycusis ultimately reduces quality of life in older adults. The aim of this study was to explore effects of cognitive impairment on self-reported hearing handicap in older adults with early-stage presbycusis. We compared K-HHIE scores between 40 elderly subjects with mild cognitive impairment (MCI) and age- and hearing-threshold matched 40 cognitively normal elderly (CNE) subjects. The results are as follows: 1) The MCI group scored significantly higher than the CNE group on the social/situational and emotional sections, and in total. 2) The MCI group scored significantly higher than the CNE group on all four subscales, and the most significant group difference was on the first subscale relating to interpersonal relationships and social handicaps. 3) Both groups scored highest on the item 8 (problems hearing whispering sounds) and item 15 (problems hearing TV or radio sounds). Besides those two items, the MCI group also scored high on the item 21 (problems hearing in a restaurant), item 6 (problems hearing when attending a party), item 3 (avoiding groups of people), and item 20 (personal or social restrictions). Our findings suggest that, among older adults with early-stage presbycusis, older adults with cognitive impairment tend to report greater everyday hearing handicap than their peers with normal cognitive function. Especially, they show significant problems hearing in background noise or multi-talker situations, which cause social restrictions and social/emotional loneliness.

• Journal of Korea Entertainment Industry Association
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• v.15 no.7
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• pp.215-223
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• 2021

The purpose of this study is to investigate the effect of computerized cognitive therapy on cognitive function and Instrumental Activities of Daily Living for elderly people with mild cognitive impairment living in the community. 22 MCI elderly people were randomly assigned to 11 experimental group and 11 control group. For a total of 10 weeks, 3 times a week, 30 minutes per session, the experimental group received CoTras and the control group received traditional cognitive rehabilitation. Neurobehavioral Cognitive Status Examination(NCSE) and Korean Instrumental Activities of Daily Living(K-IADL) were used to investigate the changes in cognitive function and performance of instrumental activities of daily living before and after the intervention. As a result of the study, the experimental group showed improvement in overall cognitive function, including attention and memory, and performance in IADL. The use of CoTras may be considered to improve cognitive function and performance of instrumental activities of daily living for the elderly with mild cognitive impairment in the community.

• Journal of Digital Convergence
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• v.19 no.3
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• pp.471-482
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• 2021

We aimed to provide evidences for developing non-pharmacological intervention in older adults with Mild Cognitive Impairment(MCI) by integrated literature review. The final 16 papers were selected as a result of an integrated literature analysis. All of them are focused on strengthening cognitive activities, while Korean studies have often merged emotional activities such as music therapy and laughter therapy rather than physical activities such as exercise therapy, international studies have combined physical activities rather than emotional activities. The effects of non-pharmacological intervention differed according to the outcome variables. The primary variables were cognitive function and depression, and secondary variables were found to have effects on physical function, activities of daily living (ADL), and self-efficacy. This study contributes to a multidisciplinary approach that can be applied in the clinical field through the development of various non-pharmaceutical intervention for the prevention of dementia in the older adults with MCI.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.749-751
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• 2016

Due to the advent of virtual reality, the past communication method using images and video through the expansion into three-dimensional space has been provided more realistic and seamless interaction environment. Unlike reality, virtual reality is under a full human control and due to this benefit can be used as a substitute for reality therefore medicine and healthcare area has attracted attention in the prevention and treatment of dementia utilizing virtual reality. The research provided in this paper is aimed to design a virtual reality-based mild cognitive impairment prevention training system, focusing on the Symptoms of Alzheimer's precursor, mild cognitive impairment.